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| 1 | Possible solutions for sludge dewatering in China显示文摘In China,over 1.43×10^(7)tons of dewatered sewage sludge,with 80%water content,were generated from wastewater treatment plants in 2007.About 60%of the COD removed during the wastewater treatment process becomes concentrated as sludge.Traditional disposal methods used by municipal solid waste treatment facilities,such as landfills,composting,or incineration,are unsuitable for sludge disposal because of its high water content.Disposal of sludge has therefore become a major focus of current environmental protection policies.The present status of sludge treatment and disposal methodology is introduced in this paper.Decreasing the energy consumption of sludge dewatering from 80%to 50%has been a key issue for safe and economic sludge disposal.In an analysis of sludge water distribution,thermal drying and hydrothermal conditioning processes are compared.Although thermal drying could result in an almost dry sludge,the energy consumption needed for this process is extremely high.In comparison,hydrothermal technology could achieve dewatered sewage sludge with a 50%–60%water content,which is suitable for composting,incineration,or landfill.The energy consumption of hydrothermal technology is lower than that required for thermal drying. | Wei WANG Yuxiang LUO Wei QIAO | 2010 | Frontiers of Environmental Science & Engineering2010，4，1： | 13 |
| 2 | The ACTIVE study protocol:apatinib or placebo plus gefitinib as first-line treatment for patients with EGFR-mutant advanced non-small cell lung cancer(CTONG1706)显示文摘Background:Gefitinib,as the first epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)approved for the treatment of advanced non-small cell lung cancer(NSCLC),has been proved to significantly improve the progression-free survival(PFS)in the first-line setting but suffers from resistance 7-10 months after treatment initia-tion.Apatinib(YN968D1),a potent vascular endothelial growth factor receptor(VEGFR)2-TKI,specifically binds to VEGFR2 and leads to anti-angiogenetic and anti-neoplastic effect.Concurrent inhibition of VEGFR and EGFR path-ways represents a rational approach to improve treatment responses and delay the onset of treatment resistance in EGFR-mutant NSCLC.This ACTIVE study aims to assess the combination of apatinib and gefitinib as a new treatment approach for EGFR-mutant NSCLC as a first-line setting.Methods:This multicenter,randomized,double-blind,placebo-controlled phase III study(NCT02824458)has been designed to assess the efficacy and safety of apatinib or placebo combined with gefitinib as a first-line treatment for patients with EGFR-mutant advanced NSCLC.A total of 310 patients with EGFR-mutation(19del or 21L858R),pathological stage IIIB to IV non-squamous NSCLC were to be enrolled.The primary endpoint is investigator assessment of PFS,and the secondary endpoints include independent radiological central(IRC)-confirmed PFS,overall survival(OS),objective response rate(ORR),disease control rate(DCR),time to progressive disease(TTPD),duration of response(DoR),quality of life(QoL)and safety.The patients are randomized in a 1:1 ratio to receive gefitinib(250 mg,p.o.q.d.)plus apatinib(500 mg,p.o.q.d.)or gefitinib plus placebo,given until disease progression or intolerable adverse events.Exploratory biomarker analysis will be performed.This study is being conducted across China and comprises of 30 participating centers.Enrollment commenced in August 2017 and finished in December 2018,most of the patients are in the follow-up period.Anticipated outcomes and significance:The present study will be the first to evaluate the efficacy and safety profile of the combination of apatinib plus gefitinib as a first-line therapy for patients with EGFR-positive advanced non-squamous NSCLC.Importantly,this trial will provide comprehensive evidence on the treatment of EGFR-TKIs combined with antiangiogenic therapy. | Zhonghan Zhang Fan Luo Yang Zhang Yuxiang Ma Shaodong Hong Yunpeng Yang Wenfeng Fang Yan Huang Li Zhang Hongyun Zhao | 2019 | Cancer Communications2019，39，1： | 5 |
