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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Prognostic Significance of Tumor-infiltrating CD8^+ or CD3^+ T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer显示文摘 | Chuntao Tian Shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang Sun Liuxing Wang | 2015 | Chinese Medical Journal2015，，1： | 11 |
| 3 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 4 | Highly stretchable pseudocapacitors based on buckled reticulate hybrid electrodes显示文摘以便与高特定的电容和突出的 stretchability 开发优秀 pseudocapacitor 与在便携的未来和 bio-implantable 系统适用的另外的设备匹配,我们在三个重要方面上集中我们的研究:混合电影电极,在不同部件之间的接口,和在基于围单人赛的碳 nanotube/polyaniline (SWCNT/PANI ) 的 supercapacitors 的 stretchability 和电气化学的综合性能的 Stretchability 预先伸长的弹性体上的合成电影。由于中等的孔,弄弯的混合电影避免裂开它发生在常规可拉长的混合电极,和两个 435 F | Nan Zhang Pingshan Luan Weiya Zhou Qiang Zhang Le Cai Xiao Zhang Wenbin Zhou Qingxia Fan Feng Yang Duan Zhao YanchunWang Sishen Xie | 2014 | Nano Research2014，7，11： | 4 |
| 5 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 6 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 7 | Pure organic room-temperature phosphorescent N-allylquinolinium salts as anti-counterfeiting materials显示文摘Pure organic room-temperature phosphorescence (RTP) materials have been attracting much attention recently. Herein, we report a facile approach combining heavy atom effect and external solvent stimuli to realize RTP. N-Allylquinolinium bromide under 365 nm UV exhibited intense green RTP emission with response upon adding chloroform. This interesting phenomenon endowed N-allylquinolinium bromide great potential as an anti-counterfeiting material. | Qingxia Xiong Chao Xu Nianming Jiao Xiang Ma Yanqiang Zhang Suojiang Zhang | 2019 | Chinese Chemical Letters2019，30，7： | 2 |
| 8 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 9 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 10 | Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells显示文摘OBJECTIVE: To study the effect of RNAi silencing of the K-Ras gene on Ras signal pathway activity in EC9706 esophageal cancer cells. METHODS: EC9706 cells were treated in the following six groups: blank group (no transfection), negative control group (transfection no-carrier), transfection group (transfected with pSilencer-siK-ras), taxol chemotherapy group, taxol chemotherapy plus no-carrier group, taxol chemotherapy plus transfection group. Immunocytochemistry, Reverse transcription-polymerase chain reaction and western blotting were used to analyze the expression of MAPK1 (mitogen-activated protein kinases 1) and cyclin D1 in response to siRNA (small interfering RNA) transfection and taxol treatment. RESULTS: K-Ras (K-Ras gene) siRNA transfection of EC9706 esophageal squamous carcinoma cells decreased the expression of K-Ras, MAPK1 and cyclinD1 at the mRNA and protein level. Reverse transcription-polymerase chain reaction indicated that the expression levels of MAPK1 and cyclin D1 mRNAs were significantly lower in the transfection group than in the blank group (P<0.05). Western blotting showed that 72 h after EC9706 cell transfection, the expression levels of MAPK1 and cyclin D1 proteins had decreased in all groups, and the expression levels in the transfection group were significantly inhibited as compared with the blank group. Apoptosis increased significantly in the transfection group or after addition of taxol as compared with the blank group and the no-carrier group. The degree of apoptosis in the taxol plus transfection group was more severe. CONCLUSION: Apoptosis increased significantly in EC9706 esophageal carcinoma cells after siRNA-mediated inhibition of Ras signaling, with the most obvious increase observed in the transfection plus taxol chemotherapy group. Ras knockdown therefore increased cellular sensitivity to the chemotherapeutic agent, taxol. Ras knockdown also down-regulated the expression of the downstream genes, MAPK1 and cyclin D1, thus inhibiting the growth, proliferation and metabolism of esophageal cancer cells. | Xinjie Wang Yuling Zheng Qingxia Fan Xudong Zhang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 11 | Remediation of petroleum-contaminated soil after composting by sequential treatment with Fenton-like oxidation and biodegradation显示文摘 | Mang Lu Zhongzhi Zhang Wei Qiao Xiaofang Wei Yueming Guan Qingxia Ma Yingchun Guan | 2009 | Bioresource Technology2009，，7： | 1 |
| 12 | Finite element analysis on mechanical behavior of column underpinning joints for building moving 显示文摘 | Yue Qingxia Zhang Xin | 2011 | Advanced Materials Research2011，158，4： | 1 |
| 13 | Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling显示文摘 | Dechun Jiang Xiangrong Bai Qingxia Zhang Wei Lu Yuqin Wang Lin Li Markus Müller | 2009 | European Journal of Clinical Pharmacology2009，，12： | 1 |
| 14 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 15 | Effect of polycarboxylate ether comb-type polymer on viscosity and interfacial properties of kaolinite clay suspensions显示文摘 | Ling Zhang Qingye Lu Zhenghe Xu Qingxia Liu Hongbo Zeng | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 16 | Microbiome analysis reveals soil microbial community alteration with the effect of animal excretion contamination and altitude in Tibetan Plateau of China显示文摘The fertile forages in the Tibetan Plateau provide natural conditions for animal husbandry,whereas it is still unclear that whether animal excretion can result in the alteration of soil microbial community.Therefore,this study was performed to investigate the impact of animal excretion contamination and land altitude on the soil microbial community in different grazing areas of Tibetan Plateau.A total of 1160,190 high-quality