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| 1 | Strong ozone production at a rural site in the North China Plain: Mixed effects of urban plumes and biogenic emissions显示文摘Regional ozone(O_3) pollution has drawn increasing attention in China over the recent decade, but the contributions from urban pollution and biogenic emissions have not been clearly elucidated. To better understand the formation of the regional O_3 problem in the North China Plain(NCP), intensive field measurements of O_3 and related parameters were conducted at a rural site downwind of Ji'nan, the capital city of Shandong province, in the summer of 2013. Markedly severe O_3 pollution was recorded, with the O_3 mixing ratios exceeding the Chinese national ambient air quality standard on 28 days(a frequency of 78%) and with a maximum hourly value of 198 ppbv. Extensive regional transport of wellprocessed urban plumes to the site was identified. An observation-constrained chemical box model was deployed to evaluate in situ photochemical O_3 production on two episodes.The results show that the in situ formation accounted for approximately 46% of the observed O_3 accumulation, while the remainder(~54%) was contributed by regional transport of the O_3-laden urban plumes. The in situ ozone production was in a mixed controlled regime that reducing either NOx or VOCs would lead to a reduction of ozone formation. Biogenic VOCs played an important role in the local ozone formation. This study demonstrates the significant mixed effects of both anthropogenic pollution from urban zones and biogenic emission in rural areas on the regional O_3 pollution in the NCP region,and may have general applicability in facilitating the understanding of the formation of secondary pollution over China. | Ruihan Zong Xue Yang Liang Wen Caihong Xu Yanhong Zhu Tianshu Chen Lan Yao Liwei Wang Junmei Zhang Lingxiao Yang Xinfeng Wang Min Shao Tong Zhu Likun Xue Wenxing Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 8 |
| 2 | A comparative study of electroacupuncture at Zhongliao (BL33) and other acupoints for overactive bladder symptoms显示文摘在 Zhongliao (BL33 ) 的 Electroacupuncture (EA ) 能改进 overactive 膀胱(OAB ) 的症状,例如尿频率,紧急,和不能自制。然而,它的表演与另外的 acupoints 相比仍然保持不清楚。这研究与由在八个组检测 urodynamics 的与 OAB 的在老鼠上的深刺破在 BL33 调查了 EA 的效果:没有干预组, D-BL33 组(在 BL33 的深刺破), S-BL33 组(在 BL33 的浅刺破), non-acupoint 组(靠着 BL33 在 non-acupoint 刺破), Weizhong ( BL40 )组, Sanyinjiao ( SP6 )组, Tongtian ( BL7 )组,并且 Hegu ( LI4 )组。结果表明在有深刺破的 BL33 的 EA, BL40,和 SP6 与 OAB 延长了老鼠的 intercontraction 间隔(帝国化学工业公司)(P = 0.001, P = 0.005, P = 0.046,分别地处理以后对 modeling 以后) 。而且,在从在 D-BL33 组的 modeling 以后的帝国化学工业公司的变化比那些显著地大没有干预和其它 EA 组(所有 P < 0.01 ) 。显著地弄短的膀胱的频尿时间(VMT ) 和提高的最大的 detrusor 压力(MDP ) 也在 D-BL33 组被观察(P = 0.017 并且 P = 0.024,分别地处理以后对 modeling 以后) 。然而,在从 modeling 以后的 VMT 和 MDP 的变化的统计上重要的差别都没在 D-BL33 和另外的 EA 组之间被观察。在结论,在有深刺破的 BL33 的 EA 可以更有效地禁止 acetic-acid-induced OAB。 | Likun Yang Yang Wang Qian Mo Zhishun Liu | 2017 | Frontiers of Medicine2017，11，1： | 7 |
| 3 | Biofilm structure and its influence on clogging in drip irrigation emitters distributing reclaimed wastewater显示文摘Using reclaimed wastewater for crop irrigation is a practical alternative to discharge wastewater treatment plant effluents into surface waters.However,biofouling has been identified as a major contributor to emitter clogging in drip irrigation systems distributing reclaimed wastewater.Little is known about the biofilm structure and its influence on clogging in the drip emitter flow path.This study was first to investigate the microbial characteristics of mature biofilms present in the emitters and the effect of flow path structures on the biofilm microbial communities.The analysis of biofilm matrix structure using a scanning electron microscopy(SEM) revealed that particles in the matrix of the biofilm coupled extracellular polysaccharides(EPS) and formed sediment in the emitter flow path.Analysis of biofilm mass including protein,polysaccharide,and phospholipid fatty acids(PLFAs) showed that emitter flow path style influenced biofilm community structure and diversity.The correlations of biofilm biomass and discharge reduction after 360 h irrigation were computed and suggest that PFLAs provide the best correlation coeffcient.Comparatively,the emitter with the unsymmetrical dentate structure and shorter flow path(Emitter C) had the best anti-clogging capability.By optimizing the dentate structure,the internal flow pattern within the flow path could be enhanced as an important method to control the biofilm within emitter flow path.This study established electron microscope techniques and biochemical microbial analysis methods that may provide a framework for future emitter biofilm studies. | YAN Dazhuang BAI Zhihui Mike Rowan GU Likun Ren Shumei YANG Peiling | 2009 | Journal of Environmental Sciences2009，21，6： | 4 |
