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| 1 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044sw9bx5fbnkxck6f5q.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 2 | Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates. | Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | A Hand Gesture Based Interactive Presentation System Utilizing Heterogeneous Cameras显示文摘In this paper, a real-time system that utilizes hand gestures to interactively control the presentation is proposed. The system employs a thermal camera for robust human body segmentation to handle the complex background and varying illumination posed by the projector. A fast and robust hand localization algorithm is proposed, with which the head, torso, and arm are sequentially localized. Hand trajectories are segmented and recognized as gestures for interactions. A dual-step calibration algorithm is utilized to map the interaction regions between the thermal camera and the projected contents by integrating a Web camera. Experiments show that the system has a high recognition rate for hand gestures, and corresponding interactions can be performed correctly. | Bobo Zeng Guijin Wang Xinggang Lin | 2012 | Tsinghua Science and Technology2012，17，3： | 2 |
| 4 | Development of optical-thermal coupled model for phosphor-converted LEDs显示文摘In this review, first, we discussed the effect of phosphor features on optical properties by the software simulation in detail. A combination of these parameters: phosphor material, phosphor particle size and particle distribution, phosphor layer concentration, phosphor layer thickness, geometry, and location of the phosphor layer, will result in the final optical performance of the phosphor layer. Secondly, we introduced how to improve light extraction efficiency with various proposed methods. Thirdly, we summarized the thermal models to predict the phosphor temperature and the junction temperature. To stabilize the optical performance of phosphor-converted light emitting diodes (PC-LEDs), much effort has been made to reduce the junction temperature of the LED chips. The phosphor temperature, a critical reliability concern for PC-LEDs, should be attracted academic interest. Finally, we summed up optical-thermal coupled model for phosphors and summarized future optical- thermal issues exploring the light quality for LEDs. We foresee that optical-thermal coupled model for PC-LEDs should be paid more attention in the future. | Xinglu QIAN Jun ZOU Mingming SHI Bobo YANG Yang LI Ziming WANG Yiming LIU Zizhuan LIU Fei ZHENG | 2019 | Frontiers of Optoelectronics2019，12，3： | 2 |
| 5 | Preparation of La0.67Ca0.23Sr0.1MnO3 thin films with interesting electrical and magnetic properties via pulsed-laser deposition显示文摘Manganese oxides with a perovskite-type Re_(1-x)D_xMnO_3(Re:heavy rare-earth elements,D:divalent alkali metal)structure have attracted interest because of the complex interaction between their electrons,lattices,and spins[1-5].Generally,manganese oxides with the structure Re_(1-x)D_xMnO_3 have special properties.For example,the half-metallic manganites,such as La_(2/3)Sr_(1/3)MnO_3 and La_(2/3)Ca_(1/3)MnO_3,wherein the conduction electrons are completely spin polarized。 | Shuai Xue XiaoLin Zhao JianLu Wang BoBo Tian Hai Huang CaiMin Meng Lan Liu Lei Ye JingLan Sun XiangJian Meng XiaoDong Zhang JunHao Chu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 2 |
| 6 | Optical and electrical properties of a spiral LED filament显示文摘This paper introduces a new type of spiral white light-emitting diodes(WLED) filament with high luminous efficiency and uniform optical performance. The optical and thermal properties of the flexible filament were investigated at different stretching heights, namely 0, 1, 2, and 3 cm. The results indicated that the filament showed the best optical characteristics at the stretching height of 2 cm, because of good heat dissipation. In addition, the radiation temperature of the filament was inversely proportional to the output luminous flux. The reliability of the filament at a stretching height of 2 cm was also evaluated after 1000 h of use. The result demonstrated that the luminous flux decay of the bulb was only 0.85%. The flexible spiral WLED filament exhibiting high luminous flux and good reliability could be adapted to promote industrial development in the near future. | Liping Wang Jun Zou Bobo Yang Wenbo Li Yang Li Mingming Shi Wei Zhu Canyun Zhang Fengchao Wang Yujie Lin | 2018 | Journal of Semiconductors2018，39，2： | 2 |
