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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Application of liquid biopsy in precision medicine: opportunities and challenges显示文摘 | Junyun Wang Shuang Chang Guochao Li Yingli Sun | 2017 | Frontiers of Medicine2017，11，4： | 14 |
| 3 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 4 | Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice显示文摘 | Jing Yingli Wu Qingbin Yuan Xiaochen Li Bingwei Liu Mingming Zhang Xiaoyan Liu Shuying Li Hongwei Xiu Ruijuan | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 5 | Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis显示文摘chemokine CXCL12 和它的受体 CXCR4 是重要的表明为人的胚囊培植和怀孕的前进要求的部件。成长证据显示 CXCL12/CXCR4 轴能调整 trophoblast 功能和改变的子宫的螺线动脉,它在胎座式和胎儿的结果起一个基本作用。孤儿受体 CXCR7 也被相信部分调整 CXCL12/CXCR4 轴的功能。另外, CXCL12/CXCR4/CXCR7 轴能提高在象子宫的自然漂亮房间那样的 trophoblasts 和蜕膜的房间和涉及 trophoblast 区别和侵略和胎盘的 angiogenesis 的规定的蜕膜的 stromal 房间之间的串音。另外,最近的研究证明那 CXCL12 表情与 preeclampsia 在胎盘和怀孕女人的中间三个月的羊膜的液体被提高,暗示 CXCL12 的 dysregulation 起在 preeclampsia 的致病的一个作用。在 trophoblast 功能和胎盘的 angiogenesis 的调停 CXCL12 的发信号的规章的机制的进一步的理解可以帮助为联系怀孕的疾病设计新奇治疗学的途径。 | Liang Wang Xueyi Li Yilin Zhao Chao Fang Yingli Lian Wenli Gou Tao Han Xiaoming Zhu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 8 |
| 6 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
| 7 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 8 | Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery显示文摘For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system yet could mimic both controlled basal insulin release and rapid prandial insulin release in response to real-time blood glucose changes. Here we reported an artificial insulin delivery system, mimicking physiological basal and prandial insulin secretion, to achieve real-time glycemic control and reduce risk of hypoglycemia. A phenylboronic acid(PBA)/galactosyl-based glucose-responsive insulin delivery system was prepared with insulin-loaded micelles embedded in hydrogel matrix. At the hyperglycemic state, both the hydrogel and micelles could swell and achieve rapid glucose-responsive release of insulin, mimicking prandial insulin secretion.When the glucose level returned to the normal state, only the micelles partially responded to glucose and still released insulin gradually. The hydrogel with increased crosslinking density could slow down the diffusion speed of insulin inside, resulting in controlled release of insulin and simulating physiological basal insulin secretion. This hydrogel-micelle composite insulin delivery system could quickly reduce the blood glucose level in a mouse model of type 1 diabetes, and maintain normal blood glucose level without hypoglycemia for about 24 h. This kind of glucose-responsive hydrogel-micelle composite may be a promising candidate for delivery of insulin in the treatment of diabetes. | Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi | 2019 | Science China Chemistry2019，62，5： | 5 |
| 9 | Commercialized non-Camellia tea:traditional function and molecular identification显示文摘Non-Camellia tea is a part of the colorful Chinese tea culture,and is also widely used as beverage and medicine in folk for disease prevention and treatment.In this study,37 samples were collected,including 33 kinds of non-Camellia teas and 4 kinds of teas(Camellia).Traditional functions of non-Camellia teas were investigated.Furthermore,non-Camellia teas of original plants were characterized and identified by molecular methods.Four candidate regions(rbcL,matK,ITS2,psbA-trnH)were amplified by polymerase chain reaction.In addition,DNA barcodes were used for the first time to discriminate the commercial non-Camellia tea and their adulterants,and to evaluate their safety.This study showed that BLASTN and the relevant phylogenetic tree are efficient tools for identification of the commercial non-Camellia tea and their adulterants.However,some sequences from original plants have not been found and there is a limitation of sequence number of original plants in GenBank.Submitting more original plant sequences to the GenBank will be helpful for evaluating the safety of non-Camellia teas. | Ping Long Zhanhu Cui Yingli Wang Chunhong Zhang Na Zhang Minhui Li Peigen Xiao | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 3 |
