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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation显示文摘 | Qiang Zhang Bin Zhang Leina Sun Qingna Yan Yu Zhang Zhenfa Zhang Yanjun Su Changli Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 4 | 在丰富多彩的活动中渗透民族团结教育显示文摘民族团结教育,是学校教育的重要组成部分。要想把民族团结教育搞得扎实有效,必须通过多种渠道来共同拓展。其中,充分利用主题班会、社会实践活动、民族传统体育等形式开展丰富多彩的活动,无疑是一种十分有效的途径。通过这些教育活动,可以让学生在潜移默化中渗透民族团结意识,认识民族团结的重要性和现实意义,从而提高学生的综合素质。 | 孟庆珍 曾剑 Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，4： | 2 |
| 5 | Dual-metal single-atomic catalyst:The challenge in synthesis,characterization,and mechanistic investigation for electrocatalysis显示文摘Dual-metal single-atom catalysts(DACs),featuring high atomic utilization efficiency,excellent selectivity,and stability originating from the atomically dispersed nature,have emerged as a new frontier in heterogeneous electrocatalysis due to the synergistic effect between diversified metal active sites in promoting their catalytic activity.In this review,the recent progress and development on the syntheses,characterizations,theoretical uniqueness,and applications for various catalytic reactions and devices(oxygen reduction reaction,oxygen evolution reaction,hydrogen evolution reaction,CO_(2) reduction reaction,N2 reduction reaction,proton exchange membrane fuel cells)are summarized and reviewed.Specifically,the synergistic effect between the two metal centers and electronic structures of catalysts is systematically discussed.Moreover,the future challenges and prospects in developing practical DACs are proposed as a possible direction for further investigation. | Changli Chen Mengru Sun Kaixuan Wang Yujing Li | 2022 | SmartMat2022，3，4： | 2 |
| 6 | 浅谈工作组与域显示文摘在整个网络中有大量的计算机,为了对这些计算机进行更好地组织和管理,同时也为了更好地管理共享的资源使其更加安全,我们引进了工作组和域的概念。 | 宋大伟 马凤娟 Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，4： | 1 |
| 7 | 利用多种教育资源 创设优秀班级文化显示文摘创建优秀班级文化,要强化班主任的自身素质,根据学生特点开展多种教育活动,还要综合学校、家庭、社会的力量共同进行。 | 张善虎 朱守荣 Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，4： | 1 |
| 8 | 心理健康教育课题实验报告——构建学校、家庭、社会沟通渠道,全方位开展心理健康教育的研究显示文摘本文对构建学校、家庭、社会心理健康教育的沟通渠道,全方位开展心理健康教育进行了有益的探讨,显示了这项课题的重要作用。 | 梁志光 宿益超 Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，4： | 1 |
| 9 | 齐鲁大学前期考证近 代教育发祥青州——山东近代教育早期历史概述显示文摘清朝末年,外国教会在青州衡王府旧址上所建立的青州培真书院、青州广德书院、青州广德医院和青州医学堂皆为齐鲁大学的前身,是山东近代教育最主要的发祥地。本文以外国教会原始史料为基本素材,对山东近代教育早期历史进行了考证,理清了外国教会在山东从开始办学到近代教育发展的历史过程。本考证澄清了历史事实,再现了青州和山东的历史辉煌,评价了历史人物的功过,补充和丰富了山东近代教育的历史资料,对记史、教化、资政、鉴古知今,服务当代都有重要价值。 | 李茂松 Mrs. Sun Changli (Translator) | 2006 | 潍坊教育学院学报2006，19，3： | 1 |
| 10 | 探索高职数学教学改革的体会显示文摘根据高职教育的要求和高职教学的特色,本文提出了高职数学教学内容和手段上改革的体会与构想。 | 王文静 Mrs. Sun Changli (Translator) | 2006 | 潍坊教育学院学报2006，19，3： | 1 |
| 11 | 如何在网络中实现VLSM和路由汇总显示文摘在大型网络设计中使用VLSM和路由汇总可以有效减少IP地址的浪费,减小路由选择表,提高网络性能。本文通过对分类网络和无类网络路由选择的原理、实现和对比,来阐述如何在网络中实现VLSM和路由汇总。 | 马凤娟 宋大伟 Mrs. Sun Changli (Translator ) | 2006 | 潍坊教育学院学报2006，19，3： | 1 |
| 12 | 构建和谐校园 确保学校和谐发展显示文摘大量的教育实践证明,只有构建和谐校园,才能保证学校的健康发展;而构建和谐校园,必须营造良好的教育环境、建立和谐的师生关系以及和谐的人际关系、创建文明的校园文化和建立有效的管理机制。 | 谭洪江 Mrs. Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，3： | 1 |
| 13 | 新课程下的语文合作教学显示文摘长期以来,我们的教师在日常教学活动中总是独立工作,互不合作,这种工作模式极不利于课程开发、课堂构建、语文评价、语文教师专业成长等。新的课程标准,提倡自主、合作,探究性学习方式,它们之间是紧密联系,相互作用的。要想在教学活动中有所突破,有所成就,就需要教师们努力探究,不断地丰富和完善合作学习的教学实践。 | 李广新 郑淑琴 Mrs. Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，3： | 1 |
