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| 1 | Carboniferous Post-collisional Rift Volcanism of the Tianshan Mountains, Northwestern China显示文摘The Tianshan Carboniferous post-collisional rift volcanic rocks occur in northwestern China as a large igneous province. Based on petrogeochemical data, the Tianshan Carboniferous post-collisional rift basic lavas can be classified into two major magma types: (1) the low-Ti/Y type situated in the eastern-central Tianshan area, which exhibits low Ti/Y (<500), Ce/Yb (<15) and SiO2 (43-55%), and relatively high Fe2O3T (6.4-11.5%); (2) the high-Ti/Y type situated in the western Tianshan area, which has high Ti/Y (>500), Ce/Yb (>11) and SiO2 (49-55%), and relatively low Fe2O3T (5.8-7.8%). Elemental data suggest that chemical variations of the low-Ti/Y and high-Ti/Y lavas cannot be explained by fractional crystallization from a common parental magma. The Tianshan Carboniferous basic lavas originated most likely from an OIB-like asthenospheric mantle source (87Sr/86Sr(t) ≈ 0.703-0.705, εNd(t) ≈ +4 to +7). The crustal contamination and continental lithospheric mantle have also contributed significantly to the formation of the basic lavas of the Tianshan Carboniferous post-collisional rift. The silicic lavas were probably generated by partial melting of the crust. The data of this study show that spatial petrogeochemical variations exist in the Carboniferous post-collisional rift volcanics province in the Tianshan region. Occurrence of the thickest volcanics dominated by tholeiitic lavas may imply that the center of the mantle-melting anomaly (mantle plume) was in the eastern Tianshan area at that time. The basic volcanic magmas in the eastern Tianshan area were generated by a relatively high degree of partial melting of the mantle source around the spinel-garnet transition zone, whereas the alkaline basaltic lavas are of the dominant magma type in the western Tianshan area, which were generated by a low degree of partial melting of the mantle source within the stable garnet region, thus the basic lavas of the western Tianshan area might have resulted from relatively thick lithosphere and low geothermal gradient. | XIA Linqi, XU Xueyi, XIA Zuchun, LI Xiangmin, MA Zhongping and WANG Lishe Xi’an Institute of Geology and Mineral Resources, China Geological Survey, Xi’an, Shaanxi 710054 E-mail: geologyx@pub.xaonline.com. Liu Shuchun and Liu Xinzhu | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 49 |
| 2 | Reassessment of petrogenesis of Carboniferous—Early Permian rift-related volcanic rocks in the Chinese Tianshan and its neighboring areas显示文摘The Carboniferous Early Permian rill-related volcanic successions.covering large areas in the Chinese Tianshan and its adjacent areas.make up a newly recognized important Phanerozoic large igneous province in the world.which can be further divided into two sub-provinces:Tianshan and Tarim. The regional unconformity of Lower Carboniferous upon basement or pre-Carboniferous rocks.the ages (360—351 Ma) of the youngest ophiolite and the peak of subduction metamorphism of high pressure-low temperature metamorphic belt and the occurrence of Ni-Cu-bearing mafic-ultramatic intrusion with age of—352 Ma and A-type granite with age of~358 Ma reveal that the final closure of the Paleo Asian Ocean might lake place in the Early Mississippian.Our summation shows that at least four criteria.being normally used to identify ancient asthenosphere upwelling(or mantle plumes),are met for this large igneous province:(1) surface uplift prior to magmatism:(2) being associated with continental ifting and breakup events:(3) chemical characteristics of asthenosphere(or plume) derived basalts;(4) close links to large-scale minerali/alion and the uncontaminaled basalts,being analogous to those of many 'ore-bearing' large igneous provinces.display Sr-Nd isotopic variations between plume and EMI