| 4 | Internal field study of 21700 battery based on long-life embedded wireless temperature sensor显示文摘The safety of lithium-ion batteries is an essential concern where instant and accurate temperature sensing is critical.It is generally desired to put sensors inside batteries for instant sensing.However,the transmission of internal measurement outside batteries without interfering their normal state is a non-trivial task due to the harsh electrochemical environment,the particular packaging structures and the intrinsic electromagnetic shielding problems of batteries.In this work,a novel in-situ temperature sensing framework is proposed by incorporating temperature sensors with a novel signal transmission solution.The signal transmission solution uses a self-designed integrated-circuit which modulates the internal measurements outside battery via its positive pole without package breaking.Extensive experimental results validate the noninterference properties of the proposed framework.Our proposed in-situ temperature measurement by the self-designed signal modulation solution has a promising potential for in-situ battery health monitoring and thus promoting the development of smart batteries. | Le Yang Na Li Likun Hu Shaoqi Wang Lin Wang Jiang Zhou Wei-Li Song Lei Sun Tai-Song Pan Hao-Sen Chen Daining Fang | 2021 | Acta Mechanica Sinica2021，37，6： | 3 |
| 5 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 6 | Electrosorption behavior of cations with carbon nanotubes and carbon nanofibres composite film electrodes显示文摘 | Yang Gao Likun Pan HaiBo Li Yanping Zhang Zhejuan Zhang Yiwei Chen Zhuo Sun | 2008 | Thin Solid Films2008，，5： | 2 |
| 7 | Electrosorption of anions with carbon nanotube and nanofibre composite film electrodes显示文摘 | Likun Pan Xinzheng Wang Yang Gao Yanping Zhang Yiwei Chen Zhuo Sun | 2008 | Desalination2008，，1： | 2 |
| 8 | Progress and perspective of Li_(1+x)Al_(x)Ti_(2-x)(PO_(4))_(3) ceramic electrolyte in lithium batteries显示文摘The replacement of liquid organic electrolytes with solid-state electrolytes(SSEs)is a feasible way to solve the safety issues and improve the energy density of lithium batteries.Developing SSEs materials that can well match with high-voltage cathodes and lithium metal anode is quite significant to develop high-energy-density lithium batteries.Li_(1+x)Al_(x)Ti_(2-x)(PO_(4))_(3)(LATP)SSE with NASICON structure exhibits high ionic conductivity,low cost and superior air stability,which enable it as one of the most hopeful candidates for all-solidstate batteries(ASSBs).However,the high interfacial impedance between LATP and electrodes,and the severe interfacial side reactions with the lithium metal greatly limit its applications in ASSBs.This review introduces the crystal structure and ion transport mechanisms of LATP and summarizes the key factors affecting the ionic conductivity.The side reaction mechanisms of LATP with Li metal and the promising strategies for optimizing interfacial compatibility are reviewed.We also summarize the applications of LATP including as surface coatings of cathode particles,ion transport network additives and inorganic fillers of composite polymer electrolytes.At last,this review proposes the challenges and the future development directions of LATP in SSBs. | Ke Yang Likun Chen Jiabin Ma Yan-Bing He Feiyu Kang | 2021 | InfoMat2021，3，11： | 2 |
| 9 | Wet-spinning fabrication of shear-patterned alginate hydrogel microfibers and the guidance of cell alignment显示文摘Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way,and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization.In this study,a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography.The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed.Afterwards,the effect of fiber topography on cellular longitudinal spread and elongation was investigated by culturing rat neuron-like PC12 cells and human osteosarcoma MG63 cells with the spun hydrogel microfibers,respectively.The results suggested that the stronger shear flow force would lead to more distinct aligned submicron topography on fiber surface,which could induce cell orientation along with fiber axis and therefore form the cell-matrix dual-alignment.Finally,a multi-hierarchical tissue-like structure constructed by dual-oriented cell-matrix assemblies was fabricated based on this wet-spinning method.This work is believed to be a potentially novel biofabrication scheme for bottom-up constructing of engineered linear tissue,such as nerve bundle,cortical bone,muscle and hepatic cord. | You Yang Jing Sun Xiaolu Liu Zhenzhen Guo Yunhu He Dan Wei Meiling Zhong Likun Guo Hongsong Fan Xingdong Zhang | 2017 | Regenerative Biomaterials2017，4，5： | 2 |
