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| 1 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 2 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 3 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 4 | Molten salt as ultrastrong polar solvent enables the most straightforward pyrolysis towards highly efficient and stable single-atom electrocatalyst显示文摘Currently,pyrolysis as the most widely used method still has some key issues not well resolved for synthesis of carbon-supported single-atom catalysts(C-SACs),e.g.,the sintering of metal atoms at high temperature as well as the high cost and complicated preparations of precursors.In this report,molten salts are demonstrated to be marvellous medium for preparation of C-SACs by pyrolysis of small molecular precursors(ionic liquid).The ultrastrong polarity on one hand establishes robust interaction with precursor and enables better carbonization,resulting in largely enhanced yield.On the other hand,the aggregation of metal atoms is effectively refrained while no nanoparticle or cluster is formed.By this strategy,a C-SAC with atomically dispersed Fe-N_(4) sites and a high specific area over 2000 m^(2) g^(-1) is obtained,which illustrates high ORR activity in both acid and alkaline media.Moreover,this SAC exhibits superior methanol tolerance and stability after acid soaking at 85℃ for 48 h.It is believed that the molten-salts-assisted pyrolysis can be developed into a routine strategy as it not only can largely simply the synthesis of C-SACs,but also can be extended to prepare other types of SACs. | Nannan Li Wei Liu Chao Zhu Ce Hao Jingya Guo Hongyu Jing Jinwen Hu Cuncun Xin Danyang Wu Yantao Shi | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 5 | Friction and Wear Behaviors of a Cylinder Liner–Piston Ring with Emulsified Bio-Oil as Fuel显示文摘 | YuFu Xu HuiQiang Yu XiaoYang Wei Zheng Cui XianGuo Hu Teng Xue DanYang Zhang | 2013 | Tribology Transactions2013，，3： | 1 |
| 6 | Defect-induced electron rich nanodomains in CoSe_(0.5)S_(1.5)/GA realize fast ion migration kinetics as sodium-ion capacitor anode显示文摘Optimizing charge migration and alleviating volume expansion in anode materials are the key to improve the electrochemical performance for sodium-ion storage devices.Herein,a hierarchical porous conducting matrix confining defect-rich selenium doped cobalt dichalcogenide(CoSe_(0.5)S_(1.5)/GA)is constructed as a promising SICs anode based on the guidance of theoretical calculation analysis.The increased defect concentration significantly enhanced the disorder degree of the compound and presented electron aggregation around the S atoms,which effectively modulated the electronic structure,further enabling high rate and ultra-capacity sodium storage.Moreover,strong interfacial coupling could construct spatial constraint to alleviate volume expansion as well as maintain electrode integrity and stability.The CoSe_(0.5)S_(1.5)/GA electrode can deliver a high capacity of 310.1 mA h g^(-1)after 2000 cycles at 1 A g^(-1),and the CoSe_(0.5)S_(1.5)/GA//AC sodium ion capacitor can exhibit an outstanding energy density of 237.5 W h kg^(-1).A series of characterization and theoretical calculation convincingly reveal that the defect moieties can regulate the Na^(+)storage and diffusion kinetics,which prove that our defect manufacture coupling with space-confined strategy can provide deep insights into the development of high-performance Na^(+)storage devices. | Tianlin Li Danyang Zhao Binghui Du Qing Yin Yongzhi Li Xiaolan Xue Fuxiang Wei Jiqiu Qi Yanwei Sui | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 7 | An energy-efficient reconfigurable asymmetric modular cryptographic operation unit for RSA and ECC显示文摘RSA and ellipse curve cryptography(ECC)algorithms are widely used in authentication,data security,and access control.In this paper,we analyze the basic operation of the ECC and RSA algorithms and optimize their modular multiplication and modular inversion algorithms.We then propose a reconfigurable modular operation architecture,with a mix-memory unit and double multiply-accumulate structures,to realize our unified,asymmetric cryptosystem structure in an operational unit.Synthesized with 55-nm CMOS process,our design runs at 588 MHz and requires only 437801µm2 of hardware resources.Our proposed design takes 21.92 and 23.36 mW for 2048-bit RSA modular multiplication and modular inversion respectively,as well as 16.16 and 15.88 mW to complete 512-bit ECC dual-field modular multiplication and modular inversion respectively.It is more energy-efficient and flexible than existing single algorithm units.Compared with existing multiple algorithm units,our proposed method shows better performance.The operation unit is embedded in a 64-bit RISC-V processor,realizing key generation,encryption and decryption,and digital signature functions of both RSA and ECC.Our proposed design takes 0.224 and 0.153 ms for 256-bit ECC point multiplication in G(p)and G(2^(m))respectively,as well as 0.96 ms to complete 1024-bit RSA exponentiation,meeting the demand for high energy efficiency. | Mengni BIE Wei LI Tao CHEN Longmei NAN Danyang YANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 0 |
