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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Structure and function of epididymal protein cysteine-rich secretory protein-1显示文摘充满半胱氨酸的能分泌的 protein-1 (CRISP-1 ) 是 theepididymal 上皮分泌的糖蛋白。它是二个保存领域和一套 16 保存半胱氨酸残余描绘的蛋白质的一个大家庭的一个成员。在哺乳动物, CRISP-1 禁止精子鸡蛋熔化和罐头压制精子 capacitation。未知的哺乳动物的 CRISPproteins 遗体的行动的分子的机制,而是某些非哺乳动物的松脆的蛋白质能堵住离子隧道。在 ther 在, CRISP-1 包括叫作蛋白质 D 和 E 的二种形式。在我们的实验室的最近的工作证明 CRISP-1 的 D 形式与精子表面短暂地联系,而 Eform 紧绑。当精子被洗时,在所有 D 形式分裂了以后, CRISP-1 的 E 形式在精子表面上坚持。Cross-linking 研究为 D 和 E 表明 differentprotein 蛋白质相互作用模式,尽管为任何一个蛋白质的有约束力的搭挡还都没被识别。集体度谱的分析在不是 D 形式上的现在的 E 形式上揭示了潜在的 post-translationalmodification。这是蛋白质 D 和 E 之间的唯一的可辨别的差别,并且大概为在老鼠 CRISP-1 的这二种形式的行为的差别负责。这些研究证明更丰富的 D 形式短暂地与精子交往,可能与精子上的特定的受体出现,与 压制capacitation 功能一致在在附睾的精子运输和存储期间,并且也证实一紧绑能在女繁殖的道行动的 E 形式的人口。 | Kenneth P. Roberts Daniel S. Johnston Michael A. Nolan Joseph L. Wooters Nicole C. Waxmonsky Laura B. Piehl Kathy M. Ensrud-Bowlin David W. Hamilton | 2007 | Asian Journal of Andrology2007，9，4： | 4 |
| 3 | Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and in Situ Models: Relationship to Absorption in Humans显示文摘 | Barbra H. Stewart O. Helen Chan Rosalind H. Lu Eric L. Reyner Heidi L. Schmid Harriet W. Hamilton Bruce A. Steinbaugh Michael D. Taylor | 1995 | Pharmaceutical Research1995，，5： | 2 |
| 4 | Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease显示文摘 | Noori S. Al-Waili MD PhD Glenn J. Butler CHT Jorge Beale MD Mahdi S. Abdullah MD R. W. Bill Hamilton Boke Y. Lee MD Paul Lucus PhD Michael W. Allen CHT Richard L. Petrillo MD Zev Carrey MD Michael Finkelstein MD | 2005 | Advances in Therapy2005，，6： | 1 |
| 5 | Large scale analysis of virulence genes in Escherichia coli strains isolated from Avalon Bay, CA显示文摘 | Matthew J. Hamilton Asbah Z. Hadi John F. Griffith Satoshi Ishii Michael J. Sadowsky | 2010 | Water Research2010，，18： | 1 |
| 6 | Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers显示文摘 | Antoun Toubaji Moujahed Achtar Maurizio Provenzano Vincent E. Herrin Robert Behrens Michael Hamilton Sarah Bernstein David Venzon Barry Gause Francesco Marincola Samir N. Khleif | 2008 | Cancer Immunology Immunotherapy2008，，9： | 1 |
| 7 | Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy显示文摘 | Delyth Graham Ngan N. Huynh Carlene A. Hamilton Elisabeth Beattie Robin A.J. Smith Helena M. Cochemé Michael P. Murphy Anna F. Dominiczak | 2009 | Hypertension2009，，2： | 1 |
| 8 | The association between statin medication and progression after surgery for localized renal cell carcinoma显示文摘 | Robert J. Hamilton Daniel Morilla Fernando Cabrera Michael Leapman Ling Y. Chen Melanie Bernstein A Ari Hakimi Victor E. Reuter Paul Russo | 2013 | The Journal of Urology2013，，： | 1 |
| 9 | 925j Optimising post-operative Crohn’s disease management: best drug therapy alone versus colonoscopic monitoring with treatment step-up. The POCER study.显示文摘 | Peter De Cruz Michael A. Kamm Amy L. Hamilton Kathryn J. Ritchie Soula Krejany Alexandra Gorelik Danny Liew Lani Prideaux Ian C. Lawrance Jane M. Andrews Peter A. Bampton Miles Sparrow Timothy H. Florin Peter R. Gibson Henry Debinski Richard B. Gearry Fin | 2013 | Gastroenterology2013，，5： | 1 |
| 10 | In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent显示文摘 | René M. Botnar Alexandra S. Perez Sonia Witte Andrea J. Wiethoff James Laredo James Hamilton William Quist Edward C. Parsons Anand Vaidya Andrew Kolodziej John A. Barrett Philip B. Graham Robert M. Weisskoff Warren J. Manning Michael T. Johnstone | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 1 |
