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| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 3 | Global nitrogen input on wetland ecosystem:The driving mechanism of soil labile carbon and nitrogen on greenhouse gas emissions显示文摘Greenhouse gas emissions from wetlands are significantly promoted by global nitrogen input for changing the rate of soil carbon and nitrogen cycling,and are substantially affected by soil labile carbon and nitrogen conversely.However,the driving mechanism by which soil labile carbon and nitrogen affect greenhouse gas emissions from wetland ecosystems under global nitrogen input is not well understood.Working out the driving factor of nitrogen input on greenhouse gas emissions from wetlands is critical to reducing global warming from nitrogen input.Thus,we synthesized 72 published studies(2144 paired observations)of greenhouse gas fluxes and soil labile compounds of carbon and nitrogen(ammonium,nitrate,dissolved organic carbon,soil microbial biomass nitrogen and carbon),to understand the effects of labile carbon and nitrogen on greenhouse gas emissions under global nitrogen input.Across the data set,nitrogen input significantly promoted carbon dioxide,methane and nitrous oxide emissions from wetlands.In particular,at lower nitrogen rates(<100 kg ha^(-1)$·yr^(-1))and with added ammonium compounds,freshwater wetland significantly promoted carbon dioxide and methane emissions.Peatland was the largest nitrous oxide source under these conditions.This meta-analysis also revealed that nitrogen input stimulated dissolved organic carbon,ammonium,nitrate,microbial biomass carbon and microbial biomass nitrogen accumulation in the wetland ecosystem.The variation-partitioning analysis and structural equation model were used to analyze the relationship between the greenhouse gas and labile carbon and nitrogen further.These results revealed that dissolved organic carbon(DOC)is the primary factor driving greenhouse gas emission from wetlands under global nitrogen input,whereas microbial biomass carbon(MBC)more directly affects greenhouse gas emission than other labile carbon and nitrogen. | Mengli Chen Lian Chang Junmao Zhang Fucheng Guo Jan Vymazal Qiang He Yi Chen | 2020 | Environmental Science and Ecotechnology2020，，4： | 2 |
| 4 | TGA study on humidified activation and desufurization performance of high-CaO coal ash at low temperature显示文摘 | Yu Juan Zhang Mingchuan Chen Mengli | 2001 | Ind Eng Chen Res2001，40，： | 1 |
| 5 | Characterization of a Tn MAVS protein from Tetraodon nigroviridis显示文摘 | Zhiming Xiang Lin Qi Weijian Chen Chuanfu Dong Zhaoyu Liu Dong Liu Mengli Huang Wei Li Gan Yang Shaoping Weng Jianguo He | 2011 | Developmental and Comparative Immunology2011，，11： | 1 |
| 6 | Efficient Catalytic Conversion of Polysulfides by Biomimetic Design of “Branch‑Leaf” Electrode for High‑Energy Sodium–Sulfur Batteries显示文摘Rechargeable room temperature sodium–sulfur(RT Na–S)batteries are seriously limited by low sulfur utilization and sluggish electrochemical reaction activity of polysulfide intermediates.Herein,a 3D“branch-leaf”biomimetic design proposed for high performance Na–S batteries,where the leaves constructed from Co nanoparticles on carbon nanofibers(CNF)are fully to expose the active sites of Co.The CNF network acts as conductive“branches”to ensure adequate electron and electrolyte supply for the Co leaves.As an effective electrocatalytic battery system,the 3D“branch-leaf”conductive network with abundant active sites and voids can effectively trap polysulfides and provide plentiful electron/ions pathways for electrochemical reaction.DFT calculation reveals that the Co nanoparticles can induce the formation of a unique Co–S–Na molecular layer on the Co surface,which can enable a fast reduction reaction of the polysulfides.Therefore,the prepared“branch-leaf”CNF-L@Co/S electrode exhibits a high initial specific capacity of 1201 mAh g^−1 at 0.1 C and superior rate performance. | Wenyan Du Kangqi Shen Yuruo Qi Wei Gao Mengli Tao Guangyuan Du Shu‑juan Bao Mingyang Chen Yuming Chen Maowen Xu | 2021 | Nano-Micro Letters2021，13，3： | 1 |
