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| 1 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 2 | The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling显示文摘Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging. | Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou | 2022 | Bone Research2022，10，3： | 5 |
| 3 | Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin显示文摘Periodontitis patients are at risk of alveolar bone loss during orthodontic treatment.The aim of this study was to investigate whether intermittent parathyroid hormone(1–34)treatment(iPTH)could reduce alveolar bone loss during orthodontic tooth movement(OTM)in individuals with periodontitis and the underlying mechanism.A rat model of OTM in the context of periodontitis was established and alveolar bone loss was observed.The control,iPTH and iPTH+stattic groups received injections of vehicle,PTH and vehicle,or PTH and the signal transducer and activator of transcription 3(STAT3)inhibitor stattic,respectively.iPTH prevented alveolar bone loss by enhancing osteogenesis and suppressing bone resorption in the alveolar bone during OTM in rats with periodontitis.This effect of iPTH was along with STAT3 activation and reduced by a local injection of stattic.iPTH promoted osteoblastic differentiation and might further regulate the Wnt/β-catenin pathway in a STAT3-dependent manner.The findings of this study suggest that iPTH might reduce alveolar bone loss during OTM in rats with periodontitis through STAT3/β-catenin crosstalk. | Cheng Zhang Tiancheng Li Chenchen Zhou Li Huang Yuyu Li Han Wang Peipei Duan Shujuan Zou Li Mei | 2020 | International Journal of Oral Science2020，12，4： | 4 |
| 4 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 5 | Controls of Acid-sensitive Minerals on Reservoir Sensitivity Testing: An Example from the Silurian Kepingtage Formation in Tazhong Area, Tarim Basin显示文摘The Silurian Kepingtage Formation in Tazhong area is regarded as an acid-sensitive hydrocarbon reservoir. However, formation mechanism of acid-sensitive of the reservoir cannot be interpreted by the existing acid-sensitive evaluation criterion based on damage rate. The contents of acid-sensitive minerals illustrated by bulk-rock XRD, scanning electron microscopy and clay mineral composition analysis exert the dominant control on acid-sensitive flow testing of the reservoir. The ironbearing minerals(including pyrite cements and chlorite cements) mainly deteriorate reservoir quality, while the iron-free minerals(including calcite cements and dolomite cements) mainly improve permeability. The permeability variation of the tested samples is controlled by the relative content of two acid-sensitive minerals. On the basis of newly established sensitivity mechanism and its influence on permeability, the corresponding ion(Fe^(2+)) stabilizer was added to the acidizing fluids during the acidification reconstruction, which inhibited the negative factors of acid-sensitive minerals and improved the target layer quality effectively. | HAN Denglin WANG Qianqian WANG Chenchen OUYANG Chuanxiang YUAN Wenfang | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 6 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice 显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，1： | 1 |
| 7 | Domestic migrant workers in China’s hotel industry: An exploratory study of their life satisfaction and job burnout显示文摘 | Han Shen Chenchen Huang | 2012 | International Journal of Hospitality Management2012，，4： | 1 |
| 8 | Reliability-aware mapping for various No C topologies and routing algorithms under performance constraints显示文摘The flexibility of manycore systems to extensive applications is achieved by reconfiguring the interconnections between processing elements(PEs) and the function of PEs. The efficiency of the system is crucially determined by the mapping technique of applications. In this paper, a highly flexible reliability-aware application mapping approach is proposed for manycore network-on-chip(No C) systems. A reliability cost model(RCM) is first presented to measure the reliability cost for a mapping pattern. This model uses the binary number 0/1 to model the reliability cost of each communication path. The overall reliability cost of a mapping pattern is evaluated by taking the cost of each path as a discrete random variable. Based on RCM,a mapping method called reliability cost ratio based branch and bound(RCRBB) is used. With this method,the best mapping among all the possible patterns is found efficiently by discarding those nonoptimal candidate mappings at early stages. The proposed application mapping approach with reliability awareness is applicable to various No C topologies and routing algorithms, while other state-of-the-art approaches on the same topic are only limited to a specific topology and routing algorithm. Even for the same No C architecture, the proposed approach shows significant superiority in many aspects. Experiments show that RCRBB achieves up to 9.07%reliability enhancement on average. Also, it outperforms other approaches in throughput and latency with a relatively low run time. | WU Chen DENG ChenChen LIU LeiBo YIN ShouYi HAN Jie WEI ShaoJun | 2015 | Science China(Information Sciences)2015，58，8： | 1 |