| 3 | Trends in sunshine duration and atmospheric visibility in the Yunnan-Guizhou Plateau,1961-2005显示文摘Using the observed data from 184 stations over the Yunnan-Guizhou Plateau (YGP) from 1961 to 2005,the long-term trends in sunshine duration,cloud amount,dry visibility (Vd),dry extinction,and water vapor over the YGP are analyzed.The results show that 85% of the stations recorded shortening annual sunshine duration,with the decrease rates between -12.2 and -173.7 h/10yr.Results of Mann-Kendall tests indicate that,among the stations with decreasing sunshine duration,63.7% of them experienced an abrupt change that started in the 1970s and peaked in the 1980s.This decreasing trend has reversed in the early years of the 21st century.The cloud cover and water vapor content in the mid and lower levels over the YGP had no obvious changes during the study period.The annual averages of Vd declined from 34 km in the 1960s to 27 km at present.The annual mean dry extinction coefficient trended upward,from 0.176 to 0.190,on the YGP from 1980 to 2005.Analyses of cloud cover,water vapor,atmos-pheric visibility,and dry extinction coefficient revealed that emitted tropospheric aerosols (including air pollutants) resulting from increased energy consumption over the YGP could be a major factor influencing the reductions of sunshine duration and atmospheric visibility. | XiaoBo Zheng TianLiang Zhao YuXiang Luo ChangChun Duan Juan Chen | 2011 | Research in Cold and Arid Regions2011，3，2： | 4 |
| 4 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 5 | The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia显示文摘Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks’gestation and is a leading cause of maternal and neonatal morbidity and mortality.The pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental implantation.However,the exact underlying mechanisms remain unclear.Placental LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT-PCR,and the metabolic profile of trophoblasts overexpressing LncZBTB39-1:2 in vitro was analysed using gas chromatography-mass spectrometry(GCeMS).In this study,we found that the expression of LncZBTB39-1:2 was significantly higher in preeclamptic placentae than in healthy placentae.Our metabolomics results have shown that tricarboxylic acid cycle intermediates and metabolites related to carbohydrate metabolism were decreased with the overexpression of LncZBTB39-1:2 in HTR8/SVneo cells.These findings were validated by detecting a lower level of intracellular ATP in HTR8/Vneo cells.Furthermore,the migration of HTR8/SVneo cells was compromised when cells were transfected with a plasmid encompassing LncZBTB39-1:2 overexpression.From these results,we conclude that abnormal levels of LncZBTB39-1:2 expression might lead to aberrant conditions in HTR-8/SVneo trophoblast cells.Aberrant conditions might be associated with dysregulated trophoblast migration and subsequent failure of uterine spiral artery remodelling,a pathogenesis recognised as a contributing factor in the aetiology of preeclampsia. | Yamin Liu Ting-Li Han Xiaofang Luo Yuxiang Bai Xuehai Chen Wei Peng Xi Xiong Philip N.Baker Chao Tong Hongbo Qi | 2018 | Genes & Diseases2018，5，3： | 3 |
| 6 | A new sodium iron phosphate as a stable high-rate cathode material for sodium ion batteries显示文摘Low-cost room-temperature sodium-ion batteries (SIBs) are expected to promote the development of stationary energy storage applications.However,due to the large size of Na+,most Na+ host structures resembling their Li+ counterparts show sluggish ion mobility and destructive volume changes during Na ion (de)intercalation,resulting in unsatisfactory rate and cycling performances.Herein,we report a new type of sodium iron phosphate (Na0.71Fe1.07PO4),which exhibits an extremely small volume change (~ 1%) during desodiation.When applied as a cathode material for SIBs,this new phosphate delivers a capacity of 78 mA·h·g-1 even at a high rate of 50 C and maintains its capacity over 5,000 cycles at 20 C.In situ synchrotron characterization disclosed a highly reversible solid-solution mechanism during charging/discharging.The findings are believed to contribute to the development of high-performance batteries based on Earth-abundant elements. | Xiaobo Zhu Takashi Mochiku Hiroki Fujii Kaibin Tang Yuxiang Hu Zhenguo Huang Bin Luo Kiyoshi Ozawa Lianzhou Wang | 2018 | Nano Research2018，11，12： | 3 |
| 7 | Dissimilatory iron reduction contributes to anaerobic mineralization of sediment in a shallow transboundary lake显示文摘Dissimilatory iron reduction(DIR)coupled with carbon cycling is increasingly being recognized as an influential process in freshwater wetland soils and sediments.The role of DIR in organic matter(OM)mineralization,however,is still largely unknown in lake sediment environments.In this study,we clarified rates and pathways of OM mineralization in two shallow lakes with seasonal hydrological connectivity and different eutrophic situations.We found that in comparison with the domination of DIR(55%)for OM mineralization in Lake Xiaoxingkai,the contribution of methanogenesis was much higher(68%)in its connected lake(Lake Xingkai).The differences in rates and pathways of sediment OM mineralization