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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Fully autonomous flying: from collective motion in bird flocks to unmanned aerial vehicle autonomous swarms显示文摘1 Introduction The unmanned aerial vehicle(UAV),an aircraft with no pilots on board,appeals to widespread applications in military and civil fields[1].In complex and dynamic mission environments,a single UAV | QIU HuaXin WEI Chen DOU Rui ZHOU ZiWei | 2015 | Science China Chemistry2015，58，12： | 12 |
| 3 | Internet of Things to network smart devices for ecosystem monitoring显示文摘Smart, real-time, low-cost, and distributed ecosystem monitoring is essential for understanding and managing rapidly changing ecosystems. However, new techniques in the big data era have rarely been introduced into operational ecosystem monitoring, particularly for fragile ecosystems in remote areas.We introduce the Internet of Things(IoT) techniques to establish a prototype ecosystem monitoring system by developing innovative smart devices and using IoT technologies for ecosystem monitoring in isolated environments. The developed smart devices include four categories: large-scale and nonintrusive instruments to measure evapotranspiration and soil moisture, in situ observing systems for CO2 and d13 C associated with soil respiration, portable and distributed devices for monitoring vegetation variables, and Bi-CMOS cameras and pressure trigger sensors for terrestrial vertebrate monitoring. These new devices outperform conventional devices and are connected to each other via wireless communication networks. The breakthroughs in the ecosystem monitoring IoT include new data loggers and longdistance wireless sensor network technology that supports the rapid transmission of data from devices to wireless networks. The applicability of this ecosystem monitoring IoT is verified in three fragile ecosystems, including a karst rocky desertification area, the National Park for Amur Tigers, and the oasis-desert ecotone in China. By integrating these devices and technologies with an ecosystem monitoring information system, a seamless data acquisition, transmission, processing, and application IoT is created. The establishment of this ecosystem monitoring IoT will serve as a new paradigm for ecosystem monitoring and therefore provide a platform for ecosystem management and decision making in the era of big data. | Xin Li Ning Zhao Rui Jin Shaomin Liu Xiaomin Sun Xuefa Wen Dongxiu Wu Yan Zhou Jianwen Guo Shiping Chen Ziwei Xu Mingguo Ma Tianming Wang Yonghua Qu Xinwei Wang Fangming Wu Yuke Zhou | 2019 | Science Bulletin2019，64，17： | 10 |
| 4 | Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor显示文摘According to the statistics of the World Health Organization,an estimated 17.9 million people die from cardiovascular diseases each year,representing 31%of all global deaths.Continuous non-invasive arterial pressure(CNAP)is essential for the management of cardiovascular diseases.However,it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression.Here,we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP.We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts,and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices.We compare the results with the blood pressure acquired by invasive(intra-arterial)blood pressure monitoring for>1500 min in total on 44 subjects in an intensive care unit.The maximum absolute errors of diastolic and systolic blood pressure were±7/±10 mm Hg,respectively,in immobilized,and±10/±14 mm Hg,respectively,in walking scenarios.These strategies provide advanced blood pressure monitoring techniques,which would directly address an unmet clinical need or daily use for a highly vulnerable population. | Haicheng Li Yinji Ma Ziwei Liang Zhouheng Wang Yu Cao Yuan Xu Hua Zhou Bingwei Lu Ying Chen Zhiyuan Han Shisheng Cai Xue Feng | 2020 | National Science Review2020，7，5： | 7 |
