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| 1 | Expenditure of hospital care on cancer in China, from 2011 to 2015显示文摘Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention.However, studies on economic burden of cancers in China are scant and the results are inconsistent.Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals.Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments(67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China.Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisioning, prevention strategies, research funding, and assessing whether the economic burden of cancer is affordable to the governments. | Yue Cai Ming Xue Wanqing Chen Maogui Hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，3： | 81 |
| 2 | Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety显示文摘Background:The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma(HCC)patients with solitary tumor and microvascular invasion(MVI)is controversial.This trial evaluated the efficacy and safety of adjuvant transcatheter arterial chemoembolization(TACE)after hepatectomy versus hepatectomy alone in HCC patients with a solitary tumor≥5 cm and MVI.Methods:In this randomized,open-labeled,phase III trial,HCC patients with a solitary tumor≥5 cm and MVI were randomly assigned(1:1)to receive either 1-2 cycles of adjuvant TACE after hepatectomy(Hepatectomy-TACE)or hepatectomy alone(Hepatectomy Alone).The primary endpoint was disease-free survival(DFS);the secondary end-points included overall survival(OS)and adverse events.Results:Between June 1,2009,and December 31,2012,250 patients were enrolled and randomly assigned to the Hepatectomy-TACE group(n=125)or the Hepatectomy Alone group(n=125).Clinicopathological characteristics were balanced between the two groups.The median follow-up time from randomization was 37.5 months[interquartile range 18.3-48.2 months].The median DFS was significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[17.45 months(95%confidence interval[CI]11.99-29.14)vs.9.27 months(95%CI 6.05-13.70),hazard ratio[HR]=0.70(95%CI 0.52-0.95),P=0.020],respectively.The median OS was also significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[44.29 months(95%CI 25.99-62.58)vs.22.37 months(95%CI 10.84-33.91),HR=0.68(95%CI 0.48-0.97),P=0.029].Treatment-related adverse events were more frequently observed in the Hepatectomy-TACE group,although these were generally mild and manageable.The most common grade 3 or 4 adverse events in both groups were neutropenia and liver dysfunction.Conclusion:Hepatectomy followed by adjuvant TACE is an appropriate option after radical resection in HCC patients with solitary tumor≥5 cm and MVI,with acceptable toxicity. | Wei Wei Pei-En Jian Shao-Hua Li Zhi-Xing Guo Yong-Fa Zhang Yi-Hong Ling Xiao-Jun Lin Li Xu Ming Shi Lie Zheng Min-Shan Chen Rong-Ping Guo | 2018 | Cancer Communications2018，38，1： | 62 |
| 3 | Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients显示文摘Objective: The purposes of this study were to identify risk factors for cervical lymph node metastasis and to examine the association between BRAF^(V600E) status and clinical features in papillary thyroid microcarcinoma(PTMC).Methods: A total of 1,587 patients with PTMC, treated in Tianjin Medical University Cancer Institute and Hospital from January2011 to March 2013, underwent retrospective analysis. We reviewed and analyzed factors including clinical results, pathology records, ultrasound results, and BRAF^(V600E) status.Results: Multivariate logistic regression analyses demonstrated that gender(male) [odds ratio(OR) = 1.845, P = 0.000], age(< 45 years)(OR = 1.606, P = 0.000), tumor size(> 6 mm)(OR = 2.137, P = 0.000), bilateralism(OR = 2.011, P = 0.000) and extrathyroidal extension(OR = 1.555, P = 0.001) served as independent predictors of central lymph node metastasis(CLNM).Moreover, CLNM(OR = 29.354, P = 0.000) served as an independent predictor of lateral lymph node metastasis(LLNM). Among patients with a solitary primary tumor, those with tumor location in the lower third of the thyroid lobe or the isthmus were more likely to experience CLNM(P < 0.05). Univariate analyses indicated that CLNM, LLNM, extrathyroidal extension, and multifocality were not significantly associated with BRAF^(V600E) mutation.Conclusions: The present study suggested that prophylactic neck dissection of the central compartment should be considered in patients with PTMC, particularly in men with tumor size greater than 6 mm, age less than 45 years, extrathyroidal extension, and tumor bilaterality. Among patients with PTMC, BRAF^(V600E) mutation is not significantly associated with prognostic factors. For a better understanding of surgical management of PTMC and the risk factors, we recommend multicenter research and long-term follow-up. | Xiangqian Zheng Chen Peng Ming Gao Jingtai Zhi Xiukun Hou Jingzhu Zhao Xi Wei Jiadong Chi Dapeng Li Biyun Qian | 2019 | Cancer Biology & Medicine2019，16，1： | 54 |
