|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Generation of arbitrary vector vortex beams on hybrid-order Poincaré sphere显示文摘We propose theoretically and verify experimentally a method of combining a q-plate and a spiral phase plate to generate arbitrary vector vortex beams on a hybrid-order Poincaré sphere. We demonstrate that a vector vortex beam can be decomposed into a vector beam and a vortex, whereby the generation can be realized by sequentially using a q-plate and a spiral phase plate. The generated vector beam, vortex, and vector vortex beam are verified and show good agreement with the prediction. Another advantage that should be pointed out is that the spiral phase plate and q-plate are both fabricated on silica substrates, suggesting the potential possibility to integrate the two structures on a single plate. Based on a compact method of transmissive-type transformation, our scheme may have potential applications in future integrated optical devices. | Zhenxing Liu Yuanyuan Liu Yougang Ke Yachao Liu Weixing Shu Hailu Luo Shuangchun Wen | 2017 | Photonics Research2017，5，1： | 18 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Effect of vernalization on tuberization and flowering in the Tibetan turnip is associated with changes in the expression of FLC homologues显示文摘The turnip(Brassica rapa var. rapa) is a biennial crop that is planted in late summer/early fall and forms fleshy tubers for food in temperate regions. The harvested tubers then overwinter and are planted again the next spring for flowering and seeds. FLOWERING LOCUS C(FLC) is a MADS-box transcription factor that acts as a major repressor of floral transition by suppressing the flowering promoters FT and SOC1. Here we show that vernalization effectively represses tuber formation and promotes flowering in Tibetan turnip. We functionally characterized four FLC homologues(BrrFLC1,FLC2, FLC3, and FLC5), and found that BrrFLC2 and BrrFLC1 play a major role in repressing flowering in turnip and in transgenic Arabidopsis. In contrast, tuber formation was correlated with BrrFLC1 expression in the hypocotyl and was repressed under cold treatment following the quantitative downregulation of BrrFLC1. Grafting experiments of non-vernalized and vernalized turnips revealed that vernalization independently suppressed tuberization in the tuber or hypocotyl of the rootstock or scion, which occurred in parallel with the reduction in BrrFLC1 activity. Together, our results demonstrate that the Tibetan turnip is highly responsive to cold exposure, which is associated with the expression levels of BrrFLC genes. | Yan Zheng Landi Luo Yuanyuan Liu Yunqiang Yang Chuntao Wang Xiangxiang Kong Yongping Yang | 2018 | Plant Diversity2018，40，2： | 7 |
| 6 | MICROSTRUCTURES OF A NOVEL HIGH STRENGTH AND WEAR-RESISTING ZINC ALLOY显示文摘MICROSTRUCTURESOFANOVELHIGHSTRENGTHANDWEAR-RESISTINGZINCALLOYLiYuanyuan;XiaWei;NgaiTungwaiLeo;LuoJunming;ZhengLingyi(Departme... | Li Yuanyuan Xia Wei Ngai Tungwai Leo Luo Junming Zheng Lingyi(Department of Mechanical Engineering,South China University of Technology, Guangzhou 51064) | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 7 |
| 7 | Dissipation of polycyclic aromatic hydrocarbons and microbial activity in a field soil planted with perennial ryegrass显示文摘 | Dengqiang FU Ying TENG Yuanyuan SHEN Mingming SUN Chen TU Yongming LUO Zhengao LI Peter CHRISTIE | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 6 |
| 8 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 9 | Effect of microstructure on the mechanical and corrosion behaviors of a hot-extruded nickel aluminum bronze显示文摘In this paper,the influence of microstructure on the corrosion behavior of a hotextruded nickel aluminum bronze was studied.Three kinds of samples subjected to the hot-extrusion,annealing and quenching conditions were prepared and immersion tests in 3.5% NaCl solution were carried out.Microstructures and corrosion surface morphologies of the samples were observed by SEM.It was found that the retained β martensite and(α+κⅢ) lamella eutectoid in the as hot-extruded material were eliminated after annealing,and