| 8 | Effect of Different Amendments on Nitrogen Conservation During Simulated Composting显示文摘The objectives of this study were to evaluate the effects of different dosages of three amendments—peat,superphosphate,mixture of Mg(OH)2+H3PO4(Magnesium Hydroxide and Phosphorus Acid)on N(Nitrogen)conservation.The simulated composting experiment was carried out in a constant temperature water bath with pig manure and corn straw.The results showed that the ammonia volatilization could be inhibited to some extent under the treatments with fixing agents.Under the same simulated composting conditions,the nitrogen fixation effect of the three kinds of fixatives with the same proportion was as follows:Mg(OH)2+H3PO4>superphosphate>peat.The fixation effect of N increased with the increase of the additives.The N fixation rate of Mg(OH)2+H3PO4 treatment was up to 66%.Compared with the CK(Control Group),the amount of cumulative ammonia emission decreased by 90.3% and the TN(Total Nitrogen)content increased by 39.31% in this treatment.Compared with other two kinds of fixing agents,Mg(OH)2+H3PO4 treatment could not only control N loss in composting process,improve the N nutrient content of compost products,but also could increase P(Phosphorus)and Mg(Magnesium)nutrients.Therefore,it had more popularization value and application prospect. | Li Danyang Qi Chuanren Wei Yanan Li Guoxue Yuan Jing | 2019 | Journal of Environmental Science and Engineering(B)2019，8，6： | 0 |
| 9 | Tuned single atom coordination structures mediated by polarization force and sulfur anions for photovoltaics显示文摘Impeding high temperature sintering is challengeable for synthesis of carbon-supported single-atom catalysts (C-SACs), which requires high-cost precursor and strictly-controlled procedures. Herein, by virtue of the ultrastrong polarity of salt melts, sintering of metal atoms is effectively suppressed. Meanwhile, doping with inorganic sulfur anions not only produces sufficient anchoring sites to achieve high loading of atomically dispersed Co up to 13.85 wt.%, but also enables their electronic and geometric structures to be well tuned. When served as a cathode catalyst in dye-sensitized solar cells, the C-SAC with Co-N4-S2 moieties exhibits high activity towards the iodide reduction reaction (IRR), achieving a higher power conversion efficiency than that of conventional Pt counterpart. Density function theory (DFT) calculations revealed that the superior IRR activity was ascribed to the unique structure of Co-N4-S2 moieties with lower reaction barriers and moderate binding energy of iodine on the Co center, which was beneficial to I2 dissociation. | Hongyu Jing Zhengyan Zhao Chunyang Zhang Wei Liu Danyang Wu Chao Zhu Ce Hao Jiangwei Zhang Yantao Shi | 2021 | Nano Research2021，14，11： | 0 |
| 10 | Analysis of total reaction cross sections for deuterons on 1p-shell-nuclei显示文摘This study aims to analyze the differential cross sections(DCSs) of elastic scattering and total reaction cross sections(TRCSs) of the loosely-bound deuteron projectile impinging on 1 p-shell nuclei, such as9 Be,12 C, and16 O, at incident energies ranging between10.6 and 171 MeV using the continuum discretized coupled channel(CDCC) method. By fitting the experimental data for the DCSs and TRCSs, energy-dependent renormalization factors for the real and imaginary parts of the nucleon-nucleus opticalmodel potentials deduced from the studies proposed by Koning and Delaroche(KD02) and by Watson, Singh, and Segel(WSS),are obtained. It is found that with the WSS potential, which was obtained specifically for 1 p-shell nuclei, the CDCC calculations can simultaneously reproduce both the DCSs and the TRCSs. The results show that it is important to choose appropriate optical potentials to describe deuteron-induced reactions. | YiDi Chen Yun Zhang JianLing Lou DanYang Pang YanLin Ye Wei Liu Ying Jiang Gen Li | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 0 |
