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| 1 | A national report from China Liver Transplant Registry: steroid avoidance after liver transplantation for hepatocellular carcinoma显示文摘Objective:We aimed to evaluate the efficacy and safety of steroid-free immunosuppression after liver transplantation(LT)for hepatocellular carcinoma(HCC).Methods:We retrospectively analyzed HCC recipients without steroids after LT(SF group,n=368)based on the China Liver Transplant Registry(CLTR)database.These recipients were matched 1:2 with patients using steroids(S group,n=736)for the same period after LT for HCC,according to propensity scores.Results:Multivariate analysis indicates that recipients with younger age[odds ratio(OR),1.053;P=0.011],preoperative hepatitis B virus(HBV)DNA≥1,000 copies/mL(OR,2.597;P=0.004)and beyond Milan criteria(OR,4.255;P<0.001)were identified as the risk factors associated with tumor recurrence in steroid avoidance recipients after LT.The patients fulfilling the Milan criteria in the SF group presented higher overall and tumor-free survival rates than those in the S group(P<0.05).Multivariate analysis revealed that recipient beyond Milan criteria was an independent prognostic factor for overall survival(OR,1.690;P<0.001)and tumor-free survival(OR,2.066;P<0.001).The incidences of new-onset diabetes mellitus(21.20% vs.33.29%,P<0.001),new-onset hypertension(10.05%vs.18.61%,P<0.001)and hyperlipidemia(4.08% vs.7.20%,P=0.042)were significantly lower in the SF group.Conclusions:Steroid-free immunosuppression could be safe and feasible for HBV-related HCC patients in LT.Age,HBV DNA level and Milan criteria maybe risk factors associated with tumor recurrence in steroid avoidance recipients.Recipient beyond Milan criteria was an independent prognostic factor and recipient fulfilling Milan criteria can benefit the most from steroid-free immunosuppression. | Qiang Wei Feng Gao Runzhou Zhuang Qi Ling Qinghong Ke Jian Wu Tian Shen Mangli Zhang Min Zhang Xiao Xu Shusen Zheng | 2017 | Chinese Journal of Cancer Research2017，29，5： | 25 |
| 2 | Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway显示文摘As an important component of the tumor microenvironment,cancer-associated fibroblasts(CAFs)secrete energy metabolites to supply energy for tumor progression.Abnormal regulation of long noncoding RNAs(lncRNAs)is thought to contribute to glucose metabolism,but the role of lncRNAs in glycolysis in oral CAFs has not been systematically examined.In the present study,by using RNA sequencing and bioinformatics analysis,we analyzed the lncRNA/mRNA profiles of normal fibroblasts(NFs)derived from normal tissues and CAFs derived from patients with oral squamous cell carcinoma(OSCC).LncRNA H19 was identified as a key lncRNA in oral CAFs and was synchronously upregulated in both oral cancer cell lines and CAFs.Using small interfering RNA(siRNA)strategies,we determined that lncRNA H19 knockdown affected proliferation,migration,and glycolysis in oral CAFs.We found that knockdown of lncRNA H19 by siRNA suppressed the MAPK signaling pathway,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3)and miR-675-5p.Furthermore,the lncRNA H19/miR-675-5p/PFKFB3 axis was involved in promoting the glycolysis pathway in oral CAFs,as demonstrated by a luciferase reporter system assay and treatment with a miRNA-specific inhibitor.Our study presents a new way to understand glucose metabolism in oral CAFs,theoretically providing a novel biomarker for OSCC molecular diagnosis and a new target for antitumor therapy. | Jin Yang Xueke Shi Miao Yang Jingjing Luo Qinghong Gao Xiangjian Wang Yang Wu Yuan Tian Fanglong Wu Hongmei Zhou | 2021 | International Journal of Oral Science2021，13，1： | 8 |