| 10 | Quantifi cation of the Atmospheric Corrosion of 304 and 2205 Stainless Steels Using Electrochemical Probes Based on Thevenin Electrochemical Equivalent Circuit Model显示文摘Stainless steel(SS)is one of the most widely used engineering materials in marine engineering.However,its corrosion in the marine atmospheric environment due to the high concentration of Cl-is a problem.The SS corrosion is a threat to the development and security of marine industry;therefore,evaluating the corrosion resistance of SSs is necessary.In this work,atmospheric corrosion detection probes based on a symmetrical electrode system were used to study the corrosion behaviors of 304 SS and 2205 duplex stainless steel(DSS)in a simulated marine atmosphere.A theoretical model for electrochemical noise(EN)data analysis based on the Thevenin electrochemical equivalent circuit(EEC)model was established.The relationship between the EN characteristic parameters and the corrosion rate was obtained.The Thevenin EEC model analysis showed that the relationship between the noise resistance(Rn),the noise impedance[Rsn(f)],and the impedance modulus(|Z(f)|)was Rn≈Rsn=■.Thus,Rn and Rsn can be used as indicators for quantitative corrosion evaluation.The results of EN detection for the 304 SS and 2205 DSS showed that in a simulated marine atmospheric environment,the passive fi lms on the two SSs were relatively intact at the initial exposure stage,and their dissolution rates were slow.The corrosion resistance of the 2205 DSS was higher than that of the 304 SS.With the deposition of Cl-on the SS surface,pitting was initiated and the dissolution rate increased.The pitting initiation process on the SS surface was random,and part of the active pores could be repassivated. | Yu Zhu Yang Song Likun Xu Zhenbo Qin Shizhe Song Wenbin Hu Da-Hai Xia | 2020 | Transactions of Tianjin University2020，26，3： | 2 |
| 11 | Experimental Analysis of Microscale Laser Shock Processing on Metallic Material Using Excimer Laser显示文摘Microscale laser shock processing (μLSP), also known as laser shock processing in microscale, is a technique that uses microscale focused laser beam to induce high pressure plasma and generates plastic deformation and compressive residual stress in target materials, thus improves fatigue or stress corrosion cracking resistance of MEMS (Micro Electromechanical Systems) devices made of such a material. Many works have been reported about the research and experiment for μLSP. But the diameters of 50–200 μm were used at the first time for this field, which was useful for treating micro-device components with larger area and curved surface. The excimer laser was used firstly on μLSP for shorter wavelength than that of used in previous researches. The determination method of laser spot size at micro-level spatial resolution was presented. Under these conditions, plastic deformation, the stress analysis and microhardness with different pulse number, pulse energy and pulse spacing were investigated. Especially the residual stress distribution with depth treated by μLSP, was first investigated. Experiment results showed that the material performance was improved remarkably after μLSP. | Zhigang Che Liangcai Xiong Tielin Shi Huayang Cheng Likun Yang | 2009 | Journal of Materials Science & Technology2009，25，6： | 2 |
