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| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | Metal-organic framework-derived CoSn/NC nanocubes as absorbers for electromagnetic wave attenuation显示文摘Metal-organic framework-derived composites have been widely used in electromagnetic wave(EMW)absorption,but the traditional synthetic strategy greatly limits the structure and species of MOFs.This research provided a solvent-free method to synthesize Co-MOF and its derivatives.Using CoSnO_(3)as the precursor,the preparation of Co-MOF is achieved by bridging the cobalt(II)ion of CoSnO_(3)and the 2-methylimidazole skeleton.The CoSn/N-doped carbon(CoSn/NC)composites derived from CoSnO_(3)-MOF(Co-MOF with CoSnO_(3)as Co source)retain the original morphology of CoSnO_(3).Besides,the polarization effect produced by the N-doped carbon layers also benefits the excellent EMW absorption performance of the CoSn/NC composites.It is reflected in the minimum reflection loss(RL)of-48.2 dB at 2.2 mm and the effective bandwidth(EBA)of 5.84 GHz.This work provides a new channel to the construction of Co-MOFs,which could be extended to other Co-based oxides and vastly expand the species of MOFs based on metallic Co. | Chenxi Wang Zirui Jia Shuangqiao He Jixi Zhou Shuo Zhang Mengli Tian Bingbing Wang Guanglei Wu | 2022 | Journal of Materials Science & Technology2022，，13： | 4 |
| 4 | In vitro comparison of the hemocompatibility of diamond-like carbon and carbon nitride coatings with different atomic percentages of N显示文摘Carbon nitride (CNx) and diamond-like carbon (DLC) coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of nitrogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.12, the CN0.22 coating showed longer dynamic clotting time (about 42 min), static clotting time (23.6 min) and recalcification time (45.6 s), as well as lower platelet adhesion (102 cells μm 2), aggregation, and activation. The presence of nitrogen in the CNx coatings induced their enhanced hemocompatibility compared with DLC. | ZHAO MengLi LI DeJun ZHANG YiTeng GUO MeiXian DENG XiangYun GU HanQing WAN RongXin | 2012 | Science China(Life Sciences)2012，55，4： | 3 |
| 5 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 6 | Global nitrogen input on wetland ecosystem:The driving mechanism of soil labile carbon and nitrogen on greenhouse gas emissions显示文摘Greenhouse gas emissions from wetlands are significantly promoted by global nitrogen input for changing the rate of soil carbon and nitrogen cycling,and are substantially affected by soil labile carbon and nitrogen conversely.However,the driving mechanism by which soil labile carbon and nitrogen affect greenhouse gas emissions from wetland ecosystems under global nitrogen input is not well understood.Working out the driving factor of nitrogen input on greenhouse gas emissions from wetlands is critical to reducing global warming from nitrogen input.Thus,we synthesized 72 published studies(2144 paired observations)of greenhouse gas fluxes and soil labile compounds of carbon and nitrogen(ammonium,nitrate,dissolved organic carbon,soil microbial biomass nitrogen and carbon),to understand the effects of labile carbon and nitrogen on greenhouse gas emissions under global nitrogen input.Across the data set,nitrogen input significantly promoted carbon dioxide,methane and nitrous oxide emissions from wetlands.In particular,at lower nitrogen rates(<100 kg ha^(-1)$·yr^(-1))and with added ammonium compounds,freshwater wetland significantly promoted carbon dioxide and methane emissions.Peatland was the largest nitrous oxide source under these conditions.This meta-analysis also revealed that nitrogen input stimulated dissolved organic carbon,ammonium,nitrate,microbial biomass carbon and microbial biomass nitrogen accumulation in the wetland ecosystem.The variation-partitioning analysis and structural equation model were used to analyze the relationship between the greenhouse gas and labile carbon and nitrogen further.These results revealed that dissolved organic carbon(DOC)is the primary factor driving greenhouse gas emission from wetlands under global nitrogen input,whereas microbial biomass carbon(MBC)more directly affects greenhouse gas emission than other labile carbon and nitrogen. | Mengli Chen Lian Chang Junmao Zhang Fucheng Guo Jan Vymazal Qiang He Yi Chen | 2020 | Environmental Science and Ecotechnology2020，，4： | 2 |
