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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Effects of Temperature and Moisture on Soil Organic Matter Decomposition Along Elevation Gradients on the Changbai Mountains, Northeast China显示文摘Decomposition of soil organic matter(SOM) is of importance for CO_2 exchange between soil and atmosphere and soil temperature and moisture are considered as two important factors controlling SOM decomposition. In this study, soil samples were collected at 5 elevations ranging from 753 to 2 357 m on the Changbai Mountains in Northeast China, and incubated under different temperatures(5, 10, 15, 20, 25, and 30?C) and soil moisture levels(30%, 60%, and 90% of saturated soil moisture) to investigate the effects of both on SOM decomposition and its temperature sensitivity at different elevations. The results showed that incubation temperature(F = 1 425.10, P < 0.001), soil moisture(F = 1 327.65, P < 0.001), and elevation(F = 1 937.54, P < 0.001) all had significant influences on the decomposition rate of SOM. The significant effect of the interaction of incubation temperature and soil moisture on the SOM decomposition rate was observed at all the 5 sampling elevations(P < 0.001). A two-factor model that used temperature and moisture as variables fitted the SOM decomposition rate well(P < 0.001) and could explain 80%–93% of the variation of SOM decomposition rate at the 5 elevations. Temperature sensitivity of SOM decomposition, expressed as the change of SOM decomposition rate in response to a 10?C increase in temperature(Q_(10)), was significantly different among the different elevations(P < 0.01), but no apparent trend with elevation was discernible. In addition, soil moisture and incubation temperature both had great impacts on the Q_(10) value(P < 0.01), which increased significantly with increasing soil moisture or incubation temperature. Furthermore, the SOM decomposition rate was significantly related to soil total Gram-positive bacteria(R^2= 0.33, P < 0.01) and total Gram-negative bacteria(R^2= 0.58, P < 0.001). These findings highlight the importance of soil moisture to SOM decomposition and its Q_(10) value,which needs to be emphasized under warming climate scenarios. | WANG Dan HE Nianpeng WANG Qing LV Yuliang WANG Qiufeng XU Zhiwei ZHU Jianxing | 2016 | Pedosphere2016，26，3： | 12 |
| 4 | Impact of the eastern water diversion from the south to the north project on the saltwater intrusion in the Changjiang Estuary in China显示文摘The south to the north project(WDP) on the saltwater intrusion in the Changjiang Estuary is studied by the improved three-dimensional(3D) numerical model.The net unit width flux in the Changjiang Estuary as well as the sectional salt flux is calculated in the North Branch(NB),the South Branch(SB),the North Channel(NC),the South Channel(SC),the North Passage(NP) and the South Passage(SP),respectively.The net seaward water flux in the SB is reduced,and the net water flux spilling over from the NB to the SB is enhanced after the eastern WDP.Under the mean river discharge condition in the dry season,the net salt flux spilling over from the NB to the SB is increased by 2.09 t/s and 0.52 t/s during the spring and neap tides,respectively,due to the eastern WDP.The saltwater intrusion in the Changjiang Estuary is enhanced by the eastern WDP.Compared with that during the spring tide,the net water diversion ratio during the neap tide in the NC is smaller,and thus the enhancement of the saltwater intrusion by the eastern WDP is smaller in the NC,and larger in the NP and the SP.The tidally averaged surface salinity at the water intakes of the Dongfengxisha Reservoir,the Chenhang Reservoir and the Qingcaosha Reservoir rises both during the spring and neap tides. | XU Kun ZHU Jianrong GU Yuliang | 2012 | Acta Oceanologica Sinica2012，31，3： | 9 |
| 5 | Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release显示文摘Thermosensitive 药交货系统(DDS ) 面对主要挑战,例如遥远、可重复的控制在 vivo 温度,尽管这些能增加药的治疗学的功效。处理这个问题,我们涂在红外线附近(NIR ) photothermal Cu 1.75 有 pH/thermos-sensitive 聚合物由的 S nanocrystals 在 situ 聚合。装载内容的 doxorubicine (纪录影片) 直到 40 wt.% ,与纪录影片在正常生理的条件下面正在被漏的不到 8.2 wt.%(pH = 7.4, 37 吗? | Sheng Huang Jing Liu Qian He Hongli Chen Jiabin Cui Suying Xu Yuliang Zhao Chunying Chen Leyu Wang | 2015 | Nano Research2015，8，12： | 7 |
| 6 | Fiber Laser Sensing System and Its Applications显示文摘An overview of fiber laser sensing is presented.The design and the characteristics of distributed feedback(DFB)fiber lasers for high performance sensing applications are described.Demodulation techniques based on unbalanced fiber interferometer are discussed,especially for the noise level,the dynamic range,and the crosstalk in dense-wavelength-division multiplexing.Finally,the fiber laser sensing system configurations and field demonstrations for different applications are illustrated. | Yuliang LIU Wentao ZHANG Tuanwei XU Jun HE Faxiang ZHANG Fang LI | 2011 | Photonic Sensors2011，1，1： | 7 |