| 10 | PagGRF12a interacts with PagGIF1b to regulate secondary xylem development through modulating PagXND1a expression in Populus alba×P.glandulosa显示文摘Growth-regulating factors(GRFs)are important regulators of plant development and growth,but their possible roles in xylem development in woody plants remain unclear.Here,we report that Populus alba×Papulus glandulosa PagGRF12a negatively regulates xylem development in poplar.PagGRF12a is expressed in vascular tissues.Compared to non-transgenic control plants,transgenic poplar plants overexpressing PagGRF12a exhibited reduced xylem width and plants with repressed expression of PagGRF12a exhibited increased xylem width.Xylem NAC domain 1(XND1)encodes a NAC domain transcription factor that regulates xylem development and transcriptional analyses revealed that PagXND1a is highly upregulated in PagGRF12a-overexpressing plants and downregulated in PagGRF12a-suppressed plants,indicating that PagGRF12a may regulate xylem development through PagXND1a.Transient transcriptional assays and chromatin immunoprecipitation-polymerase chain reaction assays confirmed that PagGRF12a directly upregulates PagXND1a.In addition,PagGRF12a interacts with the GRF-Interacting Factor(GIF)PagGIF1b,and this interaction enhances the effects of PagGRF12a on PagXND1a.Our results indicate that PagGRF12a inhibits xylem development by upregulating the expression of PagXND1a. | Jinnan Wang Houjun Zhou Yanqiu Zhao Cheng Jiang Jihong Li Fang Tang Yingli Liu Shutang Zhao Jianjun Hu Xueqin Song MengZhu Lu | 2021 | Journal of Integrative Plant Biology2021，63，10： | 3 |
| 11 | Optic and catalytic properties of gold nanoparticles tuned by homopolymers显示文摘Gold nanoparticles (GNs) are prepared through in situ reduction using NaBH4 in the presence of homopolymer PDMAEMA. The sizes of the GNs can be adjusted by alternating the molar ratio of gold to DMAEMA. Pure PDMAEMA aqueous solution shows a phase-transition at 50℃ at pH 10 and 25℃ at pH 14, while PDMAEMA-supported GNs aqueous solution shows a phase-transition at 47℃ at pH 10 because of the increasing hydrophobic property resulting from GNs. Due to the pH and tempera-ture-responsible characteristics of PDMAEMA, the resulting PDMAEMA-supported GNs exhibit pH adjustable temperature-responsive characteristics in optic and catalytic aspects. Under an acidic condi-tion (pH 2), the GNs show unchanged surface Plasmon absorbance with a peak of 518 nm in a tem-perature range from 20 to 65℃. Under a basic condition (pH 10), the GNs first show the same absorb-ance with a peak at 518 nm in a temperature range from 20 to 40℃, and then the absorbance red shifts from 518 to 545 nm as temperature increases from 40 to 65℃. When the GNs are used as catalysts to catalyze the reduction of p-nitrophenol, the catalytic activity can be adjusted by changing the permeation of reactants in the PDMAEMA layer at low and high temperatures, respectively. | CHEN Xi ZHAO DongYun ZHAO LiZhi AN YingLi MA RuJiang SHI LinQi HE QiJun CHEN Li | 2009 | Science China Chemistry2009，52，9： | 3 |
| 12 | Diversified roles of mineral transformation in controlling hydrocarbon generation process,mechanism,and pattern显示文摘Organic matter(OM)is intimately associated with minerals in clay-rich mudstones,leading to widespread organic-mineral interaction during hydrocarbon generation in argillaceous source rocks.What we are concerned is the effects of the different mineral properties on hydrocarbon generation process and mechanism during mineral transformation.In this way,pyrolysis experiments with smectite-octadecanoic acid complexes(Sm-OA and Ex-Sm-OA)were conducted to analyze correlation of mineralogy and pyrolysis behaviors.Based on organicmineral interaction,hydrocarbon generation process was divided into three phases.At 200–300℃,collapse of smectite led to desorption of OM,resulting in high yield of resin and slight increase in saturates.Subsequently,enhanced smectite illitization at 350–450℃was accompanied with large amounts of saturates