valid sequences and 25,478 operational taxonomic units were achieved from 18 samples at three different altitude sites(Linzhi,Rikaze and Shannan).Here,we found excremental contamination did not alter the richness and diversity of soil microbial community,but it resulted in a significant alteration in the proportion of some bacteria.Specifically,the proportion of Proteobacteria in the LZa was obviously increased,whereas Gemmatimonadetes was significantly decreased as compared to LZe.Moreover,significant difference can also be observed in Verrucomicrobia between RKZe and RKZa.Remarkably,we also found that excremental contamination significantly decreased the abundance of some bacterial genera,such as Sphingopyxis,Polycyclovorans,Singulisphaera Cohnella,Polycyclovorans,Defluviicoccus,and Arthrobacter,which were closely related to soil health,pollutant degradation,and nutrient metabolism.Importantly,excremental contamination increased the proportion of harmful and beneficial bacteria in soil,such as the percentage of Acidibacter,Gemmatimonadaceae and Pajaroellobacter increased,while the ratio of Pontibacter,Flavisolibacter,Parasegetibacter,and Niastella decreased.Remarkably,soil samples collected from different altitude sites also displayed different soil microbial community structures.Our results demonstrated that excremental contamination could alter the soil microbial community structure and affect the normal function of the soil by affecting the proportion of harmful bacteria to beneficial bacteria.Moreover,this study can also provide a theoretical basis for the establishment of a supervision system for soil quality in Tibet. | Aoyun Li Yaping Wang Yajing Wang Hailong Dong Qingxia Wu Khalid Mehmood Zhenyu Chang Ying Li Yung-Fu Chang Lijun Shi Zhaoxin Tang Hui Zhang | 2021 | International Soil and Water Conservation Research2021，9，4： | 1 |
| 17 | Clinical study of ischia spinous fascia fixation-a new pelvic reconstructive surgery显示文摘 | ZHU Lan LANG Jinghe ZHANG Qingxia | 2011 | lnt Urogynecol J2011，22，4： | 1 |
| 18 | Single-atomic Pt sites anchored on defective Ti0_(2) nanosheets as a superior photocatalyst for hydrogen evolution显示文摘Single-atomic site catalysts have drawn considerable attention because of their maximum atom-utilization efficiency and excellent catalytic activity.In this work,a highly active single-atomic Pt site photocatalyst was synthesized through employing defective Ti0_(2) nanosheets as solid support for photo-catalytic water splitting.It indicated that the surface oxygen vacancies on defective Ti0_(2) nanosheets could effectively stabilize the single-atomic Pt sites through constructing a three-center Ti-Pt-Ti structure.The Ti-Pt-Ti structure can hold the stability of isolated single-atomic Pt sites and facilitate the separation and transfer of photoinduced charge carriers,thereby greatly improving the photocatalytic H2 evolution.Notably,our synthesized photocatalyst exhibited a remarkably enhanced H2 evolution performance,and the H2 production rate is up to 13460.7μmol h^(-1)·g^(-1),which is up to around 29.0 and 4.7 times higher than those of Ti0_(2) nanosheets and Pt nanoparticles-Ti0_(2).In addition,a plausible enhanced reaction mechanism was also proposed combining with photo-electrochemical characterizations and density functional theoiy(DFT)calculation results.Ultimately,it is believed that this work highlights the benefits of a single-site catalyst and paves the way to rationally design the highly active and stable single-atomic site photocatalysts on metal oxide support. | Xiaolong Hu Junying Song Jingli Luo Hao Zhang Zhiming Sun Chunquan Li Shuilin Zheng Qingxia Liu | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 19 | Establishment of Indirect ELISA Diagnosis Technique based on the VP1 Protein of Foot and Mouth Disease Virus Serotype A显示文摘The VP1 protein of foot-and-mouth disease virus serotype A was prokaryotically expressed and purified to replace the traditional virus antigen for establishing a fast,safe,effective indirect ELISA method,so as to detecting antibody of foot-and-mouth disease virus serotype A. Western-Blot test showed that the VP1 recombinant protein could be used as detective antigen as it can be specifically recognized by bovine positive serum of FMDV serotype A. By employing matrix titration method,the optimal parameters were obtained as follows: 1 mg / L VP1 protein as coating antigen,Vserum∶ Vblocking solution = 1∶50 dilution for serum and Vsecondary enzyme-linked antibodies∶Vblocking solution = 1∶2 000 for enzyme combined antibodies. The results showed that the sensitivity and specificity of this method were 94. 32% and 99. 09% respectively,the coefficients of variations in intra-assay and inter-assay reproducibility tests was lower than 8%. Compared with liquid phase blocking ELISA kits,the agreement of 201 serum samples reached 92. 54%. The VP1-ELISA method established here is specific,sensitive,stable and simple,which can be used to monitor the antibody level of FMD serotype A. | Lu Qingxia Liu Chang Jin Qianyue Guo Guanpeng Xing Guangxu Liu Yunchao Deng Ruiguang Zhang Gaiping | 2014 | Animal Husbandry and Feed Science2014，6，6： | 1 |
| 20 | Determination of Acidolysis Hydrocarbons in Oil/Gas Geochemical Exploration Sample By Gas Chromatograph显示文摘1 Introduction Although a mumerous of papers were reported for the chemcial or instrumental analysis of inorganic elements for the geocheical samples(Sun and Xie,2014;Sun et al.,2014;Rao et al.,2004).However,the analytical | CHEN Weiming LI Qingxia XIAO Xilian ZHANG Qin DENG Tianlong | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
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