| 7 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 8 | A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement显示文摘Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease resistance.The mining of favorable genes from D.villosum is frustrated by the lack of a whole genome sequence.In this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for D.villosum.The assembly contains39727 high-confidence genes,and 85.31% of the sequences are repetitive.Two reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in D.villosum.The prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly expanded.RNA sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum f.sp tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in D.villosum than in Triticum urartu.MNase hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene NLR1-V.Each site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in D.villosum,and MHS1.1 was more inducible in D.villosum than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant defense.In summary,this study provides a valuable genome resource for functional genomics studies and wheat-D.villosum introgression breeding.The identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat. | Xu Zhang Haiyan Wang Haojie Sun Yingbo Li Yilong Feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang | 2023 | Molecular Plant2023，16，2： | 1 |
| 9 | Realizing a“solid to solid”process via in situ cathode electrolyte interface(CEI)by solvent-in-salt electrolyte for Li-S batteries显示文摘Lithium-sulfur batteries(LSBs)are regarded as the most promising next-generation energy system due to their high theoretical energy density.However,LSBs suffer the“shuttle effect”if undergoing the solid-liquid-solid sulfur conversion process during cycling.Herein,we design a solvent-in-salt(SIS)electrolyte with co-solvent vinylene carbonate(VC)to synthesize an in situ dense cathode electrolyte interface(CEI)and successfully change sulfur conversion into a solid-solid way to avoid shuttle effect by separating the contact of sulfur and ether solvent.Dense CEI is formed at the beginning of first discharge by the combined action of SIS electrolyte and filmogen VC.Experiments and simulations show that SIS electrolyte controls the initial formed lithium polysulfides(LiPSs)to stay very closely on the cathode surface,and then converts them into a dense CEI film.As a result,Coulombic efficiency(above 99%)and cycling performance of LSBs are improved.Furthermore,the in situ dense CEI can nearly stop the self-discharge of LSBs,and enable the LSBs to work under a pretty lean electrolyte condition. | Jiajun Huang Mengli Tao Weifeng Zhang Guangli Zheng Li Du Zhiming Cui Xiujun Wang Zhenxing Liang Shijun Liao Huiyu Song | 2023 | Nano Research2023，16，4： | 1 |
| 10 | Early warning of coal dynamic disaster by precursor of AE and EMR'quiet period'显示文摘Efcient and accurate monitoring and early warning of coal dynamic disaster and other disasters can provide guarantee for the efcient operation of mine transportation system.However,the traditional threshold early warning method often fails to warning some accidents.To address above issues,a new early warning method was proposed based on'quiet period'phenomenon of AE and EMR during fracture.It is found that,a'quiet period'of AE and EMR was present before the load reaches the peak stress,which could be used as one of the precursors to warn the imminent failure of coal and rock specimens.MS and AE signals increased abnormally followed by the phenomenon of'quiet period'before the occurrence of coal dynamic disaster on site,and the decrease of MS events in the'quiet period'is about 57%–88%compared with that in previous abnormal increase stage.During the damage evolution of coal and rock,'quiet period'phenomenon usually occurred at 85%–90%of the peak stress,where the slope of damage parameter curve is almost zero.The'quiet period'of the AE-EMR signals and the low change rate of damage parameter before failure provide a theoretical foundation for the coal dynamic disaster warning based on the'quiet period'precursor found in MS-AE-EMR monitoring system.These fndings will help reduce the number of under-reported events and improve early warning accuracy. | Shengquan He Mengli Qin Liming Qiu Dazhao Song Xiufeng Zhang | 2022 | International Journal of Coal Science & Technology2022，9，3： | 1 |
| 11 | Preparation of Gallic Acid-chitosan Copolymer and Its Antibacterial Activity against Staphylococcus Aureus and Escherichia Coli显示文摘To synthesize three different grafting ratios of gallic acid(GA)-chitosan(CS)copolymer by a free radical mediated grafting method,which is further applied to the field of antibacterial materials,crosslinking structures of the compound GA-CS copolymer were characterized,fully indicating that gallic acid is resoundingly grafted onto chitosan.The grafting ratios of three copolymers GA-CS are 45.71%(Ⅰ),36.12%(Ⅱ),and 18.96%(Ⅲ)were determined by UV-Vis spectrophotometer.The minimum inhibitory concentrations of three GA-CS copolymers are 30μg/mL against Escherichia coli and are ranged from 250 to 550μg/mL against Staphylococcus aureus.By counting viable bacterial colonies,it can be found that antibacterial property is preferable by increasing the grafting ratio of GA-CS copolymers.Findings of investigation on aforementioned bacteria experiment indicate that the CFU/mL values of GA-CS(Ⅰ,Ⅱ,Ⅲ)are 2.04×10^(6),7.56×10^(6),1.48×10^(7) to Staphylococcus aureus,and 2.96×10^(6),1.01×10^(7),2.14×10^(7) to Escherichia coli after 12 h treatment.In addition,the interaction process between GA-CS copolymer and bacteria can be observed through a transmission electron microscope.The specific manifestation is that the bacterial cell membranes are ruptured after being treated with the copolymer,which causes the cell contents to flow out,and the cell morphology is shrunk and out ofshape. | 颜春潮 肖锋 QIU Tong ZHANG Xueqiong ZHAN Siwen LU Mengli 杨梦佳 张娟 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，6： | 1 |
