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| 1 | Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1. | Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun | 2020 | International Journal of Oral Science2020，12，4： | 7 |
| 2 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 3 | Recent Progress of Electrode Materials for Flexible Perovskite Solar Cells显示文摘Flexible perovskite solar cells(FPSCs) have attracted enormous interest in wearable and portable electronics due to their high power-per-weight and low cost. Flexible and efficient perovskite solar cells require the development of flexible electrodes compatible with the optoelectronic properties of perovskite. In this review, the recent progress of flexible electrodes used in FPSCs is comprehensively reviewed. The major features of flexible transparent electrodes, including transparent conductive oxides, conductive polymer, carbon nanomaterials and nanostructured metallic materials are systematically compared. And the corresponding modification strategies and device performance are summarized. Moreover, flexible opaque electrodes including metal films, opaque carbon materials and metal foils are critically assessed. Finally, the development directions and difficulties of flexible electrodes are given. | Yumeng Xu Zhenhua Lin Wei Wei Yue Hao Shengzhong Liu Jianyong Ouyang Jingjing Chang | 2022 | Nano-Micro Letters2022，14，7： | 3 |
| 4 | An electronic nose using a single graphene FET and machine learning for water, methanol, and ethanol显示文摘The poor gas selectivity problem has been a long-standing issue for miniaturized chemical-resistor gas sensors.The electronic nose(e-nose)was proposed in the 1980s to tackle the selectivity issue,but it required top-down chemical functionalization processes to deposit multiple functional materials.Here,we report a novel gas-sensing scheme using a single graphene field-effect transistor(GFET)and machine learning to realize gas selectivity under particular conditions by combining the unique properties of the GFET and e-nose concept.Instead of using multiple functional materials,the gas-sensing conductivity profiles of a GFET are recorded and decoupled into four distinctive physical properties and projected onto a feature space as 4D output vectors and classified to differentiated target gases by using machine-learning analyses.Our single-GFET approach coupled with trained pattern recognition algorithms was able to classify water,methanol,and ethanol vapors with high accuracy quantitatively when they were tested individually.Furthermore,the gas-sensing patterns of methanol were qualitatively distinguished from those of water vapor in a binary mixture condition,suggesting that the proposed scheme is capable of differentiating a gas from the realistic scenario of an ambient environment with background humidity.As such,this work offers a new class of gas-sensing schemes using a single GFET without multiple functional materials toward miniaturized e-noses. | Takeshi Hayasaka Albert Lin Vernalyn C.Copa Lorenzo P.Lopez Jr Regine A.Loberternos Laureen Ida M.Ballesteros Yoshihiro Kubota Yumeng Liu Arnel A.Salvador Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 5 | Phase Transformation Induced Capacitance Activation for 3D Graphene‐CoO Nanorod Pseudocapacitor显示文摘 | Yun Guang Zhu Ye Wang Yumeng Shi Zhi Xiang Huang Lin Fu Hui Ying Yang | 2014 | Adv. Energy Mater2014，，9： | 1 |
| 6 | Effect of super-chilling storage on maintenance of quality and freshness of the Pacific oyster(Crassostrea gigas)显示文摘The quality changes of shelled Pacific oysters(Crassostrea gigas)were examined in relation to the effects of superchilling storage at-1 C for 28 d by measuring changes in biochemical properties(microbial analysis,adenosine triphosphate(ATP)-related compounds,pH,free amino acids)and sensory evaluations in this study.The results indicated that microorganism growth was significantly inhibited during superchilling storage.Adenosine diphosphate(ADP)and adenosine monophosphate(AMP)accumulated while ATP rapidly decreased in the adductor muscle.ATP and ADP were the primary components in the other 3 tissues including mantle,gill,and body trunk of oysters,and they remained relatively stable over time.The pH and adenylate energy charge in the adductor muscle could be utilized as freshness indicators for shelled oysters.However,there were no significant differences(P>0.05)among the free amino acids during whole storage.According to the sensory evalu-ations,oysters could be alive and tolerated up to 21 d at-1℃storage.The study demonstrated that superchilling storage at-1℃could better maintain the eating quality of shelled oysters and the shelf life was extended to 21 d. | Shiliang Dong Yabin Niu Huamao Wei Yumeng Lin Xin Lu Tetsuro Yamashita Kefeng Yu Koichi Takaki Chunhong Yuan | 2023 | Food Quality and Safety2023，7，2： | 0 |