between the two lakes were attributed to higher concentrations of carbonate associated iron oxides(Fecarb)in Lake Xiaoxingkai compared to Lake Xingkai(P=0.002),due to better deposition mixing,more contributions of terrigenous detrital materials,and higher OM content in Lake Xiaoxingkai.Results of structural equation modeling showed that Fecarb and total iron content(TFe)regulated 25%of DIR in Lake Xiaoxingkai and 76%in Lake Xingkai,accompanied by a negative effect of TFe on methanogenesis in Lake Xingkai.The relative abundance and diversity of Fe-reducing bacteria were significantly different between the two lakes,and showed a weak effect on sediment OM mineralization.Our findings emphasize the role of iron minerals and geochemical characterizations in regulating rates and pathways of OM mineralization,and deepen the understanding of carbon cycling in lake sediments. | Yuxiang Yuan Cong Ding Haitao Wu Xue Tian Min Luo Weiyi Chang Lei Qin Liang Yang Yuanchun Zou Kaikai Dong Xiaoyan Zhu Ming Jiang Marinus L.Otte | 2023 | Fundamental Research2023，3，6： | 2 |
| 8 | Bioenergy recovery from landfill gas:A case study in China显示文摘Landfill gas(LFG)utilization which means a synergy between environmental protection and bioenergy recovery was investigated in this study.Pressure swing adsorption technology was used in LFG purification,and laboratory experiment,pilot-scale test,and on-site demonstration were carried out in Shenzhen,China.In the laboratory experiment,A-type carbon molecular sieve was selected as the adsorbent by comparison of several other adsorbents.The optimal adsorption pressure and adsorption time were 0.25 MPa and 2 min,respectively,under which the product generation rate was 4.5 m^(3)/h and the methane concentration was above 90%.The process and optimization of the pilot-scale test were also reported in the paper.The product gas was of high quality compared with the National Standard of Compressed Natural Gas as Vehicle Fuel(GB18047-2000),when the air concentration in feed gas was under 10.96%.The demonstration project was composed of a collection system,production system,and utilization system.The drive performance,environmental protection performance,and economic feasibility of the product gas—as alternative fuel in passenger car,truck,and bulldozer—were tested,showing the feasibility technology for LFG utilization. | Wei WANG Yuxiang LUO Zhou DENG | 2009 | Frontiers of Environmental Science & Engineering2009，3，1： | 1 |
| 9 | MicroRNAs‐372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B显示文摘 | Hongyan Guo Haiying Liu Keith Mitchelson Huiying Rao Mingyong Luo Lan Xie Yimin Sun Liang Zhang Ying Lu Ruyu Liu Aihui Ren Shuai Liu Shaozhen Zhou Jiye Zhu Yuxiang Zhou Ailong Huang Lai Wei Yong Guo Jing Cheng | 2011 | Hepatology2011，，3： | 1 |
| 10 | Effect of bone marrow mesenchymal stem cells from blastic phase chronicmyelogenous leukemia on the growth and apoptosis of leukemia cells显示文摘 | Yuxiang Han Ying Wang Zheng Xu Jie Li Jingci Yang Yan Li Yintao Shang Jianmin Luo | 2013 | Oncology Reports2013，，2： | 1 |
| 11 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 12 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 13 | Chiral detection of biomolecules based on reinforcement learning显示文摘Chirality plays an important role in biological processes,and enantiomers often possess similar physical properties and different physiologic functions.In recent years,chiral detection of enantiomers become a popular topic.Plasmonic metasurfaces enhance weak inherent chiral effects of biomolecules,so they are used in chiral detection.Artificial intelligence algorithm makes a lot of contribution to many aspects of nanophotonics.Here,we propose a nanostructure design method based on reinforcement learning and devise chiral nanostructures to distinguish enantiomers.The algorithm finds out the metallic nanostructures with a sharp peak in circular dichroism spectra and emphasizes the frequency shifts caused by nearfield interaction of nanostructures and biomolecules.Our work inspires universal and efficient machine-learning methods for nanophotonic design. | Yuxiang Chen Fengyu Zhang Zhibo Dang Xiao He Chunxiong Luo Zhengchang Liu Pu Peng Yuchen Dai Yijing Huang Yu Li Zheyu Fang | 2023 | Opto-Electronic Science2023，2，1： | 1 |
| 14 | Absorption of trioctyl trimellitate into mass-polymerization and suspension-polymerization poly (vinyl chloride)显示文摘 | Luo Yuxiang Dai Gance | 2004 | Journal of Applied Polymer Science2004，92，4： | 1 |