| 12 | TGA study on humidified activation and desufurization performance of high-CaO coal ash at low temperature显示文摘 | Yu Juan Zhang Mingchuan Chen Mengli | 2001 | Ind Eng Chen Res2001，40，： | 1 |
| 13 | Thermocline Model for Estimating Argo Sea Surface Temperature Thermocline Model for Estimating Argo Sea Surface Temperature显示文摘Argo has become an important constituent of the global ocean observation system.However,due to the lack of sea surface measurements from most Argo profiles,the application of Argo data is still limited.In this study,a thermocline model was constructed based on three key thermocline parameters,i.e,thermocline upper depth,the thermocline bottom depth,and thermocline temperature gradient.Following the model,we estimated the sea surface temperature of Argo profiles by providing the relationship between sea surface and subsurface temperature.We tested the effectiveness of our proposed model using statistical analysis and by comparing the sea surface temperature with the results obtained from traditional methods and in situ observations in the Pacific Ocean.The root mean square errors of results obtained from thermocline model were found to be significantly reduced compared to the extrapolation results and satellite retrieved temperature results.The correlation coefficient between the estimation result and in situ observation was 0.967.Argo surface temperature,estimated by the thermocline model,has been theoretically proved to be reliable.Thus,our model generates theoretically feasible data present the mesoscale phenomenon in more detail.Overall,this study compensates for the lack surface observation of Argo,and provides a new tool to establish complete Argo data sets. | Chunling Zhang Mengli Zhang Zhenfeng Wang Song Hu Danyang Wang Shenglong Yang | 2022 | Sustainable Marine Structures2022，4，1： | 1 |
| 14 | TGA study on humidified activation and desulfurization performance of high-CaO coal ash at low temperature 显示文摘 | YU Juan ZHANG Mingchuan CHEN Mengli | 2001 | Industrial & Engineering Chemistry Research2001，40，16： | 1 |
| 15 | Soft-to-hard templating 到经由一个壶碳 / 硅石来源 copolymerization 的分散得好的做 N 的 mesoporous 碳 nanospheres显示文摘这里,我们报导一条新途径为很好驱散的做 N 的 mesoporous 碳 nanospheres (MCN ) 的合成经由碳来源(多巴胺) 和硅石来源(tetraethyl orthosilicate ) 的 copolymerization 作为 soft-to-hard templating 策略参考了,它为电气化学的 supercapacitor 展出高效。这个方法分别地克服不受管束的 dispersity 和软模板或难模板的方法的复杂过程的缺点。而且,综合 MCN 特征在一个壶合成期间由高贵金属的 nanoparticles 充实 heteroatom 做 N 和容易的 functionalization。所有上述字符在许多应用程序使同样准备的 MCN 成为一个有希望的平台。表明综合做氮的 MCN 的适用性,这材料为高效的电气化学的 supercapacitor 作为一个电极被采用了,它显示出 223 和 140 的一个电容 ? 在 0.5 和 10 的当前的密度的 F/g ? 在 1 的 A/g ? mol/L KOH 电解质分别地。 | Qinglu Kong Lingxia Zhang Min Wang Mengli Li Heliang Yao Jianlin Shi | 2016 | Science Bulletin2016，61，15： | 1 |
| 16 | Highly stable hybrid single-micelle:A universal nanocarrier for hydrophobic bioimaging agents显示文摘As the first-line technology,micelles play a pivotal role in in vivo delivery of theranostic agents because of their high biocompatibility and universality.However,in complex physiological environments(extreme dilution,pH,and oxidation or reduction,etc.),they generally suffer from structural instability and insufficient protection for encapsulated cargos.It is urgent to reinforce the structural stability of the micelles at the single-micelle level.By using the FDA-approved Pluronic F127 surfactants and indocyanine green(ICG)bioimaging agents as model,herein,we propose the silane-crosslinking assisted strategy to reinforce the structural stability of the single-micelle.Different from the traditional silane hydrolysis under the harsh experimental conditions(acidic,alkaline,and high temperature hydrothermal,etc.),the ICG loaded F127@SiO_(2) hybrid single-micelles(ICG@H-micelles)with controllable sizes(15-35 nm)are synthesized at neutral pH and room temperature,which is crucial for the maintenance of the physicochemical properties of the encapsulated cargos.With the ultra-thin SiO_(2)(<5 nm)at hydrophilic layer of the single-micelle,the structural and fluorescence stability of ICG@H-micelles are much higher than the conventional micelle(ICG@micelles)in the simulated physiological environments of dilution,oxidation or reduction,and low pH.Because of the high structural and fluorescence stability,the ICG@H-micelles also exhibit longer duration time in the tumor and gastrointestinal tract bioimaging. | Qiaoyu Zhou Tiancong Zhao Mengli Liu Dongrui Yin Minchao Liu Ahmed AElzatahry Fan Zhang Dongyuan Zhao Xiaomin Li | 2022 | Nano Research2022，15，5： | 1 |