| 9 | Generation of three-dimensional versatile vortex linear light bullets(Invited Paper)显示文摘We generate and measure the versatile vortex linear light bullet,which combines a high-order Bessel beam and an Airy pulse.This three-dimensional optical wave packet propagates without distortion in any medium,while carrying an orbital angular momentum.Its non-varying feature in linear propagation is verified by a threedimensional measurement.Such a novel versatile linear light bullet can be useful in various applications such as micromachining. | Han Li Xin Huang Qian Cao Yun Zhao Peiyun Li Chenchen Wan Andy Chong | 2017 | Chinese Optics Letters2017，15，3： | 1 |
| 10 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 11 | CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non–Small-Cell Lung Cancer显示文摘 | Kit W. Tam Wei Zhang Junichi Soh Victor Stastny Min Chen Han Sun Kelsie Thu Jonathan J. Rios Chenchen Yang Crystal N. Marconett Suhaida. A. Selamat Ite A. Laird-Offringa Ayumu Taguchi Samir Hanash David Shames Xiaotu Ma Michael Q. Zhang Wan L. Lam Adi Gaz | 2013 | Journal of Thoracic Oncology2013，，11： | 1 |
| 12 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice 显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 13 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 14 | Effects of plant diversity on greenhouse gas emissions in microcosms simulating vertical constructed wetlands with high ammonium loading显示文摘Wastewater with relatively high nitrogen concentrations is a major source of nitrous oxide(N_2O) and methane(CH_4) emissions and exerts multiple stresses on the environment.Studies have shown that plant diversity plays an important role in ecosystem functioning.However, the effects of plant species diversity on CH_4 and N_2O emissions under high ammonium(NH_4^+-N) loading rates remain unclear. In this study, a microcosm experiment simulating vertical constructed wetlands supplied with high NH_4^+-N water levels was established. The treatments included four species richness levels(1, 2, 3, 4) and 15 species compositions. There was no significant relationship between species richness and N_2O emissions. However, N_2O emissions were significantly reduced by specific plant species composition. Notably, the communities with the presence of Rumex japonicus L. reduced N_2O emissions by 62% compared to communities without this species. This reduction in N_2O emissions may have been a result of decreased N concentrations and increased plant biomass. CH_4 emissions did not respond to plant species richness or species identity.Overall, plant species identity surpassed species richness in lowering N_2O emissions from constructed wetlands with high NH_4^+-N water. The results also suggest that communities with R. japonicus could achieve higher N removal and lower greenhouse gas emissions than other wetland species. | Wenjuan Han Guiying Luo Bin Luo Chenchen Yu Hai Wang Jie Chang Ying Ge | 2019 | Journal of Environmental Sciences2019，31，3： | 1 |
| 15 | Modulating the C-terminus of DEP1 synergistically enhances grain quality and yield in rice显示文摘Grain shape is a key breeding target that influences both grain yield and appearance quality in rice. Breeding for long-slender grains is an effective strategy to improve grain quality (Jain et al., 2004;Wang et al., 2012, 2015a). In the past two decades, several quantitative trait loci (QTLs) responsible for grain size and shape have been identified, including GS3 (Fan et al., 2006), GS5 (Li et al., 2011). | Haixiang Huang Yafeng Ye Wenzhen Song Qi Li Ruixi Han Chenchen Wu Shuoxun Wang Jianping Yu Xueying Liu Xiangdong Fu Qian Liu Kun Wu | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 16 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice 显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 17 | Distributed Secure Storage Scheme Based on Sharding Blockchain显示文摘Distributed storage can store data in multiple devices or servers to improve data security.However,in today’s explosive growth of network data,traditional distributed storage scheme is faced with some severe challenges such as insufficient performance,data tampering,and data lose.A distributed storage scheme based on blockchain has been proposed to improve security and efficiency of traditional distributed storage.Under this scheme,the following improvements have