| 7 | A Four-legged Wall-climbing Robot with Spines and Miniature Setae Array Inspired by Longicorn and Gecko显示文摘In industrial applications,climbing robots are widely used for climbing and detection of rough or smooth pipe surfaces.Inspired by the special claws of longicorn is that can crawl on rough surfaces and the array of tiny bristles of geckos that can crawl on smooth surfaces,a new type of wall-climbing robot for rough or smooth surfaces is proposed in this paper.The bionic palms of the robot are suggested with special bionic hooks inspired by the longicorn and bionic adhesive materials inspired by the gecko with a good performance on adhering on the surfaces.The special bionic hooks are manufactured by the 3D printing method and the bionic adhesive materials are made by the polymer print lithography technology.These two different bionic adhere accessory are used on the robot’s palm to achieve climbing on the different surfaces.This foldable climbing robot can not only bend its own body to accommodate the cylindrical contact surfaces of different diameters,but also crawl on vertical rough and smooth surfaces using their bionic palms. | Shiyuan Bian Yuliang Wei Feng Xu Deyi Kong | 2021 | Journal of Bionic Engineering2021，18，2： | 4 |
| 8 | Synthesis of fulleropyrrolidine derivatives of C_(60)显示文摘1 Experimental ORGANIC chemical derivatization of fullerene by cycloaddition reactions has attracted in-tense interest. It has been found that C60 can undergo a series of cycloaddition reactions associ-ated with poorly-conjugated and electron-deficient alkenes, including [4+2], [3+2], [2+2] and [2+1] cycloaddition reaction, 1, 3-dipolar cycloaddition reactions. [3+2] cycloaddi-tion reactions of azomethine ylides to C60 have been widely used to prepare N-substituted | LI Yuliang, ZHENG Dagui, XU Juhua, MAO Zhong, YANG Jingkui, BAI Fenglian and ZHU DaobenInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China | 1997 | Chinese Science Bulletin1997，42，14： | 3 |
| 9 | Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells显示文摘Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the pons.Here we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. | Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 10 | Development of powdery mildew resistant derivatives of wheat variety Fielder for use in genetic transformation显示文摘Genetic transformation is widely used to improve target traits and to study gene function in wheat.However,transformation efficiency depends on the physiological status of the recipient genotype and that is affected by several factors including powdery mildew(PM)infection.The widely used recipient variety Fielder is very susceptible to PM.Therefore,it would be beneficial to develop PM resistant derivatives with high regeneration ability for use in genetic transformation.In the present study PM resistant lines CB037 and Pm97033 carrying genes Pm21 and PmV,respectively,were backcrossed to Fielder with selection for PM resistance.Five lines,NT89,NT90,NT154,and WT48 with Pm21 and line FL347 with PmV were developed,identified by molecular markers and genomic in situ hybridization(GISH)or fluorescent in situ hybridization(FISH),and further subjected to detailed assessment of agronomic traits and regeneration ability following genetic transformation capacity.Lines FL347,WT48,NT89 and NT154 assessed as being equal to,or superior,to Fielder in regeneration and transformation ability are recommended as suitable materials for the replacement of Fielder for wheat gene transfer and genome editing study. | Xiaona Liang Xiaomin Bie Yuliang Qiu Ke Wang Zujun Yang Yuqi Jia Zhiying Xu Mei Yu Lipu Du Zhishan Lin Xingguo Ye | 2023 | The Crop Journal2023，11，2： | 2 |
| 11 | A Case Study of Applying Metagenomic Sequencing in Precise Epidemiology for the COVID-19 Pandemic-Sichuan Province, China, 2020显示文摘Introduction:Determining the transmission chain of a virus in its incipient stages is extremely time consuming in traditional approaches that rely mainly on case incidence and interview-based contact data.With the development of high-throughput sequencing technology,genome-based epidemiology approach is showing promise in detecting viral transmission.However,there is still insufficient evidence for the relationship between the viral genetic variations and real viral transmission.Methods:To explore the possible relationship between transmission chains and viral genetic variations,we combined both epidemiological data and viral genomes of COVID-19 virus collected from Sichuan Province.A phylogenetic approach was used to infer the transmission chain,which was then compared to the transmission chain that came from epidemiological data.Results:We found that the putative transmission chains were highly concordant to the true transmission chains from epidemiological data,suggesting a strong correlation between viral genetic variations and the viral transmission chain.Discussion:Our results showed advantages of viral genomic sequencing in tracking and perceiving pathogen transmission,which allowed for potential improvements in the design and implementation of population-level public health interventions. | Jianan Xu Ye Wang You Li Huiping Yang Ming Pan Jian Liu Lina Shi Yuliang Feng Li Liu Jin Li Li Zhang Shusen He | 2020 | China CDC weekly2020，2，47： | 2 |
