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| 1 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 2 | Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling显示文摘Fas/FasL 系统播送细胞内部的 apoptotic 发信号,导致房间 apoptosis。然而,船边交货发信号也除了导致肿瘤房间 apoptosis 施加 non-apoptotic 功能。例如,船边交货发信号导致肺癌症肿瘤房间生产前列腺素 E2 (PGE2 ) 和成员导出 myeloid 的 suppressor 房间(MDSC ) 。激活的细胞毒素的 T 淋巴细胞(CTL ) 导致并且表示 FasL 在房间仍然是的 apoptosis 抵抗的肿瘤上在 CTL 开始的船边交货激活的 FasL,而是效果的高水平大部分不清楚。我们从 OT-1 老鼠净化了激活的 CD8 + T 房间,在肿瘤房间逃跑上评估了船边交货激活的规章的效果并且调查了相关机制。我们发现 CTL 导致了肿瘤细胞分泌 PGE2 和增加肿瘤经由船边交货发信号的 MDSC 的调停房间的 chemoattraction,它对肿瘤生长有利。我们的结果显示 CTL 可以参予肿瘤免疫者避免过程。就我们的知识而言,这是 CTL 在肿瘤逃跑由起一个作用的新奇机制。我们的调查结果含有经由对肿瘤的否定有免疫力的回答的减小提高 antitumor 免疫者反应的策略通过船边交货发信号由 CTL 支持了。 | Fei Yang Yinxiang Wei Zhijian Cai Lei Yu Lingling Jiang Chengyan Zhang Huanmiao Yan Qingqing Wang Xuetao Cao Tingbo Liang Jianli Wang | 2015 | Cellular & Molecular Immunology2015，12，1： | 6 |
| 3 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 4 | Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy显示文摘Despite great success in cancer immunotherapy,immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy.Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anticancer immunity,which may result in immune checkpoint blockade therapy being ineffective,in addition to other novel immunotherapies in cancer patients.In the present review,we discuss the deficiencies of current cancer immunotherapies.More importantly,we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance,immunological evasion,and the potential for their further translation into clinical practice.Based on their general targetability in clinical therapy,we believe that tumor immune microenvironment regulators are promising cancer immunotherapeutic targets.Targeting the tumor immune microenvironment,alone or in combination with immune checkpoint-targeting drugs,might benefit cancer patients in the future. | Tianyu Tang Xing Huang Gang Zhang Zhengtao Hong Xueli Bai Tingbo Liang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 3 |
| 5 | Multiplex imaging reveals the architecture of the tumor immune microenvironment显示文摘The tumor immune microenvironment(TME)is composed of a variety of components,such as tumor cells,immune cells,and the extracellular matrix.The TME has been studied through transcriptomic,proteomic,metabolomic,and phosphoproteomic approaches,which have provided researchers with a wealth of TME-related molecular information. | Junlei Zhang Jinyuan Song Jianpeng Sheng Xueli Bai Tingbo Liang | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 6 | 节段性小肠移植手术中采用自体髂内血管进行血管重建显示文摘背景:本研究旨在评估自体髂内动静脉可否用于异体及自体节段性小肠移植手术的血管重建。方法:2011年1月至2019年1月间34例小肠移植患者纳入研究,其中19例为亲属活体移植,15例为自体移植。收集患者临床资料、血管重建类型及术后并发症进行分析。结果:全组男性20例,女性14例,中位年龄35岁。在34例小肠移植中,22例(64.7%,其中异体移植和自体移植各11例)采用自体髂内动脉脉进行血管重建,12例(35.3%)直接行血管吻合。血管重建耗时(21˘6)min。与直接吻合组相比,血管重建组患者手术总时长(530˘226 vs 440˘116 min,P=0.208)和冷缺血时间(159˘49 vs 125˘66 min,P=0.097)均有延长的趋势,但差异并未达到统计学意义。直接吻合组术后血栓形成发生率较血管重建组有增高的趋势(16.7%vs 0%,P=0.118)。中位随访36.9个月,无一例出现静脉狭窄或假性动脉瘤。19例异体移植患者中,4例(21.1%)发生急性排斥反应,1例(5.2%)出现慢性排斥反应。结论:本组数据显示,采用自体髂内动静脉进行血管重建可有力促进小肠移植的开展,同时有望降低术后血管并发症的风险。 | Guosheng Wu Yinglun Wu Mian Wang Wentong Zhang Chaoxu Liu Tingbo Liang | 2021 | Gastroenterology Report2021，9，4： | 2 |
| 7 | Auto-intestine transplantation for pancreatic tumors with mesenteric root involvement:a systematic review and survival-based analysis显示文摘To analyze a long-term survival outcome of an auto-intestine transplantation(aINTx)for the patients with locally advanced pancreatic tumor and identify the potential prognostic factors,databases were carefully searched for the studies reporting the patients with a locally advanced pancreatic tumor which typically underwent aINTx.We performed a database search using PubMed,the Cochrane Library,EMBASE,and MEDLINE to identify multiple case series of the patients who had pancreatic tumors with mesenteric root involvement and underwent