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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Near-infrared light activated persistent luminescence nanoparticles via upconversion显示文摘坚持的光 nanoparticles (PLNP ) 和 upconversion nanoparticles (UCNP ) 是二特殊光成像 nanoprobes。在这研究,有效 upconverted 坚持的光(UCPL ) 被把他们的唯一的特征合为 polymethyl methacrylate 认识到,形成一部电影 PLNP 和 UCNP 创作了。红坚持的光(~ 640 nm ) PLNP (CaS : Eu, Tm, Ce ) 能被 UCNP 的 upconverted 绿色排放激活(-NaYF4:Yb,Er@NaYF4) 由在红外线附近的光(NIR ) 激动。用这策略,两 PLNP 和 UCNP 的唯一的光性质能是最佳地 synergized,因此产生的有效 upconversion,光致发光,和 UCPL 同时。UCPL 系统有潜在的应用在在由简单地监视 biocompatible 的 vivo bioimaging NIR-light-excited 的低力量密度坚持的光。由于它的简洁,我们预计为 UCPL 合成罐头的准备的这个方法容易为很多 biophotonic 和 photonic 应用用另外的可得到的 upconversion 和坚持的黄磷对被调整。 | Zhanjun Li Ling Huang YuanweiZhang Yang Zhao Hong Yang Gang Han | 2017 | Nano Research2017，10，5： | 6 |
| 3 | The influence of different underlying surface on sand-duststorm in northern China显示文摘In thispaper,a quantitative research on the relationship between differentunderlying surface and sand-duststorm has been made by using 40 years meteorologicaldata offive differenttypes of underlying surface in northern China,which include farmland,grassland,sandland,gobiand saltcrust. These metrologicaldata comprise sand-duststorm days and strong wind days.By analyzing,we can find that there are certain correlations between the days of sand-dust storm and strong wind for differentunderlying surface,which has greatinfluence on sand-duststorm.Butthere are pronounced differences in differenttypes ofunderlying surface.The sand-duststorm days ofgrassland,gobiand saltcrust,with smallerinterannualvariation are obviously less than strong wind days.On the other hand,the sand-duststorm days offarmland and sandland increase evidently,even in many years,are much more than strong wind days.The differencesare mainly induced by the influencing mechanism of different underlying surface on sand-dust storm. Grassland, gobi and salt crust with stable underlying surface are not prone to sand-dust storm under strong wind condition. W hereas, the underlying surface offarmland and sandland isunstable,thatiseasy to induce sand-duststorm under strong wind condition. | SONG Yang QUAN Zhanjun LIU Lianyou YAN Ping CAO Tong | 2005 | Journal of Geographical Sciences2005，15，4： | 4 |
| 4 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 5 | Impact of copy number of distinct SV40PolyA segments on expression of a GFP reporter gene显示文摘The presence of Alu repeats downregulates the expression of the green fluorescent protein(GFP) gene.We found that SV40PolyA(PolyA,240 bp),in either orientation,eliminated the inhibition of GFP gene expression induced by Alu repeats when it was placed between the GFP gene and the Alu repeats.In this study,4 different segments(each 60 bp) were amplified from antisense PolyA(PolyAas) by PCR,and inserted upstream of Alu14 in pAlu14 plasmid(14 Alu repeats inserted downstream of the GFP gene in vector pEGFP-C1 in a head-tail tandem manner).Segments 1F1R(the first 60 bp segment at the 5' end of PolyAas) and 4F4R(the fourth 60 bp segment from the 5' end of PolyAas) did not activate GFP gene expression,whereas 2F2R and 3F3R(the middle two segments) did(as detected by Northern blot analysis and fluorescent microscopy).Different copy numbers of 2F2R and 3F3R segments,in a head and tail tandem manner,were inserted downstream of the GFP gene in pAlu14.p2F2R*4-Alu28,p3F3R*4-Alu18 and p3F3R*4-Alu28 were used as length controls to verify that the decrease in the expression of GFP was not due to the increased length of the inserted segment in the expression vectors.We found that 2 and 4 copies of 2F2R or 3F3R activated the GFP gene more strongly than one copy of them.However,more than 8 copies of 2F2R or 3F3R reduced the activation of the GFP gene.We concluded that SV40PolyAas contained at least two gene-activating elements(2F2R and 3F3R) and 2-4 copies of 2F2R or 3F3R were optimal for the expression of the GFP gene. | YIN Kang,WANG XiuFang,MA Huan,XIE Ying,FENG JingJing,YANG QinQing & Lü ZhanJun Hebei Key Lab of Laboratory Animal,Department of Genetics,Hebei Medical University,Shijiazhuang 050017,China | 2010 | Science China(Life Sciences)2010，53，5： | 2 |