corrosion resistance of the alloy was improved.As to the as-quenched material,its corrosion rate was higher than that of the as hotextruded material since the volume fraction of β phase which was anodic to α phase increased after quenching.As regards the mechanical properties,the as-quenched sample possesses the highest hardness and tensile strength among the three kinds of samples,while the as-annealed sample possesses the highest elongation.That is to say,heat treatment plays different roles in the mechanical properties and corrosion resistance of the experimental alloy. | Datong ZHANG Ruiping CHEN Weiwen ZHANG Zongqiang LUO Yuanyuan LI | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，2： | 5 |
| 10 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 11 | Rapid growth of industrial nitrogen fluxes in China: Driving forces and consequences显示文摘Human activities are strongly modifying the global nitrogen (N) cycle through increasing input, N species diversity, and pool size of industrial reactive N (Nr). However, the fluxes, fates and environmental consequences of industrial Nr (excluding synthesized N fertilizer) remain poorly understood and quantified. We report here that industrial Nr flux has increased 13.4-fold over the past 30 years in China, reaching 3.7Tg N (1 Tg=10 12g) in 2008, accounting for over 50% of China's food Nr flux. Socioeconomic development (per capita GDP, urbanization and household size) significantly drives the growth of industrial Nr fluxes. This leads to 'hotspots' of industrial Nr, mainly in relatively developed Eastern China. Industrial Nr loss rate during production is only 5%, much lower than that of cropland (50%) and livestock (80%). However, industrial Nr loss is point source pollution, and Nr release in concentrated doses produces serious risk in small regions. The contribution of structural N to total industrial Nr with a lifespan longer than one year (e.g., synthetic fiber, plastic) increased from 20% in 1980 to 70% in 2008. There was about 2.6 Tg N structural industrial Nr accumulated in human settlements in 2008, which could be one ex- planation of an unknown Nr sink of anthropogenic Nr input (mainly Haber-Bosch N fixation). Legacy effects caused by structural N accumulation have long-term consequences for environmental and human health, although structural N delays Nr release and reduces short-term Nr pollution. Industrial Nr use generates new features of modern global N biogeochemistry, such as increasing Nr species diversity, reducing Nr turnover rate. Future dynamics simulation of the earth system should involve industrial Nr. Explicit consideration and accounting of the fluxes and environmental consequences of industrial Nr would provide decision-makers a novel view of regional sustainable development. | GU BaoJing YANG GuoFu LUO WeiDong DU YuanYuan GE Ying CHANG Jie | 2013 | Science China Earth Sciences2013，56，4： | 4 |
| 12 | Enhancing electrocatalytic N_(2)-to-NH_(3) fixation by suppressing hydrogen evolution with alkylthiols modified Fe_(3)P nanoarrays显示文摘Electrocatalytic N_(2) reduction provides an attractive alternative to Haber-Bosch process for artificial NH_(3) synthesis.The difficulty of suppressing competing proton reduction,however,largely impedes its practical use.Herein,we design a hydrophobic octadecanethiol-modified Fe_(3)P nanoarrays supported on carbon paper(C18@Fe_(3)P/CP)to effectively repel water,concentrate N_(2),and enhance N_(2)-to-NH_(3) conversion.Such catalyst achieves an NH_(3) yield of 1.80×10^(-10) mol s^(-1)·cm^(-2) and a high Faradaic efficiency of 11.22%in 0.1 M Na_(2)SO_(4),outperforming the non-modified Fe_(3)P/CP(2.16×10^(-11) mol s^(-1)·cm^(-2),0.9%)counterpart.Significantly,C18@Fe_(3)P/CP renders steady Nrfixing activlty/selectivity in cycling test and exhibits durability for at least 25 h.First-principles calculations suggest that the surface electronic structure and chemical activity of Fe_(3)P can be well tuned by the thiol modification,which facilitates N_(2) electroreduction activity and catalytic formation of NH_(3). | Tong Xu Jie Liang Yuanyuan Wang Shaoxiong Li Zhaobai Du Tingshuai Li Qian Liu Yonglan Luo Fang Zhang Xifeng Shi Bo Tang Qingquan Kong Abdullah M.Asiri Chun Yang Dongwei Ma Xuping Sun | 2022 | Nano Research2022，15，2： | 4 |
