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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Galloping Vibration Monitoring of Overhead Transmission Lines by Chirped FBG Array显示文摘A distributed online fiber sensing system based on the phase-sensitive optical time domain reflectometer(Φ-OTDR)enhanced by the drawing tower fiber Bragg grating(FBG)array is presented and investigated experimentally for monitoring the galloping of overhead transmission lines.The chirped FBG array enhanced Φ-OTDR sensing system can be used to measure the galloping behavior of the overhead transmission lines(optical phase conductor or optical power ground wire),which are helpful for monitoring the frequency response characteristics of the ice-induced galloping,evaluating the motion tendencies of these cables,and avoiding the risk of flashover during galloping.The feasibility of the proposed online monitoring system is demonstrated through a series of experiments at the Special Optical Fiber Cable Laboratory of State Grid Corporation of China(Beijing,China).Results show that the proposed system is effective and reliable for the monitoring of galloping shape and characteristic frequency,which can predict the trend of destructive vibration behavior and avoid the occurrence of cable breaking and tower toppling accidents,and these features are essential for the safety operation in smart grids. | Qizhong YAN Ciming ZHOU Xuebin FENG Chi DENG Wenyu HU Yimin XU | 2022 | Photonic Sensors2022，12，3： | 5 |
| 3 | APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease显示文摘Current evidence shows that apolipoprotein E(APOE), apolipoprotein CI(APOC1) and low density lipoprotein receptor-related protein(LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. | Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang | 2014 | Neural Regeneration Research2014，9，6： | 4 |
| 4 | A Decoupling Control Model on Perturbation Method for Twin-Roll Casting Magnesium Alloy Sheet显示文摘To better understand the twin-roll casting process,based on the analysis of the solidification phenomenon,the geometry shape of the molten metal pool,the continuity of metal and the balance of energy and momentum,five critical partial equations were established separately including the equations of pool level,solidification process,roll separating force,roll gap and casting speed.Meanwhile,to obtain a uniform sheet thickness and keep a constant roll separating force,a decoupling control model was built on the perturbation method to eliminate the interference of process parameters.The simulation results show that the control model is valuable to quickly and accurately determine the control parameters.Moreover,Mg alloy sheets with high quality were cast by applying this model. | Wenyu Zhang Dongying Ju Hongyang Zhao Xiaodong Hu Yao Yao Yujun Zhang | 2015 | Journal of Materials Science & Technology2015，31，5： | 4 |
| 5 | Bayesian machine learning-based method for prediction of slope failure time显示文摘The data-driven phenomenological models based on deformation measurements have been widely utilized to predict the slope failure time(SFT).The observational and model uncertainties could lead the predicted SFT calculated from the phenomenological models to deviate from the actual SFT.Currently,very limited study has been conducted on how to evaluate the effect of such uncertainties on SFT prediction.In this paper,a comprehensive slope failure database was compiled.A Bayesian machine learning(BML)-based method was developed to learn the model and observational uncertainties involved in SFT prediction,through which the probabilistic distribution of the SFT can be obtained.This method was illustrated in detail with an example.Verification studies show that the BML-based method is superior to the traditional inverse velocity method(INVM)and the maximum likelihood method for predicting SFT.The proposed method in this study provides an effective tool for SFT prediction. | Jie Zhang Zipeng Wang Jinzheng Hu Shihao Xiao Wenyu Shang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 2 |