| 14 | Assessment of Geological Security and Integrated Assessment Geo-environmental Suitability in Worst-hit Areas in Wenchuan Quake显示文摘在 2008 的 Wenchuan 地震和地震触发的 geo 危险为象建设,交通和电一样的基础结构引起了大损害和死亡以及破坏损坏。为与高大小地震在高多山的区域构造的镇区和城市选择相对安全的区域是迫切的。这篇论文与高大小地震在高山和沟壑为重建论述基本想法,评估索引和地质的安全评估,水和陆地资源安全示范和对 geo 环境的适用性的综合评价的评估方法,它在最糟点击的区域(12 个县) 被使用。综合评价显示出那:(1 ) 在 Longmenshan 差错地区定位了,评估区域具有差的地区性的外壳稳定性,在哪个不稳定并且第二个不稳定的区域说明 79% 总数;(2 )geo 危险危险性在评估区域高。地震触发的 geo 危险的点主要在中等、高的山区与更高的分发沿着活跃差错地区被散布,在哪个为 40.1% 总数的高、中等的危险性 zoning 报道的区域;(3 ) 地质的安全在评估区域是差的,在哪个区域不合适,建设分别地为 8.3% 评估区域, 9.3% 和 9.3% 在合适的构造区域,地质的安全的区域,第二安全和紧张 zoning 报道占据 73.1% ;(4 )geo 环境的适用性在评估区域,适用性的区域和基本适用性 zoning 在说明 3.5% 整个评估区域和 7.3% 是差的。 | LI Wenpeng WEN Dongguang ZHOU Aiguo SUN Xiaoming MENG Hui SHI Jusong CHEN Zongyu ZHANG Liqin FENG Xiaoming LIU Changli ZHOU Jianwei | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 1 |
| 15 | Novel UML and Interaction Design Based Paradigm of Multimedia Software Design显示文摘 | Chang Liu Changli Sun Ting Han | 2017 | International Journal of Technology Management2017，，1： | 0 |
| 16 | 在办学实践中认真学习贯彻“依法治国”与“以德治国”重要思想——学习《江泽民文选》体会显示文摘实行依法治国和以德治国的基本方略,是建设有中国特色社会主义的重要内容和重要保证,也是在坚持以人为本、科学发展观指导下构建和谐社会的必然要求。作为培养社会主义建设者和接班人的高等学校,要根据依法治国与以德治国相结合治国方略的要求,立足校园,以建为本,搞好学校内部管理制度建设和校园公共场所公德建设。 | 无 Mrs. Sun Changli(Translator) | 2006 | 潍坊教育学院学报2006，19，3： | 0 |
| 17 | Novel Data Structure Modeling Model based on Hierarchical Data Analysis and Parsing显示文摘 | Chang Liu Ting Han Changli Sun | 2017 | International Journal of Technology Management2017，，2： | 0 |
| 18 | 披文仰贤 观字赏心——赏读明代状元赵秉忠《山其山集·自叙》显示文摘明代状元赵秉忠的《山其山集.自叙》用作者的草体手书印制。本文对《自叙》用正楷按原文转行排版,详加注释,译成现代文,并根据作者当时的处境和遭遇,对《自叙》的内容进行了探幽索隐的尝试。 | 栾绪夫 Mrs. Sun Changli(Translator ) | 2006 | 潍坊教育学院学报2006，19，3： | 0 |
| 19 | Rational design of Fe-N-C electrocatalysts for oxygen reduction reaction:From nanoparticles to single atoms显示文摘As an alternative energy,hydrogen can be converted into electrical energy via direct electrochemical conversion in fuel cells.One important drawback of full cells is the sluggish oxygen reduction reaction(ORR)promoted by the high-loading of platinum-group-metal(PGM)electrocatalysts.Fe-N-C family has been received extensive attention because of its low cost,long service life and high oxygen reduction reaction activity in recent years.In order to further enhance the ORR activity,the synthesis method,morphology regulation and catalytic mechanism of the active sites in Fe-N-C catalysts are investigated.This paper reviews the research progress of Fe-N-C from nanoparticles to single atoms.The structure-activity relationship and catalytic mechanism of the catalyst are studied and discussed,which provide a guidance for rational design of the catalyst,so as to promote the more reasonable design of Fe-N-C materials. | Mengru Sun Changli Chen Menghao Wu Danni Zhou Zhiyi Sun Jianling Fan Wenxing Chen Yujing Li | 2022 | Nano Research2022，15，3： | 0 |
| 20 | Research on the Application of Reading Recommendation System in High Medical College Library Based on the Local Data显示文摘This paper summarizes the feasibility of constructing the recommended reading system in the library of high medical college, andanalyzes the core technology-recommendation algorithm in the recommendation system. At the same time, it introduces the innovative design ofthe recommendation model of the recommendation system of high medical institutions. Based on the local data to promote the implementation ofthe model, the domestic library to provide recommended services to the future made a prospect. | Changli Sun Guojun Wang Chang Liu Songgen Jin Yanjiu Hu Liying Wu | 2017 | International Journal of Technology Management2017，，6： | 0 |
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