geochemical signatures.These suggest that a Carboniferous asthenosphere upwelling and an Early Permian plume played the central role in the generation of the Tianshan—Tarim(central Asia) large igneous province. | Linqi Xia Xueyi Xu Xiangmin Li Zhongping Ma Zuchun Xia | 2012 | Geoscience Frontiers2012，3，4： | 30 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Mid—Late Neoproterozoic rift-related volcanic rocks in China:Geological records of rifting and break-up of Rodinia显示文摘Early Cambrian and Mid-Late Neoproterozoic volcanic rocks in China are widespread on several Precambrian continental blocks,which had aggregated to form part of the Rodinia supercontinent by ca.900 Ma.On the basis of petrogeochemical data,the basic lavas can be classified into two major magma types:HT(Ti/Y>500) and LT(Ti/Y<500) that can be further divided into HT1 (Nb/La>0.85) and HT2(Nb/La≤0.85),and LT1(Nb/La>0.85) and LT2(Nb/La≤0.85) subtypes, respectively.The geochemical variation of the HT2 and LT2 lavas can be accounted for by lithospheric contamination of asthenosphere-(or plume-) derived magmas,whereas the parental magmas of the HT1 and LT1 lavas did not undergo,during their ascent,pronounced lithospheric contamination.These volcanics exhibit at least three characteristics:(1) most have a compositional bimodality;(2) they were formed in an intracontinental rift setting;and(3) they are genetically linked with mantle plumes or a mantle surperplume.This rift-related volcanism at end of the MidNeoproterozoic and Early Cambrian coincided temporally with the separation between AustraliaEast Antarctica,South China and Laurentia and between Australia and Tarim,respectively. The Mid—Late Neoproterozoic volcanism in China is the geologic record of the rifting and break-up of the supercontinent Rodinia. | Linqi Xia Zuchun Xia Xueyi Xu Xiangmin Li Zhongping Ma | 2012 | Geoscience Frontiers2012，3，4： | 18 |
| 5 | Relationships between Basic and Silicic Magmatism in Continental Rift Settings:A Petrogeochemical Study of Carboniferous Post-collisional Rift Silicic Volcanics in Tianshan,NW China显示文摘Petrogeochemical data are reported for silicic volcanic rocks from the Tianshan Carboniferous rift, with the aim of discussing the petrogenesis of silicic magmas. Incompatible element vs. incompatible element diagrams display smooth positive trends for the Tianshan Carboniferous rift-related volcanic rocks; the isotope ratios of the silicic lavas [87Sr/86Sr(t)=0.69988–0.70532; εNd(t)=4.76–8.00; 206Pb/204Pb(t)=17.435–18.017; 207Pb/204Pb(t)=15.438–15.509; 208Pb/204Pb(t) = 37.075–37.723] encompass those of the basic lavas. These data suggest a genetic link between rhyolites and basalts, but are not definitive in establishing whether silicic rocks are related to basalts through fractional crystallization or partial melting. Geochemical modeling of incompatible vs. compatible elements excludes the possibility that silicic melts are generated by the melting of basaltic rocks, and indicates a derivation by fractional crystallization plus moderate assimilation of wall rocks (AFC) starting from intermediate rocks to silicic rocks. Continuous AFC from basalt to rhyolite, with small rates of crustal assimilation, best explains the geochemical data. The presence or absence of bimodal volcanism (the “Daly Gap”) might be related to cooling rates of magma chambers. In central and eastern Tianshan, the crust was thinner and the cooling rates of the magma chamber within the crust were greater. These conditions resulted in a rapid fall in temperature within the magma reservoir and caused a narrow temperature interval over which intermediate melts formed, effectively reducing the volume of the intermediate melts. | XIA Linqi XIA Zuchun XU Xueyi LI Xiangmin MA Zhongping WANG Lishe | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 14 |