| 6 | The application of combined gravity and seismic data formation separation for revealing deep structure显示文摘在有 3D 的一些油矿地震数据,更深的结构不能由于差的优秀深地震的数据被观察。层脱衣用地震并且严肃数据是这个问题的一个解决方案,但是因为在形成密度的水平变化被忽略,它不能得到令人满意的结果。我们在场一种可变密度的形成分离技术到地址这个问题。把地震速度数据基于地震深度数据和旁边地变量密度从 3D 导出的 3D,上面的形成严肃效果被向前当模特儿计算并且从 Bouguer 严肃搬迁了。有可变密度的分开形成的严肃异例被获得,它主要反映更深地质的结构。在诺思非洲的块 XX,浅形成地震数据是优秀的,但是在地下室的顶的数据是差的。在地震数据与已知的地震解释和井适合很好的 3D 的控制下面处理的分开形成的严肃异例。它使地质的解释更可靠。 | WeiYan Yang Zhanjun | 2006 | Applied Geophysics2006，3，4： | 2 |
| 7 | Bird nest-like zinc oxide nanostructures for sensitive electrochemical glucose biosensor显示文摘In this research,a novel bird nest-like zinc oxide(BN-ZnO)nanostructures were prepared by a simple solvothermal method.A sensitive electrochemical glucose biosensor was for the first time developed based on the immobilization of glucose oxidase(GOx)on nanostructured BN-ZnO modified electrode.The BN-ZnO nanostructure and the resultant biosensor were characterized by scanning electron microscope,X-ray diffraction spectroscopy,Fourier transform infrared spectroscopy,and electrochemical impedance spectroscopy.BN-ZnO nanostructures have large specific surface area and can load large amounts of GOx molecules.Meanwhile,BN-ZnO provides an excellent microenvironment to retain the native bioactivity of enzymes and to promote direct electron transfer between GOx and electrode surface.The proposed biosensor shows a wide linear range of 0.005–1.6 mmol/L,high sensitivity of15.6 mA L mol^(-1)cm^(-2)with a low detection limit of 0.004 mmol/L.The resulting biosensor also shows excellent selectivity,acceptable stability and reproducibility,and can be successfully applied in the detection of glucose in human serum samples at-0.37 V. | Feng Shi Jinming Xu Zhongfang Hu Chuanli Ren Yadong Xue Yongcai Zhang Juan Li Chengyin Wang Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 8 | The “bottom-up” synthesis and applications of persistent luminescence nanoparticles显示文摘Persistent luminescence refers to the phenomenon whereby luminescence remains after excitation ceases.In the past few decades,various kinds of persistent luminescent materials have been developed and widely employed in numerous applications,such as security signs,medical diagnostics and photocatalysis.Persistent luminescent materials offer distinctive advantages for biomedical applications,especially for bioimaging,as they can efficiently avoid autofluorescence and tissue-scattered light interference[1]. | Nuo Yu Yang Li Zhanjun Li Gang Han | 2018 | Science China Chemistry2018，61，7： | 1 |
| 9 | Enrichment of arsenic, antimony, thallium and selenium in high-arsenic coal from Xingren County, Guizhou Province显示文摘 | Zhanjun YANG Yuegang TANG Xiao ZHENG Juanjuan LI Weilong HAN Shuting YANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 10 | A methodology for engineering ontology acquisition and validation显示文摘 | LI Zhanjun YANG M C RAMANI K | 2009 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2009，23，1： | 1 |
| 11 | A novel photoe|ectrochemical sensor for the organophosphorus pesticide dichlofenthion based on nanometer- sized titania coupled with a screen-printed electrode 显示文摘 | Li Hongbo Li Jing Yang Zhanjun | 2011 | Analytical Chemistry2011，83，13： | 1 |