| 7 | TGA study on humidified activation and desulfurization performance of high-CaO coal ash at low temperature 显示文摘 | YU Juan ZHANG Mingchuan CHEN Mengli | 2001 | Industrial & Engineering Chemistry Research2001，40，16： | 1 |
| 8 | Effect of pH on biologic degradation of Microcystis aeruginosa by alga-lysing bacteria in sequencing batch biofilm reactors显示文摘In this paper, the effect of pH on biological degradation of Microcystis aeruginosa by alga-lysing bacteria in laboratory-scale sequencing batch biofilm reactors (SBBRs) was investigated. After 10 d filming with waste activated sludge, the biological film could be formed, and the bioreactors in which laid polyolefin resin filler were used to treat algal culture. By comparing the removal efficiency of chlorophyll a at different aerobic time, the optimum time was determined as 5 h. Under pH 6.5, 7.5, and 8.5 conditions, the removal rates of Microcystis aeruginosa were respectively 75.9%, 83.6%, and 78.3% (in term of chlorophyll a), and that of Chemical Oxygen Demand (CODMn) were 30.6%, 35.8%, and 33.5%. While the removal efficiencies of ammonia nitrogen (NH+ -N) were all 100%. It was observed that the sequence of the removal efficiencies of algae, NH+ -N and organic matter were pH 7.5 〉 pH 8.5 〉 pH 6.5. The results showed that the dominant alga-lysing bacteria in the SBBRs was strain HM-01, which was identified as Bacillus sp. by Polymerase Chain Reaction (PCR) amplification of the 16S rRNA gene, Basic Local Alignment Search Tool (BLAST) analysis, and compar- ison with sequences in the GenBank nucleotide database. The algicidal activated substance which HM-01 strain excreted could withstand high temperature and pressure, also had better hydrophily and stronger polarity. | Hongjing LI Mengli HAO Jingxian LIU Chen CHEN Zhengqiu FAN Xiangrong WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，2： | 1 |
| 9 | Emissive Mononuclear Cu(Ⅰ) Triphenylphosphine Complexes with Functionalized 6-tert-Butoxycarbonyl-2,2 '-bipyridine显示文摘 | LUO Yansheng ZENG Xuehua WANG Wanman CHEN Jinglin HE Lihua ZHANG Mengli LIU Suijun WEN Herui | 2018 | Chemical Research in Chinese Universities2018，34，1： | 0 |
| 10 | A“Catalyst+Support”Strategy for Salicylaldimine Nickel Catalyzed Ethylene Polymerization and Copolymerization with Polar Monomers显示文摘Polyolefins,as one of the most productive synthetic polymer materials,have been widely used in industry and daily life[1-2].However,due to their'non-polar'nature,polyolefins have poor compatibility and adhesion to polar materials,limiting their application in many fields[3-5]. | WANG Zihao YANG Lei XU Mengli TAN Chen CHEN Changle | 2023 | Chemical Research in Chinese Universities2023，39，5： | 0 |
| 11 | A Empirical Study on Impact Factors of Employee's Knowledge Capital in Supply Chain: Social NetworkPerspective显示文摘 | Chen Limin Ma Mengli Sun Lixin | 2014 | International Journal of Technology Management2014，，7： | 0 |
| 12 | Effect of wetland plant fermentation broth on nitrogen removal and bioenergy generation in constructed wetland-microbial fuel cells显示文摘Constructed wetlands(CWs)are widely used as a tertiary treatment technology,and the addition of carbon sources can significantly improve advanced nitrogen removal.However,excessive carbon sources would lead to an increase in the effluent chemical oxygen demand in CWs,and microbial fuel cells(MFCs)can convert these into electricity.In this study,constructed wetland-microbial fuel cells(CW-MFCs)were built to achieve simultaneous nitrogen removal and electricity generation,using wetland plant litter fermentation broths as carbon sources.The total nitrogen removal in the groups with fermentation broth addition(FGs)reached 83.33%,which was 19.64%higher than that in the