and a mere gaseous hydrocarbon.Featured by neoformed plagioclase,ankerite,and illite,500C saw plenty of asphaltene and methane-rich gaseous hydrocarbons,revealing cracking reactions of OM.Noteworthy is that saturated and gaseous hydrocarbons in Ex-Sm-OA were considerably more than that in Sm-OA during second and third phases.Quantitative calculation of hydrogen revealed organic hydrogen provided by cross-linking of OM could not balance hydrogen consumed by cracking reactions,but supply of inorganic hydrogen ensured cracking could readily occur and consequently greatly promoted hydrocarbon generation.Further investigating characteristics of mineralogy and pyrolytic products,as well as effects of solid acidity on hydrocarbon generation,we concluded desorption of OM and decarboxylation promoted by Lewis acid were dominated at 200–300C,resulting in lowdegree hydrocarbon generation.While high yield of saturated and gaseous hydrocarbons in second and third phases,together with occurrence of ankerite,indicated predominance of decarboxylation and hydrogenation promoted by Lewis and Brønsted acid,respectively.Variations in organic-mineral interactions indicated(1)the controls of mineral transformation on hydrocarbon generation process and mechanism include desorption,decarboxylation,and hydrogenation reactions;(2)clay minerals acted as reactants evolving together with OM rather than catalysts.These findings are profoundly significant for understanding the hydrocarbon generation mechanisms,organic-inorganic interactions,and carbon cycle. | Jiazong Du Jingong Cai Tianzhu Lei Yingli Li | 2021 | Geoscience Frontiers2021，12，2： | 2 |
| 13 | MicroRNA expression profile and lipid metabolism characteristics in liver of rat undergoing high-fat diet显示文摘This study aimed to investigate the microRNA expression profile and the characteristics of lipid metabolism in the livers of rats undergoing a high-fat diet.Fifty male Sprague-Dawley(SD)rats were divided into a standard chow group(C group,N=10)and a high-fat diet group(H group,N=40).After 12 weeks,the rat body weight,body length,fat mass,and serum lipid concentration were measured.The expression profile of microRNAs and the gene and protein expression levels involved in lipid metabolism in rat liver were detected.Body fat and serum lipid concentrations were all significantly higher in the H group than those in the C group(p<0.05 or p<0.01).The expression of 10 microRNAs showed significant differences in the liver(p<0.05).In particular,the let-7 family expression levels significantly increased(p<0.05)in the H group compared with those in the C group.Compared with the C group,the high-fat diet resulted in low FAS,CPT1A,and ApoAI mRNA expression levels(p<0.05 or p<0.01)and high PPARαand FAT/CD36 mRNA expression levels in the H group rat liver(p<0.01).Meanwhile,the protein PPARα,FAS,CPT1A,FAT/CD36,and ApoAI expression levels were all significantly lower in the H group than those in the C group(p<0.05 or p<0.01).In conclusion,the high-fat diet increased the body fat and serum lipid levels and altered the 10 microRNA expression levels in the liver.The high-fat diet may affect hepatic carbohydrate metabolism and increase ectopic fat accumulation through let-7 family overexpression.The high-fat diet for 12 weeks decreased lipid metabolism level in the liver,thereby decreasing fatty acid synthesis,oxidation,and transport by down-regulating the PPARα,FAS,CPT1A,FAT/CD36,and ApoAI protein levels. | WEN JING CHUANFEN LI YINGLI LU LIANSHI FENG | 2019 | BIOCELL2019，43，3： | 2 |