| 4 | Network Pharmacology Evaluation Method Guidance-Draft显示文摘Foreword Note:Some of the document contents may involve certain patents,the identification of which is not the responsibility of the institution that releases the document.Main drafting organizations:Tsinghua University,Specialty Committee of Network Pharmacology of World Federation of Chinese Medicine Societies(WFCMS). | Shao Li Yi-Tao Chen Qing-Yang Ding Jian-Ye Dai Xian-Chun Duan Yuan-Jia Hu Xin-Xing Lai Qing-Fei Liu Ming Niu Rong-Wu Xiang Zheng Xiang Hai-Yu Xu Xin Wang Hong-Jun Yang Kuo Yang Ming Yang Hai-Yang Yu Bo Zhang Peng Zhang Qian-Ru Zhang Hui-Hui Zhao Jing Zhao | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 32 |
| 5 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 6 | Spatial Characteristics of Extreme Rainfall over China with Hourly through 24-Hour Accumulation Periods Based on National-Level Hourly Rain Gauge Data显示文摘Hourly rainfall measurements of 1919 national-level meteorological stations from 1981 through 2012 are used to document,for the first time,the climatology of extreme rainfall in hourly through 24-h accumulation periods in China. Rainfall amounts for 3-,6-,12- and 24-h periods at each station are constructed through running accumulation from hourly rainfall data that have been screened by proper quality control procedures. For each station and for each accumulation period,the historical maximum is found,and the corresponding 50-year return values are estimated using generalized extreme value theory. Based on the percentiles of the two types of extreme rainfall values among all the stations,standard thresholds separating Grade I,Grade II and Grade III extreme rainfall are established,which roughly correspond to the 70th and 90th percentiles for each of the accumulation periods. The spatial characteristics of the two types of extreme rainfall are then examined for different accumulation periods. The spatial distributions of extreme rainfall in hourly through 6-h periods are more similar than those of 12- and 24-h periods. Grade III rainfall is mostly found over South China,the western Sichuan Basin,along the southern and eastern coastlines,and in the large river basins and plains. There are similar numbers of stations with Grade III extreme hourly rainfall north and south of 30°N,but the percentage increases to about 70% south of 30°N as the accumulation period increases to 24 hours,reflecting richer moisture and more prolonged rain events in southern China. Potential applications of the extreme rainfall climatology and classification standards are suggested at the end. | Yongguang ZHENG Ming XUE Bo LI Jiong CHEN Zuyu TAO | 2016 | Advances in Atmospheric Sciences2016，33，11： | 28 |
| 7 | Dielectric metasurfaces for complete and independent control of the optical amplitude and phase显示文摘Metasurfaces are optically thin metamaterials that promise complete control of the wavefront of light but are primarily used to control only the phase of light.Here,we present an approach,simple in concept and in practice,that uses meta-atoms with a varying degree of form birefringence and rotation angles to create high-efficiency dielectric metasurfaces that control both the optical amplitude and phase at one or two frequencies.This opens up applications in computer-generated holography,allowing faithful reproduction of both the phase and amplitude of a target holographic scene without the iterative algorithms required in phase-only holography.We demonstrate all-dielectric metasurface holograms with independent and complete control of the amplitude and phase at up to two optical frequencies simultaneously to generate two-and three-dimensional holographic objects.We show that phaseamplitude metasurfaces enable a few features not attainable in phase-only holography;these include creating artifactfree two-dimensional holographic images,encoding phase and amplitude profiles separately at the object plane,encoding intensity profiles at the metasurface and object planes separately,and controlling the surface textures of three-dimensional holographic objects. | Adam C.Overvig Sajan Shrestha Stephanie C.Malek Ming Lu Aaron Stein Changxi Zheng Nanfang Yu | 2019 | Light(Science & Applications)2019，8，1： | 27 |