| 6 | Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival显示文摘Cancer cells remodel their metabolic network to adapt to variable nutrient availability. Pentose phosphate pathway(PPP) plays protective and biosynthetic roles by oxidizing glucose to generate reducing power and ribose. How cancer cells modulate PPP activity in response to glucose supply remains unclear. Here we show that ribose-5-phosphate isomerase A(RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1(CARM1) and is methylated at arginine 42(R42). R42 methylation up-regulates the catalytic activity of RPIA. Furthermore, glucose deprivation strengthens the binding of CARM1 with RPIA to induce R42 hypermethylation. Insufficient glucose supply links to RPIA hypermethylation at R42, which increases oxidative PPP flux. RPIA methylation supports ROS clearance by enhancing NADPH production and fuels nucleic acid synthesis by increasing ribose supply. Importantly, RPIA methylation at R42 significantly potentiates colorectal cancer cell survival under glucose starvation. Collectively, RPIA methylation connects glucose availability to nucleotide synthesis and redox homeostasis. | Jizheng Guo Qixiang Zhang Ying Su Xiaochen Lu Yiping Wang Miao Yin Weiguo Hu Wenyu Wen Qun-Ying Lei | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 7 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 8 | Tailoring interlayer spacing in MXene cathodes to boost the desalination performance of hybrid capacitive deionization systems显示文摘Capacitive deionization(CDI)is a promising technology to satisfy the global need for fresh water,since it can be both economical and sustainable.While two-dimensional transition metal carbides/nitrides(MXenes)exhibit great characteristics for use as CDI electrode materials,their tightly spaced layered structure renders intercalation inefficiency.In this study,the interlayer distance of MXenes is precisely modulated by inserting different quantity of one-dimensional bacterial fibers(BC),forming freestanding MXene/BC composite electrodes.Among the studied samples,MXene/BC-33%electrode with the interlayer spacing of 15.2Åcan achieve an optimized tradeoff among various desalination performance metrics and indicators.The salt adsorption capacity(SAC),the average salt adsorption rate(ASAR),the energy normalized adsorbed salt(ENAS),and the thermodynamic energy efficiency(TEE)of the MXene/BC-33%electrode are improved by 24%,46%,13%,and 66%respectively compared with those of pure MXene electrode.While the insertion of BC improves the ion diffusion pathways and facilitates the intercalation kinetics,the desalination performance decreases when the insertion amount of BC exceeds 40%.This is attributed to the overlarge resistance of the composite and the resulting increased energy consumption.This study reveals the desalination performance tradeoffs of MXene-based electrodes with different interlayer distances and also sheds light on the fundamental ion storage mechanisms of intercalation materials in a CDI desalination system. | Bei Li Kang Sun Wenyu Xu Xiaojing Liu Ao Wang Steven Boles Bin Xu Haibo Hu Dongrui Yao | 2023 | Nano Research2023，16，5： | 1 |
| 9 | Repurposing FDA-approved drugs for SARS- CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)global pandemic is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which instigates severe and often fatal symptoms.As of September 4th,2020,more than 26 million cases of COVID-19 and almost 900,000 deaths have been reported to WHO.Based on Kissler and colleagues’modeled projections of future viral transmission scenarios,a resurgence in SARS-CoV-2 could occur over the next five years(Kissler et al.,2020). | Wenyu Fu Yujianan Chen Kaidi Wang Aubryanna Hettinghouse Wenhuo Hu Jing-Quan Wang Zi-Ning Lei Zhe-Sheng Chen Kenneth A.Stapleford Chuan-ju Liu | 2021 | Protein & Cell2021，12，7： | 1 |
| 10 | Enhanced thermoelectric performance and atomic-resolution interfacial structures in BiSbTe thermo-electro-magnetic nanocomposites incorporating magnetocaloric LaFeSi nanoparticles显示文摘Incorporating magnetic nanoparticles in thermoelectric(TE)materials introduce magnetic interfaces with additional electron and phonon scattering mechanism for high TE performance.However,the influence of heterogeneous interfaces between magnetic nanoparticles and TE matrix on electronic and thermal transport remains elusive in the thermo-electric-magnetic nanocomposites.Here,using p-type TE material Bi_(0.3)Sb_(1.7)Te_(3)(BST)as matrix and magnetocaloric(MC)material La(Fe_(0.92)Co_(0.08))_(11.9)Si_(1.1)(LFS)nanoparticles as a second phase,TE/MC nanocomposites xLFS/BST(x=0.1%,0.2%,0.3% and 0.4%)were synthesized using spark plasma sintering method.The atomic-resolution interfacial structures