| 5 | A review:Photonics devices,architectures,and algorithms for optical neural computing显示文摘The explosive growth of data and information has motivated various emerging non-von Neumann computational approaches in the More-than-Moore era.Photonics neuromorphic computing has attracted lots of attention due to the fascinating advantages such as high speed,wide bandwidth,and massive parallelism.Here,we offer a review on the optical neural computing in our research groups at the device and system levels.The photonics neuron and photonics synapse plasticity are presented.In addition,we introduce several optical neural computing architectures and algorithms including photonic spiking neural network,photonic convolutional neural network,photonic matrix computation,photonic reservoir computing,and photonic reinforcement learning.Finally,we summarize the major challenges faced by photonic neuromorphic computing,and propose promising solutions and perspectives. | Shuiying Xiang Yanan Han Ziwei Song Xingxing Guo Yahui Zhang Zhenxing Ren Suhong Wang Yuanting Ma Weiwen Zou Bowen Ma Shaofu Xu Jianji Dong Hailong Zhou Quansheng Ren Tao Deng Yan Liu Genquan Han Yue Hao | 2021 | Journal of Semiconductors2021，42，2： | 7 |
| 6 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 7 | Automatic Modulation Recognition Based on CNN and GRU显示文摘Based on a comparative analysis of the Long Short-Term Memory(LSTM)and Gated Recurrent Unit(GRU)networks,we optimize the structure of the GRU network and propose a new modulation recognition method based on feature extraction and a deep learning algorithm.High-order cumulant,Signal-to-Noise Ratio(SNR),instantaneous feature,and the cyclic spectrum of signals are extracted firstly,and then input into the Convolutional Neural Network(CNN)and the parallel network of GRU for recognition.Eight modulation modes of communication signals are recognized automatically.Simulation results show that the proposed method can achieve high recognition rate at low SNR. | Fugang Liu Ziwei Zhang Ruolin Zhou | 2022 | Tsinghua Science and Technology2022，27，2： | 5 |
| 8 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 9 | Research on parametric design method for energy efficiency of green building in architectural scheme phase显示文摘 | Borong Lin Qiong Yu Ziwei Li Xiaoru Zhou | 2013 | Frontiers of Architectural Research2013，2，1： | 4 |
| 10 | Estimation of tropical cyclone parameters and wind fields from SAR images显示文摘The traditional method of Synthetic Aperture Radar(SAR)wind field retrieval is based on an empirical relation between the near surface winds and the normalized radar backscatter cross section to estimate wind speeds,where this relation is called the geophysical model function(GMF).However,the accuracy rapidly decreases due to the impact of rainfall on the measurement of SAR and the saturation of backscattered intensity under the condition of tropical cyclone.Because of no available instrument synchronously monitoring rain rate on the satellite platform of SAR,we have to derive the precipitation of the SAR observation time from non-simultaneous passive microwave observations of rain in combination with geostationary IR images,and then use the model of rain correction to remove the impact of rain on SAR wind field measurements.For the saturation of radar backscatter cross section in high wind speed conditions,we develop an approach to estimate tropical cyclone parameters and wind fields based on the improved Holland model and the SAR image features of tropical cyclone.To retrieve the low-to-moderate wind speed,the wind direction of tropical cyclone is estimated from the SAR image using wavelet analysis.And then the maximum wind speed and the central pressure of tropical cyclone are calculated by a least square minimization of the difference between the improved Holland model and the low-to-moderate wind speed retrieved from SAR.In addition,wind fields are estimated from the improved Holland model using the above-mentioned parameters of tropical cyclone as input.To evaluate the accuracy of our approach,the SAR images of typhoon Aere,typhoon Khanun,and hurricane Ophelia are used to estimate tropical cyclone parameters and wind fields,which are compared with the best track data and reanalyzed wind fields of the Joint Typhoon Warning Center(JTWC)and the Hurricane Research Division(HRD).The results indicate that the tropical cyclone center,maximum wind speed,and central pressure are generally consistent with the best track data,and wind fields agree well with reanalyzed data from HRD. | ZHOU Xuan YANG XiaoFeng LI ZiWei YU Yang BI HaiBo MA Sheng LI XiaoFeng | 2013 | Science China Earth Sciences2013，56，11： | 4 |