| 7 | Research on High Temperature and High Density White Oil Based Drilling Fluid and Its Application in Well 201H7-6显示文摘As the depth and horizontal length of shale gas development wells increase,the requirement for the temperature resistance and the ability of the drilling fluids to stabilize the shale formation becomes higher.A new type of high temperature and high density white oil based drilling fluid system has been developed in laboratory.Research shows that the drilling fluid system has good rheological property,low filtration loss,strong anti-debris pollution capability and good plugging performance at high temperature and high density.The system has been successfully applied in the 201H7-6 well.Application results show that the drilling fluid rheology,high temperature and high pressure fluid loss and demulsification voltage meet the field requirements.The drilling fluid performance is stable in drilling an 1800 m horizontal section,and no stuck or shale swelling and wellbore collapsing are induced.It is the first well drilled successfully with domestic white oil-based drilling fluid in Zigong Region.It also sets several new records including the deepest well,the shortest drilling cycle,and the fastest drilling speed in that region,which provides valuable experience for the future drilling activities. | Bobo Qin Yidi Wang Chunzhi Luo Gang Liu | 2019 | Open Journal of Yangtze Oil and Gas2019，4，3： | 2 |
| 8 | A novel coating technology for fast sealing of air leakage in underground coal mines显示文摘Air leakage in underground coal mines presents a serious hazard for coal production and the safety of miners.Coating technology is commonly used as an efficient means for preventing air leakage.To address existing problems with high dust concentrations in large operations involving complex processes and the high cost of traditional coating technology,a novel coating technology that ensures intrinsic safety by utilizing water pressure and wind pressure was developed.This new coating technology was designed to suction and spray,and the technical parameters of its spray performance was also studied.The experimental tests and evaluation indicated the optimum working range is 0.3–0.7 MPa of wind pressure,1.2–10.2 L/min of water quantity,and 1.0–3.5 m of spraying distance.Moreover,this novel coating technology was tested in the Dashuitou Coal Mine in Gansu Province of China.Compared with conventional counterparts,the proposed new technology is safe,efficient,and convenient to operate.During spraying,dust concentrations were kept at less than 10 mg/m3,and the average rebound ratio resilient rate of solid materials was below 13%.After spraying,the average leakage every 100 m was 4 m3/min,and the oxygen volume fraction in the adjacent goaf was approximately 4%,demonstrating excellent air leakage prevention. | Sihua Shao Chunlei Wu Min Hao Xiaolin Song Xueyou Su Weihan Wang Guosheng Li Bobo Shi | 2021 | International Journal of Mining Science and Technology2021，31，2： | 2 |
| 9 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
| 10 | Crowd Density Estimation Based on ELM learning Algorithm 显示文摘 | YANG Shan BAO Hong WANG Bobo | 2013 | Journal of Software2013，8，11： | 1 |
| 11 | Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers(Panthera tigris altaica)in northeast China显示文摘INTRODUCTION Pentatrichomonas hominis,an anaerobic flagellated protozoan that inhabits the large intestines of mammals and belongs to the Trichomonadidae family(Wenrich 1944;Kim et al.2010;Li et al.2014b,2016,2018a,2020;Maritz et al.2014;Zhang et al.2019),is mainly transmitted through the fecal-oral route.It was originally presumed to be a commensal protozoan(Tolbert et al.2012)but was found to cause gastrointestinal symptoms. | Hongbo ZHANG Nan ZHANG Pengtao GONG Shuqin CHENG Xiaocen WANG Xin LI Zhijun HOU Chang LIU Tianqi BI Bobo WANG Yidan CHENG Jianhua LI Xichen ZHANG | 2022 | Integrative Zoology2022，17，4： | 1 |