| 17 | Emissive Mononuclear Cu(Ⅰ) Triphenylphosphine Complexes with Functionalized 6-tert-Butoxycarbonyl-2,2 '-bipyridine显示文摘 | LUO Yansheng ZENG Xuehua WANG Wanman CHEN Jinglin HE Lihua ZHANG Mengli LIU Suijun WEN Herui | 2018 | Chemical Research in Chinese Universities2018，34，1： | 0 |
| 18 | Growth substrates alter aboveground plant microbial and metabolic properties thereby influencing insect herbivore performance显示文摘The gut microbiome of plant-eaters is affected by the food they eat,but it is currently unclear how the plant metabolome and microbiome are influenced by the substrate the plant grows in and how this subsequently impacts the feeding behavior and gut microbiomes of insect herbivores.Here,we use Plutella xylostella caterpillars and show that the larvae prefer leaves of cabbage plants growing in a vermiculite substrate to those from plants growing in conventional soil systems.From a plant metabolomics analysis,we identified 20 plant metabolites that were related to caterpillar feeding performance.In a bioassay,the effects of these plant metabolites on insects'feeding were tested.Nitrate and compounds enriched with leaves of soilless cultivation promoted the feeding of insects,while compounds enriched with leaves of plants growing in natural soil decreased feeding.Several microbial groups(e.g.,Sporolactobacillus,Haliangium)detected inside the plant correlated with caterpillar feeding performance and other microbial groups,such as Ramlibacter and Methylophilus,correlated with the gut microbiome.Our results highlight the role of growth substrates on the food metabolome and microbiome and on the feeding performance and the gut microbiome of plant feeders.It illustrates how belowground factors can influence the aboveground properties of plant-animal systems,which has important implications for plant growth and pest control. | Jun Yuan Tao Wen Shengdie Yang Chao Zhang Mengli Zhao Guoqing Niu Penghao Xie Xiaoyu Liu Xinyuan Zhao Qirong Shen T.Martijn Bezemer | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
| 19 | Proteome-wide epitope mapping identifies a resource of antibodies for SARS-CoV-2 detection and neutralization显示文摘Dear Editor,Since December 2019,the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a worldwide pandemic.1 Significant efforts have been made to generate antibodies to help study COVID-19 pathogenesis,perform diagnostic testing,and develop treatment to neutralize SARS-CoV-2 activity.However,the specific sequence of amino acids recognized and bound by an antibody,the'epitope'is unknown for most antibodies.In this study,we developed a high-throughput epitope mapping platform using a peptide-based SARS-CoV-2 proteome microarray.2 to detect the binding epitopes of 57 commercial antibodies to ORFlab,nudeocapsid(N);spike(S),envelop(E),membrane(M),ORF3a,ORF6,ORF7a,and ORF8 proteins(Supplementary Table S1). | Te Liang Mengli Cheng Fei Teng Hongye Wang Yongqiang Deng Jiahui Zhang Chengfeng Qin Shubin Guo Hui Zhao Xiaobo Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 20 | LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection显示文摘The activation of NLRC4 is a major host response against intracellular bacteria infection.However,NLRC4 activation after a host senses diverse stimuli is difficult to understand.Here,we found that the IncRNA LNCGM1082 plays a critical role in the activation of NLRC4.LNCGM1082 in macrophages affects the maturation of interleukin(IL)-1βand pyroptotic cell death only after exposure to an NLRC4 ligand.Similar to NLRC4-/-mice,LNCGM1082-/-mice were highly sensitive to Salmonella Typhimurium(S.T)infection.LNCGM1082 deficiency in mouse or human macrophages inhibited IL-1βmaturation and pyroptosis.Mechanistically,LNCGM1082 induced the binding of PKCS with NLRC4 in both mice and humans.In contrast,NLRC4 did not bind PKCo in LNCGM1082-/-macrophages.The activity of the IncRNA LNCGM1082 induced by S.T may be mediated through TLR5 in the macrophages of both mice and humans.In summary,our data indicate that TLR5-mediated LNCGM1082 activity can promote the binding of PKC with NLRC4 to activate NLRC4 and induce resistance to bacterial infection. | Yunhuan Gao Yazheng Yang Jianmei Wei Jianmei Yue Ya Wang Qianjing Zhang Mengli Jin Rong Wang Xiaorong Yang Junqi Zhang Xinqi Liu Lin Liu Yuan Zhang Rongcun Yang | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
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