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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 3 | Single-port transperitoneal robotic-assisted laparoscopic radical prostatectomy (spRALP): Initial experience显示文摘Objective:To assess the feasibility of single-port transperitoneal robotic-assisted laparoscopic radical prostatectomy(spRALP)and discuss its surgical technique.Methods:A 60-year-old male was admitted with an elevated prostate-specific antigen(PSA)level of 13.89 ng/mL and confirmed with prostate cancer on biopsy showing three of 22 positive cores with a Gleason score of 3þ4=7.Multiparametric magnetic resonance(MR)and bone scintigraphy showed organ-confined disease.spRALP was performed using da Vinci Si HD surgical system,with access of a quadri-channel laparoscopic port placed supraumbilically.Two drainage tubes were placed before wound closure.The surgical procedure was largely in consistence with a conventional robotic-assisted laparoscopic radical prostatectomy.Results:The surgery was successfully carried out with a duration of 152 min and an estimated blood loss of 100 mL.The patient was discharged on postoperative Day 4 after removal of both pelvic drainage tubes.Foley catheter was removed on postoperative Day 14.No major complications were encountered.Postoperative pathology showed a Gleason score of 3þ4=7 with no extraprostatic extension and negative surgical margins.Conclusion:Single-port robotic prostatectomy is feasible using the currently available robotic instruments in most Chinese robotic urological centers.Meticulous preoperative planning and careful patient selection are mandatory.Further studies concerning perioperative complications and pentafecta outcome compared with the conventional multi-port robotic prostatectomy is required. | Yifan Chang Xiaojun Lu Qingliang Zhu Chuanliang Xu Yinghao Sun Shancheng Ren | 2019 | Asian Journal of Urology2019，6，3： | 9 |
| 4 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 5 | A scalable sulfuration of WS2 to improve cyclability and capability of lithium-ion batteries显示文摘二维的转变金属 dichalcogenides (WS 2 和 SnS 2) 最近加入了精力存储材料的家庭(为锂离子电池和 supercapacitors ) 由于他们的有利离子置闰。到目前为止,在阶段纯的 WS 2, 的合成的挑战严重地在 WS 2 nanosheets,低电子传导性,和 WS 2, 的易碎的性质之间重新叠限制它的使用 Li 离子电池申请。此处,我们开发灵巧的低温度解决方案硫化进程戏剧性地改进电池性能。硫化过程被表明在把 WO 3 杂质变换成 WS 2, 并且在修理硫空缺有效,到改进 cyclability 和率能力。锂离子电池大小证明 WS 2 阳极的稳定的能力能被 48.4% 经由硫化 reprocessing 提高,即,从在 0.8 的相对高的当前的密度的 381.7 ~ 566.8 mAh/g,在 50 以后的 A/g 骑车。我们进一步证明硫化进程能乐意地被扩大到另外的 dichalcogenides,并且可以为锂离子电池向万用的电极材料的一个类提供改进电气化学的特征。 | Liyan Zhou Shancheng Yan Lijia Pan Xinran Wang Yuqiao Wang Yi Shi | 2016 | Nano Research2016，9，3： | 7 |
| 6 | SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance显示文摘Androgen deprivation therapy(ADT)is an important treatment strategy that can be used to delay the progression of prostate cancer.However,after an initial response,which varies significantly among patients,the disease eventually progresses despite the low levels of testosterone in the systemic circulation.1 The mechanism underlying the progression of prostate cancer to castration-resistant prostate cancer(CRPC)is not yet clear,and further investigation is needed. | Fei Liu Chao Wang Hai Huang Yue Yang Lihe Dai Sujun Han Nianzeng Xing Shancheng Ren | 2021 | Cellular & Molecular Immunology2021，18，3： | 5 |
| 7 | Current oscillations during the electrochemical oxidation of sulfide in the presence of an external resistor显示文摘The electrochemical oxidation of sulfide on a polycrystalline platinum electrode was studied under potentiostatic condition when an external resistor is in series with the working electrode. Only two os- cillatory regions can be obtained in the absence of the external resistance, but four oscillatory regions, including two new current oscillations, were found in this system by controlling the external resistance. It is demonstrated that three oscillatory regimes, which arise on the positive branch of current-potential curve, can be classified as HN-NDR (Hidden N-shaped Negative Differential Resistance) oscillators. For the first oscillatory region, various transient complex phenomena, which result from the change of the electrode/electrolyte interface by accumulation of adsorbed element sulfur on the electrode, have been observed. The dynamic behavior of NDR (Negative Differential Resistance) oscillations, appearing along with negative branch of polarization curve, can transform from oscillations into bistability with a sufficient large external resistance in series. Two oscillatory regions in high-potential region classified as HN-NDR type oscillations are separated by a saddle-loop bifurcation. They displayed a sequence of bursting oscillations and irregular oscillations, respectively. The electrochemical oxidation of sulfide provides a model system for studying complex dynamics and possible application in sulfur removal. | FENG JiaMin GAO QingYu LI Jun LIU Li MAO ShanCheng | 2008 | Science China Chemistry2008，51，4： | 3 |