| 3 | Daily Variation of Natural Emission of Methane to the Atmosphere and Source Identification in the Luntai Fault Region of the Yakela Condensed Oil/Gas Field in the Tarim Basin,Xinjiang,China显示文摘静态的流动房间方法被使用在 Yakela 的 Luntai 差错区域学习甲烷的自然排出物到空气在 Tarim 盆的压缩油 / 气体地, Xinjiang 自治市,西北的中国。用一个联机方法,它一起联合煤气的 chromatography/high-temperature 变换/同位素比率团 spectrometry ( GC/C/MS ),在流动房间的甲烷的^( 13 )C/^( 12 ) C 比率被测量并且证明甲烷气体是容易的通过差错区域和那从深油/气体水库移居到表面移植甲烷的部分,它遗体 unoxidized 能被射出进空气。甲烷排放率被发现在早上最高,在下午然后增加最低逐渐地在晚上。甲烷排放率在差错区域在不同地点戏剧性地变化了。最高的甲烷排放率是 10.96 mg/m^2 · d,最低 4.38 mg/m^2,和一般水准 7.55 mg/ m^2 · d。在流动房间的甲烷的 ^(13 )C/^(12 ) C 比率作为集中逐渐地增加了的围住的甲烷变得更重,它揭示免除差错区域的那甲烷可能来自深压缩的油 / 气体水库的 thermogenic 甲烷。 | TANG Junhong BAO Zhengyu XIANG Wu GOU Qinghong | 2007 | Acta Geologica Sinica(English Edition)2007，81，5： | 7 |
| 4 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 5 | Geological emission of methane from the Yakela condensed oil/gas field in Talimu Basin, Xinjiang, China显示文摘A static flux chamber method was applied to study natural emissions of methane into the atmosphere in the Yakela condensed oil/gas field in Talimu Basin, Xinjiang, China. Using an online method, which couples a gas chromatography/high-temperature conversion/isotope ratio mass spectrometry (GC/C/MS) together, the 13C/12C ratios of methane in the flux chambers were measured. The results demonstrated that methane gases were liable to migrate from deep oil/gas reservoir to the surface through microseepage and pervasion, and that a part of the migrated methane that remained unoxidized could emit into the atmosphere. Methane emission rates varied less in the oil/gas field because the whole region was homogeneous in geology and geography, with a standard deviation of less than 0.02 mg/(m2·h). These were the differences in methane emission flux in the day and at night in the oil/gas field. The maximum methane emission flux reached 0.15 mg/(m2·h) at 5:00-6:00 early in the morning, and then decreased gradually. The minimum was shown 0.10 mg/(m2·h) at 17:00-18:00 in the afternoon, and then increased gradually. The daily methane released flux of the study area was 2.89 mg/(m2·d), with a standard deviation of 0.43 mg/(m2·d), using the average methane flux of every hour in a day for all chambers. δ13C of methane increased with the increase of methane concentration in the flux chambers, further indicating that the pyrogenetic origin of methane was come from deep oil/gas reservoirs. | Tang Junhong Bao Zhengyu Xiang Wu Gou Qinghong | 2008 | Journal of Environmental Sciences2008，20，9： | 6 |
| 6 | Interface Engineering via Ti_(3)C_(2)T_(x) MXene Electrolyte Additive toward Dendrite-Free Zinc Deposition显示文摘Zinc metal batteries have been considered as a promising candidate for next-generation batteries due to their high safety and low cost.However,their practical applications are severely hampered by the poor cyclability that caused by the undesired dendrite growth of metallic Zn.Herein,Ti_(3)C_(2)T_(x) MXene was first used as electrolyte additive to facilitate the uniform Zn deposition by controlling the nucleation and growth process of Zn.Such MXene additives can not only be absorbed on Zn foil to induce uniform initial Zn deposition via providing abundant zincophilic-O groups and subsequently participate in the formation of robust solid-electrolyte interface film,but also accelerate ion transportation by reducing the Zn^(2+) concentration gradient at the electrode/electrolyte interface.Consequently,MXene-containing electrolyte realizes dendrite-free Zn plating/striping with high Coulombic efficiency(99.7%)and superior reversibility(stably up to 1180 cycles).When applied in full cell,the Zn-V_(2)O_(5)cell also delivers significantly improved cycling performances.This work provides a facile yet effective method for developing reversible zinc metal batteries. | Chuang Sun Cuiping Wu Xingxing Gu Chao Wang Qinghong Wang | 2021 | Nano-Micro Letters2021，13，6： | 4 |