aINTx,to evaluate the treatment outcomes,and calculated the patient survival using the Kaplan–Meier method and Cox proportional hazard regression analysis to properly identify an independent predictor of the survival.A total of 9 retrospective studies with a total of 29 patients were included in our study.The calculated 1-,2-,and 3-year survival rates for the patients with pancreatic cancer and benign or low grade pancreatic tumors were 49.64%,22.06%,and 0%versus 100%,100%,and 80%,respectively.The corresponding median survival time was 13.4months and 84months,respectively.Moreover,when stratifying the pancreatic cancer patients undergoing aINTx on the basis of neoadjuvant chemotherapy(aINTx+neoadjuvant vs aINTx-neoadjuvant)there was a significant difference in the survival(P=0.01).The 1-and 2-year survival rates were 75%and 75%versus 34.1%and 0%,respectively.Corresponding median survival times were 24months and 10months,respectively.Our analysis shows the long-term survival benefit with acceptable morbidity and mortality of pancreatoduodenectomy and aINTx for the pancreatic tumors with the mesenteric root involvement that are otherwise unresectable by the conventional surgical techniques.However,from an oncological point of view,a larger study with the control group is required to determine its safety compared to less aggressive surgical treatment. | Dipesh Kumar Yadav Xing Huang Qi Zhang Gang Zhang Xueli Bai Tingbo Liang | 2021 | Journal of Pancreatology2021，4，4： | 1 |
| 8 | Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2显示文摘 | Gengting Dong Tingbo Chen Xuecong Ren Zhifeng Zhang Weixue Huang Liang Liu Pei Luo Hua Zhou | 2016 | Mitochondrion2016，，： | 1 |
| 9 | Blocking PD-L1 for anti-liver cancer immunity:USP22 represents a critical cotarget显示文摘MULTIPLE LEVELS OF PD-L1 REGULATION IN CANCER IMMUNOTHERAPY To date,the PD-1/PD-L1 blockade strategy has been tested in a variety of cancer types.However,only bladder cancer,melanoma,mismatch repair-deficient colorectal cancer,and certain hematopoietic malignancies have been highly responsive in terms of clinical outcomes.1,2 It is presumed that the expression level of the PD-L1 protein largely determines the therapeutic efficacy of PD-1/PD-L1-targeted cancer immunotherapy.3,4 Previous studies have shown that several transcriptional factors are involved in the upregulation of PD-L1 by directly binding to its promoter region.5 For instance,individual activation of STAT1,NF-κB,HIF-1α,c-Myc,or MAPK increased PD-L1 transcription and immune evasion of tumor cells.On the other hand,oncogenic RAS signaling reportedly stabilizes PD-L1 mRNA to promote tumor immunoresistance. | Xing Huang Xiaozhen Zhang Xueli Bai Tingbo Liang | 2020 | Cellular & Molecular Immunology2020，17，7： | 1 |
| 10 | mRNA vaccines in disease prevention and treatment显示文摘mRNA vaccines have emerged as highly effective strategies in the prophylaxis and treatment of diseases,thanks largely although not totally to their extraordinary performance in recent years against the worldwide plague COVID-19. | Gang Zhang Tianyu Tang Yinfeng Chen Xing Huang Tingbo Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 1 |
| 11 | Biomaterials based cardiac patches for the treatment of myocardial infarction显示文摘Myocardial infarction(MI)is one of the common cardiovascular diseases that occurs with a blockage in one or more of the coronary arteries to lead to the damage of the myocardium,resulting in a lifethreatening condition.To repair the damaged myocardium in MI,researchers are looking forwards to new ways to postpone the progression of myocardial injury.Cardiac patches,the scaffolds layered on the heart surface,can provide mechanical support for the infarction site and improve cardiac function by delivering various bioactive factors or cells,showing considerable curative effect in the treatment of MI.Biomaterials with certain biocompatibility and mechanical