| 12 | Damage identification of hinged joints of prefabricated slab bridges based on transient dynamics analysis显示文摘 | ZOU Yisong YUANG Bobo WANG inhui | 2011 | Journal of Chongqing Jiaotong University: Natural Science2011，30，1： | 1 |
| 13 | Potential Antiviral Target for SARS-CoV-2:A Key Early Responsive Kinase during Viral Entry显示文摘Currently,there is no effective antiviral medication for coronavirus disease 2019(COVID-19)and the knowledge on the potential therapeutic target is in great need.Guided by a time-course transmission electron microscope(TEM)imaging,we analyzed early phosphorylation dynamics within the first 15 min during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral entry.Based on alterations in the phosphorylation events,we found that kinase activities such as protein kinase C(PKC),interleukin-1 receptor-associated kinase 4(IRAK4),MAP/microtubule affinity-regulating kinase 3(MARK3),and TANK-binding kinase 1(TBK1)were affected within 15 min of infection.Application of the corresponding kinase inhibitors of PKC,IRAK4,and p38 showed significant inhibition of SARS-CoV-2 replication.Additionally,proinflammatory cytokine production was reduced by applying PKC and p38 inhibitors.By an acquisition of a combined image data using positiveand negative-sense RNA probes,as well as pseudovirus entry assay,we demonstrated that PKC contributed to viral entry into the host cell,and therefore,could be a potential COVID-19 therapeutic target. | Siwen Liu Lin Zhu Guangshan Xie Bobo Wing-Yee Mok Zhu Yang Shaofeng Deng Siu-Ying Lau Pin Chen Pui Wang Honglin Chen Zongwei Cai | 2022 | CCS Chemistry2022，4，1： | 1 |
| 14 | Crowd density esti- mation based on texture feature extraction显示文摘 | WANG Bobo BAO Hong YANG Shan | 2013 | Journal of Muhime- dia2013，8，4： | 1 |
| 15 | Crowd Density Estimation Based on Texture Feature Extraction显示文摘 | Wang Bobo Bao Hong Yang Shan | 2013 | Journal of Multimedia2013，8，4： | 1 |
| 16 | In situ XRD and electrochemical investigation on a new intercalation-type anode for high-rate lithium ion capacitor显示文摘A new intercalation-type anode material is reported herein to improve the lithium storage kinetics for high-rate lithium ion capacitors.The crystal structure of orthorhombic NaNbO3 indicates two possible tunnels for lithium ions insertion into NaNbO3 host along the<101>and<141>directions.Moreover,in situ XRD is conducted to investigate the lithium storage mechanism and structural evolution of the NaNb O_(3) anode,demonstrating its intercalation behavior through(101)and(141)planes.Furthermore,the rGO nanosheets are introduced to facilitate the charge transfer,which also effectively prevent the aggregation of NaNbO3 nanocubes.As expected,the NaNbO_(3)/rGO nanocomposites possess remarkable reversible capacity(465 mA h g^(-1) at 0.1 A g^(-1)),superior rate capability(325 mA h g^(-1) at 1.0 A g^(-1))and cycling stability,attributed to their synergistic effect and high Li+diffusion coefficient DLi[D(NaNbO_(3)/rGO)/D(NaNbO_(3))≈31.54].Remarkably,the NaNbO3/rGO-based LIC delivers a high energy density of 166.7 W h kg^(-1) at 112.4 W kg^(-1) and remains 24.1 W h kg^(-1) at an ultrahigh power density of26621.2 W kg^(-1),with an outstanding cycling durability(90%retention over 3000 cycles at 1.0 A g^(-1)).This study provides new insights on novel intercalation-type anode material to enrich the materials system of LICs. | Bobo Zou Ting Wang Shengyuan Li Rong Kang Guochun Li Sherif AEl-Khodary Dickon HLNg Xianhu Liu Jingxia Qiu Yan Zhao Jiabiao Lian Huaming Li | 2021 | Journal of Energy Chemistry2021，30，6： | 1 |
| 17 | Enhanced production of pigments by addition of surfactants in submerged fermentation of Monascus purpureus H1102显示文摘 | Yonghui Wang Bobo Zhang Liping Lu | 2013 | J Sci Food Agric2013，93，： | 1 |
