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| 1 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 3 | Preparation,characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral显示文摘Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry,with a need for development of optimal bone biomaterials to predictably rebuild these tissues.To address this problem,we fabricated a novel bone block using platelet-rich fibrin(PRF)and Deproteinized Bovine Bone Mineral(DBBM),and characterized their mechanical and biological properties.The bone block was prepared by mixing DBBM,Liquid-PRF,and Solid-PRF fragments in various combinations as follows:(1)BLOCK-1 made with Solid-PRF fragments+DBBM,(2)BLOCK-2 made with Liquid-PRF+DBBM,(3)BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM.The time for solidification and the degradation properties were subsequently recorded.Scanning electron microscopy(SEM)and tensile tests were carried out to investigate the microstructure and mechanical properties of each block.The bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay,cell migration assay,alkaline phosphatase(ALP)staining,and alizarin red staining(ARS),as well as by real-time PCR for genes encoding runt-related transcription factor 2(RUNX2),ALP,collagen type I alphal(COLIv41)and osteocalcin(OCN).BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM had by far the fastest solidification period(over a 10-fold increase)as well as the most resistance to degradation.SEM and tensile tests also revealed that the mechanical properties of BLOCK-3 were superior in strength when compared to all other groups and further induced the highest osteoblast migration and osteogenic differentiation confirmed by ALP,ARS and real-time PCR.PRF bone blocks made through the combination of Solid-PRF fragments+Liquid-PRF+DBBM had the greatest mechanical and biological properties when compared to either used alone.Future clinical studies are warranted to further support the clinical application of PRF bone blocks in bone regeneration procedures. | Mengge Feng Yulan Wang Yan Wei Xiaoxin Zhang Leyi Xiao Zijjian Gong Masako Fujioka-Kobayashi Anton Sculean Richard J Miron Scott Froum Yufeng Zhang | 2022 | Fundamental Research2022，2，2： | 3 |
| 4 | Real-time Online Analysis of Power Grid显示文摘The unprecedented operational complexity and se-curity risks in operating the Chinese UHV AC/DC power grid calls for a new generation of real-time(sec-order)online analysis systems to provide decision support.Our recent Digital Twin based online analysis research and development work to address the needs is presented.In addition,a high-level solution architec-ture for the future real-time online analysis systems is proposed for realizing:a)The delay of the virtual model to mirror the physical power grid is in sub-sec range;b)The downstream online analysis applications could have sec-order responsiveness. | Mike Zhou Jianfeng Yan Xiaoxin Zhou | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 5 | Microstructure characteristics of 12Cr ferritic/martensitic steels with various yttrium显示文摘12Cr ferritic/martensitic steels with 0, 0.1 wt%, 0.2 wt% and 0.3 wt% theoretical yttrium(Y) additions were fabricated by vacuum inducting melting and casting method. Solubilities of Y in the 12Cr steels are0.027, 0.078 and 0.17 for 12Cr-0.1 Y, 12Cr-0.2 Y and 12Cr-0.3 Y, respectively. Phase transformations and microstructure characteristics under different heat-treatment schedules were investigated. The starting temperature of ferrite-to-austenite transformation A^(c1) are maintained about 850℃, but the finishing temperature of ferrite-to-austenite transformation A^(c3) are about 950, 970, 980 and 1000℃ for 12Cr-0 Y,12Cr-0.1 Y, 12Cr-0.2 Y and 12Cr-0.3 Y, respectively, which indicates that A^(c3) increases gradually with the addition of Y. Martensite accompanied with a few δ-ferrite is the dominant structure in all the steels. The amount of δ-ferrite shows a strong dependence with the Y content and austenitizing temperature. Area fraction of δ-ferrite increases with the content of Y, which is the ferrite favouring element. The minimum amount of δ-ferrite are achieved at 950℃ for 12Cr-0 Y, 12Cr-0.1 Y, 12Cr-0.2 Y and 1000℃ for 12Cr-0.3 Y.Besides, more carbides precipitate along the martensite laths and grain boundaries in the Y-bearing steel due to the redistribution of carbon between austenite and ferrite resulting from the ferrite favouring element of Y. | Yingxue Chen Feifei Zhang Qingzhi Yan Xiaoxin Zhang Zhiyuan Hong | 2019 | Journal of Rare Earths2019，37，5： | 3 |
