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| 1 | nflammasomes in cancer: a double-edgecl sword显示文摘 | Ryan Kolb Guang-Hui Liu Ann M. Janowski Fayyaz S. Sutterwala Weizhou Zhang | 2014 | Protein & Cell2014，5，1： | 34 |
| 2 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 3 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 4 | Molecular Genetic Evidence for a Common Clonal Origin of Urinary Bladder Small Cell Carcinoma and Coexisting Urothelial Carcinoma显示文摘 | Liang Cheng Timothy D. Jones Ryan P. McCarthy John N. Eble Mingsheng Wang Gregory T. MacLennan Antonio Lopez-Beltran Ximing J. Yang Michael O. Koch Shaobo Zhang Chong-Xian Pan Lee Ann Baldridge | 2005 | The American Journal of Pathology2005，，5： | 2 |
| 5 | The Effects of Radiofrequency Energy Treatment on Chondrocytes and Matrix of Fibrillated Articular Cartilage显示文摘 | Anne Ryan Alicia L | 2003 | The American Journal of Sports Medicine2003，31，3： | 1 |
| 6 | Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning显示文摘 | Samuel Davis Thomas H Aldrich Pamela F Jones Ann Acheson Debra L Compton Vivek Jain Terence E Ryan Joanne Bruno Czeslaw Radziejewski Peter C Maisonpierre George D Yancopoulos | 1996 | Cell1996，，7： | 1 |
| 7 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Xiao-Jun Ma Zuncai Wang Paula D Ryan Steven J Isakoff Anne Barmettler Andrew Fuller Beth Muir Gayatry Mohapatra Ranelle Salunga J.Todd Tuggle Yen Tran Diem Tran Ana Tassin Paul Amon Wilson Wang Wei Wang Edward Enright Kimberly Stecker Eden Estepa-Sabal Ba | 2004 | Cancer Cell2004，，6： | 1 |
| 8 | Neoadjuvant chemotherapy with gemcitabine/cisplatin vs. methotrexate/vinblastine/doxorubicin/cisplatin for muscle-invasive urothelial carcinoma of the bladder: A retrospective analysis from the University of Southern California显示文摘 | Adrian S. Fairey Siamak Daneshmand David Quinn Tanya Dorff Ryan Dorin Gary Lieskovsky Anne Schuckman Jie Cai Gus Miranda Eila C. Skinner | 2012 | Urologic Oncology: Seminars and Original Investigations2012，，： | 1 |
| 9 | Functional Toll-like receptors in primary first-trimester trophoblasts显示文摘 | Line H. Tanger?s Guro S. St?dle Guro D. Olsen Ann-Helen Leknes Astrid S. Gundersen Bente Skei Anne Jorunn Vikdal Liv Ryan Bj?rg Steinkjer Merete F. Myklebost Mette Langaas Rigmor Austgulen Ann-Charlotte Iversen | 2014 | Journal of Reproductive Immunology2014，，： | 1 |
| 10 | MR imaging of term infants with HIE as a predictor of neurodevelopmental outcome and late MRI appearances显示文摘 | Eilish Twomey Anne Twomey Stephanie Ryan et aI | 2010 | Pediatric Radiology2010，40，9： | 1 |
| 11 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 12 | Method for the deter- mination of organophosphorus and pyrethroid pesticides in food via gas chromatography with electron-capture detection显示文摘 | Ronald E H J Anne M R Ryan P B | 2010 | J Agric Food Chem2010，58，： | 1 |
| 13 | Determinants of Changes in Linear Growth and Body Composition in Incident Pediatric Crohn’s Disease显示文摘 | Meena Thayu Lee A. Denson Justine Shults Babette S. Zemel Jon M. Burnham Robert N. Baldassano Krista M. Howard Anne Ryan Mary B. Leonard | 2010 | Gastroenterology2010，，2： | 1 |
| 14 | Multicenter Evaluation of Rectal cancer ReImaging pOst Neoadjuvant (MERRION) Therapy显示文摘 | Ann M. Hanly Elizabeth M. Ryan Ailín C. Rogers Deborah A. McNamara Robert D. Madoff Desmond C. Winter | 2014 | Annals of Surgery2014，，4： | 1 |
| 15 | Growth Abnormalities Persist in Newly Diagnosed Children With Crohn Disease Despite Current Treatment Paradigms显示文摘 | Marian Pfefferkorn Georgine Burke Anne Griffiths James Markowitz Joel Rosh David Mack Anthony Otley Subra Kugathasan Jonathan Evans Athos Bousvaros M Susan Moyer Robert Wyllie Maria Oliva-Hemker Ryan Carvalho Wallace Crandall David Keljo TD Walters Neal L | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，2： | 1 |
| 16 | From chaos to cohesionComplexity in tourism structures:An analysis of New Zealand's regional tourism organirations显示文摘 | Anne Zahra and Chris Ryan | 2007 | Tourism Management2007，28，3： | 1 |
| 17 | Improved Clinical Outcomes With Liver Transplantation for Hepatitis B-Induced Chronic Liver Failure Using Passive Immunization显示文摘 | Robert G. Sawyer Robert W. McGory Michael J. Gaffey Christopher C. McCullough Barbara L. Shephard C. Webster Houlgrave Terry S. Ryan Mary Kuhns Anne McNamara Stephen H. Caldwell Abdulmajeed Abdulkareem Timothy L. Pruett | 1998 | Annals of Surgery1998，，6： | 1 |
| 18 | MR imaging of term infants with hypoxic-ischaemic encephalopathy as a predictor of neurodevelopmental outcome and late MRI appearances显示文摘 | Eilish Twomey Anne Twomey Stephanie Ryan John Murphy Veronica B. Donoghue | 2010 | Pediatric Radiology2010，，9： | 1 |
| 19 | Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study显示文摘 | Aleksandra Gentry-Maharaj Chloe Karpinskyj Clara Glazer Matthew Burnell Andy Ryan Lindsay Fraser Anne Lanceley Ian Jacobs Myra S. Hunter Usha Menon | 2015 | Menopause2015，，4： | 1 |
| 20 | Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications显示文摘 | Paul Galvin Damien Thompson Katie B. Ryan Anna McCarthy Anne C. Moore Conor S. Burke Maya Dyson Brian D. MacCraith Yurii K. Gun’ko Michelle T. Byrne Yuri Volkov Chris Keely Enda Keehan Michael Howe Conor Duffy Ronan MacLoughlin | 2012 | Cellular and Molecular Life Sciences2012，，3： | 1 |
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