| 7 | Impact of Cold Spells on Ischemic Stroke Severity and Clinical Outcomes in Tianjin, China显示文摘There are several studies on the impact of extreme weather on the incidence and mortality of stroke, but the research on the effect of extreme weather events on severity and outcome of ischemic stroke is scarce. This study aimed to evaluate the impact of cold spells on the severity and clinical outcomes of patients with initial acute ischemic stroke in a hospital-based study. We enrolled 553 patients with initial ischemic stroke during the cold seasons between 2016 and 2019. Patients were separated into the mild stroke group and moderate-to-severe stroke group according to the National Institutes of Health Stroke Scale(NIHSS) of the U.S., and good outcome group and poor outcome group according to modified Rankin Scale(mRS) scores. There are nine different definitions of cold spells according to intensities and duration time. After adjustment for climate factors, air quality index, and common risk factors, it is found that cold spells were associated with moderate-to-severe neurological deficits and clinical outcomes in overall ischemic stroke patients. Furthermore, the delay effect for stroke severity started at the beginning of the cold wave(Lag 0) and lasted up to 14 days(Lags 0–14). In addition, when a cold spell was set as a daily mean temperature < 3rd or 5th percentile and with a duration ≥ 2 or 3 consecutive days, cold spells had a significant impact on clinical outcomes, and there was a definite delay effect of at least 7 days(Lags 0–7) and it lasted up to 14days(Lags 0–14). At last, we concluded that cold spells may be a contributory factor for more severe neurological deficits and worse outcomes in patients with initial ischemic stroke. | Juanjuan XUE Chanjuan WEI Xiaoshuang XIA Xuemei QI Yumeng GU Zhongyan WANG Suqin HAN Lin WANG Xin LI | 2023 | Journal of Meteorological Research2023，37，4： | 0 |
| 8 | Online optimization for optical readout of a single electron spin in diamond显示文摘The nitrogen-vacancy(NV)center in diamond has been developed as a promising platform for quantum sensing,especially for magnetic field measurements in the nano-tesla range with a nano-meter resolution.Optical spin readout performance has a direct effect on the signal-to-noise ratio(SNR)of experiments.In this work,we introduce an online optimization method to customize the laser waveform for readout.Both simulations and experiments reveal that our new scheme optimizes the optically detected magnetic resonance in NV center.The SNR of optical spin readout has been witnessed a 44.1%increase in experiments.In addition,we applied the scheme to the Rabi oscillation experiment,which shows an improvement of 46.0%in contrast and a reduction of 12.1%in mean deviation compared to traditional constant laser power SNR optimization.This scheme is promising to improve sensitivities for a wide range of NV-based applications in the future. | Xue Lin Jingwei Fan Runchuan Ye Mingti Zhou Yumeng Song Dawei Lu Nanyang Xu | 2023 | Frontiers of physics2023，18，2： | 0 |
| 9 | In-depth understanding of ionic liquid assisted perovskite film formation mechanism for two-step perovskite photovoltaics显示文摘Ionic liquids(ILs)have been widely applied in the one-step fabrication of perovskite with noticeable enhancement in the device performance.However,in-depth mechanism of ionic-liquid-assisted perovskite film formation is not well understood for also important two-step perovskite fabrication method,with better control of crystallization behavior.In this work,we introduced ionic liquid methylammonium formate(MAFa)into organic salt to produce perovskite film via a two-step method.Systematic investigations on the influence of MAFa on the perovskite thin film formation mechanism were performed.Ionic liquid is shown to assist lowering the perovskite formation enthalpy upon the density functional theory(DFT)calculation,leading to an accelerated crystallization process evidenced by in-situ UV-Vis absorption measurement.A gradient up-down distribution of ionic liquid has been confirmed by timeof-flight SIMS.Importantly,besides the surface passivation,we found the HCOO-can diffuse into the perovskite crystals to fill up the halide vacancies,resulting in significant reduction of trap states.Uniform perovskite films with significantly larger grains and less defect density were prepared with the help of MAFa IL,and the corresponding device efficiency over 23%was obtained by two-step process with remarkably improved stability.This research work provides an efficient strategy to tune the morphology and opto-electronic properties of perovskite materials via ionic-liquid-assisted two-step fabrication method,which is beneficial for upscaling and application of perovskite photovoltaics. | Fei Wang Patrick Wai-Keung Fong Zhiwei Ren Hai-Lun Xia Kang Zhou Kai Wang Jiajie Zhu Xiaoxi Huang Xiao-Yuan Liu Hao Wang Yumeng Shi Haoran Lin Quanyao Zhu Gang Li Hanlin Hu | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 10 | LIANGHEKOU:Regeneration of an Ancient Tujia Village along the Salt Road显示文摘Profile:In the upcoming tourism development,Lianghekou Village will resume its commercial function during the period of Salt Road trading and become a gathering place for locals and tourists.Timber Loggia and Silankarp Workshop in Lianghe-kou village show that the self-adaptaility of traditional Tujia wooden construction techniques can be transmitted to meet modern needs in contemporary architectural design.This project was exhibited and themed'Lianghekou:A Tujia Vllage of Re-Living-Together'on the 17th International Architecture Exhibition-La Biennale di Venezia in 2021. | ZHANG Tong XU Han WANG Chuan MA Yumeng SUI Mingming CHEN Siyu YANG Chen RENG Ziqiu ZOU Yue LIN Siyuan | 2022 | Frontiers of Architectural Research2022，11，5： | 0 |
| 11 | Present-Day PM_(2.5)over Asia:Simulation and Uncertainty in CMIP6 ESMs显示文摘This study assesses the ability of 10 Earth System Models(ESMs)that participated in the Coupled Model Intercomparison Project Phase 6(CMIP6)to reproduce the present-day inhalable particles with diameters less than 2.5 micrometers(PM_(2.5))over Asia and discusses the uncertainty.PM_(2.5)accounts for more than 30%of the surface total aerosol(fine and coarse)concentration over Asia,except for central Asia.The simulated spatial distributions of PM_(2.5)and its components,averaged from 2005 to 2020,are consistent with the Modern-Era Retrospective Analysis for Research and Applications version 2(MERRA-2)reanalysis.They are characterized by the high PM_(2.5)concentrations in eastern China and northern India where anthropogenic components such as sulfate and organic aerosol dominate,and in northwestern China where the mineral dust in PM_(2.5)fine particles(PM_(2.5)DU)dominates.The present-day multimodel mean(MME)PM_(2.5)concentrations slightly underestimate ground-based observations in the same period of 2014–2019,although observations are affected by the limited coverage of observation sites and the urban areas.Those model biases partly come from other aerosols(such as nitrate and ammonium)not involved in our analyses,and also are contributed by large uncertainty in PM_(2.5)simulations on local scale among ESMs.The model uncertainties over East Asia are mainly attributed to sulfate and PM_(2.5)DU;over South Asia,they are attributed to sulfate,organic aerosol,and PM_(2.5)DU;over Southeast Asia,they are attributed to sea salt in PM_(2.5)fine particles(PM_(2.5)SS);and over central Asia,they are attributed to PM_(2.5)DU.They are mainly caused by the different representations of aerosols within individual ESMs including the representation of aerosol size distributions,dynamic transport,and physical and chemistry mechanisms. | Xiaole SU Tongwen WU Jie ZHANG Yong ZHANG Junli JIN Qing ZHOU Fang ZHANG Yiming LIU Yumeng ZHOU Lin ZHANG Steven T.TURNOCK Kalli FURTADO | 2022 | Journal of Meteorological Research2022，36，3： | 0 |
| 12 | Parallel Extraction of Marine Targets Applying OIDA Architecture显示文摘Computing resources are one of the key factors restricting the extraction of marine targets by using deep learning.In order to increase computing speed and shorten the computing time,parallel distributed architecture is adopted to extract marine targets.The advantages of two distributed architectures,Parameter Server and Ring-allreduce architecture,are combined to design a parallel distributed architecture suitable for deep learning–Optimal Interleaved Distributed Architecture(OIDA).Three marine target extraction methods including OTD_StErf,OTD_Loglogistic and OTD_Sgmloglog are used to test OIDA,and a total of 18 experiments in 3categories are carried out.The results show that OIDA architecture can meet the timeliness requirements of marine target extraction.The average speed of target parallel extraction with single-machine 8-core CPU is 5.75 times faster than that of single-machine single-core CPU,and the average speed with 5-machine 40-core CPU is 20.75 times faster. | LIU Lin LI Wanwu ZHANG Jixian SUN Yi CUI Yumeng | 2022 | Journal of Ocean University of China2022，21，3： | 0 |
| 13 | Ionic liquid engineering enabled in-plane orientated 1D perovskite nanorods for efficient mixed-dimensional perovskite photovoltaics显示文摘Mixed-dimensional engineering of perovskite material has been demonstrated as a facile and promising strategy to improve both photovoltaic performance and long-term stability of perovskite solar cells(PSCs).In this study,we report an in-plane preferred orientation of 1D perovskite induced by an ionic liquid(IL)of 1-(3-cyanopropyl)-3-methylimidazolium chloride(CPMIMCl)for the first time via sequential deposition approach,leading to a mixed dimensional perovskite thin films.The generated one-dimensional(1D)CPMIMPbI3 with in-plane orientation resides at the grain boundaries of three-dimensional(3D)perovskite can be appreciably observed from the morphology level,leading to creation of high-quality