| 6 | Beta-amyloid precursor protein cleavage enzyme-1 expression in adult rat retinal neurons in the early period after lead exposure显示文摘Previous studies have reported that non-human primates and rodents exposed to lead during brain development may become dependent on the deposition of pre-determined β-amyloid protein (Aβ),and exhibit upregulation of β-site amyloid precursor protein expression in old age.However,further evidence is required to elucidate the precise relationship and molecular mechanisms underlying the effects of early lead exposure on excessive Aβ production in adult mammals.The present study investigated the effects of lead exposure on expression of β-amyloid precursor protein cleavage enzyme-1 (BACE-1) in the rat retina and the production of Aβ in early development,using the retina as a window for studying Alzheimer's disease.Adult rats were intraocularly injected with different doses of lead acetate (10μmol/L,100μmol/L,1 mmol/L,10 mmol/L and 100 mmol/L).The results revealed that retinal lead concentration,BACE-1 and its cleavage products β-C-terminal fragment and retina Aβ1-40 were all significantly increased in almost all of the lead exposure groups 48 hours later in a dose-dependent manner.The only exception was the 10μmol/L group.The distribution of BACE-1 in the retina did not exhibit obvious changes,and no distinctive increase in the activation of retinal microglia was apparent.Similarly,retinal synaptophysin expression did not exhibit any clear changes.These data suggest that lead exposure can result in the upregulation of retinal neuron BACE-1 expression in the early period of development and further increase the overproduction of Aβ1-40 in the retina.Our results provided novel insight into the molecular mechanisms underlying environmentally-induced Alzheimer's disease. | Jufang Huang Kai Huang Lei Shang Hui Wang Xiaoxin Yan Kun Xiong | 2011 | Neural Regeneration Research2011，6，14： | 3 |
| 7 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 8 | REMOTE SENSING OF ALGAL BLOOMS USING A TURBIDITY-FREE FUNCTION FOR NEAR-INFRARED ANDRED SIGNALS显示文摘This article presents a method for real- time mapping of algal blooms in turbid coastal waters using the remote sensing reflectance of red band (Channel 1, 580-680 nm) and near-infrared band (Channel 2, 720-1100 nm) of the AVHRR sensor on the NOAA series satellites. A turbidity-free function for near-infrared and red signals, α0 = (bb(1)/bb(2))(a(2)/ a(1)) based on the first order bb/(a+bb) model deduc-ing equation Rrs(2)?1 = α0 Rrs(1) ?1+ g?1 (1?α0), were se-lected as a chlorophyll-a related index for detecting algal blooms, and the algal blooms with chlorophyll-a concentration of 64-256 mg/L could be defined by window of 1.6 < α0 < 5.2 and 0.01< Rrs(2)/g < 0.2. Such turbidity-free two-band method is supported by both sea-truth data and remote sensing experiment for an algal blooms event on the near-shore water off the Minjiang estuary of southeastern China during early June of 2003. Comparisons of this algorithm with other published algorithms, one-band method (i.e. method of bright water) or two-band methods (i.e. method of ratio, method of NDVI, and method of subtracting) have suggested that the turbidity-free function method could be regarded as a standard algorithm in capabilities of AVHRR imagery or other high resolution but wide near-infrared and red band imagery for detecting algal blooms events in coastal waters. | LI Yan SHANG Shaoling ZHANG Caiyun MA Xiaoxin HUANG Liwei WU Jingyu ZENG Yindong | 2006 | Chinese Science Bulletin2006，51，4： | 2 |
| 9 | Study onproperties of Cyperus esculentus starch grown in Xinjiang,China显示文摘 | Siqun Jing Xiaoxin Yan Weiqi Ouyang | 2012 | Starch/Starke2012，64，8： | 1 |