| 8 | Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes显示文摘AIM:To evaluate the correlation between nonalcoholic fatty liver disease(NAFLD) and microvascular complications in type 2 diabetes mellitus(T2DM).METHODS:Data were obtained from 1217 inpatients with T2DM(757 females,460 males;aged 63.39 ± 12.28 years).NAFLD was diagnosed by hepatic ultrasonography.Diabetic nephropathy(DN),diabetic peripheral neuropathy(DPN),and diabetic retinopathy(DR) were diagnosed according to their respective criteria.The prevalence of NAFLD and the independent correlations of clinical characteristics with NAFLD were determined by cross-tabulation and logistic regression,respectively.RESULTS:Approximately 61% of inpatients with T2DM in Qingdao,China had NAFLD,which decreased significantly with increase in age and prolonged course of diabetes.The prevalence of NAFLD in patients presenting with DN,DPN and DR was 49.4%,57.2% and 54.9%,respectively.These rates were significantly lower than those of patients without DN,DPN and DR(65.9%,65.6% and 66.1%,respectively,P < 0.05).Participants with NAFLD had greater body weight,waist circumference(WC),body mass index(BMI),fasting blood glucose(FBG),hemoglobin A1c,alanine aminotransferase,aspartate aminotransferase,γ-glutamyltransferase,blood pressure,as well as triglyceride(TG) levels and lower high-density lipoprotein(HDL) concentration than those without NAFLD(P < 0.05).NAFLD was positively correlated with BMI,WC,TG,FBG,diastolic blood pressure,and systolic blood pressure but negatively correlated with the duration of diabetes,DR,DPN,DN,and HDL.CONCLUSION:Despite the benign nature of NAFLD,efforts should be directed toward early diagnosis,intensive blood glucose and blood pressure control,and effective dyslipidemia correction. | Wen-Shan Lv Rui-Xia Sun Yan-Yan Gao Jun-Ping Wen Rong-Fang Pan Li Li Jing Wang Yu-Xin Xian Cai-Xia Cao Ming Zheng | 2013 | World Journal of Gastroenterology2013，19，20： | 26 |
| 9 | Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases显示文摘Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic disorders.Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte apoptosis.In addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate conditions.Although remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in detail.Furthermore,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials.This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases. | Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi Fu-Sheng Wang | 2011 | Cellular & Molecular Immunology2011，8，1： | 26 |
| 10 | Tri-Co Robot: a Chinese robotic research initiative for enhanced robot interaction capabilities显示文摘Since the invention of the first industrial robot in 1959, the missions of robots have evolved from basic mechanical transfer or assistance to a diverse range of tasks through close interactions with environment, their human counterparts and robot peers. Through adaptation to uncertain and dynamic environments. | Han Ding Xuejun Yang Nanning Zheng Ming Li Yinan Lai Hao Wu | 2018 | National Science Review2018，5，6： | 24 |
| 11 | Iron Extraction From Oolitic Iron Ore by a Deep Reduction Process显示文摘A laboratory experiment was carried out to extract iron from oolitic iron ore by a deep reduction and magnetic separation technique.The raw coal with fixed carbon of 66.54% was used as the reductant.The iron was successfully extracted from the oolitic iron ore which otherwise is nearly impossible to be separated due to its extremely fine-grain and mosaic nature.The results showed that an iron recovery rate of 90.78% and an iron content of 92.53% of iron concentrate could be obtained by such a technique.The optimized roast temperature is 1200 ℃ and time is 60 min.The subsequent magnetic separation was performed by using a magnetic field intensity of 111 kA·m-1 and a grinding fineness less than 45 μm of 96.19% for the sintered product. | LI Ke-qing NI Wen ZHU Ming ZHENG Mei-juan LI Yuan | 2011 | Journal of Iron and Steel Research(International)2011，18，8： | 22 |
| 12 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 13 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 14 | Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site显示文摘Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis.Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed.We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models.The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status.Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement.In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node metastases.The cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients. | Xi Wei Meng Wang Xiaoqing Wang Xiangqian Zheng Ying Li Yi Pan Yueguo Li Jiali Mu Yang Yu Dapeng Li Ming Gao Sheng Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 22 |