| 6 | Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis显示文摘chemokine CXCL12 和它的受体 CXCR4 是重要的表明为人的胚囊培植和怀孕的前进要求的部件。成长证据显示 CXCL12/CXCR4 轴能调整 trophoblast 功能和改变的子宫的螺线动脉,它在胎座式和胎儿的结果起一个基本作用。孤儿受体 CXCR7 也被相信部分调整 CXCL12/CXCR4 轴的功能。另外, CXCL12/CXCR4/CXCR7 轴能提高在象子宫的自然漂亮房间那样的 trophoblasts 和蜕膜的房间和涉及 trophoblast 区别和侵略和胎盘的 angiogenesis 的规定的蜕膜的 stromal 房间之间的串音。另外,最近的研究证明那 CXCL12 表情与 preeclampsia 在胎盘和怀孕女人的中间三个月的羊膜的液体被提高,暗示 CXCL12 的 dysregulation 起在 preeclampsia 的致病的一个作用。在 trophoblast 功能和胎盘的 angiogenesis 的调停 CXCL12 的发信号的规章的机制的进一步的理解可以帮助为联系怀孕的疾病设计新奇治疗学的途径。 | Liang Wang Xueyi Li Yilin Zhao Chao Fang Yingli Lian Wenli Gou Tao Han Xiaoming Zhu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 8 |
| 7 | The geochemical characteristics,geochronology and tectonic significance of the Carboniferous volcanic rocks of the Santanghu area in northeastern Xinjiang,China显示文摘The Santanghu area is located on the northeastern margin of the Junggar Basin,northern Xinjiang,Northwest China.The Carboniferous volcanic rocks in this area are widely distributed in Kaokesaiergaishan,Santanghu,Daheishan and Naomaohu districts,which are located to the north of the Kalameili Fault.These rocks,sourced from a cognate magma,consist of basic,intermediate,and acidic lavas,and pyroclastic rock.The basic volcanic rocks are enriched with large-ion lithophile elements(LILE),but are relatively depleted in high field strength elements(HFSE),and have an obvious negative Nb-Ta-Ti anomaly.They were most probably derived from a depleted mantle source,and during their ascent,these magmas were not contaminated by the crustal material as they underwent magma crystallization differentiation.Based on the Carboniferous volcanic assemblage and geochemical data,it is apparent that the early Carboniferous volcanism occurred in a subduction-related tectonic setting.New LA-ICP-MS zircon U-Pb analyses constrain the age of the andesite within the volcanic rocks as the early Carboniferous(328.9-331.3 Ma).Combined with the regional geological record,comprehensive analysis of the isotope geochronological data indicates that the subduction of the Junggar Ocean predates the early Carboniferous,and that the Santanghu island arc magmatism was induced by the subduction of the Junggar Ocean in the Carboniferous. | LI Wei LIU YiQun DONG YunPeng ZHOU XiaoHu LIU XiaoMing LI Hong FAN TingTing ZHOU DingWu XU XueYi CHEN JunLu | 2013 | Science China Earth Sciences2013，56，8： | 8 |
| 8 | Geology and geochemistry of the Bingdaban ophiolitic mélange in the boundary fault zone on the northern Central Tianshan Belt,and its tectonic implications显示文摘The properties and tectonic significance of the fault bound zone on the northern margin of the Central Tianshan belt are key issues to understand the tectonic framework and evolutionary history of the Tianshan Orogenic Belt. Based on the geological and geochemical studies in the Tianshan orogenic belt, it is suggested that the ophiolitic slices found in the Bingdaban area represent the remaining oceanic crust of the Early Paleozoic ocean between the Hazakstan and Zhungaer blocks. Mainly com-posed of basalts, gabbros and diabases, the ophiolites were overthrust onto the boundary fault be-tween the Northern Tianshan and Central Tianshan belts. The major element geochemistry is charac-terized by high TiO2 (1.50%-2.25%) and MgO (6.64%-9.35%), low K2O (0.06%-0.41%) and P2O5 (0.1%-0.2%), and Na2O>K2O as well. Low ΣREE and depletion in LREE indicate that the original magma was derived from a depleted mantle source. Compared with a primitive mantle, the geochemistry of the basalts from the Bingdaban area is featureded by depletion in Th, U, Nb, La, Ce and Pr, and unfrac-tionated in HFS elements. The ratios of Zr/Nb, Nb/La, Hf/Ta, Th/Yb and Hf/Th are similar to those of the typical N-MORB. It can be interpreted that the basalts in the Bingdaban area were derived from a de-pleted mantle source, and formed in a matured mid-oceanic ridge setting during the matured evolu-tionary