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| 1 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 2 | Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway显示文摘 | Huanlong Liu Xueyan Chen Yu Han Chaoyi Li Pingping Chen Yongjian Zhang Zhenhua Pan | 2013 | Biomedicine & Pharmacotherapy2013，，： | 2 |
| 3 | Detection and Prevention of Environmental Hormone显示文摘The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced. | Qili Chen Ling Pan Yanhong Xv Xuan Fu Hongzhen Sun Hongyan Li Pingping Liu | 2013 | Meteorological and Environmental Research2013，4，12： | 1 |
| 4 | Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome显示文摘In the present study, electrical stimulation to the rat insular cortex induced apnea or respiratory disturbance, reduced amplitude of genioglossal electromyogram, and decreased electromyogram integrals. In addition, arterial blood gas analysis showed arterial blood acidosis, reduced pH values, increased alkali reserve negative values, decreased peripheral blood 5-hydroxytryptamine content, and increased 5-hydroxytryptamine expression in cerebellar Purkinje cells. Following lidocaine injection to block the habenular nucleus, abnormalities in breath, genioglossal electromyogram, and blood gas values disappeared, and peripheral blood 5-hydroxytryptamine content returned to levels prior to electric stimulation. However, 5-hydroxytryptamine expression in cerebellar Purkinje cells remained high. The results suggested that 5-hydroxytryptamine expression in Purkinje cells did not correlate with ventilation function involving insular cortex and habenular nucleus. | Liping Peng Jinghua Wang Lihong Zhang Pan Liu Min Wang Min Huang Shengnan Liu Pingping He Li Cui Mingxian Li Shao Wang | 2012 | Neural Regeneration Research2012，7，8： | 1 |
| 5 | Ultra-compact tunable graphene-based plasmonic multimode interference power splitter in mid infrared frequencies显示文摘In this paper, we propose graphene-based plasmonic multimode interference power splitters with ultra-compact size working in mid infrared range. Further, the arbitrary-ratio 1×2 power splitter with a size of 140 nm×232 nm, where the splitting ratio can be tuned continuously from 1:1 to 100:0, is numerically demonstrated. Meanwhile, the graphene-based arbitrary-ratio 1×2 power splitters with different frequencies and chemical potentials are also investigated. The proposed multimode interference structure with a deep nanoscale footprint might be a fundamental component of the future high density integrated plasmonic circuit or on-chip plasmonic interconnect techniques. | Pingping QIU Weibin QIU Zhili LIN Houbo CHEN Yixin TANG Jiaxian WANG Qiang KAN Jiaoqing PAN | 2017 | Science China(Information Sciences)2017，60，8： | 1 |
| 6 | The effects of medical insurance and patients’ preference on manufacturer encroachment in a pharmaceutical supply chain显示文摘With the development of e-commerce,manufacturers have opportunities to sell products to consumers through direct channels in addition to independent retailers.Although manufacturers’encroachment upon the retailing market of traditional goods has been extensively studied,there is a lack of research on manufacturers’encroachment in a pharmaceutical supply chain.This paper analyzes a pharmaceutical manufacturer encroachment strategy by taking into account the distinctive features of drugs,in which drug expenses are covered by medical insurance only in the physical channel and patients'channel preference is also considered.We find that under certain circumstances,the manufacturer encroachment may lead to a win-win outcome for both the manufacturer and the retailer,contradicting the conventional wisdom that the manufacturer's encroachment into retail space is detrimental to the independent retailer.Additionally,the manufacturer is more likely to encroach when the incurred extra cost is sufficiently small,the perceived quality of the drug selling through the direct channel is sufficiently high and the out-of-pocket percentage cost of the drug selling in the physical channel is high.We further study the impact of manufacturer encroachment on social welfare and find that the introduction of encroachment decreases the social welfare when patients'perceived quality of the drug obtained through the online store is low and improves the social welfare when the perceived quality exceeds a certain threshold. | Yanfei Lan Pingping Lu Chen Pan Sarmajit Kar Weifeng Li | 2022 | Journal of Management Science and Engineering2022，7，2： | 1 |
| 7 | Axiotaxy driven growth of belt-shaped InAs nanowires in molecular beam epitaxy显示文摘In this study,we demonstrate the axiotaxy driven growth of belt-shaped InAs nanowires using Au catalysts by molecular beam epitaxy.It is found that,the zinc-blende structured InAs nanowires,with the features of[113]growth direction and extensive{110}side-surfaces,are induced by catalysts in Au–In α phase through the axiotaxy growth,in which the lattice mismatch between the projections of atomic planes onto nanowire/catalyst interfaces is minimized by forming extraordinary tilted interfaces.Our atomic-resolution in situ TEM heating experiments show that the catalysts remained in the solid state of Au–In α phase during the axiotaxy growth,by which the vapor–solid–solid growth mechanism can be confirmed.Through manipulating the growth direction,this unusual growth mechanism can provide a practical pathway to control the morphology of the low-dimensional nanomaterials,from conventional nanowires to belt-shaped nanowires utilizing a significant lateral growth,simply using nanoparticles as catalyst. | Qiang Sun Dong Pan Xutao Zhang Jianhua Zhao Pingping Chen Wei Lu Jin Zou | 2021 | Nano Research2021，14，7： | 0 |