| 11 | Executive summary of Chinese expert consensus for topical application of anti-microbial agents for lower respiratory tract infection in adults显示文摘In recent years,with the increased prevalence of multi-drug resistant(MDR)bacterial infection and chronic pulmonary infection,the topical application of anti-microbial agents,mainly inhaled antibiotics,has come back to clinical practice.Several formulations for nebulization and dry powder inhaler(DPI)have been approved for inhaled anti-infective therapy.Meanwhile,evidence and experience have been accumulated in the use of anti-microbial agents delivered via airway.However,the available studies in this field are heterogenous in the study population,drug delivery route and dosages.The efficacy and safety of inhaled anti-infective therapy in various types of lower respiratory tract infections(LRTIs)need to be evaluated.Moreover. | Jing Zhang Qijian Cheng Yi Huang Hong Fan Guoxiang Lai Xiangdong Mu Wei Sha Danyang She Ning Shen Xin Su Jinfu Xu Feng Ye Xinlun Tian Tiantuo Zhang Hua Zhou Youning Liu Lixian He Heping Xiao Bei He Yi Shi Xiangyan Zhang Bin Cao Jieming Qu on behalf of Pulmonary Infection Assembly of Chinese Thoracic Society | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 12 | Enhanced monopole transition strength from the cluster decay of ^(13)C显示文摘The inelastic excitations and cluster decay of ^(13)C have been measured using the reaction,9Be(^(13)C, ^(13)C* →~9Be + α)~9Be. We observe strong excitation to the 14.3-MeV(1/2-) resonant state from the cluster-decay channel, leading to an enhanced monopole matrix element of(6.3 ± 0.6) fm^2. This large cluster-related monopole strength is a clear indication of the cluster-structure domination of this state and is consistent with the recent prediction of the orthogonality condition model(OCM). It would be interesting to further explore the three-center molecular rotational band that is initiated from the observed band-head. | Jun Feng YanLin Ye Biao Yang ChengJian Lin HuiMin Jia DanYang Pang ZhiHuan Li JianLing Lou QiTe Li XiaoFei Yang Jing Li HongLiang Zang Qiang Liu Wei Jiang ChenGuang Li Yang Liu ZhiQiang Chen HongYi Wu ChunGuang Wang Wei Liu Xiang Wang JingJing Li DiWen Luo Ying Jiang ShiWei Bai JinYan Xu NanRu Ma LiJie Sun DongXi Wang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 0 |
| 13 | Melatonin biosynthesis pathways in nature and its production in engineered microorganisms显示文摘Melatonin is a biogenic amine that can be found in plants,animals and microorganism.The metabolic pathway of melatonin is different in various organisms,and biosynthetic endogenous melatonin acts as a molecular signal and antioxidant protection against external stress.Microbial synthesis pathways of melatonin are similar to those of animals but different from those of plants.At present,the method of using microorganism fermentation to produce melatonin is gradually prevailing,and exploring the biosynthetic pathway of melatonin to modify microorganism is becoming the mainstream,which has more advantages than traditional chemical synthesis.Here,we review recent advances in the synthesis,optimization of melatonin pathway.L-tryptophan is one of the two crucial precursors for the synthesis of melatonin,which can be produced through a four-step reaction.Enzymes involved in melatonin synthesis have low specificity and catalytic efficiency.Site-directed mutation,directed evolution or promotion of cofactor synthesis can enhance enzyme activity and increase the metabolic flow to promote microbial melatonin production.On the whole,the status and bottleneck of melatonin biosynthesis can be improved to a higher level,providing an effective reference for future microbial modification. | Xiaotong Xie Dongqin Ding Danyang Bai Yaru Zhu Wei Sun Yumei Sun Dawei Zhang | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 0 |
| 14 | A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma显示文摘Objective:The immunoscore,which is used to quantify immune infiltrates,has greater relative prognostic value than tumor,node,and metastasis(TNM)stage and might serve as a new system for classification of colorectal cancer.However,a comparable immunoscore for predicting lung adenocarcinoma(LUAD)prognosis is currently lacking.Methods:We analyzed the expression of 18 immune features by immunohistochemistry in 171 specimens.The relationship of immune marker expression and clinicopathologic factors to the overall survival(OS)was analyzed with the Kaplan-Meier method.A nomogram was developed by using the optimal features selected by least absolute shrinkage and selection operator(LASSO)regression in the training cohort(n=111)and evaluated in the validation cohort(n=60).Results:The indicators integrated in the nomogram were TNM stage,neuron-specific enolase,carcino-embryonic antigen,CD8 center of tumor(CT),CD8 invasive margin(IM),Fox P3 CT,and CD45 ROCT.The calibration curve showed prominent agreement between the observed 2-and 5-year OS and that predicted by the nomogram.To