been made in this paper.This paper first analyzes the problems faced by distributed storage.Then proposed to build a new distributed storage blockchain scheme with sharding blockchain.The proposed scheme realizes the partitioning of the network and nodes by means of blockchain sharding technology,which can improve the efficiency of data verification between nodes.In addition,this paper uses polynomial commitment to construct a new verifiable secret share scheme called PolyVSS.This new scheme is one of the foundations for building our improved distributed storage blockchain scheme.Compared with the previous scheme,our new scheme does not require a trusted third party and has some new features such as homomorphic and batch opening.The security of VSS can be further improved.Experimental comparisons show that the proposed scheme significantly reduces storage and communication costs. | Jin Wang Chenchen Han Xiaofeng Yu Yongjun Ren R.Simon Sherratt | 2022 | Computers, Materials & Continua2022，，3： | 1 |
| 18 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice显示文摘 | Li Junfai Niu Chenchen Han Song | 2005 | Brain Res2005，1060，12： | 1 |
| 19 | A New Discovery of Ag-Pb-Zn Mineralization via Modern Portable Analytical Technology and Stream Sediment Data Processing Methods in Dajiacuo Area, Western Tibet(China)显示文摘Tibet, which is rich in mineral resources, is a treasure trove for geological explorers. However, prospecting work has been slow, especially in the western part, due to the precipitous terrain, changeable climate and low access. Hence, modern advanced field analytical technology and effective data processing methods play significant roles in rapid and efficient exploration in Tibet. In this paper, spectrum-area fractal modeling and portable X-ray fluorescence analysis(pXRFA) were used to identify and verify geochemical anomalies associated with Ag-Pb-Zn mineralization based on a stream-sediment dataset of 39 elements in the Dajiacuo-Xurucuo region of western Tibet. First, staged factor analysis(SFA) was used to obtain the Ag-Pb-Zn-Cd geochemical assemblage. Second, the first-factor pattern obtained using SFA was dissociated by a spectrum-area(S-A) fractal model and a digital elevation model(DEM)-based geochemical model(DGM) was constructed. Finally, the sections of Ag, Cd, Pb, and Zn were obtained using pXRFA. The results show that Ag-Pb-Zn-Cd enrichment zones were mostly located around the contact belt of volcanic rocks and intrusions, or along SE-NW trending faults. Considering the variable terrain and catchment basin, the extension of long axes of Ag-Pb-Zn-Cd anomalies into higher elevation areas that are favorable for Ag-Pb-Zn mineralization should be investigated. Anomaly maps created with the aid of a DGM show promising potential for mineralization in the Dajiacuo-Xurucuo region, and abundant Ag-Pb-Zn mineralization was identified with the assistance of pXRFA in the source areas for the geochemical anomalies in the Dajiacuo. We conclude that SFA and the S-A fractal model constitute a valid tool to identify or verify geochemical anomalies in areas of low-density stream-sediment sampling. The pXRFA can accurately determine the source of geochemical anomalies and improve anomaly verification efficiency. | Xiaojia Jiang Xin Chen Shunbao Gao Youye Zheng Huan Ren Denghui Han Chenchen Yan Junsheng Jiang | 2020 | Journal of Earth Science2020，31，4： | 0 |
| 20 | Unraveling the Rheology of Nanocellulose Aqueous Suspensions:A Comprehensive Study on Biomass-Derived Nanofibrillated Cellulose显示文摘The rheological properties of nanocellulose aqueous suspensions play a critical role in the development of nanocellulose-based bulk materials.High-crystalline,high-aspect ratio,and slender nanofibrillated cellulose(NFC)were extracted from four biomass resources.The cellulose nanofibrils and nanofibril bundles formed inter-connected networks in the NFC aqueous suspensions.The storage moduli of the suspensions with different concentrations were higher than their corresponding loss moduli.As the concentration increased,the storage and loss modulus of NFC dispersion increased.When the shear rate increased to a certain value,there were differences in the changing trend of the rheological behavior of NFC aqueous suspensions derived from different biomass resources and the suspensions with different solid concentrations.NFC dispersion’s storage and loss modulus increased when the temperature rose to nearly 80℃.We hope this study can deepen the understanding of the rheological properties of NFC colloids derived from different biomass resources. | Mingyue Miao Fei Wang Qing Li Longchen Tao Chenchen Dai Yu Liu Shujuan Han Wenshuai Chen Ping Lu | 2024 | Journal of Renewable Materials2024，12，3： | 0 |
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