stage of the Northern Tianshan ocean. In comparison with the basalts, the diabases from the Bingdaban area show higher contents of Al2O3, ∑REE and HFS elements as well as unfractionated incompatible elements except Cs, Rb and Ba, and about 10 times the values of the primitive mantle. Thus, the diabases are thought to be derived from a primitive mantle and similar to the typical E-MORB. The diabases also have slight Nb depletion accompanying no apparent Th enrichment compared with N-MORB. From studies of the regional geology and all above evidence, it can be suggested that the diabases from the Bingdaban area were formed in the mid-oceanic ridge of the Northern Tianshan ocean during the initial spreading stage. | DONG YunPeng ZHANG GuoWei ZHOU DingWu LUO JinHai ZHANG ChengLi XIA LinQi XU XueYi LI XiangMin | 2007 | Science China Earth Sciences2007，50，1： | 5 |
| 9 | Optimization of Wind Farm Collection Line Structure under Symmetrical Grid Fault显示文摘A power-transmission collection line is connected to each wind turbine of a wind farm and then connected to the incoming switchgear at the low-voltage side of the booster station at a certain distance.Therefore,the grouping of the wind turbines in the wind farm determines the layout of the lines and affects the line impedance.The line structure and composition of the wind farm are analyzed,and the relationship between the impedance of the collection line and reactive power generated by the wind turbine at low-voltage ride through is derived.We conclude that the smaller the equivalent impedance of the wind farm collection line structure is,the greater the reactive power at the wind farm collection line point is.In addition,the economic aspect of the collection line needs to be considered in the design.The economic aspect and impedance values have contrasting characteristics.Therefore,according to the condition of minimum impedance and optimized economic aspect,an optimization model of a wind-farm collector-circuit structure is proposed.The optimal structure of the wind farm collector circuit is calculated using the Monte Carlo method,and the theoretical analysis is verified by simulation. | Huan Jin Xueyi Zhang Yang Zhang Qianghui Xiao Juan Li Ya Liu | 2019 | Chinese Journal of Electrical Engineering2019，5，3： | 3 |
| 10 | Numerical simulation of flow and heat transfer of continous cast steel slab under traveling magnetic field显示文摘A unified numerical model for simulating solidification transport phenomena (STP) of steel slab in electromagnetic continuous casting (EMCC) process was developed. In order to solve the multi-physics fields coupled problem conveniently, the complicated bidirectional coupled process between EM and STP was simplified as a unidirectional one, and a FEM/FVM-combined numerical simulation technique was adopted. The traveling magnetic fields (TMFs) applied to the EMCC process were calculated using the ANSYS11.0 software, and then the EM-data output by ANSYS were converted to FVM-format using a data-format conversion program developed previously. Thereafter, the governing equations were solved using a pressure-based Direct-SIMPLE algorithm. The simulation results of the STP in CC-process show that, due to the influences of Lorentz force and Joule heat, the two strong circulating flows and the temperature field can be obviously damped and changed once TMF with one pair of poles (1-POPs) or 2-POPs is applied, which would accordingly improve the quality of casting. It was found in the present research that the integrated actions of 2-POPs TMF are superior to 1-POPs. All the computations indicate that the present numerical model of EM-STP as well as the FEM/FVM-combined technique is successful. | Gong Haijun Li Xinzhong Fan Xueyi Qie Juhong Xu Daming Guo Jingjie | 2013 | China Foundry2013，10，2： | 3 |