| 8 | Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration-Resistant Prostate Cancer显示文摘 | Shancheng Ren Yawei Liu Weidong Xu Yi Sun Ji Lu Fubo Wang Min Wei Jian Shen Jianguo Hou Xu Gao Chuanliang Xu Jiaoti Huang Yi Zhao Yinghao Sun | 2013 | The Journal of Urology2013，，： | 2 |
| 9 | Genome-wide association studies on prostate cancer:the end or the beginning?显示文摘Prostate cancer(PCa)is the second most frequently di-agnosed malignancy in men.Ge nome-wide association st udies(GWAS)has been highly successful in discover-ing susceptibility loci for prostate cancer.Currently,more than twenty GWAS have identified more than fifty com-mon variants associated with susceptibility with PCa.Yet with the increase in loci,voices from the scientifi c society are calling for more.In this review,we summarize current fi ndings,discuss the common problems troubling current studies and shed light upon possible breakthroughs in the future.GWAS is the beginning of something wonder-ful.Although we are quite near the end of the beginning,post-GWAS studies are just taking off and future studies are needed extensively.It is believed that in the future GWAS information will be helpful to build a comprehen-sive system intergraded with PCa prevention,diagnosis,molecular classifi cation,personalized therapy. | Rui Chen Shancheng Ren Yinghao Sun | 2013 | Protein & Cell2013，4，9： | 2 |
| 10 | Targeting signaling pathways in prostate cancer:mechanisms and clinical trials显示文摘Prostate cancer(PCa)affects millions of men globally.Due to advances in understanding genomic landscapes and biological functions,the treatment of PCa continues to improve.Recently,various new classes of agents,which include next-generation androgen receptor(AR)signaling inhibitors(abiraterone,enzalutamide,apalutamide,and darolutamide),bone-targeting agents(radium-223 chloride,zoledronic acid),and poly(ADP-ribose)polymerase(PARP)inhibitors(olaparib,rucaparib,and talazoparib)have been developed to treat PCa.Agents targeting other signaling pathways,including cyclin-dependent kinase(CDK)4/6,Ak strain transforming(AKT),wingless-type protein(WNT),and epigenetic marks,have successively entered clinical trials.Furthermore,prostate-specific membrane antigen(PSMA)targeting agents such as 177Lu-PSMA-617 are promising theranostics that could improve both diagnostic accuracy and therapeutic efficacy.Advanced clinical studies with immune checkpoint inhibitors(ICIs)have shown limited benefits in PCa,whereas subgroups of PCa with mismatch repair(MMR)or CDK12 inactivation may benefit from ICIs treatment.In this review,we summarized the targeted agents of PCa in clinical trials and their underlying mechanisms,and further discussed their limitations and future directions. | Yundong He Weidong Xu Yu-Tian Xiao Haojie Huang Di Gu Shancheng Ren | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 11 | Time-domain Spectral Finite Element Method for Wave Propagation Analysis in Structures with Breathing Cracks显示文摘Guided waves are generally considered as a powerful approach for crack detection in structures,which are commonly investigated using the finite element method(FEM).However,the traditional FEM has many disadvantages in solving wave propagation due to the strict requirement of mesh density.To tackle this issue,this paper proposes an efficient time-domain spectral finite element method(SFEM)to analyze wave propagation in cracked structures,in which the breathing crack is modeled by definiiig the spectral gap element.Moreover,novel orthogonal polynomials and Gauss-Lobatto-Legendre quadrature rules are adopted to construct the spectral element.Meanwhile,a separable hard contact is utilized to simulate the breathing behavior.Finally,a comparison of the numerical results between the FEM and the SFEM is conducted to demonstrate the high efficiency and accuracy of the proposed method.Based on the developed SFEM,the nonlinear features of waves and influence of the incident mode are also studied in detail,which provides a helpful guide for a physical understanding of the wave propagation behavior in structures with breathing cracks. | Zexing Yu Chao Xu Fei Du Shancheng Cao Liaiigxian Gu | 2020 | Acta Mechanica Solida Sinica2020，33，6： | 2 |
| 12 | Protein characteristics of Chinese black-grained wheat显示文摘 | Wende Li Trust Beta Shancheng Sun Harold Corke | 2005 | Food Chemistry2005，，3： | 1 |