| 12 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 13 | Self-Motivated Supramolecular Combination Chemotherapy for Overcoming Drug Resistance Based on Acid-Activated Competition of Host–Guest Interactions显示文摘In this work,we propose a nanoparticle-based strategy of self-motivated supramolecular combination chemotherapy that carries drugs stably and releases them actively in the acidic tumor microenvironment to overcome the drug resistance of cancer cells.This self-motivated nanoparticle consists of a cucurbit[7]uril-containing polymer(PCB)-based core. | Hua Wang Han Wu Yu Yi Ke-Fei Xue Jiang-Fei Xu Hao Wang Yuliang Zhao Xi Zhang | 2021 | CCS Chemistry2021，3，8： | 2 |
| 14 | Current status and technical description of Chinese 2<ce:hsp sp='0.25'/>×<ce:hsp sp='0.25'/>250<ce:hsp sp='0.25'/>MW th HTR-PM demonstration plant显示文摘 | Zuoyi Zhang Zongxin Wu Dazhong Wang Yuanhui Xu Yuliang Sun Fu Li Yujie Dong | 2009 | Nuclear Engineering and Design2009，，7： | 2 |
| 15 | Noise Reduction of UAV Using Biomimetic Propellers with Varied Morphologies Leading-edge Serration显示文摘The Leading-Edge(LE)serrations on owls'wings are known to be responsible for silent flight.However,this design has rarely been applied to reduce the noise of rotational rotor propellers and the morphologies of the existing serration designs are diverse.Here,we present a comparative study ofLE serrations with different morphologies in terms of the effectiveness in suppressing noise and promoting thrust forces.The performances of biomimetic propellers are investigated by Computational Fluid Dynamics(CFD)simulations and rotation experiments.The simulation results reveal that LE serrations could reduce velocity fluctuations and change the lamina-turbulent transition and turbulence distribution on the suction surface of propeller,but the morphology of the serrations influences its effectiveness.Rotation testing results indicate that the sawtooth propeller has the best performance on noise reduction(on average 2.43 dB and in maximum 4.18 dB)and simultaneously enhancing the thrust forces(3.53%).The largest practical noise reductions(4.73 dB and 3.79 rdB)using the sawtooth propeller are observed when the quad-rotor Unmanned-Aerial Vehicle(UAV)is hovering at heights of 5 m and 8 m,respectively.Our results indicate the robustness and usefulness of owl-inspired biomimetic serration devices for aero-acoustic control and aerodynamic performance promotion on propeller designs.This finding is expected to con^bute to suppressing the sound of propeller and the rotor-based aircraft. | Yuliang Wei Feng Xu Shiyuan Bian Deyi Kong | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 16 | Upregulation of MicroRNA-107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1显示文摘 | Fan Li Baohua Liu Yu Gao Yuliang Liu Yu Xu Weidong Tong Anping Zhang | 2013 | FEBS Letters2013，，： | 1 |
| 17 | Effect of surfactant on zeta potential and rheology behavior of methylene bis (thiocyanate) suspension concentrate显示文摘Methylene bis(thiocyanate)(MBT) is insoluble in water, so suspension concentrate(SC) of MBT is extremely relied on surfactants. In this paper, SC of MBT was prepared with wet-grinding technology, and the effect of surfactants,such as Morwet D425(D425) and Morwet EFW(EFW)(two kinds of dispersant), on the Zeta potential and rheology behavior of MBT SC were investigated. The results showed that the Zeta potential absolute value of MBT SC increased with the increasing content of D425, and it decreased with the increasing content of EFW at acidic solution(pH = 4.5). In the combination system of D425 and EFW, Zeta potential of MBT SC decreased first and then increased with the increasing content of EFW. The relationship between shear rate(γ) and viscosity(η) was studied according to Herschel–Bulkley model: η = η0+ k/γ, and the relationship between shear rate(γ) and shear force(τ) was investigated according to:τ = τ0+Kγ~n. It was revealed that the mixed fluid belonged to Yield Pseudoplastic Fluid. | Jianfeng Hu Yan Cai Shan Lu Jiezhen Xu Zhongrun Yun Jianheng Huang Yuliang Wen Jinqing Qu | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 1 |
| 18 | Photoconductivity of fullerene derivatives显示文摘Two fullerene derivatives (compounds 1 and 2) have been synthesized. Their redox properties have been measured by cyclic voltammetry. The photoconductivities of poly(N_vinylcarbazo_le) (PVK) doped with fullerene and with their derivatives have been studied to explore the possible relationship between the reductibility of fullerenes and the photoconductivity of fullerenes_doped PVK. The charge generation efficiencies of PVK doped with fullerene and with its derivatives have changed remarkably: the diversity of charge generation efficiency is obvious in different doping systems. The result indicates that there is charge transfer between fullerenes and PVK. | LI Fengying, XU Juhua, LI Yuliang, FAN Louzhen, REN Deyuan and ZHU Daoben Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China | 1998 | Chinese Science Bulletin1998，43，24： | 1 |
| 19 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 20 | Effects of myasthenia gravis patients' sera with different autoantibodies on slow K+ current at mouse motor nerve terminals显示文摘 | Xu Tonghui Jun Ding Shi Yuliang | 2003 | Neurol Res2003，25，1： | 1 |
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