| 7 | Coprinus comatus-derived nitrogen-containing biocarbon electrocatalyst with the addition of self-generating graphene-like support for superior oxygen reduction reaction显示文摘The development of nitrogen-rich biomassderived carbon catalysts provides an attractive perspective to substitute for Pt-based electrocatalysts for oxygen reduction reaction(ORR). We here report a facile strategy for synthesis of a nitrogen-doped biocarbon/graphene-like composite electrocatalyst by pyrolyzing a solid-state mixture of coprinus comatus biomass and melamine under nitrogen protection. The graphtic carbon nitride formed by polycondensation of melamine at 600 °C acts as a selfsacrificing template to generate the nitrogen-doped graphene-like sheet, which can function as an inserting agent and self-generating support. The composite catalyst exhibits the most promising catalytic activity towards the fourelectron ORR with a half-wave potential of around 0.83 V(vs. RHE), and more excellent stability and tolerance to methanol/ethanol compared to the commercial Pt/C catalyst. It is interestingly found that both a higher content of nitrogen and a larger ratio of graphitic-nitrogen species,which may derive from self-addition of graphene-like support into the catalyst, can effectively improve the electrocatalytic activity. The planar N group may be the nitrogen functionality that is most responsible for maintaining the ORR activity in alkaline medium. This study can largely encourage the exploration of high-performance carbon-based catalysts from economical and sustainable fungus biomass. | Chaozhong Guo Wenli Liao Zhongbin Li Lingtao Sun Haibo Ruan Qingshan Wu Qinghong Luo Jie Huang Changguo Chen | 2016 | Science Bulletin2016，61，12： | 4 |
| 8 | Zephyranthes-like Co2NiSe4 arrays grown on 3D porous carbon frame-work as electrodes for advanced supercapacitors and sodium-ion batteries显示文摘Developing suitable electrode materials for electrochemical energy storage devices by biomorph assisted design has become a fascinating topic due to the fantastic properties derived from bio-architectures.Herein,zephyranthes-like Co_(2)NiSe_(4)arrays grown on butterfly wings derived three-dimensional(3D)carbon framework(Z-Co_(2)NiSe_(4)/BWC)is fabricated via hydrothermal assembly and further conversion method.Benefiting from its unique structure and multi-components,the obtained Z-Co_(2)NiSe_(4)/BWC electrode for supercapacitor delivers an excellent specific capacitance of 2,280 F·g^(-1)at 1 A·g^(-1).Impressively,the constructed asymmetric supercapacitor using Co_(2)NiSe_(4)/BWC as positive electrode and activated butterfly wings carbon as negative electrode acquires a high energy density of 42.9 Wh·kg^(-1)at a power density of 800 W·kg^(-1)with robust stability of 94.6%capacitance retention at 10 A·g^(-1)after 5,000 cycles.Moreover,the Z-Co_(2)NiSe_(4)/BWC as anode for sodium-ion batteries exhibits a high specific capacity of 568 mAh·g^(-1)at 0.1 A·g^(-1)and high cycling stability(maintaining 80.1%of the second cycle after 100 cycles).The outstanding electrochemical performances are ascribed to that the synergistic effect of bimetallic selenides and N-doped carbon improves electrochemical activities and conductivity.One-dimensional(1D)nanoneedles grown on 3D porous framework increase the exposure of redox-active sites,endow adequate transmission channels of electrons/ions,and guarantee stability of the electrode during charge/discharge processes.This study will shed light on the avenue towards extending such nanohybrids to excellent energy storage applications. | Yanchun Xue Xingmei Guo Mengrong Wu Jiale Chen Mengting Duan Jing Shi Junhao Zhang Fu Cao Yuanjun Liu Qinghong Kong | 2021 | Nano Research2021，14，10： | 3 |