| 11 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 12 | Surface modification with ionic liquid for efficient CsPbI2Br perovskite solar cells显示文摘The presence of numerous trap states on the perovskite surface severely affects the performance of inorganic CsPbI_(2)Br perovskite solar cells.Surface modification has been proven to be an effective strategy to passivate the surface trap states of CsPbI_(2)Br perovskite.However,most modifiers behave high volatility and insulation,not enough to further develop the CsPbI_(2)Br solar cells.Herein,an ionic liquid of 1-viny-3-propionate ethyl imidazolium chloride([PEVIM]Cl)is applied to modify the CsPbI_(2)Br film surface,yielding a compact film with enhanced crystallinity.The surface trap states of CsPbI_(2)Br film are effectively passivated via the interaction between carbonyl group of[PEVIM]Cl and uncoordinated metal cations of CsPbI_(2)Br perovskite,leading to charge recombination suppression and charge transport enhancement.Consequently,the power conversion efficiency(PCE)of[PEVIM]Cl modified CsPbI_(2)Br device is obviously enhanced from 12.49% to 14.19% with an improved open-circuit voltage of 1.160 V.Moreover,the non-encapsulated device presents excellent thermal stability,still maintaining 91%PCE when heated at 85℃ in nitrogen atmosphere for 360 h.Meanwhile,the non-encapsulated device degrades only 11% PCE after stored at 50% relative humidity for 960 h.This simple and efficient approach provides a promising direction to fabricate high-efficiency and stable inorganic perovskite devices. | Xingyu Pu Jian Han Shuangjie Wang Hui Zhou Qi Cao Jiabao Yang Ziwei He Xuanhua Li | 2021 | Journal of Materiomics2021，7，5： | 3 |
| 13 | Distribution characteristics and indicator significance of Dechloranes in multi-matrices at Ny-lesund in the Arctic显示文摘In recent years, Dechloranes have been widely detected in the environment around the world.However, understanding and knowledge of Dechloranes in remote regions, such as the Arctic,remain lacking. Therefore, the concentrations of 5 Dechloranes in surface seawater, sediment,soil, moss, and dung collected from Ny-lesund in the Arctic were measured with the concentrations 93 pg/L, 342, 325, 1.4, and 258 pg/g, respectively, which were much lower than those in Asian and European regions. The mean ratios of anti-Dechlorane Plus(DP) to total DP(fanti) in seawater, sediment, soil, moss, dung, and atmospheric samples were 0.36, 0.21, 0.18,0.27, 0.66, and 0.43, respectively. Results suggested that the main source of DP in seawater,sediment, soil, and moss was long-range atmospheric transport. However, the ratio identified in dung was different, for which the migration behavior of the organism is probably the main source of DP. | Guangshui Na Wei Wei Shiyao Zhou Hui Gao Xindong Ma Lina Qiu Linke Ge Chenguang Bao Ziwei Yao | 2015 | Journal of Environmental Sciences2015，27，2： | 3 |
| 14 | Current status of medical support in military operations other than war in domestic and overseas显示文摘Objective: To investigate the current status of medical support in military operations other than war (MOOTW) in domestic and overseas. Methods: This paper mainly adopts the descriptive, comparative and induction research methods. The current status of medical support in MOOTW in China, America, Russia, Israel, Canada, had been studied through some official papers, and series of professional books by analysis the precise date in various kinds of emergency event. Results: The contrast shows that there is still a quite huge development in medical support in MOOTW, no matter in China, or in other countries. Conclusion: In order to strengthen the forces, besides building professional rescue teams, it is necessary to take a regular revise of plans, according to missions` needs. | Huang Jian Wang Yungui Cheng Xiaobin Zhou Lin Wu Ziwei | 2012 | Journal of Medical Colleges of PLA(China)2012，27，6： | 3 |