demonstrate that Te vacancies originating from LFS-BST interfacial reaction decreases the hole concentration of the LFS/BST nanocomposites and enhances the Seebeck coefficient.The LFS/BST nanocomposites exhibit lower thermal conductivity due to enhanced phonon scattering by interfaces and defects.All the nanocomposites have higher ZT than BST matrix,with 0.2% LFS/BST nanocomposite achieving highest ZT=1.11 at 380 K.At working current 1.4 A,the device fabricated using 0.2% LFS/BST nanocomposite achieves maximal cooling temperature 4.9 K,which is 58% higher than the matrix.Moreover,the MC properties are retained in all the nanocomposites,which make them a promising candidate to achieve high TE performance and dual TE/MC properties for future applications. | Lin Xing Wenjun Cui Xiahan Sang Fengxia Hu Ping Wei Wanting Zhu Xiaolei Nie Qingjie Zhang Wenyu Zhao | 2021 | Journal of Materiomics2021，7，5： | 1 |
| 11 | Variability of Atlantic Meridional Overturning Circulation in FGOALS-g2显示文摘The variability of Atlantic Meridional Overturning Circulation(AMOC) in the pre-industrial control experiment of the Flexible Global Ocean–Atmosphere–Land System model, Grid-point Version 2(FGOALS-g2) was investigated using the model outputs with the most stable state in a 512-yr time window from the total 1500-yr period of the experiment. The period of AMOC in FGOALS-g2 is double peaked at 20 and 32 years according to the power spectrum, and 22 years according to an auto-correlation analysis, which shows very obvious decadal variability. Like many other coupled climate models, the decadal variability of AMOC in FGOALS-g2 is closely related to the convection that occurs in the Labrador Sea region. Deep convection in the Labrador Sea in FGOALS-g2 leads the AMOC maximum by 3–4 years. The contributions of thermal and haline effects to the variability of the convection in three different regions [the Labrador, Irminger and Greenland–Iceland– Norwegian(GIN) Seas] were analyzed for FGOALS-g2. The variability of convection in the Labrador and Irminger Seas is thermally dominant, while that in the colder GIN Seas can be mainly attributed to salinity changes due to the lower thermal expansion. By comparing the simulation results from FGOALS-g2 and 11 other models, it was found that AMOC variability can be attributed to salinity changes for longer periods(longer than 35 years) and to temperature changes for shorter periods. | HUANG Wenyu WANG Bin LI Lijuan DONG Li LIN Pengfei YU Yongqiang ZHOU Tianjun LIU Li XU Shiming XIA Kun PU Ye WANG Lu LIU Mimi SHEN Si HU Ning WANG Yong SUN Wenqi DONG Fang | 2014 | Advances in Atmospheric Sciences2014，31，1： | 1 |
| 12 | Effects of a major earth- quake on the status of pre-existing physical illness and levels of psychosocial distress in community inhabitants 显示文摘 | Chiu TY Hu Wenyu Lue BH | 2002 | J Formos Med Assoe2002，101，5： | 1 |
| 13 | OBV(obscure vein),a C_(2)H_(2)zinc finger transcription factor,positively regulates chloroplast development and bundle sheath extension formation in tomato(Solanum lycopersicum)leaf veins显示文摘Leaf veins play an important role in plant growth and development,and the bundle sheath(BS)is believed to greatly improve the photosynthetic efficiency of C_(4) plants.The OBV mutation in tomato(Solanum lycopersicum)results in dark veins and has been used widely in processing tomato varieties.However,physiological performance has difficulty explaining fitness in production.In this study,we confirmed that this mutation was caused by both the increased chlorophyll content and the absence of bundle sheath extension(BSE)in the veins.Using genome-wide association analysis and map-based cloning,we revealed that OBV encoded a C_(2)H_(2) L domain class transcription factor.It was localized in the nucleus and presented cell type-specific gene expression in the leaf veins.Furthermore,we verified the gene function by generating CRISPR/Cas9 knockout and overexpression mutants of the tomato gene.RNA sequencing analysis revealed that OBV was involved in regulating chloroplast development and photosynthesis,which greatly supported the change in chlorophyll content by mutation.Taken together,these findings demonstrated that OBV affected the growth and development of tomato by regulating chloroplast development in leaf veins.This study also provides a solid foundation to further decipher the mechanism of BSEs and to understand the evolution of photosynthesis in land plants. | Jinghua Lu Chunyang Pan Xin Li Zejun Huang Jinshuai Shu Xiaoxuan Wang Xiaoxiao Lu Feng Pan Junling Hu Hui Zhang Wenyue Su Min Zhang Yongchen Du Lei Liu Yanmei Guo Junming Li | 2021 | Horticulture Research2021，8，1： | 1 |