| 9 | Design theories and maintenance technologies of slab tracks for high-speed railways in China:a review显示文摘The durability and reliability of slab track structures are essential for the long-term safety and stable operation of high-speed railways.In order to provide a solid theoretical basis and technical reference for the advancement of high-speed railway quality,this paper comprehensively discusses design theories of slab track structures,service performance evolution and maintenance technologies,and reviews the innovation happening in the industry.On top of that,the damage evolution,fatigue features and durability of slab tracks,which are highly relevant to serviceability,are summarized,and the future research trend of slab track service behaviours is pointed out.In addition,this paper summarizes the rules of establishing standards for damage maintenance,typical solutions for repairing damage and methods of evaluating the maintenance outcomes that combine field tests and numerical simulations.It also envisions a future direction where advanced testing technologies would assist the evaluation of maintenance effects. | Juanjuan Ren Shijie Deng Kaiyao Zhang Wei Du Qinghong Wu | 2021 | Transportation Safety and Environment2021，3，4： | 2 |
| 10 | Latest Advances in High-Voltage and High-Energy-Density Aqueous Rechargeable Batteries显示文摘Aqueous rechargeable batteries(ARBs)have become a lively research theme due to their advantages of low cost,safety,environmental friendliness,and easy manufacturing.However,since its inception,the aqueous solution energy storage sys-tem has always faced some problems,which hinders its development,such as the narrow electrochemical stability window of water,poor percolation of electrode materials,and low energy density.In recent years,to overcome the shortcomings of the aqueous solution-based energy storage system,some very pioneering work has been done,which also provides a great inspiration for further research and development of future high-performance aqueous energy storage systems.In this paper,the latest advances in various ARBs with high voltage and high energy density are reviewed.These include aqueous rechargeable lithium,sodium,potassium,ammonium,zinc,magnesium,calcium,and aluminum batteries.Further chal-lenges are pointed out. | Xinhai Yuan Fuxiang Ma Linqing Zuo Jing Wang Nengfei Yu Yuhui Chen Yusong Zhu Qinghong Huang Rudolf Holze Yuping Wu Teunis van Ree | 2021 | Electrochemical Energy Reviews2021，4，1： | 2 |
| 11 | Biomechanical Study on the Novel Biomimetic Hemi-Pelvis Prosthesis显示文摘 | Zikai Hua Yongwei Fan Qinghong Cao Xianbo Wu | 2013 | Journal of Bionic Engineering2013，10，4： | 2 |
| 12 | Improving Thermal and Flame Retardant Properties of Epoxy Resin with Organic NiFe-Layered Double Hydroxide-Carbon Nanotubes Hybrids显示文摘在环氧基树脂树脂(EP ) 改进碳 nanotubes (CNT ) 和分层的双氢氧化物(LDH ) 的火焰 retardancy 的分散,器官的镍铁分层的双氢氧化物(ONiFe-LDH-CNTs ) 混血儿通过一起沉淀被装配。这些混血儿进一步被用作增强 filler in EP。与 ONiFe-LDH 和 CNT 的不同比率包含 ONiFe-LDH-CNTs 的 4 wt% 的 EP/ONiFe-LDH-CNTs nanocomposites 被治好的超声的分散和节目温度准备。获得的混血儿的结构和形态学被不同技术描绘。在 EP 矩阵的 nanofillers 的分散被传播电子显微镜学(TEM ) 观察。结果揭示了 exfoliated 的共存并且设置在聚合物矩阵的 ONiFe-LDH- CNT。有 EP 矩阵的上述 nanofillers 的强壮的联合提供了一有效热并且为 nanocomposites 的火焰 retardant 改进。它证明 EP/ONiFe-LDH-CNTs nanocomposites 与 EP 相比展出了优异火焰 retardant 和热性质。如此的改进热性质能被归因于更好同类的分散,更强壮的界面的相互作用, ONiFe-LDH 的优秀 charring 表演和在 ONiFe-LDH 和 CNT 之间的 synergistic 效果。 | Qinghong Kong Ting Wu Yingqi Tang Lemin Xiong Hong Liu Junhao Zhang Ruihua Guo Feng Zhang | 2017 | Chinese Journal of Chemistry2017，35，12： | 1 |
