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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay:optimization,standardization and diagnostic criteria显示文摘Serologicaldiagnosisofnasopharyngealcarcinomabyenzymelinkedimmunosorbantasay:optimization,standardizationanddiagnosticcriteri... | M.H. Ng, H.L. Chen, R.X. Luo, K.H. Chan, P.C.Y. Woo, J.S.T. Sham, J. Huang, W.H.Seto P. Smith and B.E. Griffin | 1998 | Chinese Medical Journal1998，，6： | 8 |
| 3 | NUMERICAL MODELING OF HEAVY METAL POLLUTANT TRANSPORT-TRANSFORMATION IN FLUVIAL RIVERS:A REVIEW显示文摘A detailed discussion of existing three kinds of mathematical models of heavy metal pollutant transport-transformation in fluvial rivers is presented, with an emphasis on the mathematical model of heavy metal pollutant transport-transformation dynamics. The imperfection of two kinds of mathematical models, that is, mathematical model of chemical thermodynamic equilibrium and that of chemical reaction kinetics, and the shortcoming of existing mathematical models of heavy metal pollutant transport-transformation dynamics are pointed out. Furthermore, the structure of mathematical model of heavy metal pollutant transport-transformation dynamics in fluvial rivers is suggested. Equations in the mathematical model of heavy metal pollutant transport-transformation dynamics in fluvial rivers will be discussed in the following paper. | S. L. HUANG Z. H. WAN P. SMITH | 2007 | International Journal of Sediment Research2007，22，1： | 5 |
| 4 | Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease显示文摘 | Maitreyi Raman Iftikhar Ahmed Patrick M. Gillevet Chris S. Probert Norman M. Ratcliffe Steve Smith Rosemary Greenwood Masoumeh Sikaroodi Victor Lam Pam Crotty Jennifer Bailey Robert P. Myers Kevin P. Rioux | 2013 | Clinical Gastroenterology and Hepatology2013，，7： | 5 |
| 5 | 透水混凝土路面砖路面的微生物学显示文摘因为透水路面砖系统(本文专指透水混凝土路面砖铺设的路面,两者可互换使用)能够滞留和降解路面上的碳氢化合物,而引起人们关注。试验研究证明:清除路面上油污的关键,是在路面砖上自然存在着微生物作用的结果。英国Formpave公司和Coventry大学的联合研究表明,一旦油污渗透至能滞留油污的坚固土工织物薄膜层上,则迅速成为某些微生物的食物源。油污经有氧细菌和真菌的代谢作用,转化为糖类成分,如葡萄糖。随着时间的推移,微生物数量逐渐增加,形成一个网络遍布在Inbitex土工布上,形成一层生物'膜',进一步改善了路面系统的过滤和净化功能。由于油污提供了大量食物源,会将较大的掠夺性生物,例如单细胞微生物和多细胞动物吸引到生物膜上。这些生物对保持土工织物的透水畅通等特性起到重要作用,也对降解油污的微生物体的连续存在起着关键作用。为了优化透水路面砖路面系统的功能,有必要了解用透水路面砖铺设路面系统是如何有利于环保的。 | A. P. Newman S. J. Coupe H. G. Smith T. Puehmeier P. Bond 崔玉忠(翻译) 刘黎(校核) 杜建东(校核) | 2008 | 建筑砌块与砌块建筑2008，，1： | 4 |
| 6 | Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation显示文摘 | Elizabeth A. Griffiths Steven D. Gore Craig Hooker Michael A. McDevitt Judith E. Karp B. Douglas Smith Helai P. Mohammad Ying Ye James G. Herman Hetty E. Carraway | 2010 | Leukemia & Lymphoma2010，，9： | 3 |
| 7 | Altered central pain processing after pancreatic surgery for chronic pancreatitis显示文摘 | S. A. Bouwense U. Ahmed Ali R. P. ten Broek Y. Issa C. H. van Eijck O. H. Wilder‐Smith H. van Goor | 2013 | Br J Surg2013，，13： | 3 |
| 8 | The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C显示文摘 | Kathleen B. Schwarz Regino P. Gonzalez–Peralta Karen F. Murray Jean P. Molleston Barbara A. Haber Maureen M. Jonas Philip Rosenthal Parvathi Mohan William F. Balistreri Michael R. Narkewicz Lesley Smith Steven J. Lobritto Stephen Rossi Alexandra Valsamaki | 2011 | Gastroenterology2011，，2： | 2 |
| 9 | Provocative Mesenteric Angiography for Lower Gastrointestinal Hemorrhage: Results from a Single-institution Study显示文摘 | Charles Y. Kim Paul V. Suhocki Michael J. Miller Mazhar Khan Gemini Janus Tony P. Smith | 2010 | Journal of Vascular and Interventional Radiology2010，，4： | 2 |
| 10 | Characteristics of Missed or Interval Colorectal Cancer and Patient Survival: A Population-Based Study显示文摘 | N. Jewel Samadder Karen Curtin Thérèse M.F. Tuohy Lisa Pappas Ken Boucher Dawn Provenzale Kerry G. Rowe Geraldine P. Mineau Ken Smith Richard Pimentel Anne C. Kirchhoff Randall W. Burt | 2014 | Gastroenterology2014，，4： | 2 |
| 11 | Induced autophagy reduces virus output in dengue infected monocytic cells显示文摘 | Mingkwan Panyasrivanit Michael P. Greenwood David Murphy Ciro Isidoro Prasert Auewarakul Duncan R. Smith | 2011 | Virology2011，，1： | 2 |