| 15 | Brain-wide N2cG compensation permits glycoprotein-deleted rabies virus to trace neural circuits across multiple synapses显示文摘Rabies-viruses-based retrograde tracers can spread across multiple synapses in a retrograde direction in the nervous system of rodents and primates,making them powerful tools for determining the structure and function of the complicated neural circuits of the brain.However,they have some limitations,such as posing high risks to human health and the inability to retrograde trans-synaptic label inputs from genetically-de¯ned starter neurons.Here,we established a new retrograde trans-multi-synaptic tracing method through brain-wide rabies virus glycoprotein(RVG)compensation,followed by glycoprotein-deleted rabies virus(RV-△G)infection in specific brain regions.Furthermore,in combination with the avian tumor virus receptor A(TVA)controlled by a cell-type-specific promoter,we found that EnvA-pseudotyped RV-△G can mediate e±cient retrograde trans-multi-synaptic transduction from cell-type-specific starter neurons.This study provides new alternative methods for neuroscience researchers to analyze the input neural networks of rodents and nonhuman primates. | Nengsong Luo Zengpeng Han Jiaxin Kou Yuxiang Cai Xin Yang Jie Wang Kunzhang Lin Fuqiang Xu | 2023 | Journal of Innovative Optical Health Sciences2023，16，6： | 1 |
| 16 | A new perspective to develop regiorandom polymer acceptors with high active layer ductility,excellent device stability,and high efficiency approaching 17%显示文摘The recently reported efficient polymerized small-molecule acceptors(PSMAs)usually adopt a regioregular backbone by polymerizing small-molecule acceptors precursors with a low-reactivity 5-brominated 3-(dicyanomethylidene)indan-1-one(IC)end group or its derivatives,leading to low molecular weight,and thus reduce active layer mechanical properties.Herein,a series of newly designed chlorinated PSMAs originating from isomeric IC end groups are developed by adjusting chlorinated positions and copolymerized sites on end groups to achieve high molecular weight,favorable intermolecular interaction,and improved physicochemical properties.Compared with regioregular PY2Se-Cl-o and PY2Se-Cl-m,regiorandom PY2Se-Cl-ran has a similar absorption profile,moderate lowest unoccupied molecular orbital level,and favorable intermolecular packing and crystallization properties.Moreover,the binary PM6:PY2Se-Cl-ran blend achieves better ductility with a crack-onset strain of 17.5% and improved power conversion efficiency(PCE)of 16.23% in all-polymer solar cells(all-PSCs)due to the higher molecular weight of PY2Se-Cl-ran and optimized blend morphology,while the ternary PM6:J71:PY2Se-Cl-ran blend offers an impressive PCE approaching 17% and excellent device stability,which are all crucial for potential practical applications of all-PSCs in wearable electronics.To date,the efficiency of 16.86% is the highest value reported for the regiorandom PSMAs-based all-PSCs and is also one of the best values reported for the all-PSCs.Our work provides a new perspective to develop efficient all-PSCs,with all high active layer ductility,impressive PCE,and excellent device stability,towards practical applications. | Qunping Fan Ruijie Ma Wenyan Su Qinglian Zhu Zhenghui Luo Kai Chen Yabing Tang Francis RLin Yuxiang Li He Yan Chuluo Yang Alex K.-Y.Jen Wei Ma | 2023 | Carbon Energy2023，5，2： | 0 |
| 17 | Toward accurate link between code and software documentation显示文摘Recovering traceability links between source code and software documentation is an important research topic in software maintenance and software reuse. There have been a lot of research efforts in recovering traceability between documentation and code elements(class, interface, method, etc.), mostly based on program analysis. However, there are still a lot of noise links being established in existing work. In this paper, we propose a novel approach to classifying code elements, occurring in a document, into contextual code elements and salient code elements. As a result, we can filter the noise traceability links between a software document and its contextual code elements and get a higher quality link set. Our classifier is trained based on open source project Lucene's source code and 1899 Stack Overflow answer documents about Lucene.We extract code elements from these documents and represent each of these code elements with a 7-dimension feature vector, then we use a decision-tree-based learning model to classify them as salient or not. In the experiments, we get a precision of 70.7% in recognizing the salient code elements of these documents and get12% improvement compared with Rigby's work. We can filter out 56.5%~69.3% noise traceability links with different thresholds in our classifier. It can improve the quality of traceability links between source code and their related software documents in application. | Yingkui CAO Yanzhen ZOU Yuxiang LUO Bing XIE Junfeng ZHAO | 2018 | Science China(Information Sciences)2018，61，5： | 0 |