CG(group without fermentation broth),and the mean voltages in the FGs were at least 2.6 times higher than that of the CG.Furthermore,two main components of the fermentation broths,acetic acid(Ac)and humic acid(HA),were identified using a three-dimensional excitation emission matrix and gas chromatograph and added to CW-MFCs to explore the influence mechanism on the treatment performance.Denitrification and electrogenesis presented the same tendency:Ac&HA>Ac>CG’(groups without Ac and HA).These results indicate that Ac and HA increased the abundance of functional genes associated with nitrogen metabolism and electron transfer.This study demonstrated that CW-MFC fermentation broth addition can be a potential strategy for the disposal of secondary effluent and bioelectricity generation. | Yiting Chen Jun Yan Mengli Chen Fucheng Guo Tao Liu Yi Chen | 2022 | Frontiers of Environmental Science & Engineering2022，16，12： | 0 |
| 13 | Heterogeneousα-Diimine Nickel Catalysts with Improved Catalytic Performance in Ethylene Polymerization显示文摘Heterogenization can improve the thermal tolerance of olefin polymerization catalysts and result in good product morphology con-trol,which are two important parameters for industrial polyethylene production.In this work,α-diimine nickel catalysts bearing-OH or-ONa anchoring groups were designed and prepared.The anchoring groups can enable facile heterogenization of the cata-lysts on silica.The heterogeneous catalysts demonstrated enhanced thermal stabilities,along with high catalytic activity at 120℃(up to 5.5×10^(6)g·PE·mol·Ni^(-1)·h^(-1)).Furthermore,the heterogenization process results in the improvements of many other parame-ters,including polymer morphology control,catalytic activity(up to 1.9×10^(7)g·PE·mol·Ni^(-1)·h^(-1))and polyethylene molecular weight(Mn up to 2.3×10^(6)g·mol^(-1)).More importantly,the structure and properties of the polymer products can be controlled by catalyst structures,polymerization conditions and heterogenization to achieve good mechanical properties and elasticity. | Zhanshan Ma Mengli Xu Ningning Zhu Chen Tan Changle Chen | 2023 | Chinese Journal of Chemistry2023，41，10： | 0 |
| 14 | Current diagnostic and therapeutic strategies for COVID-19显示文摘The outbreak and spread of novel coronavirus disease 2019(COVID-19) with pandemic features, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), have greatly threatened global public health. Given the perniciousness of COVID-19 pandemic, acquiring a deeper understanding of this viral illness is critical for the development of new vaccines and therapeutic options. In this review, we introduce the systematic evolution of coronaviruses and the structural characteristics of SARS-CoV-2. We also summarize the current diagnostic tools and therapeutic strategies for COVID-19. | Binbin Chen Mengli Liu Chengzhi Huang | 2021 | Journal of Pharmaceutical Analysis2021，11，2： | 0 |
| 15 | Antifungal Activity of Schinifoline Against Candida Albicans in Caenorhabditis Elegans显示文摘Zanthoxylum schinifolium has been used as spices and traditional medicine in China for hundreds of years.A variety of active substances have been isolated from Zanthoxylum schinifolium using biological and chemical techniques.Among these substances,the effect of schinifoline has gradually attracted much attention.Candida albicans is one of the most common pathogens isolated from the gastrointestinal tract,vagina,and mouth in healthy individuals.In a healthy population,there are various mechanisms in host,such as the microbial flora,the epithelial barriers,and the innate immune system,that can control the presence of Candida albicans.However,when host immunity is compromised,an invasive fungal infection is more likely to occur.In this study,we explored the antifungal activity of schinifoline against Candida albicans in Caenorhabditis elegans.To determine the optimal concentration of schinifoline,we investigated the