| 10 | The heart-protective mechanism of Qishaowuwei formula on murine viral myocarditis induced by CVB3显示文摘 | Liu Fengqin Wang Yulin Zhu Xiaoxin Jin Youpeng Chen Yan Wang Qing-qing Chang Hong Song Jia Huang Lei | 2009 | Journal of Ethnopharmacology2009，，2： | 1 |
| 11 | International Meridian Circle Program显示文摘The Earth is buffered from the ferocious onslaught of the solar wind by a thin layer of matter known as the atmosphere and geospace.This layer absorbs energy from irradiance and outburst from the Sun,as well as from disasters,transient phenomena and anthropogenic emissions originated from Earth.Through complicated physics,the absorbed energy changes the atmospheric and geospace state and sometimes gets re-released to power extreme events such as space weather.Taking place globally,these complicated processes cannot be understood unless they are studied globally.The Chinese scientists have proposed the International Meridian Circle Program(IMCP)to meet this demand.By operating nearly 1000 instruments encompassing all latitudes along with the 120°E–60°W longitudes,IMCP aims,for the first time,to construct comprehensive 3D data representation of the atmosphere and geospace on a global scale and empower interdisciplinary research to tackle key questions related to Earth’s environment and climate change. | LIU William WANG Chi SHEN Xuhui WU Jian BLANC Michel YAN Yihua FU Suiyan YUE Xinan LEI Jiuhou GONG Wei ZHANG Shaodong ZHANG Qinghe WANG Xin YANG Jing ZHANG Xiaoxin GAO Jing XU Jiyao YANG Guotao LI Hui REN Liwen YANG Fang | 2020 | 空间科学学报2020，40，5： | 1 |
| 12 | Expert consensus on the management process of gynecological emergency under the regular epidemic prevention and control of COVID-19显示文摘At present,China is in the stage of the COVID-19 epidemic where regular prevention and control measures are required to contain the spread of disease.Reports of new sporadic cases are still widespread across China and medical personnel remain at high risk of exposure to infection.This is especially the case for medical staff working within emergency departments.Most gynecological emergency cases are complex and a high proportion require emergency surgical treatment.By referring to national regulations and requirements on COVID-19 prevention and control,and by summarizing our experiences in the battle against COVID-19 within Wuhan,this consensus report provides recommendations on the triage,reception,consultation,admission and surgical management of gynecological emergency patients.We also make suggestions for the environmental layout and disinfection and the medical waste management.This consensus aims to optimize the diagnosis and treatment process of gynecological emergency patients and reduce the exposure risk of medical staff within the current context of routine COVID-19 prevention and control. | Hongbo Wang Wei Zhang Xin Du Yan Kuang Xiaomao Li Xiaoxin Ma Lan Xiao Xiaojun Chen Yu Zhang Donglin Li Lang Zheng Yanhui Li Jianliu Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，2： | 0 |
| 13 | The authors acknowledge the financial support from the National Natural Science Foundation of China(project No.31971247).显示文摘Mineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration.At present,autograft harvest procedures may cause secondary trauma to patients,while bone scaffold materials lack osteogenic activity,resulting in a limited application.Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft,but the explosive release of growth factor may also cause side effects.In this study,we innovatively used platelet-rich fibrin(PRF)-modified bone scaffolds(Bio-Oss®)to replace autograft,and used cytokine(BMP-2)to enhance osteogenesis.Encouragingly,this mixture,which we named“Autograft Mimic(AGM)”,has multiple functions and advantages.(1)The fiber network provided by PRF binds the entire bone scaffold together,thereby shaping the bone grafts and maintaining the space of the defect area.(2)The sustained release of BMP-2 from bone graft promoted bone regeneration continuously.(3)AGM recruited bone marrow mesenchymal stem cells(BMSCs)and promote their proliferation,migration,and osteogenic differentiation.Thus,AGM developed in this study can improve osteogenesis,and provide new guidance for the development of clinical bone grafts. | Yan Wei Guixin Zhu Zifan Zhao Chengcheng Yin Qin Zhao Hudi Xu Jinyang Wang Jinglun Zhang Xiaoxin Zhang Yufeng Zhang Haibin Xia | 2021 | International Journal of Oral Science2021，13，2： | 0 |