| 11 | Growth and characterization ofβ-Ga_(2)O_(3)thin films grown on off-angled Al_(2)O_(3)substrates by metal-organic chemical vapor deposition显示文摘Beta-gallium oxide(β-Ga_(2)O_(3))thin films were deposited on c-plane(0001)sapphire substrates with different mis-cut angles along<>by metal-organic chemical vapor deposition(MOCVD).The structural properties and surface morphology of as-grownβ-Ga_(2)O_(3)thin films were investigated in detail.It was found that by using thin buffer layer and mis-cut substrate technology,the full width at half maximum(FWHM)of the()diffraction peak of theβ-Ga_(2)O_(3)film is decreased from 2°on c-plane(0001)Al_(2)O_(3)substrate to 0.64°on an 8°off-angled c-plane(0001)Al_(2)O_(3)substrate.The surface root-mean-square(RMS)roughness can also be improved greatly and the value is 1.27 nm for 8°off-angled c-plane(0001)Al_(2)O_(3)substrate.Room temper-ature photoluminescence(PL)was observed,which was attributed to the self-trapped excitons formed by oxygen and gallium vacancies in the film.The ultraviolet-blue PL intensity related with oxygen and gallium vacancies is decreased with the increas-ing mis-cut angle,which is in agreement with the improved crystal quality measured by high resolution X-ray diffraction(HR-XRD).The present results provide a route for growing high qualityβ-Ga_(2)O_(3)film on Al_(2)O_(3)substrate. | Yabao Zhang Jun Zheng Peipei Ma Xueyi Zheng Zhi Liu Yuhua Zuo Chuanbo Li Buwen Cheng | 2022 | Journal of Semiconductors2022，43，9： | 3 |
| 12 | Geochemistry, geochronology and Hf isotope of granitoids in the Chinese Altai: Implications for Paleozoic tectonic evolution of the Central Asian Orogenic Belt显示文摘The Chinese Altai in northwestern Xinjiang has numerous outcrops of granitoids which provide critical information on accretionary orogenic processes and crustal growth of the Central Asian Orogenic Belt.Zircon U-Pb ages, Hf-isotopic compositions and whole-rock geochemistry of monzogranite and granodiorites in the Qinghe County are employed to elucidate Paleozoic tectonics of the Chinese Altai. Granodiorites have crystallization ages of 424.6 ± 3.1 Ma(MSWD = 0.23) and 404.0 ± 3.4 Ma(MSWD = 0.18);monzogranite was emplaced in the early Permian with a crystallization age of 293.7 ± 4.6 Ma(MSWD = 1.06). Both granodiorites and monzogranite are I-type granites with A/CNK ratios of 0.92 -0.97 and 1.03 -1.06, respectively. They also show similar geochemical features of high HREE and Y contents, low Sr contents and Sr/Y ratios, as well as enrichment of Cs, Rb, Th and U, and depletion of Nb, Ta, P and Ti.These geochemical features indicate that the monzogranite and granodiorites were formed in an arc setting related to subduction. The gneissic monzogranites display high SiO_2 and K_2 O contents, and belong to the high-K calc-alkaline series. In the chondrite normalized REE distribution pattern, the monzogranite samples exhibit enrichment of LREE with strong negative Eu anomalies(σE u =0.44 -0.53), zircon εHf(t) values from +7.24 to +12.63 and two-stage Hf model ages of 463 -740 Ma. This suggests that the monzogranite was generated from the mixing of pelitic and mantle material. The granodiorite samples are calc-alkaline granites with lower contents of Si O_2 and Na_2 O + K_2 O, higher contents of TiO_2, Fe_2O_3~t, MgO and CaO compared to the monzogranite samples. They also show enrichment of LREE and moderate negative Eu anomalies(σE u= 0.54 =0.81), as well as slightly higher differentiation of LREE than that of HREE. The425 Ma granodiorite has zircon εHf(t) values from -0.51 to +1.98 and two-stage Hf model ages of 1133 -1240 Ma, whereas the 404 Ma granodiorite displays those of +2.52 to +7.50 and 816 -1071 Ma.Geochemistry and zircon Hf isotopic compositions indicate that granodiorites were formed by partial melting of juvenile lower crust. Together with regional geology and previous data, the geochemical and geochronological data of the monzogranite and granodiorites from this study suggest long-lived subduction and accretion along the Altai Orogen during ca. 425 -294 Ma. | Dengfeng He Yunpeng Dong Xueyi Xu Junlu Chen Xiaoming Liu Wei Li Xiangmin Li | 2018 | Geoscience Frontiers2018，9，5： | 3 |