| 12 | Alkoxy substituted benzodithiophene-alt-fluorobenzotriazole copolymer as donor in non-fullerene polymer solar cells显示文摘A new benzodithiophene(BDT)-alt-fluorobenzotriazole(FBTA) D-A copolymer J40 was designed and synthesized by introducing 2-octyldodecyloxy side chains on its BDT units, for expanding the family of the BDT- alt-FBTA-based copolymers and investigating the side chain effect on the photovoltaic performance of the polymer in non-fullerene polymer solar cells(PSCs).J40 exhibits complementary absorption spectra and matched electronic energy levels with the n-type organic semiconductor(n-OS)(3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2′,3′-d′]-sindaceno[1,2-b:5,6-b′]dithiophene)(ITIC) acceptor, and was used as polymer donor in the non-fullerene PSCs with ITIC as acceptor. The power conversion efficiency(PCE) of the PSCs based on J40:ITIC(1:1, w/w) with thermal annealing at 120 °C for 10 min reached 6.48% with a higher open-circuit voltage(Voc) of 0.89 V. The high Voc of the PSCs is benefitted from the lower-lying highest occupied molecular orbital(HOMO) energy level of J40. Although the photovoltaic performance of the polymer J40 with alkoxy side chain is lower than that of J60 and J61 with alkylthio-thienyl conjugated side chains, the PCE of6.48% for the J40-based device is still a relatively higher photovoltaic efficiency in the non-fullerene PSCs reported so far. The results indicate that the family of the BDT-alt-FBTA-based D-A copolymers are high performance polymer donor materials for non-fullerene PSCs and the side chain engineering plays an important role in the design of high performance polymer donors in the non-fullerene PSCs. | Haijun Bin Lian Zhong Zhi-Guo Zhang Liang Gao Yankang Yang Lingwei Xue Jing Zhang Zhanjun Zhang Yongfang Li | 2016 | Science China Chemistry2016，59，10： | 1 |
| 13 | Antifertility Effects of Orally Administration of Low Dose Gossypol Acetic Acid Combined with Methyltestosterone Plus Ethinyl Estradiol on Male Rat显示文摘Objective To investigate the feasibility and optimal regimen of orally administration of low dose gossypol acetic acid(GA) combined with methyltestosterone(MT) plus ethinyl estradiol(EE) for contraception in males. Methods Wistar male rats were randomly assigned into four groups,20 in each group. Animals in group A or B were administered daily with 1% methyl cellulose or GA(12 mg/kg) suspended in 1% methyl cellulose,respectively. Rats in group C or D took firstly GA 12 mg/kg+MT 20 mg/kg+EE 0.1 mg/kg or MT 20 mg/kg+EE 0.1 mg/kg,in a suspension with 1% methyl cellulose,via gastric intubation. After the infertilities were initiated(6 weeks for group C,8 weeks for group D) ,GA was served alone while MT+EE were withdrawn in rats of groups C and D. The treatment was ceased after 18 weeks and some males from group C were permitted to recover. Fertility testing,10 males per group,was served for determining infertility or restoration of fertility in treated rats. Examinations of histology and biochemistry in treated rats were used to examine the morphologic influences on sperm,testis,epididymides and viscera,and biochemical changes in blood. The growth and development of F1 generation of the rats would also be tested in a series of behavioral tests. Results Ten rats from group C were infertile at week 6 after treatment,and the fulfilled infertility was maintained with low-dose GA(12 mg/kg) only daily. Six weeks after cessation of treatment,all of treated males recovered their fertility. However,8 of 10 rats from group D were in sterility at 6th week of treatment and all at 8th week oftreatment,but the infertility could not be kept with the similar dose GA alone later on. Moreover,no adverse effects were found in our present experiments. Conclusion Administration of oral low dose GA combined with MT and EE as loading dose could successfully induce infertility in short term,whereafter the efficacy could completely be maintained by similar low dose of GA alone for long term. The combined regimen should be safe,effective,reversible and long term,and then optimal and promised contraception for male. | Zhanjun YANG Wei-san YE Lan WANG Yan GUO She-pu XUE | 2008 | Journal of Reproduction and Contraception2008，19，4： | 1 |