| 14 | The Effect of Solar Cycle on Climate of Northeast Asia显示文摘The impact of solar activity on climate system is spatiotemporally selective and usually more significant on the regional scale. Using statistical methods and solar radio flux(SRF) data, this paper investigates the impact of the solar11-yr cycle on regional climate of Northeast Asia in recent decades. Significant differences in winter temperature,precipitation, and the atmospheric circulation over Northeast Asia are found between peak and valley solar activity years. In peak years, temperature is higher over vast areas of the Eurasian continent in middle and high latitudes, and prone to producing anomalous high pressure there. Northeast Asia is located to the south of the anomalous high pressure, where the easterlies prevail and transport moisture from the western Pacific Ocean to the inland of East Asia and intensify precipitation there. In valley years, temperature is lower over the Eurasian continent and northern Pacific Ocean in middle and high latitudes, and there maintain anomalous low pressure systems in the two regions. Over the Northeast Asian continent, north winds prevail, which transport cold and dry air mass from the high latitude to Northeast Asia and reduce precipitation there. The correlation coefficient of winter precipitation in Northeast China and SRF reaches 0.4, and is statistically significant at the 99% confidence level based on the Student's t-test. The latent heat flux anomalies over the Pacific Ocean caused by solar cycle could explain the spatial pattern of abnormal winter precipitation of China, suggesting that the solar activity may change the climate of Northeast Asia through air–sea interaction. | Yan SONG Zhicai LI Yu GU Kuo-Nan LIOU Xiaoxin ZHANG Ziniu XIAO | 2019 | Journal of Meteorological Research2019，33，5： | 0 |
| 15 | Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat显示文摘Iodoacetic acid(IAA) has been applied to different species to acutely induce photoreceptor degeneration.The purpose of the present study was to use this toxin to thoroughly eliminate photoreceptors and induce complete blindness in the cat.IAA was delivered by single ear vein injection(20 mgkg-1).Six months after the IAA treatment,functional evaluations including pupillary light reflex(PLR),electroretinogram(ERG),visual behavior tests were performed.Morphological examinations were carried out after the functional evaluation.The present result shows that,six months after the IAA application,animals lost visual functions and became completely blind.High dose IAA application via ear vein delivery created an acute and reliable complete photoreceptor degeneration model in the cat.This model can be applied to genetic and cellular therapies for visual function restoration. | NAN Yan ZHANG Qin REN ChaoRan HUANG Xin GAO Jie LI XiaoXin PU MingLiang | 2013 | Science China(Life Sciences)2013，56，6： | 0 |
| 16 | Catalytic ozonation in advanced treatment of kitchen wastewater:multi-scale simulation and pilot-scale study显示文摘Catalytic ozonation is regarded as a promising technology in the advanced treatment of refractory organic wastewater.Packed-bed reactors are widely used in practical applications due to simple structures,installation and operation.However,mass transfer of packed-bed reactors is relatively restrained and amplified deviations usually occurred in scale-up application.Herein,a multi-scale packed-bed model of catalytic ozonation was established to guide pilot tests.First,a laboratory-scale test was conducted to obtain kinetic parameters needed for modeling.Then,a multi-scale packed-bed model was developed to research the effects of water distribution structure,catalyst particle size,and hydraulic retention time(HRT)on catalytic ozonation.It was found that the performance of packed bed reactor