| 15 | TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2显示文摘Endothelial activation plays an essential role in the pathogenesis of sepsis-induced acute lung injury,however,the detailed regulatory mechanisms remain largely unknown.Here,we reported that TRIM47,an E3 ubiquitin ligase of the tripartite motifcontaining protein family,was highly expressed in vascular endothelial cells.TRIM47-deficient mice were effectively resistant to lipopolysaccharide(LPS)-induced acute lung injury and death by attenuating pulmonary inflammation.TRIM47 was upregulated during TNFα-induced endothelial activation in vitro.Knockdown of TRIM47 in endothelial cells inhibited the transcription of multiple pro-inflammatory cytokines,reduced monocyte adhesion and the expression of adhesion molecules,and suppressed the secretion of IL-1βand IL-6 in endothelial cells.By contrast,overexpression of TRIM47 promoted inflammatory response and monocyte adhesion upon TNFαstimulation.In addition,TRIM47 was able to activate the NF-κB and MAPK signaling pathways during endothelial activation.Furthermore,our experiments revealed that TRIM47 resulted in endothelial activation by promoting the K63-linked ubiquitination of TRAF2,a key component of the TNFαsignaling pathway.Taken together,our studies demonstrated that TRIM47 as a novel activator of endothelial cells,promoted LPS-induced pulmonary inflammation and acute lung injury through potentiating the K63-linked ubiquitination of TRAF2,which in turn activates NF-κB and MAPK signaling pathways to trigger an inflammatory response in endothelial cells. | Yisong Qian Ziwei Wang Hongru Lin Tianhua Lei Zhou Zhou Weilu Huang Xuehan Wu Li Zuo Jie Wu Yu Liu Ling-Fang Wang Xiao-Hui Guan Ke-Yu Deng Mingui Fu Hong-Bo Xin | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 16 | Generation of Tripotent Neural Progenitor Cells from Rat Embryonic Stem Cells显示文摘老鼠是为药理学和生理的研究的一个珍贵模型。胚胎的茎(物件) 房间衬里的 Germline 能干的老鼠成功地被建立了,维持物件细胞的自我更新的、无差别的状态的分子的网络也好揭开。然而,很少对区别策略和这些真老鼠 pluripotent 干细胞怎么产生特定的房间类型的内在的机制被知道。这研究的目的是调查物件房间的神经区别能力。借助于一个修改过程基于 激活mitogen 的蛋白质 kinase ( MAPK )和肝糖 synthase kinase 的以前的出版物联合 3 ( GSK3 )禁止者(二个禁止者, 2i )与喂调节中等,我们成功地从物件房间获得了高质量的老鼠胚胎植物或动物身体(美国南北战争时南军士兵)然后区分了他们到 tripotent 神经祖先。这些物件导出房间的神经祖先房间(rNPCs ) 能够自我更新并且产生所有三个神经的系,包括的星形细胞, oligodendrocytes,和神经原。而且,这些导出房间的神经原染色了的物件为 -aminobutyric 酸(伽马氨基丁酸) 和酷氨酸 hydroxylase (TH ) 积极。在摘要,我们为区分物件房间到 tripotent 开发一个试验性的系统神经祖先,它可以为学习象 Parkinson 的疾病和老鼠神经系统的开发那样的许多 neurodegenerative 混乱的致病为药理学测试和一个珍贵平台提供一个强大的工具。 | Zhenkun Wang Chao Sheng Tianda Li Fei Teng Lisi Sang Fenglin Cao Ziwei Wang Wanwan Zhu Wei Li Xiaoyang Zhao Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，12： | 2 |
| 17 | Self-assembled 3D flower-like NaY(MoO 4 ) 2 :Eu 3+ microarchitectures: Hydrothermal synthesis, formation mechanism and luminescence properties显示文摘 | Ying Huang Liqun Zhou Lan Yang Ziwei Tang | 2010 | Optical Materials2010，，6： | 1 |
| 18 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 19 | Increased CD133^+ cell infiltration in the rat brain following fluid percussion injury显示文摘The prominin-1/CD133 epitope is expressed in undifferentiated cells. Studies have reported that craniocerebral trauma in animal models of fluid percussion injury induces production of a specific stem cell subgroup. It has been hypothesized that fluid percussion injury induces CD133+ cell infiltration in the brain tissue. The present study established a traumatic brain injury model through fluid percussion injury. Immunohistochemical staining showed significantly increased CD133 antigen expression in the rat brain following injury. CD133+ cells were mainly distributed in hippocampal CA1-3 regions, as well as the dentate gyrus and hilus, of the lesioned hemisphere. Occasional cells were also detected in the cortex. In addition, reverse transcription-PCR revealed that no change in CD133 mRNA expression in injured brain tissue. These results suggested that fluid percussion injury induced CD133 antigen expression in the brain tissues as a result of conformational epitope changes, but not transcriptional expression. | Ming Wei Ziwei Zhou Shenghui Li Chengwei Jing Dashi Zhi Jianning Zhang | 2012 | Neural Regeneration Research2012，7，4： | 1 |
| 20 | A study on the structure transformation and luminescence of Eu(Ⅲ) titanate nanotubes synthesized at various hydrothermal temperatures 显示文摘 | Tang Ziwei Zhou Liqun Yang Lan Wang Fen | 2009 | Journal of Alloys and Compounds2009，481，： | 1 |
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