| 14 | Daily power demand prediction for buildings at a large scale using a hybrid of physics-based model and generative adversarial network显示文摘Power demand prediction for buildings at a large scale is required for power grid operation.The bottom-up prediction method using physics-based models is popular,but has some limitations such as a heavy workload on model creation and long computing time.Top-down methods based on data driven models are fast,but less accurate.Considering the similarity of power demand patterns of single buildings and the superiority of generative adversarial network(GAN),this paper proposes a new method(E-GAN),which combines a physics-based model(EnergyPlus)and a data-driven model(GAN),to predict the daily power demand for buildings at a large scale.The new E-GAN method selects a small number of typical buildings and utilizes EnergyPlus models to predict their power demands.Utilizing the prediction for those typical buildings,the GAN then is adopted to forecast the power demands of a large number of buildings.To verify the proposed method,the E-GAN is used to predict 24-hour power demands for a set of residential buildings.The results show that(1)4.3%of physics-based models in each building category are required to ensure the prediction accuracy;(2)compared with the physics-based model,the E-GAN can predict power demand accurately with only 5%error(measured by mean absolute percentage error,MAPE)while using only approximately 9%of the computing time;and(3)compared with data-driven models(e.g.,support vector regression,extreme learning machine,and polynomial regression model),E-GAN demonstrates at least 60%reduction in prediction error measured by MAPE. | Chenlu Tian Yunyang Ye Yingli Lou Wangda Zuo Guiqing Zhang Chengdong Li | 2022 | Building Simulation2022，15，9： | 2 |
| 15 | Effects of sleep deprivation on polysomnography and executive function in patients with depression显示文摘 | Lu Yingzhi Ren Qingtao Zong Li Wu Yingli Zhang Qinfeng Ma Xiuqing Pu Jinyu Dong Hanzhen Liu Qingqing Tang Yunxiang Song Lisheng Chen Xingshi Pan Xiao Cui Yi | 2014 | Chinese Medical Journal2014，，18： | 2 |
| 16 | Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs显示文摘 | Wei Jiang Jilong Wang Jinbin Yang Zhiwei He Zhenhui Hou Yingli Luo Li Wang Jing Liu Houbing Zhang Yangyang Zhao Guoqing Zhang Fang Huang Xuechang Zhou Lifeng Yan Xianzhu Yang Yucai Wang Jun Wang | 2018 | Nano Research2018，11，10： | 2 |
| 17 | Mitochondrial apoptosis of lymphocyte is induced in type 2 diabetes显示文摘 | Xu Hui Chen Yanbo Li Yanxiang Xia Fangzhen Han Bing Zhang Huixin Zhai Hualing Wu Hui Li Ying Lu Yingli | 2014 | Chinese Medical Journal2014，，2： | 2 |
| 18 | Development of polyclonal antibody based enzyme-linked immunosorbent assay for the analysis of the agricultural insecticide imidacloprid:food quality and safety显示文摘 | Li Zhixiong Liu Yingli Sun Yuanming | | 0，，： | 1 |
| 19 | NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition显示文摘NES1 gene is thought to be a tumor-suppressor gene.Our previous study found that overexpression of NES1 gene in PC3 cell line could slow down the tumor proliferation rate,associated with a mild decrease in BCL-2 expression.The BCL-2 decrease could increase the sensitivity of radiotherapy to tumors.Thus,we supposed to have an“enhanced firepower”effect by combining overexpressed NES1 gene therapy and 131I radiation therapy uptake by overexpressed hNIS protein.We found a weak endogenous expression of hNIS protein in PC3 cells and demonstrated that the low expression of hNIS protein in PC3 cells might be the reason for the low iodine uptake.By overexpressing hNIS in PC3,the radioactive iodine uptake ability was significantly increased.Results of in vitro and in vivo tumor proliferation experiments and 18F-fluorothymidine(18F-FLT)micro-positron emission tomography/computed tomography(micro-PET/CT)imaging showed that the combined NES1 gene therapy and 131I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferative inhibition effect.Immunohistochemistry showed an obvious decrease of Ki-67 expression and the lowest BCL-2 expression.These data suggest that via inhibition of BCL-2 expression,overexpressed NES1 might enhance the effect of radiation therapy of 131I uptake in hNIS overexpressed PC3 cells. | Jiajia Hu Wenbin Shen Qian Qu Xiaochun Fei Ying Miao Xinyun Huang Jiajun Liu Yingli Wu Biao Li | 2019 | Frontiers of Medicine2019，13，6： | 1 |
| 20 | Development of polyclonal antibody based enzymelinked immunosorbent assay for the analysis of the agricultural insec- ticide imidacloprid: food quality and safety 显示文摘 | Zhixiong Li MSc yingli Liu DSe Yuanming Sun phD | 2007 | Asia Pac J Clin Nutr2007，16，1： | 1 |
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