| 13 | Epoxidation of styrene with molecular oxygen catalyzed by cobalt (Ⅱ)-containing molecular sieves显示文摘 | Tang Qinghua Zhang Qinghong Wu Hongli | 2005 | Journal of Catalysis2005，230，2： | 1 |
| 14 | Iron-based heterogeneous catalysts for epoxidation of alkenes using molecular oxygen显示文摘 | LIANG JUN ZHANG QINGHONG WU HONGLI | 2004 | Catalysis Communications2004，5，11： | 1 |
| 15 | Epoxidation of styrene with molecular oxygen catalyzed by cobalt(II)-containing molecular sieves显示文摘 | Qinghu Tang Qinghong Zhang Hongli Wu | 2005 | Journal of Catalysis2005，23，： | 1 |
| 16 | Iron-based heterogeneous catalysts for epoxidation of alkenes using molecular oxygen 显示文摘 | Liang Jun Zhang Qinghong Wu Hongli | 2004 | Catalysis Communications2004，5，11： | 1 |
| 17 | Epoxidation of styrene with molecular oxygen catalyzed by cobalt(Ⅱ)-containing molecular sieves显示文摘 | Zhang Qinghong Wu Hongli | 2005 | Journal of Catalysis2005，230，2： | 1 |
| 18 | A Study of Lead Corrosion of Diesel Engine Oil显示文摘The effect of base oils,sulfur-containing multi-functional additives and dispersants in formulated diesel lubricants on lead corrosion was evaluated by a self-established high temperature corrosion bench test.Test lead coupons were analyzed by XPS to determine the resulting surface chemistry.The results showed a close correlation between the oxidation stability of base oil blend and the lead corrosion of formulated diesel lubricants.The zinc dialkyldithiophosphate(ZDDP)and zinc dialkyldithiocarbamate(ZDDC)have formed different protective films on lead coupon surfaces.A more or less amount of the protective film formed is the main factor affecting the degree of lead corrosion.The glassy zinc phosphates protective film formed by ZDDP is more effective than the zinc sulfides film formed by ZDDC.The interaction between dispersants and ZDDP had a significant impact on lead corrosion. | Xu Jie Xia Qinghong Zhang Feng Wu Zhiqiang | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 1 |
| 19 | Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner显示文摘Myeloid-derived suppressor cells(MDSCs)are well known for their capacity to suppress antitumor T-cell responses,but their effects on B-cell function and antibody production remain unclear.Here,we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B cells.In the presence of MDSCs,the antibody reaction to a surrogate antigen was significantly enhanced in mice,especially the immunoglobulin(Ig)A subtype.Co-culture with MDSCs promoted both proliferation and differentiation of B cells into IgA-producing plasma cells in vitro.Interestingly,the cross talk between MDSCs and B cells required cell-cell contact.MDSCs from tumor necrosis factor receptor(TNFR)2^(−/−)mice,but not from TNFR1^(−/−)mice,failed to promote B-cell responses.Further investigation suggested that interleukin-10 and transforming growth factor-β1 were crucial for the MDSC-mediated promotion of IgA responses.These results demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth. | Xia Xu Qinghong Meng Ulrike Erben Peigang Wang Rainer Glauben Anja A Kühl Hao Wu Chung Wah Ma Minghua Hu Yuanyuan Wang Wei Sun Junying Jia Xinyi Wu Wei Chen Britta Siegmund Zhihai Qin | 2017 | Cellular & Molecular Immunology2017，14，7： | 1 |
| 20 | 显示文摘 | MEI Surong YAO Qinghong WU Caiying | 2005 | J Chromatogr: B2005，827，1： | 1 |
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