| 12 | Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers显示文摘This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry(LC–MS/MS)and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers.After sample preparation of plasma by liquid–liquid extraction with ethyl acetate,the analyte and internal standard,urapidil,were separated by reversed phase chromatography in a run time of 4 min and detected by positive ion electrospray ionization followed by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 326.2-308.1 for ifenprodil and m/z 388.4-205.3 for IS.The assay was linear in the concentration range 0.2–50.0 ng/mL with recovery 476.4%.In the pharmacokinetic study of single intravenous infusions of 5,10 and 15 mg ifenprodil,peak plasma concentrations and areas under the plasma concentration–time curve were both linearly related to dose.In the pharmacokinetic study of multiple once daily intravenous infusions of 10 mg ifenprodil for 7 days,pharmacokinetic parameters were similar to those after the single dose showing that ifenprodil does not accumulate on repeated administration. | Jing Yang Chengtao Lu Wei Song Jiankang Li Yi Ding Yanrong Zhu Jinyi Cao Likun Ding Yanyan Jia Aidong Wen | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 2 |
| 13 | Increased serum cathepsin S in patients with atherosclerosis and diabetes 显示文摘 | Liu Jian Ma Likun Yang Jintian | 2006 | Atherosclerosis2006，186，2： | 1 |
| 14 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 15 | Reversed micelle polymerization : A new route for the synthesis of DBSA- polyaniline nanoparticles显示文摘 | Han Dongxue Chu Ying Yang Likun | 2005 | Colloids and Surfaces A Physicochemical and Engineering Aspects2005，259，13： | 1 |
| 16 | Research on the Evaluation System of National Standards显示文摘This paper presents an evaluation system of national standardlevels composed of certain indicators and their respective weights.The goalof quantitatiye evaluation of national standards was achieved by expels decidingon indicators of a single national standard.This evaluation system provideda reasonable basis to evaluate the national standard level.It will alsoplay an important role in regulating standards and improving the nationalstandards level. | Yang Feng Guo Likun | 2009 | China Standardization2009，54，5： | 1 |
| 17 | Heritable alteration in DNA methylation pattern occurred specifically at mobile elements in rice plants following hydrostatic pressurization显示文摘 | Likun Long Xiuyun Lin Jinzuo Zhai Hongping Kou Wei Yang Bao Liu | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 18 | Preparation and Characterization of Ag_2S/PMMA Nanocomposites by Microemulsion显示文摘Ag_2S nanoparticles in polymethyl methacrylate(PMMA) are prepared in n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate/water microemulsions.The Ag_2S nanoparticles dispersed in the polymer are characterized by FT-IR spectrum,UV-Vis absorption spectroscopy,transmission electron microscopy(TEM),and X-ray powder diffraction(XRD).The FT-IR spectrum shows that the composite has the characteristic bands of nano-Ag_2S and pure PMMA.The TEM photograph of the sample shows that the Ag_2S nanoparticles are elliptical.The phase structure of the composite is characterized by XRD,which reveals that Ag_2S particles are formed.The UV-Vis absorption recorded at various times indicates an initial rapid formation of the nanoparticles and the quantum confinement effect of Ag_2S nanoparticles. | Yuzhen Li Lizhen Gao Wenjun Chen Weike Zhang Lili Gao Yanqing Yang Likun Shang Meilu Wang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 1 |
| 19 | Heat transfer characteristics in a narrow confined channel with discrete impingement cooling显示文摘Heat transfer characteristics in a narrow confined channel with discrete impingement cooling were investigated using thermal infrared camera. Detailed heat transfer distributions and comparisons on three surfaces with three impact diameters were experimentally studied in the range of Reynolds number of 3000 to 30000. The experimental results indicated that the strong impingement jet leaded to a high strength heat transfer zone in the ΔX=±2.5D;range of the impact center,which was 1.3–2.5 times of the average heat transfer value of the impingement wall. With the same coolant mass flow rate, small diameter case had lower heat transfer coefficient on both inner wall and outside wall, while the impingement wall was insensitive to the impact diameter. The surface averaged Nusselt number of inner wall was only 43%–57% of impingement wall, while the outside wall can reach up to 80%–90%. The larger the diameter, the higher heat transfer enhancement and the smaller the channel flow resistance was observed in term of Reynolds number. The surface averaged Nusselt numbers were developed as the function of Reynolds number and the impingement height-to-diameter for further engineering applications. | Yang LI Tao LIU Jianjun TAO Weihua YANG Likun DONG | 2022 | Chinese Journal of Aeronautics2022，35，4： | 1 |
| 20 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
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