was increased with evenly distributed water inlet,HRT of 60 min,and catalyst diameter of about 3-7 mm.Last,an optimized reactor was manufactured and a pilot-scale test was conducted to treat kitchen wastewater using catalytic ozonation process.In the pilot-scale test with an ozone dosage of 50 mg/L and HRT of 60 min,the packed-bed reactor filled with catalysts I was able to reduce chemical oxygen demand(COD)from 117 to 59 mg/L.The performance of the catalytic ozonation process in the packed-bed reactor for the advanced treatment of actual kitchen wastewater was investigated via both multi-scale simulation and pilot-scale tests in this study,which provided a practical method for optimizing the reactors of treating refractory organic wastewater. | Zuoyong Zhou Ni Yan Mengxi Yin Tengfei Ren Shuning Chen Kechao Lu Xiaoxin Cao Xia Huang Xiaoyuan Zhang | 2023 | Frontiers of Environmental Science & Engineering2023，17，12： | 0 |
| 17 | Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha显示文摘Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned metabolic engi-neering.Ogataea polymorpha,one of the methylotrophic yeasts,possesses advantages in broad substrate spec-trum,thermal-tolerance,and capacity to achieve high-density fermentation.However,a limited number of available promoters hinders the engineering of O.polymorpha for bio-productions.Here,we systematically characterized native promoters in O.polymorpha by both GFP fluorescence and fatty alcohol biosynthesis.Ten constitutive promoters(P_(PDH),P_(PYK),P_(FBA),P_(PGM),P_(GLK),P_(TRI),P(GPI),P_(ADH1),P_(TEF1) and P_(GCW14))were obtained with the activity range of 13%–130% of the common promoter P_(GAP)(the promoter of glyceraldehyde-3-phosphate de-hydrogenase),among which P_(PDH) and P_(GCW14) were further verified by biosynthesis of fatty alcohol.Furthermore,the inducible promoters,including ethanol-induced P_(ICL1),rhamnose-induced P_(LRA3) and P_( LRA4),and a bidirectional promoter(P_(Mal)-P_(Per))that is strongly induced by sucrose,further expanded the promoter toolbox in O.polymorpha.Finally,a series of hybrid promoters were constructed via engineering upstream activation sequence(UAS),which increased the activity of native promoter P LRA3 by 4.7–10.4 times without obvious leakage expression.Therefore,this study provided a group of constitutive,inducible,and hybrid promoters for metabolic engineering of O.polymorpha,and also a feasible strategy for rationally regulating the promoter strength. | Chunxiao Yan Wei Yu Xiaoxin Zhai Lun Yao Xiaoyu Guo Jiaoqi Gao Yongjin J.Zhou | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 0 |
| 18 | SorCS2 neurofibrillary tangles-like lesions in AD human cerebrum显示文摘Recent findings have indicated that SorCS2,a member of the vacuolar protein sorting 10 protein(VPS10P)family,has relevance to bipolar disorder,schizophrenia,and Alzheimer's disease(AD).We observed SorCS2 can accumulate as neurofibrillary tangles(NFTs)-like lesions in AD human brain cerebrum.Then we set to explore NFTs-like lesions from SorCS2 in aged and AD human cerebrum,and whether this pathological hallmark is unique to AD human brains.We characterized SorCS2 changes in postmortem human brains(n=10)from aged and AD subjects. | Hu Dandan Li Yanan Tu Tian Jiang Juan Yan Xiaoxin Pan Aihua | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 19 | Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications显示文摘Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug resistance.Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy.Metabotropic glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity.Dysregulated mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy.In this review,we first introduce the three groups of mGluRs and their associated signaling pathways.Then,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis.In addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized.We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs. | Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long Bo Xiao Xiaoxin Yan Lily Wan | 2024 | Neural Regeneration Research2024，19，2： | 0 |
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