| 13 | An acoustical pump capable of significantly increasing pressure ratio of thermoacoustic heat engines显示文摘Pressure ratio is one of the important parameters for evaluating a thermoacoustic heat en- gine. A so-called acoustical pump, which is capable of significantly increasing pressure ratio of a ther- moacoustic heat engine, is proposed. Its operating principle is given. Also, a verification experiment is done with nitrogen gas in the energy-focused ther- moacoustic heat engine, showing that the pressure ratio increased from 1.25 to 1.47. | LUO Ercang HU Jianying DAI Wei CHEN Yuanyuan | 2006 | Chinese Science Bulletin2006，51，8： | 4 |
| 14 | Energy conservation and emissions reduction strategies in foundry industry显示文摘Current energy conservation and emissions reduction strategies in iron and steel industry were reviewed. Since foundry industry is one of the major source of energy consumption and pollution emission (especially CO 2 ), issues concerning energy-saving and emission-reduction have been raised by governments and the industry. Specialists from around the world carried out multidimensional analyses and evaluation on the potentials in energy conservation and emissions reduction in iron and steel industry, and proposed various kinds of analyzing models. The primary measures mainly focus on the targeted policies formulation and also on clean and highefficient technologies development. The differences and similarities in energy conservation and emission reduction in foundry industry between China and other countries were discussed, while, the future development trend was also pointed out. | Li Yuanyuan Chen Weiping Huang Dan Luo Jie Liu Zhe Chen Yongcheng Liu Qiping Su Shifang | 2010 | China Foundry2010，7，4： | 4 |
| 15 | Rice metabolic regulatory network spanning the entire life cycle显示文摘As one of the most important crops in the world,rice(Oryza sativa)is a model plant for metabolome research.Although many studies have focused on the analysis of specific tissues,the changes in metab-olite abundance across the entire life cycle have not yet been determined.In this study,combining both tar-geted and nontargeted metabolite profiling methods,a total of 825 annotated metabolites were quantified in rice samples from different tissues covering the entire life cycle.The contents of metabolites in different tissues of rice were significantly different,with various metabolites accumulating in the plumule and radicle during seed germination.Combining these data with transcriptome data obtained from the same time period,we constructed the Rice Metabolic Regulation Network.The metabolites and co-expressed genes were further divided into 12 clusters according to their accumulation patterns,with members within each cluster displaying a uniform and clear pattern of abundance across development.Using this dataset,we established a comprehensive metabolic profile of the rice life cycle and used two independent strategies to identify novel transcription factors-namely the use of known regulatory genes as bait to screen for new networks underlying lignin metabolism and the unbiased identification of new glycerophospholipid metabolism regulators on the basis of tissue specificity.This study thus demonstrates how guilt-by-association analysis of metabolome and transcriptome data spanning the entire life cycle in cereal crops provides novel resources and tools to aid in understanding the mechanisms underlying important agro-nomic traits. | Chenkun Yang Shuangqian Shen Shen Zhou Yufei Li Yuyuan Mao Junjie Zhou Yuheng Shi Longxu An Qianqian Zhou Wenju Peng Yuanyuan Lyu Xuemei Liu Wei Chen Shouchuang Wang Lianghuan Qu Xianqing Liu Alisdair R.Fernie Jie Luo | 2022 | Molecular Plant2022，15，2： | 3 |