lifespan,defecation cycle and locomotion behavior of Caenorhabditis elegans after treatment with schinifoline.In addition,we examined colony formation in the intestine of Caenorhabditis elegans after Candida albicans infection.The results indicated that 100 and 200 mg/L of schinifoline could prolonged the lifespan,shorten the defecation cycle and increased the locomotion behavior of Caenorhabditis elegans,with 100 mg/L of schinifoline being the optimal concentration.Moreover,100 mg/L of schinifoline increased the lifespan of Caenorhabditis elegans after infection and inhibited the colony formation of Candida albicans in Caenorhabditis elegans intestine.Therefore,we concluded that schinifoline exhibits anti-fungal effects and its potential use as natural drugs should be further explored in future studies. | Chengjie Shu Mengli Zhang Weiming Zhang Shihong Ma Guoqing Chen Baojun Shi | 2019 | Phyton-International Journal of Experimental Botany2019，88，3： | 0 |
| 16 | Predicting Illness Severity and Short-Term Outcomes of COVID-19:A Retrospective Cohort Study in China显示文摘Introduction COVID-19,caused by SARS-CoV-2,is a highly contagious disease.1 By April 8,2020,more than 1,350,000 patients were diagnosed with COVID-19 globally,with more than 79,000 deaths worldwide attributable to the disease.2 Recent clinical data reported that mild and critical patients manifested different symptoms.Most of the mild patients with COVID-19 had symptoms such as fever,cough,and mild pneumonia,whereas the critical cases presented dyspnea,respiratory failure,sepsis,organ dysfunction,and even eventual death. | Chuming Chen Haihui Wang Zhichao Liang Ling Peng Fang Zhao Liuqing Yang Mengli Cao Weibo Wu Xiao Jiang Peiyan Zhang Yinfeng Li Li Chen Shiyan Feng Jianming Li Lingxiang Meng Huishan Wu Fuxiang Wang Quanying Liu Yingxia Liu | 2020 | The Innovation2020，1，1： | 0 |
| 17 | Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy显示文摘Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment strategy.However,most of the reported cascade catalytic systems are designed based on symmetric-or co-assembly of multiple catalytic active sites,in which their functions are difficult to perform independently and may interfere with each other.Especially in cascade catalytic system that involves fragile natural-enzymes,the strong oxidation of free-radicals toward natural-enzymes should be carefully considered,and the spatial distribution of the multiple catalytic active sites should be carefully organized to avoid the degradation of the enzyme catalytic activity.Herein,a spatially-asymmetric cascade nanocatalyst is developed for enhanced CDT,which is composed by a Fe_(3)O_(4)head and a closely connected mesoporous silica nanorod immobilized with glucose oxidase(mSiO_(2)-GOx).The mSiO_(2)-GOx subunit could effectively deplete glucose in tumor cells,and meanwhile produce a considerable amount of H_(2)O_(2)for subsequent Fenton reaction under the catalysis of Fe_(3)O_(4)subunit in the tumor microenvironment.Taking the advantage of the spatial isolation of mSiO_(2)-GOx and Fe_(3)O_(4)subunits,the catalysis of GOx and freeradicals generation occur at different domains of the asymmetric nanocomposite,minimizing the strong oxidation of free-radicals toward the activity of GOx at the other side.In addition,direct exposure of Fe_(3)O_(4)subunit without any shelter could further enhance the strong oxidation of free-radicals toward objectives.So,compared with traditional core@shell structure,the long-term stability and efficiency of the asymmetric cascade catalytic for CDT is greatly increased by 138%,thus realizing improved cancer cell killing and tumor restrain efficiency. | Minchao Liu Hongyue Yu Liang Chen Tiancong Zhao Meng Fang Mengli Liu Qiaoyu Zhou Fatemah Farraj AlHarbi Ahmed Mohamed El-Toni Fan Zhang Dongyuan Zhao Xiaomin Li | 2023 | Nano Research2023，16，7： | 0 |
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