| 11 | The ef- fect of screen size on video - based perceptual decision mak- ing tasks in sport显示文摘 | Michael Spittlel Peter Kremerl& Justin Hamilton | 2010 | International Journal of Sport and Exer- cise Psychology2010，8，4： | 1 |
| 12 | Arrhythmia and Mortality After the Mustard Procedure: A 30-Year Single-Center Experience显示文摘 | Mark Gelatt Robert M Hamilton Brian W McCrindle Michael Connelly Andrew Davis Louise Harris Robert M Gow William G Williams George A Trusler Robert M Freedom | 1997 | Journal of the American College of Cardiology1997，，1： | 1 |
| 13 | Biomimetic modification of titanium dental implant model surfaces using the RGDSP-peptide sequence: A cell morphology study显示文摘 | Martin Schuler Gethin Rh. Owen Douglas W. Hamilton Michael de Wild Marcus Textor Donald M. Brunette Samuele G.P. Tosatti | 2006 | Biomaterials2006，，21： | 1 |
| 14 | High - throughput and quantitative procedure for determining sources of Escherichia coli in waterways by using host - specific DNA marker genes 显示文摘 | Tao Yah Matthew J Hamilton Michael J Sadowsky | 2007 | Appl Enviton Microbiol2007，73，3： | 1 |
| 15 | Genuine Savings Rates in Developing Countries显示文摘 | Kirk Hamilton Michael Clemens | 1999 | World Bank Economic Review1999，13，2： | 1 |
| 16 | Cost-effectiveness of Crohn's disease post-operative care显示文摘AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn's disease following intestinal resection.METHODS: In the 'POCER' study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care(6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin(FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 mo.RESULTS: Sixty patients(active care n = 43, standardcare n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those inremission [ $ 26347( IQR 25045-27485) vs $2729(IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence prevented. CONCLUSION: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated. | Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny Liew | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 17 | Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease显示文摘 | Noori S. Al-Waili MD PhD Glenn J. Butler CHT Jorge Beale MD Mahdi S. Abdullah MD R. W. Bill Hamilton Boke Y. Lee MD Paul Lucus PhD Michael W. Allen CHT Richard L. Petrillo MD Zev Carrey MD Michael Finkelstein MD | 2005 | Advances in Therapy2005，，6： | 1 |
| 18 | A review on the visible light active titanium dioxide photocatalysts for environmental applications显示文摘 | Miguel Pelaez Nicholas T. Nolan Suresh C. Pillai Michael K. Seery Polycarpos Falaras Athanassios G. Kontos Patrick S.M. Dunlop Jeremy W.J. Hamilton J.Anthony Byrne Kevin O’Shea Mohammad H. Entezari Dionysios D. Dionysiou | 2012 | Applied Catalysis B: Environmental2012，，： | 1 |
| 19 | Goal-directed therapy in high-risk surgical patients: a 15-year follow-up study显示文摘 | Andrew Rhodes Maurizio Cecconi Mark Hamilton Jan Poloniecki Justin Woods Owen Boyd David Bennett R. Michael Grounds | 2010 | Intensive Care Medicine2010，，8： | 1 |
| 20 | Impact of Teaching Facility Status and High-Volume Centers on Outcomes for Lung Cancer Resection: An Examination of 13,469 Surgical Patients显示文摘 | Michael C. Cheung MD Kara Hamilton MS Recinda Sherman BS Margaret M. Byrne PhD Dao M. Nguyen MD Dido Franceschi MD Leonidas G. Koniaris MD | 2009 | Annals of Surgical Oncology2009，，1： | 1 |
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