| 18 | Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants显示文摘SARS-CoV-2 continues to threaten human society by generating novel variants via mutation and recombination.The high number of mutations that appeared in emerging variants not only enhanced their immune-escaping ability but also made it difficult to predict the pathogenicity and virulence based on viral nucleotide sequences.Molecular markers for evaluating the pathogenicity of new variants are therefore needed.By comparing host responses to wild-type and variants with attenuated pathogenicity at proteome and metabolome levels,six key molecules on the polyamine biosynthesis pathway including putrescine,SAM,dc-SAM,ODC1,SAMS,and SAMDC were found to be differentially upregulated and associated with pathogenicity of variants.To validate our discovery,human airway organoids were subsequently used which recapitulates SARS-CoV-2 replication in the airway epithelial cells of COVID-19 patients.Using ODC1 as a proof-ofconcept,differential activation of polyamine biosynthesis was found to be modulated by the renin-angiotensin system(RAS)and positively associated with ACE2 activity.Further experiments demonstrated that ODC1 expression could be differentially activated upon a panel of SARS-CoV-2 variants of concern(VOCs)and was found to be correlated with each VOCs’pathogenic properties.Particularly,the presented study revealed the discriminative ability of key molecules on polyamine biosynthesis as a predictive marker for virulence evaluation and assessment of SARS-CoV-2 variants in cell or organoid models.Our work,therefore,presented a practical strategy that could be potentially applied as an evaluation tool for the pathogenicity of current and emerging SARS-CoV-2 variants. | Guangshan Xie Lin Zhu Siwen Liu Cun Li Xin Diao Yanhao Zhang Xiuli Su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan Jin Jie Zhou Honglin Chen Zongwei Cai | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 19 | Freestanding metal nanohole array for high-performance applications显示文摘Plasmonic devices using periodic metallic nanostructures have recently gained tremendous interest for color filters,sensing,surface enhanced spectroscopy,and enhanced photoluminescence,etc.However,the performance of such plasmonic devices is severely hampered by the solid substrates supporting the metallic nanostructures.Here,a strategy for freestanding metallic nanomembranes is introduced by taking advantages of hollow substrate structures.Large-area and highly uniform gold nanomembranes with nanohole array are fabricated via a flexible and simple replication-releasing method.The hollow structures include a hollow core fiber with 30μm core diameter and two ferrules with their hole diameter as 125 and 500μm,respectively.As a proof-of-concept demonstration,2 times higher sensitivity of the bulk refractive index is obtained with this platform compared to that of a counterpart on a solid silica substrate.Such a portable and compact configuration provides unique opportunities to explore the intrinsic properties of the metal nanomembranes and paves a new way to fabricate high-performance plasmonic devices for biomolecule sensing and color filter. | Bobo Du Yinlan Ruan Dexing Yang Peipei Jia Shoufei Gao Yingying Wang Pu Wang Heike Ebendorff-Heidepriem | 2020 | Photonics Research2020，8，11： | 0 |
| 20 | Study on the mechanism of color coordinate shift of LED package显示文摘In the paper, the influences of the chip, silicone and phosphors on the color coordinate shift of LED were studied. In the process of LED baking, it was found that the effect of the chip and silicone on the color coordinate drift is less than 3% through the analysis of each influencing factor. But the influence of the phosphors is large and accounted for 11.11% of the overall impact factors. Therefore, it is important to select the better green phosphors in thermal stability for the LED package and it has a guiding significance to the color coordinate of LED distribution. | Yunyi Zhuang Yong Wang Bobo Yang Zhanguo Li Lei Yang Jun Zou | 2017 | Journal of Semiconductors2017，38，7： | 0 |
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