| 13 | Leaching behavior of metals from a limonitic nickel laterite using a sulfation–roasting–leaching process显示文摘 | Xueyi Guo Dong Li Kyung-Ho Park Qinghua Tian Zhan Wu | 2009 | Hydrometallurgy2009，，： | 2 |
| 14 | Overpressure distribution and pressuring mechanism on the southern margin of the Junggar Basin, Northwestern China显示文摘On the basis of the pressure data ob- tained from the southern margin of the Junggar Basin, Northwestern China, the distribution and evolution of overpressures in high permeable sandy and in low-permeability shale formations are characterized. The evolution of overpressures in various structural processes, especially in erosion and mechanical de- formation, is quantified by numerical modeling stud- ies. The modeling results show that anomalies of high pressure observed in boreholes are likely a combination of several effects, i.e. 1) the compaction caused by overloading, 2) the compaction caused by lateral tectonic stressing, 3) lateral transmission of hydraulic pressure associated with fold formation, and 4) vertical hydraulic connection caused by opening faults crossing formations with different initial excessive pressures. The main mechanisms of overpressures and their distributions are defined. | LUO Xiaorong LIU Loujun LI Xueyi | 2006 | Chinese Science Bulletin2006，51，19： | 2 |
| 15 | CUMS and dexamethasone induce depression- like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation显示文摘Background Although the link between gut microbiota and depression has been suggested,changes of gut microbiota vary largely among individuals with depression.Aims Explore the heterogeneity of microbiota-gut-brain axis and new pathogenic characteristics in murine models of depression.Methods Adolescent female mice were randomly divided into control(CON)group(n=10),chronic unexpected mild stress(CUMS)group(n=15)and dexamethasone(DEX)group(n=15).Mice in the DEX group were gavaged twice a day with 0.2 mg/kg of DEX for 5 weeks,whereas CON mice were given the same amount of solvent.Mice in the CUMS group were exposed to stressors.After behavioural evaluations,all mice were sacrificed for harvesting tissues and blood samples.Enzyme-linked immunosorbent assay(ELISA)was conducted for measuring levels of corticosterone(CORT)and interleukin-1β(IL-1β)in sera,whereas levels of protein expression in colon and hippocampal tissues were examined by western blot.Faecal microbial communities were analysed by sequencing 16S rDNAs.Results Mice in CUMS and DEX groups exhibited severe depression-like behaviours.Compared with CON mice,CUMS-exposed mice showed a significant increase in bothαandβdiversity.Prevotellaceae and Desulfovibrio were enriched,whereas Bacilli were decreased in the faeces of mice in the CUMS group.DEX-treated mice had a decrease in the abundance of Clostridium XVIII.Levels of occludin in colon tissue of DEX-treated mice were reduced.Relative to mice in the CON and CUMS groups,DEX-treated mice contained higher serum levels of CORT and IL-1β.Compared with CON mice,mice in the DEX and CUMS groups had higher levels of IL-1βin sera and lower levels of glial fibrillary acidic protein(GFAP),Nestin,Synapsin-1 and P2Y12 receptor in the hippocampus.Conclusions Changes of gut microbiota diversity,intestinal integrity and neuroinflammation in the brain contribute to CUMS-induced depression,whereas pathobionts and excessive immunosuppression with damaged neuronal synapses is a basis of the DEX-induced depression. | Jing Wu Jinhang Li Chhetri Gaurav Usman Muhammad Yantian Chen Xueyi Li Jinghong Chen Zejian Wang | 2021 | General Psychiatry2021，34，6： | 2 |