properties have received widespread attention for the application in cardiac patches.In this review,we focus on the recent progress on these biomaterialsbased cardiac patches,which could be categorized into two types according to the sources of materials including(ⅰ)natural materials and(ⅱ)synthetic materials.The major advantages and current challenges of each type are discussed and a brief perspective on the future research directions is presented. | Tianqi Chang Chunxia Liu Kunyan Lu Yong Wu Mingzhu Xu Qian Yu Zhenya Shen Tingbo Jiang Yanxia Zhang | 2021 | Journal of Materials Science & Technology2021，，35： | 1 |
| 12 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 13 | Starch granules size distribution in superior and inferior grains of wheat is related to enzyme activities and their gene expressions during grain filling显示文摘 | Chuanhui Zhang Dong Jiang Fulai Liu Jian Cai Tingbo Dai Weixing Cao | 2009 | Journal of Cereal Science2009，，2： | 1 |
| 14 | Eating self for not be eaten:Pancreatic cancer suppresses selfimmunogenicity by autophagy-mediated MHC-I degradation显示文摘In a recent study in Nature,1 Yamamoto et al.reported that MHC-I is a selective substrate of autophagy in tumor immune evasion.Furthermore,it was reported that autophagy-mediated lysosomal degradation of MHC-I suppresses pancreatic cancer immunogenicity and the effectiveness of immunotherapy.These findings indicate the potential of autophagy inhibition as a strategy to activate anti-pancreatic cancer immunity. | Xing Huang Xiaozhen Zhang Xueli Bai Tingbo Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 15 | POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy显示文摘The current feasibility of nanocatalysts in clinical anti-infection therapy,especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation.Herein,a novel Ag/Bi2MoO6(Ag/BMO)nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction.The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus(MRSA)(~99.9%).The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity,NIR-II photodynamic behavior,and acidity-enhanced release of Ag^(+).As revealed by theoretical calculations,the introduction of Ag to BMO made it easier to separate photo-triggered electronhole pairs for ROS production.And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O_(2) to·O_(2)^(−).Under 1064 nm laser irradiation,the electron transfer to BMO was beneficial to the reversible change of Mo^(5+)/Mo^(6+),further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism.In vivo,the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds.This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy. | Changyu Cao Tingbo Zhang Nan Yang Xianghong Niu Zhaobo Zhou Jinlan Wang Dongliang Yang Peng Chen Liping Zhong Xiaochen Dong Yongxiang Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 16 | Identification of a class of potent USP25/28 inhibitors with broad-spectrum anti-cancer activity显示文摘Dear Editor,An increasing body of evidence suggests that USP28 could be a target for cancer treatment^(1-4).To identify its inhibitors,we screened a 100-thousand synthetic compound library and found 3 lead compounds,CT1001-1003,that showed significant inhibitory activity(Supplementary Fig.1a).The optimization of these compounds led to CT1018,a much stronger inhibitor(Supplementary Fig.1b). | Jin Peng Kun Jiang Xiao Sun Lingzhi Wu Jiewei Wang Xiaomei Xi Xu Tan Tingbo Liang Changheng Tan Pumin Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 17 | Epigenetic modification associated with climate regulates betulin biosynthesis in birch显示文摘The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unclear.In this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence it.Whole-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast China.ZEB treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent manner.The methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic dose-response.In the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively correlated.Thus climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin biosynthesis.This study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production. | Jiang Wang Bowei Chen Shahid Ali Tianxu Zhang Yu Wang He Zhang Lishan Wang Yonglan Zhang Linan Xie Tingbo Jiang Jing Yin Heike W.Sederoff Gaurav Zinta Ronald R.Sederoff Yuhua Li Qingzhu Zhang | 2023 | Journal of Forestry Research2023，34，1： | 0 |