| 8 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 9 | Range-spread target detector via coherent energy accumulation and block thresholding denoising显示文摘A range-spread target(RST)detector is proposed for wideband radar.The detector,referred to as a conjugate multiplication and block thresholding(CMBT)detector,is simple for implementation in existing radar systems and has the advantage of minor calculation.First,the target energy of adjacent stretched echoes is coherently accumulated via conjugate multiplication and Fourier transform operations.It is noted that conjugate multiplication of two complex Gaussian distributed noise is complex double Gaussian distributed,leading to a signal to noise ratio(SNR)loss.Subsequently,considering the sparsity and clustering characteristics of the conjugate multiplication amplitude spectrum(CMAS),the block thresholding method is adopted for denoising,where the noise and cross-terms are adaptively smoothed,and the signal terms can be basically preserved.Finally,numerical simulation results for both synthetic and real radar data validate the effectiveness of the proposed detector,comparing with the conventional integration detector(ID),the spatial scattering density(SSD)detector,and waveform entropy(WE)and waveform contrast(WC)based detectors. | ZHANG Yunjian PAN Pingping DENG Zhenmiao WU Gang | 2021 | Journal of Systems Engineering and Electronics2021，32，4： | 0 |
| 10 | Phenotyping of poplar seedling leaves based on a 3D visualization method显示文摘In plant research,there is a demand for non-destructive and non-invasive trait measurement methods for phenotyping that can be used to accurately analyze various aspects of plants,such as stem length,leaf area,and leaf inclination.In this study,a method for measuring the leaf geometric characteristics of poplar seedlings based on 3D visualization via the use of time-of-flight(ToF)and digital cameras was proposed.Firstly,the average distance density function method was applied to process outliers of leaves.Secondly,to improve the accuracy of data fitting,a specific method using the angle of adjacent two-point normal vectors was introduced to filter redundant data,kept essential sample values as the control points,and then used the control points to fit the leaf surface based on non-uniform rational B-splines(NURBS).At the same time,NURBS was used to fit the trunk according to its control points and an iterative method to fit the other branches.Finally,3D visualization of poplar seedlings was achieved,and leaf traits,including leaf width,leaf length,leaf area,and leaf inclination angle,were calculated.To obtain accurate results,multiple experiments were conducted including assessments of poplar seedlings exhibiting normal growth and those grown under water shortage.The results of the proposed method were compared with the real values of the leaves.The RMSE for leaf width,leaf length,leaf area,and leaf angle were 0.18 cm,0.21 cm,1.14 cm^(2),and 1.97°,respectively.The results proved that this approach could be used to accurately measure the leaf characteristics of poplar seedlings via visualization. | Chunhua Hu Pingping Li Zhou Pan | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 0 |
| 11 | Role of Natural Product Eriocalyxin B in Promoting Apoptosis of Colon Cancer Cells through ERK1/2 Pathway显示文摘[Objectives] To investigate the role of Eriocalyxin B (EriB) in promoting colon cancer cell apoptosis through ERK1/2 pathway in vitro, and to provide a natural candidate drug for colon cancer treatment. [Methods] Colon cancer cells treated with different concentrations of EriB were detected by CCK-8 assay;cell scratch assay and crystal violet staining were used to detect the invasion and migration of colon cancer cell;cell apoptosis was detected by Annexin V/PI double staining, and cell cycle was detected by PI staining;Western Blotting was used to detect epithelial-mesenchymal transition and apoptosis-related proteins in colon cancer cells treated with EriB. [Results] After EriB treatment, the proliferation, migration and apoptosis of colon cancer cells were significantly inhibited, and the ratio of P-ERK1/2 to ERK was significantly decreased. [Conclusions] EriB can effectively inhibit the proliferation of colon cancer cells and promote the apoptosis of colon cancer cells through ERK1/2 pathway. | Pingping TIAN Wei SHI Ying PAN Xiaocong XIANG Jin CHEN | 2023 | Medicinal Plant2023，14，4： | 0 |
| 12 | Hydraulic path dependence of shear strength for compacted loess显示文摘Shear strength is an essential geotechnical parameter for assessing the landslide potential of loess slopes under rainfall infiltration and farm irrigation conditions on the loess plateau.However,the hydraulic path dependence of shear strength for compacted loess under varying rainfall infiltration conditions has not been thoroughly investigated yet.To this end,a series of direct shear tests and nuclear magnetic resonance(NMR)measurements are carried out on compacted loess.The shear strength tests were continuously implemented on loess specimens under scanning wetting paths besides initial drying paths.The experimental data quantitatively verify the significant effect of hydraulic paths applied to specimens on shear strength of compacted loess.The unique failure envelope of shear strength of loess is identified under the effective stress framework based on intergranular stress,which verifies that the effective stress framework can consider the effect of hydraulic paths on shear strength.Based on the effective stress,a shear strength formula is proposed to characterize shear strengths under varying hydraulic paths,in which the parameters from the soil-water retention curve and shear strength at saturated state are simply required.The proposed shear strength formula can properly predict the measured shear strength data of compacted loess experiencing three hydraulic paths.Furthermore,the distribution curves of transverse relaxation time for pore water in soil under varying hydraulic paths are simultaneously measured using the NMR method.The physical mechanism for the difference in shear strength of loess subjected to different hydraulic paths can be uncovered based on soil-water evolutions in pores in microscale. | Pan Chen Shengao Jia Xiaoqi Wei Pingping Sun Panpan Yi Changfu Wei | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，7： | 0 |
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