| 14 | Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors显示文摘Peptides that are composed of dextrorotary(D)-amino acids have gained increasing attention as a potential therapeutic class.However,our understanding of the in vivo fate of D-peptides is limited.This highlights the need for whole-body,quantitative tracking of D-peptides to better understand how they interact with the living body.Here,we used mouse models to track the movement of a programmed death-ligand 1(PD-L1)-targeting D-dodecapeptide antagonist(DPA)using positron emission tomography(PET).More specifically,we profiled the metabolic routes of[^(64)Cu]DPA and investigated the tumor engagement of[^(64)Cu/^(68)Ga]DPA in mouse models.Our results revealed that intact[^(64)Cu/^(68)Ga]DPA was primarily eliminated by the kidneys and had a notable accumulation in tumors.Moreover,a single dose of[^(64)Cu]DPA effectively delayed tumor growth and improved the survival of mice.Collectively,these results not only deepen our knowledge of the in vivo fate of D-peptides,but also underscore the utility of D-peptides as radiopharmaceuticals. | Kuan Hu Wenyu Wu Lin Xie Hao Geng Yiding Zhang Masayuki Hanyu Lulu Zhang Yinghuan Liu Kotaro Nagatsu Hisashi Suzuki Jialin Guo Yundong Wu Zigang Li Feng Wang Mingrong Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 15 | Analysis of direct torque control in permanent synchronous motor drives显示文摘 | ZHONG L RAHMAN M F HU Wenyu | 1997 | IEEE Trans on Power Electronics1997，12，3： | 1 |
| 16 | Estimating the time interval between transmission generations and the presymptomatic period by contact tracing surveillance data from 31 provinces in the mainland of China显示文摘The global pandemic of 2019 coronavirus disease(COVID-19)is a great assault to public health.Presymptomatic transmission cannot be controlled with measures designed for symptomatic persons,such as isolation.This study aimed to estimate the interval of the transmission generation(TG)and the presymptomatic period of COVID-19,and compare the ftting effects of TG and serial interval(S)based on the SEIHR model incorporating the surveillance data of 3453 cases in 31 provinces.These data were allocated into three distributions and the value of AIC presented that the Weibull distribution fitted well.The mean of TG was 5.2 days(95%C:4.6-5.8).The mean of the presymptomatic period was 2.4 days(95%CI:1.5-3.2).The dynamic model using TG as the generation time performed well.Eight provinces exhibited a basic reproduction number from 2.16 to 3.14.Measures should be taken to control presymptomatic transmission in the COVID-19 pandemic. | Zhongxing Ding Kai Wang Mingwang Shen Kai Wang Shi Zhao Wenyu Song Rui Li Zhongjie Li Liping Wang Ganzhu Feng Zhiliang Hu Hongxia Wei Yanni Xiao Changjun Bao Jianli Hu Liguo Zhu Yong Li Xufeng Chen Yi Yin Weiming Wang Yongli Cai Zhihang Peng Hongbing Shen | 2021 | Fundamental Research2021，1，2： | 1 |
| 17 | Quick fabrication of evenly porous PbO_(2) through potential linear increase electrodeposition显示文摘Anodic oxidation electrodeposition is the primary way to prepare lead dioxide anode. The regulation of the external circuit for the reaction is a unique advantage of electrocatalytic reaction, which can regulate crystallization and accelerate the reaction process. In this study, lead dioxide coatings with uniform pore size distribution were quickly prepared on three different substrates by potential linear increase electrodeposition(PLIED). Morphology and structure analysis shows that the prepared electrodes have uniform porous morphology, and Ti/SnO_(2)/PLIED has the smallest grain size. Three electrodes all display well degradation performance to azophloxine and diclofenac sodium. Ti/PLIED, and Ti/SnO_(2)/PLIED are appreciated for degrading organics with a simple structure in low concentrations. At the same time,Ti/SnO_(2)/PLIED is more suitable for complex organics in high concentrations. Electrochemical activity tests indicate the different mechanisms of the PLIED electrodes that build the other degradation performance.Three PLIED electrodes show excellent electrical and electrochemical stability during the cycle