| 13 | A class of nonbinary LDPC codes with fast encoding and decoding algorithms 显示文摘 | Zhao Shancheng Ma Xiao Zhang Xiaoyi | 2013 | IEEE Transactions on Communications2013，61，1： | 1 |
| 14 | Developments in stability and passivation strategies for black phosphorus显示文摘Black phosphorus(BP),a promising two-dimensional layer material,has attracted increasing attention due to its high carrier mobility,thickness-dependent tunable bandgap,in-plane anisotropy,and other advantageous characteristics.Because of these excellent characteristics,BP has been considered for applications in optics,electronics,optoelectronics,sensors,and energy storage.However,early studies found that BP has high chemical activity due to the lone pair electrons of P atoms on the surface and edges,resulting in rapid degradation under ambient conditions and limiting many applications.Recently,these thorny issues have been alleviated through superior physical and chemical passivation techniques,and passivated BP can be used in various devices under ambient and water conditions with excellent performance over a long period.This review,highlights the critical problems addressed in solving the serious instability of BP in a harsh environment by effective passivation technology.These unique strategies can provide more researchers with a fundamental study of the fascinating properties of BP.Finally,we found that passivated BP not only showed good stability under ambient conditions but also exhibited excellent performance compared with the original BP.Therefore,it is anticipated that this overview can contribute to the application of BP. | Haizeng Song Han Wu Tianqi Ren Shancheng Yan Tianhong Chen Yi Shi | 2021 | Nano Research2021，14，12： | 1 |
| 15 | Construction of High-Perform- ance Array-Based Non-Binary LDPC Codes With Moderate Rates显示文摘 | Shancheng Zhao Xiao Ma | 2016 | IEEE Communications letters2016，20，1： | 1 |
| 16 | Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer显示文摘 | Ren Shancheng Liu Yawei | 2013 | J Urol2013，190，6： | 1 |
| 17 | Vascular endothelial growth factor plays a critical role in the formationof the pre-metastatic niche via prostaglandin E2显示文摘 | Shili Liu Man Jiang Qiang Zhao Shancheng Li Yanping Peng Pengfei Zhang Mingyong Han | 2014 | Oncology Reports2014，，： | 1 |
| 18 | Synthesis of Ru/multiwalled carbon nanotubes by microemulsion for electrochemical supercapacitor 显示文摘 | Shancheng Yan Peng Qu Haitao Wang | 2008 | Materials Research Bulletin2008，43，10： | 1 |
| 19 | Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy显示文摘Objective:This study aimed to evaluate the effects of mitochondrial pyruvate carrier(MPC)blockade on the sensitivity of detection and radiotherapy of prostate cancer(PCa).Methods:We investigated glycolysis reprogramming and MPC changes in patients with PCa by using metabolic profiling,RNASeq,and tissue microarrays.Transient blockade of pyruvate influx into mitochondria was observed in cellular studies to detect its different effects on prostate carcinoma cells and benign prostate cells.Xenograft mouse models were injected with an MPC inhibitor to evaluate the sensitivity of 18F-fluorodeoxyglucose positron emission tomography with computed tomography and radiotherapy of PCa.Furthermore,the molecular mechanism of this different effect of transient blockage towards benign prostate cells and prostate cancer cells was studied in vitro.Results:MPC was elevated in PCa tissue compared with benign prostate tissue,but decreased during cancer progression.The transient blockade increased PCa cell proliferation while decreasing benign prostate cell proliferation,thus increasing the sensitivity of PCa cells to 18F-PET/CT(SUVavg,P=0.016;SUVmax,P=0.03)and radiotherapy(P<0.01).This differential effect of MPC on PCa and benign prostate cells was dependent on regulation by a VDAC1-MPC-mitochondrial homeostasis-glycolysis pathway.Conclusions:Blockade of pyruvate influx into mitochondria increased glycolysis levels in PCa but not in non-carcinoma prostate tissue.This transient blockage sensitized PCa to both detection and radiotherapy,thus indicating that glycolytic potential is a novel mechanism underlying PCa progression.The change in the mitochondrial pyruvate influx caused by transient MPC blockade provides a critical target for PCa diagnosis and treatment. | Huan Xu Junyi Chen Zhi Cao Xi Chen Caihong Huang Jin Ji Yalong Xu Junfeng Jiang Yue Wang Guowang Xu Lina Zhou Jingyi He Xuedong Wei Jason Boyang Wu Zhong Wang Shancheng Ren Fubo Wang | 2022 | Cancer Biology & Medicine2022，19，9： | 1 |
| 20 | Protein characteristics of Chinese black-grained wheat显示文摘 | Li Wende Beta Trust Sun Shancheng | 2006 | Food Chemistry2006，98，： | 1 |
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