films with large grain size with more efficient defect passivation.Moreover,the dispersion of IL in the bulk phase of perovskite material allows for the formation of 1D perovskite for multiple level passivation to inhibit non-radiative recombination and optimize carrier transport.This IL engineering strategy not only yields a mixed-dimensional perovskite heterostructure with in-plane orientation 1D perovskite nano-rods but also significantly improves the opto-electronic property with suppressed trap states.As a result,the CPMIMCl-treated PSCs show an enhanced photovoltaic performance with a champion power conversion efficiency(PCE)up to 24.13%.More importantly,benefiting from the hydrophobicity of formed 1D perovskite and defects suppression,the corresponding PSC demonstrates an excellent longterm stability and maintain 97.1%of its pristine PCE at 25C under 50%RH condition over 1000 h.This research provides an innovative perspective for employing the low dimensional engineering to optimize the performance and stability of photovoltaic devices. | Fei Wang Dawei Duan Kang Zhou YZBXue Xiao Liang Xianfang Zhou Chuangye Ge Chao Zhou Jin Xiang Jiajie Zhu Quanyao Zhu Haoran Lin Yumeng Shi Yonghua Chen Gang Li Hanlin Hu | 2023 | InfoMat2023，5，8： | 0 |
| 14 | E3 ligase MG53 suppresses tumor growth by degrading cyclin D1显示文摘Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.In particular,the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only the pathogenesis of malignancies but also the refractory to cancer treatment regiments with CDK4/6 inhibitors.Here we show that in colorectal and gastric cancer patients,MG53 is downregulated in more than 80%of tumors compared to the normal gastrointestinal tissues from the same patient,and the reduced MG53 expression is correlated with increased cyclin D1 abundance and inferior survival.Mechanistically,MG53 catalyzes the K48-linked ubiquitination and subsequent degradation of cyclin D1.Thus,increased expression of MG53 leads to cell cycle arrest at G1,and thereby markedly suppresses cancer cell proliferation in vitro as well as tumor growth in mice with xenograft tumors or AOM/DSS induced-colorectal cancer.Consistently,MG53 deficiency results in accumulation of cyclin D1 protein and accelerates cancer cell growth both in culture and in animal models.These findings define MG53 as a tumor suppressor via facilitating cyclin D1 degradation,highlighting the therapeutic potential of targeting MG53 in treating cancers with dysregulated cyclin D1 turnover. | Meng Fang Hong-Kun Wu Yumeng Pei Yan Zhang Xiangyu Gao Yanyun He Gengjia Chen Fengxiang Lv Peng Jiang Yumei Li Wenwen Li Peng Jiang Lin Wang Jiafu Ji Xinli Hu Rui-Ping Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 15 | Visualization of Ferroelectric Domains in Thin Films of Molecular Materials Using Confocal Micro-Raman Spectroscopy显示文摘Ferroelectrics are an important class of functional materials.Among all their unique properties,the study of their ferroelectric domains and domain walls is of great interest due to their importance in ferroelectric applications.There are many methods to characterize ferroelectric domains,namely,scanning probe microscopy,optical microscopy,electron microscopy,etc.Currently,newly emerged molecular ferroelectrics are attracting much attention from chemists,physicists and researchers in material sciences due to their structural flexibility,light mass,simple fabrication,etc.However,for the characterization of molecular ferroelectric domains,most conventional methods require either a complicated preparation process or direct contact between physical probes and material surfaces,limiting the development of molecular ferroelectric materials.In this report,we have demonstrated that confocal micro-Raman spectroscopy,as a nondestructive and noncontact in-situ method,is very suitable for studying the ferroelectric polarization and structures of domains in molecular ferroelectrics.Taking recently reported molecular ferroelectric trimethylchloromethyl ammonium trichlorocadmium(II)(TMCM-CdCl_(3))as an example,the non-180°domains have been characterized and visualized at different temperatures.Such a simple and extendable method requires minimum sample preparation,which would further benefit the research of molecular ferroelectric domain engineering and promote the miniaturization and integration of molecular ferroelectric films. | ZHOU Wenqin FENG Zijie XIONG Yuan DU Guowei LIN Xiumei SU Qidong LOU Yuheng AN Shili YOU Yumeng | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