| 18 | Correction To:POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsqfbp5nncpu6x6xfq.ffgz.tsg.suse.edu.cn/10.1038/s41392-022-00900-8,published online 28 March 2022 The plate photo from Control in Figure 4c of the published work was mistakenly used when editing the photos,and the corrected version is demonstrated below.The results and conclusions of this paper were not affected by this error. | Changyu Cao Tingbo Zhang Nan Yang Xianghong Niu Zhaobo Zhou Jinlan Wang Dongliang Yang Peng Chen Liping Zhong Xiaochen Dong Yongxiang Zhao | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 19 | The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination显示文摘Despite recent progress in hepatitis treatment,there have been no significant advances in the development of liver cancer vaccines in recent years.In this study,we investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor(MET,also known as HGFR)on tumor vaccinations for liver cancer in mice.Herein,we demonstrate that MET expression is significantly associated with the immunogenicity of liver cancer in mice and humans,and that MET depletion dramatically enhances the protective efficacy of chemotherapy-based anti-liver cancer vaccination.Mechanistically,MET repressed liver cancer immunogenicity independent of the traditional PI3K–AKT cascade,and MET interacted with vacuolar ATP synthase(V-ATPase)and mediated the activation of mammalian target of rapamycin(MTOR),thus suppressing liver cancer immunogenicity.The efficacy of chemotherapy-based liver cancer vaccination was markedly enhanced by targeting the MET–V-ATPase–MTOR axis,highlighting a translational strategy for identifying MET-associated drug candidates for cancer prevention. | Xing Huang Xingyuan Xu Xun Wang Tianyu Tang Enliang Li Xiaozhen Zhang Jian Xu Hang Shen Chengxiang Guo Tao Xu Jianhong Ren Xueli Bai Tingbo Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | Function of arsATorf7orf8 of Bacillus sp. CDB 3 in arsenic resistance显示文摘Bacillus sp. CDB3 isolated from an arsenic contaminated cattledip site possesses an uncommon arsenic resistance (ars) operon bearing eight genes in the order of arsRYCDATorf7orf8. We investigated the functions of arsA, arsT, orf7 and orf8 in arsenic resistance using a plasmid-based gene knockout approach in the ars genedeficient Escherichia coli strain AW3110. The CDB3 arsA genewas shown to play a significant role in resistance, suggesting that the encoded ArsA may couplewith the arsenite transporter, forming an ArsAY complex that can enhance arsenite extrusion efficiency. Thedisruption of either arsT or orf7was not observed to affect arsenic resistance in the heterologous E. coli host, but their involvement in arsenic resistance can not be excluded. The orf8 gene is predicted to encode a putativedual-specificity protein phosphatasewhich also shares certain homology to arsenate reductases. The function loss of orf8 resulted in a remarkabledecrease in resistance to arsenate, though not arsenite. To examine if this effectwasdue to the reduction of arsenate by orf8, the arsC genewithin the 8-gene operonwasdisrupted. The resulting abolishment of arsenate resistance suggests that the involvement of orf8 in arsenic resistance is not via reductase activity. | Wei Zheng James Scifleet Xuefei Yu Tingbo Jiang Ren Zhang | 2013 | Journal of Environmental Sciences2013，25，7： | 0 |
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