| 12 | Exome Resequencing Identifies Potential Tumor‐Suppressor Genes that Predispose to Colorectal Cancer显示文摘 | Christopher G. Smith Marc Naven Rebecca Harris James Colley Hannah West Ning Li Yuan Liu Richard Adams Timothy S. Maughan Laura Nichols Richard Kaplan Michael J. Wagner Howard L. McLeod Jeremy P. Cheadle | 2013 | Human Mutation2013，，7： | 2 |
| 13 | Subnormothermic Machine Perfusion for Ex Vivo Preservation and Recovery of the Human Liver for Transplantation显示文摘 | B. G. Bruinsma H. Yeh S. ?zer P. N. Martins A. Farmer W. Wu N. Saeidi S. Op den Dries T. A. Berendsen R. N. Smith J. F. Markmann R. J. Porte M. L. Yarmush K. Uygun M.‐L. Izamis | 2014 | American Journal of Transplantation2014，，6： | 2 |
| 14 | microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells显示文摘 | Elena Vigorito Kerry L. Perks Cei Abreu-Goodger Sam Bunting Zou Xiang Susan Kohlhaas Partha P. Das Eric A. Miska Antony Rodriguez Allan Bradley Kenneth G.C. Smith Cristina Rada Anton J. Enright Kai-Michael Toellner Ian C.M. MacLennan Martin Turner | 2007 | Immunity2007，，6： | 2 |
| 15 | OPTN/SRTR 2011 Annual Data Report: Liver显示文摘 | W. R. Kim P. G. Stock J. M. Smith J. K. Heimbach M. A. Skeans E. B. Edwards A. M. Harper J. J. Snyder A. K. Israni B. L. Kasiske | 2012 | American Journal of Transplantation2012，，： | 2 |
| 16 | Investigation of blood pulse PPG signal regulation on toe effect of body posture and lower limb height显示文摘Objective: To study the regulation of blood pulse volume via photoplethysmography (PPG) signal detected from toe, while the lower limb is passively raised in different height positions. Methods: Use a modified non-invasive PPG technique to detect the blood pulse signal on toe with infrared (IR) photo sensor. A protocol consisting of two postures, i.e., supine and 45° reclining, was designed to conduct laboratory trial in this study. During the period of performing the protocol of these postures, the lower limb was passively raised from the heights of 10 cm to 60 cm randomly and individually with sponge blocks underneath the foot. Results: In the supine posture, the higher the foot was passively raised, the more the blood PPG signal decreased. In the 45° reclining posture, the blood PPG signal increased at the beginning and then decreased in the foot height position from 10 cm to 60 cm. In both postures the normalized AC signal changes significantly while the normalized DC signal changes little. Conclusion: The toe PPG signals can obviously indicate the regulated blood volume change with the designated postural procedures due to the heart level position. | XIN Shang-zhi HU Sijung CRABTREE Vincent P. ZHENG Jia AZORIN-PERIS Vincent ECHIADIS Angelos SMITH Peter R. | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，6： | 2 |
| 17 | Intrarectal Amifostine During External Beam Radiation Therapy for Prostate Cancer Produces Significant Improvements in Quality of Life Measured by EPIC Score显示文摘 | Nicole L. Simone Cynthia Ménard Benjamin P. Soule Paul S. Albert Peter Guion Sharon Smith Denise Godette Nancy S. Crouse Linda C. Sciuto Theresa Cooley-Zgela Kevin Camphausen C. Norman Coleman Anurag K. Singh | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，1： | 2 |
| 18 | ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data显示文摘 | M.B. Chadwick M. Herman P. Oblo?insky M.E. Dunn Y. Danon A.C. Kahler D.L. Smith B. Pritychenko G. Arbanas R. Arcilla R. Brewer D.A. Brown R. Capote A.D. Carlson Y.S. Cho H. Derrien K. Guber G.M. Hale S. Hoblit S. Holloway T.D. Johnson T. Kawano B.C. Kiedr | 2011 | Nuclear Data Sheets2011，，12： | 2 |
| 19 | Yield of tissue sampling for submucosal lesions evaluated by EUS显示文摘 | Gordon C. Hunt Pam P. Smith Douglas O. Faigel | 2003 | Gastrointestinal Endoscopy2003，，1： | 2 |
| 20 | Soluble TNF-α receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight显示文摘 | William T. Shearer James M. Reuben Janet M. Mullington Nicholas J. Price Bang-Ning Lee E.O’Brian Smith Martin P. Szuba Hans P.A. Van Dongen David F. Dinges | 2001 | The Journal of Allergy and Clinical Immunology2001，，1： | 2 |
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