simplify the nomogram,we developed a new immune-serum scoring system(I-SSS)based on the points awarded for each factor in the nomogram.Our I-SSS was able to stratify same-stage patients into different risk subgroups.The combination of I-SSS and TNM stage had better prognostic value than the TNM stage alone.Conclusions:Our new I-SSS can accurately and individually predict LUAD prognosis and may be used to supplement prognostication based on the TNM stage. | Qiujuan Huang Tongyuan Qu Lisha Qi Changxu Liu Yuhong Guo Qianru Guo Guangning Li Yalei Wang Wenshuai Zhang Wei Zhao Danyang Ren Leina Sun Shengguang Wang Bin Meng Baocun Sun Bin Zhang Wenjuan Ma Wenfeng Cao | 2021 | Cancer Biology & Medicine2021，18，2： | 0 |
| 15 | A first comprehensive evaluation of China's GNSS-R airborne campaign: part II—river remote sensing显示文摘The Global Navigation Satellite System Reflectometry(GNSS-R) has been proven to be a powerful technique for retrieving geophysical parameters of ocean and land. Airborne GNSS-R is an important experimental platform, because it is not only needed as validation for spaceborne application, but also possesses the advantages to be capable of remote sensing of small and medium scale targets, such as rivers and lakes. This paper presents an overview of China's airborne GNSS-R campaign conducted on May 30, 2014, in Henan. The campaign has two objectives, i.e.:(1) to examine the capability of a GNSS-R payload developed by National Space Science Center,Chinese Academy of Sciences(NSSC, CAS) for airborneobservations and(2) to study the algorithms for soil moisture and river remote sensing, including altimetry and flow velocity measurement. A previous paper has presented results of soil moisture retrieval as part I, and in this paper,initial results of the Yellow River remote sensing are presented as part II. This paper presents the river altimetry results and explores a new potential application of GNSS-R technology, which is used to detect the flow velocity of the river. The river surface height results observed by code delay altimetry method were consistent with the height results of GPS dual-frequency differential positioning altimetry. The GNSS-R altimetry results showed that decimeter level heights were achieved in 1-min sliding average. Comparing with in situ measurements, the GNSSR flow velocity result was reasonable; the error was about0.027 m/s, which indicated the validity and feasibility of using GNSS-R technique to detect river flow velocity. | Weihua Bai Junming Xia Wei Wan Limin Zhao Yueqiang Sun Xiangguang Meng Congliang Liu Hua Chen Qifei Du Dongwei Wang Danyang Zhao Xianyi Wang Cheng Cheng | 2015 | Science Bulletin2015，60，17： | 0 |
| 16 | Monitoring the delicate operations of surgical robots via ultra-sensitive ionic electronic skin显示文摘The arrival of surgical robots in high-end medical equipment is a landmark,and the realization of tactile sensation a major challenge in this important cutting-edge research field.Aiming to address this issue,we present ultra-sensitive ionic electronic skin in the form of flexible capacitive pressure sensors,which incorporate multistage bionic microstructures in ion gels for the purpose of monitoring the delicate operations of surgical robots.Significantly,the ionic skin exhibits an ultra-high sensitivity of 9484.3 kPa^(-1)(<15 kPa),and the sensitivity remains higher than 235 kPa^(-1)in the wide range of 15-155 kPa.The device has also achieved a detection limit as low as 0.12 Pa or,equivalently,0.31 mg,fast response within 24 ms,and high robustness(loading/unloading for 5000 cycles without fatigue).The sensor facilitates the challenging task of tele-operated robotic threading,which exceeds the human tactile perception limit when threading a needle.We have also confirmed that ionic skin can be used in robot-assisted invasive surgery,such as incision/resection of tissues and suturing of wounds,providing tactile information to surgeons to improve operation success rates.The flexible ionic skin is capable of conforming to the various shapes of robotic manipulators,thus has great promise for applications in robotic dexterous manipulation,prosthetics and human-machine interfaces. | Danyang Wei Jiajie Guo Yuqi Qiu Shaoyu Liu Jiangyan Mao Yutian Liu Zhenbing Chen Hao Wu Zhouping Yin | 2022 | National Science Review2022，9，12： | 0 |