| 18 | Review on Large Eddy Simulation of Turbulent Premixed Combustion in Tubes显示文摘This paper reviews the existing knowledge on the large eddy simulation(LES) of turbulent premixed combustion in empty tubes and obstructed tubes. From the view of model development in LES, this review comprehensively analyzes the development history and applicability of the important Sub-Grid Scale(SGS) viscosity models and SGS combustion models. LES is also used to combine flow and combustion models to reproduce industrial explosion including deflagration and detonation and the transition from deflagration to detonation(DDT). The discussion about models and applications presented here leads readers to understand the progress of LES in the explosion of tube and reveals the deficiencies in this area. | LUO Gang DAI Haidong DAI Lingpeng QIAN Yunlou SHA Ce ZHANG Yuxiang WU Bingxin | 2020 | Journal of Thermal Science2020，29，4： | 0 |
| 19 | The m^(6)A reader SiYTH1 enhances drought tolerance by affecting the messenger RNA stability of genes related to stomatal closure and reactive oxygen species scavenging in Setaria italica显示文摘Foxtail millet(Setaria italica),a vital drought-resistant crop,plays a significant role in ensuring food and nutritional security.However,its drought resistance mechanism is not fully understood.N6-methyladenosine(m^(6)A)modification of RNA,a prevalent epi-transcriptomic modification in eukaryotes,provides a binding site for m^(6)A readers and affects plant growth and stress responses by regulating RNA metabolism.In this study,we unveiled that the YT521-B homology(YTH)family gene SiYTH1 positively regulated the drought tolerance of foxtail millet.Notably,the siyth1 mutant exhibited reduced stomatal closure and augmented accumulation of excessive H_(2)O_(2)under drought stress.Further investigations demonstrated that SiYTH1 positively regulated the transcripts harboring m^(6)A modification related to stomatal closure and reactive oxygen species(ROS)scavenging under drought stress.SiYTH1 was uniformly distributed in the cytoplasm of SiYTH1-GFP transgenic foxtail millet.It formed dynamic liquid-like SiYTH1 cytosol condensates in response to drought stress.Moreover,the cytoplasmic protein SiYTH1 was identified as a distinct m^(6)A reader,facilitating the stabilization of its directly bound SiARDP and ROS scavenging-related transcripts under drought stress.Furthermore,natural variation analysis revealed SiYTH1AGTG as the dominant allele responsible for drought tolerance in foxtail millet.Collectively,this study provides novel insights into the intricate mechanism of m^(6)A reader-mediated drought tolerance and presents a valuable genetic resource for improving drought tolerance in foxtail millet breeding. | Weiwei Luo Yuxiang Tang Shenglan Li Linlin Zhang Yuwei Liu Renliang Zhang Xianmin Diao Jingjuan Yu | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 20 | A conserved unusual posttranscriptional processing mediated by short,direct repeated (SDR) sequences in plants显示文摘In several stress responsive gene loci of monocot cereal crops,we have previously identified an unusual posttranscriptional processing mediated by paired presence of short direct repeated (SDR) sequences at 5' and 3' splicing junctions that are distinct from conventional (U2/U12-type) splicing boundaries.By using the known SDR-containing sequences as probes,24 plant candidate genes involved in diverse functional pathways from both monocots and dicots that potentially possess SDR-mediated posttranscriptional processing were predicted in the GenBank database.The SDRs-mediated posttranscriptional processing events including cis-and trans-actions were experimentally detected in majority of the predicted candidates.Extensive sequence analysis demonstrates several types of SDR-associated splicing peculiarities including partial exon deletion,exon fragment repetition,exon fragment scrambling and trans-splicing that result in either loss of partial exon or unusual exonic sequence rearrangements within or between RNA molecules.In addition,we show that the paired presence of SDR is necessary but not sufficient in SDR-mediated splicing in transient expression and stable transformation systems.We also show prokaryote is incapable of SDR-mediated premRNA splicing. | Xiangli Niu Di Luo Shaopei Gao Guangjun Ren Lijuan Chang Yuke Zhou Xiaoli Luo Yuxiang Li Pei Hou Wei Tang Bao-Rong Lu Yongsheng Liu | 2010 | Journal of Genetics and Genomics2010，37，1： | 0 |
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