degradation process. The results provide a reference for the subsequent anodic oxidation electrodeposition research and the regulating effect of the external circuit on coating properties. | Hua Guo Wenyu Hu Zekun Zhang Duowen Yang Siyuan Guo Xiaosheng Jing Hao Xu Wei Yan | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 18 | Experimental Research on Inlet Steady Swirl Distortion in an Axial Compressor with Non-Uniform Tip Clearance显示文摘The inlet swirl distortion and non-uniform tip clearance have great effects on aero-engine performance and stall margin.In this paper,the effects of paired swirl distortion on the aerodynamic stability and stall inception of a single stage axial compressor with non-uniform tip clearance are quantitatively analyzed by using the swirl distortion descriptors.The experimental results show that the paired swirl distortion dominated by co-rotating swirl improves the stability of the axial compressor.For a single-stage axial compressor with eccentricity of 100%,the stall inception starts at the maximum tip clearance with clean inlet.The initial position of the stall inception is determined by the maximum tip clearance when the small intensity paired swirl distortion exists at the compressor inlet.As the swirl intensity increases,it shifts towards the position of the counter rotating swirl vortex core.The inlet swirl will not change the type of stall inception. | XU Rong HU Jun WANG Xuegao JIANG Chao LI Wenyu | 2023 | Journal of Thermal Science2023，32，1： | 0 |
| 19 | The Establishment and Validation of the Human U937 Cell Line as a Cellular Model to Screen Immunomodulatory Agents Regulating Cytokine Release Induced by Influenza Virus Infection显示文摘Severe influenza infections are often associated with the excessive induction of pro-inflammatory cytokines,which is also referred to as'cytokine storms'.Several studies have shown that cytokine storms are directly associated with influenzainduced fatal acute lung injury and acute respiratory distress syndrome.Due to the narrow administration window,current antiviral therapies are often inadequate.The efforts to use immunomodulatory agents alone or in combination with antiviral agents in the treatment of influenza in animal models have resulted in the achievement of protective effects accompanied with reduced cytokine production.Currently,there are no immunomodulatory drugs for influenza available for clinical use.Animal models,despite being ideal to study the anti-inflammatory responses to influenza virus infection,are very costly and time-consuming.Therefore,there is an urgent need to establish fast and economical screening methods using cellbased models to screen and develop novel immunomodulatory agents.In this study,we screened seven human cell lines and found that the human monocytic cell U937 supports the replication of different subtypes of influenza viruses as well as the production of the important pro-inflammatory cytokines and was selected to develop the cell-based model.The U937 cell model was validated by testing a panel of known antiviral and immunomodulatory agents and screening a drug library consisting of 1280 compounds comprised mostly of FDA-approved drugs.We demonstrated that the U937 cell model is robust and suitable for the high-throughput screening of immunomodulators and antivirals against influenza infection. | Ge Liu Si Chen Ao Hu Li Zhang Wenyu Sun Jungang Chen Wei Tang Haiwei Zhang Chunlan Liu Chang Ke Xulin Chen | 2019 | Virologica Sinica2019，34，6： | 0 |
| 20 | How to Comprehensively Utilize the Discarded Fresh Tobacco Leaf ?显示文摘This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of biogas production facility in some villages of local tobacco area,this paper selects Longwan Village of Fengshiyan Town as the experimental site and explores the rational way of discarded fresh tobacco leaf biogas fermentation. Results show that cutting and fermentation of discarded fresh tobacco leaf before adding into biogas digester is conductive to improving p H in fermentation process,reducing crust amount,and effectively improving biogas production amount and rate. The study can provide reference for effective processing and rational utilization of discarded fresh tobacco leaf. | Xiqing LIU Weiping FENG Zhifu XU Dongyang HU Zairan DENG Wenyu LI | 2015 | Asian Agricultural Research2015，7，12： | 0 |
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