| 15 | Characteristics, Management, and Outcomes of Acute Heart Failure in the Emergency Department: A Multicenter Registry Study with 1-year Follow-up in a Chinese Cohort in Beijing显示文摘 | Guo-Gan Wang Si-Jia Wang Jian Qin Chun-Sheng Li Xue-Zhong Yu Hong Shen Li-Pei Yang Yan Fu Ya-An Zheng Bin Zhao Dong-Min Yu Fu-Jun Qin De-Gui Zhou Ying Li Fu-Jun Liu Wei Li Wei Zhao Xin Gao Zheng Wang Ming Jin Hong Zeng Yi Li Guo-Xing Wang Hong Zhou Xiao-Lu Sun Peng-Bo Wang Kam-Sang Woo | 2017 | Chinese Medical Journal2017，，16： | 21 |
| 16 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 17 | Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis显示文摘瞄准:为了在 trinitrobenzene 上调查杂种狗枯茗(杂种狗) 的治疗学的效果,磺基酸(TNBS ) 在 Th1/Th2 cytokines 的平衡上导致了大肠炎和杂种狗的效果。方法:大肠炎被 TNBS 导致并且与杂种狗对待(30 mg/kg/d, ip ) ,地塞米松(Dex, 2 mg/kg/d ) ,或杂种狗正地塞米松(Cur+Dex, 30 mg/kg/d 杂种狗 ip+2 mg/kg/d Dex, ip ) 。在冒号粘膜的 mRNA 被即时量的聚合酶链反应检测。细胞内部的 cytokines 被流动血细胞计数和 cytokines 的集中在重量的单位检测一被连接酶的免疫吸着剂分析检测。结果:杂种狗和 Dex 改进了体重损失,改善组织学的图象和减少的宏观的分数和 myeloperoxidase 活动。杂种狗减少了 Th1 cytokines 的表示(IL-12, IFN-gamma, TNF-alpha, IL-1 ) 并且在冒号粘膜增加了 Th2 cytokines (IL-4 和 IL-10 ) 的表示。杂种狗也在 splenocytes 和发行量增加了 IFN-gamma/IL-4 的比例。Dex 和 Cur+Dex 减少了 Th1 cytokines 的表示但是不能增加 Th2 cytokines 的表示和 IFN-gamma/IL-4 的比例。结论:杂种狗由从 Th1 调整移动到 Th2 在大肠炎上施加了治疗学的效果。 | Ming ZHANG Chang-sheng DENG Jia-ju ZHENG Jian XIA | 2006 | Acta Pharmacologica Sinica2006，27，8： | 20 |
| 18 | Hydraulic fracture initiation theory for a horizontal well in a coal seam显示文摘A series of experiments were performed to determine rock mechanical parameters related to hydraulic fracturing of coal.The effect of confining pressure and pore pressure on the strength of coal was studied.Experimental results show that the coal seam in the study areas has a relatively low elastic modulus,high Poisson's ratio,high fragility and is easily broken and compressed.The coal seam is considered as a transversely isotropic medium,since the physical properties in the direction of bedding plane and orthogonal to the bedding plane vary markedly.Based on the generalized plane strain model,stress distribution for an arbitrarily orientated wellbore in the coal seam was determined.In a horizontal well,hydraulic fracturing was found to initiate in the coal seam mass due to tensile failure,or from cleats due to shear or tensile failure.For those coal seams with abundant natural cleats,hydraulic fracture initiation can be induced by any of these mechanisms.In this study,hydraulic fracture initiation criteria for a horizontal well in a coal seam were established. | Hou Bing Chen Mian Wang Zheng Yuan Jianbo Liu Ming | 2013 | Petroleum Science2013，10，2： | 18 |
| 19 | Expression of epha2 and vascular endothelial growth factor in squamous cell carcinoma of the tongue: correlation with the angiogenesis and clinicopathologic outcome显示文摘 | Zhe Shao Wen Feng Zhang Xin Ming Chen Zheng Jun Shang | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 18 |
| 20 | Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein显示文摘Background:Abnormal aggregation of brainα-synuclein is a central step in the pathogenesis of Parkinson’s disease(PD),thus,it is reliable to promote the clearance ofα-synuclein to prevent and treat PD.Recent studies have revealed an essential role of glymphatic system and meningeal lymphatic vessels in the clearance of brain macromolecules,however,their pathophysiological aspects remain elusive.Method:Meningeal lymphatic drainage of 18-week-old A53T mice was blocked via ligating the deep cervical lymph nodes.Six weeks later,glymphatic functions and PD-like phenotypes were systemically analyzed.Results:Glymphatic influx of cerebrospinal fluid tracer was reduced in A53T mice,accompanied with perivascular aggregation ofα-synuclein and impaired polarization of aquaporin 4 expression in substantia nigra.Cervical lymphatic ligation aggravated glymphatic dysfunction of A53T mice,causing more severe accumulation ofα-synuclein,glial activation,inflammation,dopaminergic neuronal loss and motor deficits.Conclusion:The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology. | Wenyan Zou Tinglin Pu Weixi Feng Ming Lu Ying Zheng Renhong Du Ming Xiao Gang Hu | 2019 | Translational Neurodegeneration2019，8，1： | 17 |
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