| 14 | Systemic PPARgamma deletion impairs circadian rhythms of behavior and metabolism显示文摘 | YANG Guangrui JIA Zhanjun AOYAGI T | 2012 | PLoS One2012，7，38： | 1 |
| 15 | Aligned carbon nanotube-reinforced silicon carbide composites produced by chemical vapor infiltration显示文摘 | Zhanjun Gu Yingchao Yang Kaiyuan Li Xinyong Tao Gyula Eres Jane Y. Howe Litong Zhang Xiaodong Li Zhengwei Pan | 2011 | Carbon2011，，7： | 1 |
| 16 | Study of the sensitization of tetradecyl benzyl dimethyl ammonium chloride for spectrophotometr ic determination of dopamine hydmchloride using sodium 1,2-naph thoquinone--4-sulfonate as the chemical derivative chromogenic rea gent 显示文摘 | Li Quanmin Li Juan Yang Zhanjun | 2007 | Analytica Chimica Acta2007，583，1： | 1 |
| 17 | Self-assembly of highly oriented one--dimensional h-WO3 nanostruetures 显示文摘 | Gu Zhanjun Ma Ying Yang Wensheng | 2005 | Chem Commun2005，，： | 1 |
| 18 | Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial显示文摘We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March 2016.They were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or placebo.Their clinical and immunological parameters were monitored during the 96-week follow-up study.We found that hUC-MSC treatment was safe and well-tolerated.Compared with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control group.Kaplan-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three groups.In summary,hUC-MSC treatment is safe.However,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study. | Lifeng Wang Zheng Zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang Mi Zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou Ming Shi Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 19 | The mechanism study of glycosides of cistanches improv ing cognitive performance dysfunction in senescence accelerated mouse prone 8 by AMPK/mTOR signaling pathway显示文摘To investigate the mechanism of glycosides of cistanches improving cognitive performance dysfunction in SAMP8 mice by AMPK/mTOR signaling pathway.Male 7-month-old SAMP8 mice were randomly divided into 5 groups:model group,GCs group,GCs+3-MA group,GCs+compound C group,Vehicle group.Morris water maze was used to detect the ability of learning and memory.Western blot was used to detect the protein expression of SYN,PSD-95,BDNF,LC3,AMPK and m-TOR.The escape latency of GCs group,GCs+3-MA group and GCs+compound C group were significantly shortened(P<0.05).Compared with GCs group,the escape latency and percent of time spent in the target quadrant of GCs+compound C group were significantly increased(P<0.05). | Liu Xinlang Zhou Lili Sun Yihong Mo Chaoran Jia Jianxin Yang Zhanjun | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 20 | Sodium dodecyl sulfate sensitized electrochemical method for subnanomole level determination of ortho-phenylphenol at a novel disposable electrode显示文摘The electrochemical behavior of ortho-phenylphenol(OPP) at a disposable electrode(an improved wax-impregnated graphite electrode) in the presence of sodium dodecyl sulfate(SDS) was studied for the first time.The results demonstrated that the electrocatalytic oxidation process of OPP was accompanied with two-charge-two-proton transference.The electronic transmission coefficient(α) and diffusion coefficient(DR) for OPP were calculated to be 0.8126 and 3.61 × 10-2 cm2/s,respectively.The electrochemical signal was apparently improved by SDS at the disposable electrode and the oxidative peaks current was proportional to the concentration of OPP over the range from 1.0 × 10-9 to 4.0 × 10-6 mol/L with the detection limit of 8.7 × 10-10 mol/L.This novel and highly sensitive method can be successfully applied to detect OPP in the orange rind sample. | LI HongBo LI Jing MENG DongMei PENG JinYun QIAO QiuJu YANG ZhanJun XU Qin HU XiaoYa | 2011 | Science China Chemistry2011，54，7： | 0 |
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