| 16 | Microstructural evolution and mechanical properties of FeCoCrNiCu high entropy alloys:a microstructure-based constitutive model and a molecular dynamics simulation study显示文摘High entropy alloys(HEAs)attract remarkable attention due to the excellent mechanical performance.However,the origins of their high strength and toughness compared with those of the traditional alloys are still hardly revealed.Here,using a microstructure-based constitutive model and molecular dynamics(MD)simulation,we investigate the unique mechanical behavior and microstructure evolution of FeCoCrNiCu HEAs during the indentation.Due to the interaction between the dislocation and solution,the high dislocation density in FeCoCrNiCu leads to strong work hardening.Plentiful slip systems are stimulated,leading to the good plasticity of FeCoCrNiCu.The plastic deformation of FeCoCrNiCu is basically affected by the motion of dislocation loops.The prismatic dislocation loops inside FeCoCrNiCu are formed by the dislocations with the Burgers vectors of a/6[112]and a/6[112],which interact with each other,and then emit along the<111>slip direction.In addition,the mechanical properties of FeCoCrNiCu HEA can be predicted by constructing the microstructure-based constitutive model,which is identified according to the evolution of the dislocation density and the stress-strain curve.Strong dislocation strengthening and remarkable lattice distortion strengthening occur in the deformation process of FeCoCrNiCu,and improve the strength.Therefore,the origins of high strength and high toughness in FeCoCrNiCu HEAs come from lattice distortion strengthening and the more activable slip systems compared with Cu.These results accelerate the discovery of HEAs with excellent mechanical properties,and provide a valuable reference for the industrial application of HEAs. | Gangjie LUO Li LI Qihong FANG Jia LI Yuanyuan TIAN Yong LIU Bin LIU Jing PENG P.K.LIAW | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，8： | 3 |
| 17 | Branched-chain amino acids regulate plant growth by affecting the homeostasis of mineral elements in rice显示文摘Dear Editor,Branched-chain amino acids(BCAAs)are essential amino acids that must be obtained from the diet for humans and animals.Branched-chain amino acid transaminases(BCATs)catalyze a key step in the BCAA synthesis pathway,however,little is known about their biological roles in planta.In this study,we functionally characterized two BCATs,OsBCAT4 and OsBCAT5,in rice and showed that they regulate the development of rice roots by affecting the levels of mineral elements. | Cheng Jin Yangyang Sun Yuheng Shi Yuanyuan Zhang Kai Chen Yuan Li Guige Liu Fang Yao Deng Cheng Jie Li Junjie Zhou Lianghuan Qu Xianqing Liu Jie Luo | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 18 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 19 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 20 | AgBF_4/[emim][BF_4] supported ionic liquid membrane for carbon monoxide/nitrogen separation显示文摘In this paper,AgBF_4/[emim][BF_4] supported ionic liquid membranes(SILMs) were prepared successfully for CO/N_2 separation using nitrogen pressure immobilization procedures.The incorporation of AgBF_4 could decrease membrane weight loss,improve the pressure-resistant ability,and keep the critical pressure(0.45 MPa) of the SILMs.The high viscosity and undissolved Ag BF_4 solids in membrane liquid would disturb gas molecular transport through membrane and give rise to the gas transport resistance.Therefore,the gas permeability decreased remarkably with increasing AgBF_4 carrier content in the membrane.When the molar ratio of AgBF_4 to [emim][BF_4] increased from 0:1 to 0.3:1,the CO/N_2 selectivity of the SILMs showed a great increase from ~1 to ~9 at 20 °C and 0.4 MPa,suggesting that AgBF_4 was an effective carrier for CO facilitated transport.The permeabilities of N_2 and CO increased at higher transmembrane pressure,indicating that molecular transport would dominate the transport process at high pressure.The temperature-dependent gas permeability followed the Arrhenius equation.Moreover,the differences between the activation energies of CO and N_2 became larger after introducing AgBF_4,resulting in more obvious decrease in the CO/N_2 selectivity at higher operating temperature. | Shichao Feng Yuanyuan Wu Jianquan Luo Yinhua Wan | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员