| 16 | Highly conductive and robust composite anion exchange membranes by incorporating quaternized MIL-101(Cr)显示文摘With well-defined channels and tunable functionality, metal-organic frameworks(MOFs) have inspired the design of a new class of ion-conductive compounds. In contrast to the extensive studies on protonconductive MOFs and related membranes attractive for fuel cells, rare reports focus on MOFs in preparation of anion exchange membranes. In this study, chloromethylated MIL-101(Cr) was prepared and incorporated into chloromethylated poly(ether ether ketone)(PEEK) as a multifunctional filler to prepare imidazolium PEEK/imidazolium MIL-101(Cr)(Im PEEK/Im MIL-101(Cr)) anion exchange membrane after synchronous quaternization. The successful synthesis and chloromethylation of MIL-101(Cr) were verified by transmission electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy while the enhanced performance of composite membranes in hydroxide conductivity, mechanical strength and dimensional stability were evaluated by alternating-current impedance, electronic stretching machine and measurement of swelling ratio. Specifically, incorporating 5.0 wt% Im MIL-101(Cr)afforded a 71.4% increase in hydroxide conductivity at 20 °C, 100% RH. Besides, the composite membranes exhibited enhanced dimensional stability and mechanical strength due to the rigid framework of Im MIL-101(Cr). At room temperature and the Im MIL-101(Cr) content of 10 wt%, the swelling ratio of the Im PEEK/Im MIL-101(Cr) was 70.04% lower while the tensile strength was 47.5% higher than that of the pure membrane. | Xueyi He Mingyue Gang Zhen Li Guangwei He Yongheng Yin Li Cao Bei Zhang Hong Wu Zhongyi Jiang | 2017 | Science Bulletin2017，62，4： | 2 |
| 17 | Preparation and ζ-potential characterization of highly dispersible phosphate—functionalized magnetite nanoparticles显示文摘By the combination of high-temperature organometallic synthesis and phase transfer through complete ligand-exchange withmixed phosphate, highly water-dispersible Fe3O4nanoparticles with narrow size distribution are obtained, which show appli-cable response to magnetic field. IR and -potential characterization of this system provides insights into ligand structures onparticle surface. | LI XueYi TANG Yan GE GuangLu | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 2 |
| 18 | DISCRIMINANT INDEPENDENT COMPONENT ANALYSIS AS A SUBSPACE REPRESENTATION显示文摘Subspace modeling plays an important role in face recognition. Independent Component Analysis (ICA), a multivariable statistical analysis technique, can be seen as an extension of traditional Principal Component Analysis (PCA) technique, which addresses high order statistics as well as second order statistics. In this paper, a new scheme of subspace-based representation called Discriminant Independent Component Analysis (DICA) is proposed, which combines the strength of unsupervised learning of ICA and supervised learning of Linear Discriminant Analysis (LDA), and efficiently enhances the generalization ability of ICA-based representation method. Based on DICA subspace analysis, a set of optimal vectors called 'discriminant independent faces' are learned from face samples. The effectiveness of our method is demonstrated by performance comparisons with some popular methods such as ICA, PCA, and PCA+LDA. On the large scale database of IIS, significant improvements are observed when there are fewer training samples per person available. | Long Fei He Jinsong Ye Xueyi Zhuang Zhenquan Li Bin | 2006 | Journal of Electronics(China)2006，23，1： | 2 |
| 19 | Leaching behavior of metals from a limonitic nickel laterite using a sulfation-roasting-leaching process显示文摘 | Xueyi Guo Dong Li Kyung-Ho Park | 2009 | Hydronaetallurgy2009，99，3： | 1 |
| 20 | DNA-binding and Cleavage Studies of Novel Copper( Ⅱ) Complex with L-phe- nylalaninate and 1,4,8,9-tetra-aza-triphenylene Ligands显示文摘 | LI Hong LE Xueyi PANG Daiwen | 2005 | J Inorg Biochem2005，99，11： | 1 |
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