| 17 | Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model显示文摘Activated G-protein-coupled receptor 39(GPR39)has been shown to attenuate inflammation by interacting with sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α).However,whether GPR39 attenuates neuropathic pain remains unclear.In this study,we established a Sprague-Dawley rat model of spared nerve injury-induced neuropathic pain and found that GPR39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated rats.Intrathecal injection of TC-G 1008,a specific agonist of GPR39,significantly alleviated mechanical allodynia in the rats with spared nerve injury,improved spinal cord mitochondrial biogenesis,and alleviated neuroinflammation.These changes were abolished by GPR39 small interfering RNA(siRNA),Ex-527(SIRT1 inhibitor),and PGC-1αsiRNA.Taken together,these findings show that GPR39 activation ameliorates mechanical allodynia by activating the SIRT1/PGC-1αpathway in rats with spared nerve injury. | Longqing Zhang Xi Tan Fanhe Song Danyang Li Jiayi Wu Shaojie Gao Jia Sun Daiqiang Liu Yaqun Zhou Wei Mei | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 18 | Exploring the anti-aging effects of chlorogenic acid and the underlying mechanisms based on a Caenorhabditis elegans model显示文摘Objective:To explore the anti-aging effects of chlorogenic acid(CGA)and the underlying mechanisms based on a Caenorhabditis elegans(C.elegans)model.Methods:The anti-agingactivityofCGAwasstudied basedon thebodylength,exercisebehavior,lipofuscin content,antioxidative stress ability,swallowing frequency,body-bending frequency,and head-swinging ability of C.elegans.Through DAF-16 nuclear translocation and SOD-3-GFP fluorescence experiments,the effects of CGA on ROS levels,antioxidant enzyme activities,MDA content,mutant-strain lifespan,and anti-aging molecular signaling pathways were explored,as well as the underlying mechanisms.Results:CGA improved multiple indices of the nematode:body length was increased(all P<0.001),head-swing frequency and body-bending frequency were increased(all P<0.05),nematode longevity was prolonged(P=0.0021),lipofuscin deposition in nematodes was slowed down(all P<0.001),the chemotaxis index was improved(P=0.0012),ROS levels were reduced(all P<.001),and SOD activity and MDA content were reduced(SOD:P=0.0017 between the low-concentration group and the control group,P<.001 between the high-concentration and medium-concentration groups and the control group;MDA:P=0.0135 between the low-concentration group and the control group,and P<0.001 between the high-concentration and medium-concentration groups and the control group).In addition,CGA also activated the DAF-16 transcription factor,promoted DAF-16 nuclear translocation under oxidative stress conditions(both P<0.001 between the high-concentration and medium-concentration groups and the control group),and increased SOD-3 gene expression in nematodes(all P<0.001).Conclusion:CGA plays an anti-aging role in C.elegans.The underlying mechanisms include activation of the insulin/IGF-1 signaling pathway and enhancement of DAF-16 activity.This study lays a foundation for further research into the anti-aging effects of CGA. | Yuqian Yang Xu Chen Danyang Ye Chuanyu Wei Xinxin Pang Chuchu Kong Yongsheng Fang Hongliu Yang Yuanyuan Zhang Yonggang Liu | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，2： | 0 |
| 19 | Adjacent Pt Nanoparticles and Sub-nanometer WO_(x)Clusters Determine Catalytic Isomerization of C_(7)H_(16)显示文摘Processes for the isomerization of light alkanes have been commercialized;however,the isomerization of paraffins(C_(n)H_(2n+2),n≥7)remains a challenge.On mesoporous tungsten-zirconia catalyst supported Pt catalysts(Pt/WZrOx),initial isomerization productivity of 5249 moli-C7/molPt/h was obtained for n-heptane reforming at 275°C and 5 bar of hydrogen. | Bin Zhang Wei Zhou Jie Zhang Zirui Gao Danyang Cheng Lipeng Tang Xingwu Liu Yueqin Song Chunyang Dong Yao Xu Jie Yan Mi Peng Huizhen Liu Mark Douthwaite Meng Wang Ding Ma | 2022 | CCS Chemistry2022，4，8： | 0 |
| 20 | Hypoxic-ischemic encephalopathy induced cognitive decline secondary to upper gastrointestinal bleeding: a case report显示文摘Hypoxic-ischemic encephalopathy(HIE)occurs more in neonatal and rarely in adults.In adults,HIE is commonly caused by carbon monoxide(CO)poisoning,shock,cardiac arrest,respiratory depression,anesthesia and drug overdose.[1–3]In patients with acute gastrointestinal bleeding,decreased circulating blood supply causes cerebral ischemia and hypoxia,leading to dizziness,syncope and even sudden death.However,these conditions are more common especially in elderly patients with cerebrovascular stenosis,acute massive blood loss,using hemostatic agents,and high-risk factors of cardiovascular and cerebrovascular disease.[4]Here,we reported a middle-aged male patient,who was diagnosed with HIE after upper gastrointestinal bleeding without these high-risk factors. | Rui Wei Danyang Jing Xiangchen Meng Hongtao Wei | 2023 | World Journal of Emergency Medicine2023，14，4： | 0 |
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