| 16 | Health literacy of college students in Beijing and the demands of health education显示文摘Health literacy is the main component of health quality and a comprehensive health indicator reflecting related idea,cognition,behavior and skills.In this paper,we investigated the overall level and characteristics of health literacy based on the survey data of college students in Beijing.The differences of health literacy level among sub-groups were compared,and the influencing factors of health literacy were discussed.The results showed that college students had a higher level in overall health literacy than other peers,but a lower level in the prevention of chronic disease and infectious disease.The level of health literacy of college students was mainly affected by their major,hometown,and situation of health-related elective.Besides,we also found that the way college students used to acquire health knowledge was inconsistent with their expectations,and the requirements for health education were also very high.More systematic and comprehensive health education should be provided in universities,with an emphasis on the knowledge of lifestyle and daily habits. | Jing Guo Yumeng Guo Lin Zhu Linlin Fu | 2020 | China Population and Development Studies2020，4，5： | 0 |
| 17 | Cryptic divergences and repeated hybridizations within the endangered “living fossil” dove tree(Davidia involucrata) revealed by whole genome resequencing显示文摘The identification and understanding of cryptic intraspecific evolutionary units(lineages) are crucial for planning effective conservation strategies aimed at preserving genetic diversity in endangered species.However, the factors driving the evolution and maintenance of these intraspecific lineages in most endangered species remain poorly understood. In this study, we conducted resequencing of 77 individuals from 22 natural populations of Davidia involucrata, a “living fossil” dove tree endemic to central and southwest China. Our analysis revealed the presence of three distinct local lineages within this endangered species, which emerged approximately 3.09 and 0.32 million years ago. These divergence events align well with the geographic and climatic oscillations that occurred across the distributional range.Additionally, we observed frequent hybridization events between the three lineages, resulting in the formation of hybrid populations in their adjacent as well as disjunct regions. These hybridizations likely arose from climate-driven population expansion and/or long-distance gene flow. Furthermore, we identified numerous environment-correlated gene variants across the total and many other genes that exhibited signals of positive evolution during the maintenance of two major local lineages. Our findings shed light on the highly dynamic evolution underlying the remarkably similar phenotype of this endangered species. Importantly, these results not only provide guidance for the development of conservation plans but also enhance our understanding of evolutionary past for this and other endangered species with similar histories. | Yumeng Ren Lushui Zhang Xuchen Yang Hao Lin Yupeng Sang Landi Feng Jianquan Liu Minghui Kang | 2024 | Plant Diversity2024，46，2： | 0 |
| 18 | Regulating the self-assembly of rigid 2D ribbon-like amphiphilic homopolymer via tailoring its holistic conformation显示文摘Amphiphilic rigid backbone polymers are traditionally seemed as one-dimensional(1D)rods and show distinct self-assembly behavior to flexible polymers,but they could hardly adapt morphology-tunable self-assembly by changing their holistic conformation upon external stimuli.In this study,we synthesized a series of amphiphilic homopolymers poly(acetylene azobenzene oligoethylene glycol)(P(AAzo-EGx))containing conjugated polyacetylene mainchain,azobenzene pendants and oligo ethylene glycol tails in each unit.This comb-like amphiphilic polymer could be treated as two-dimensional(2D)nanoribbons with tunable holistic conformation via meticulous tailoring intrastrand repulsion and interchainπ-πinteraction of azobenzene pendants by light,temperature,and solvent swelling.P(AAzo-EG_(2))could self-assemble into large vesicles in ambient,whereas transformed to supramolecular helix bundles(SHBs)at 65℃as well as depicted by dissipative particle dynamics(DPD)simulation,and then turned into grass leaf-like micelles upon sequential ultraviolet(UV)and blue light irradiation.The three assemblies featured different stacking mode of PAAzo skeletons although showed similar aggregate induce emission(AIE)effect.In this holistic macromolecular chain conformation-induced self-assembly and morphology transformation,temperature influenced the stacking of hydrophobic parts mainly by tuning the torsion of PAAzo skeleton.Certain amount of good solvent played a vital role by swelling of hydrophobic PAAzo skeleton,and helping the movement and rearrangement of azobenzene pendants and polyacetylene mainchains like a lubricant.The length and diameter of SHBs could be tuned by changing EGxtails.This work uncovered a facile strategy to tailor the self-assembly of rigid backbone polymers for fabrication of functional nanodevices. | Yumeng Gao Weisheng Feng Yao Sun Yuan Yao Liquan Wang Shaoliang Lin | 2023 | Science China Chemistry2023，66，8： | 0 |
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