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| 1 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial显示文摘 | Ann-Lii Cheng Zhongzhen Guan Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Tsai-Sheng Yang Won Young Tak Hongming Pan Shiying Yu Jianming Xu Fang Fang Jessie Zou Giuseppe Lentini Dimitris Voliotis Yoon-Koo Kang | 2011 | European Journal of Cancer2011，，10： | 4 |
| 4 | A new member of the topological semimetals family显示文摘In topological semimetals(TSMs),the quasi-particle excitations of electrons can be described by the Dirac or Weyl equation,mimicking the elusive massless Dirac or Weyl fermions in the low-frequency regime as emergent phenomena.The realization of elementary excitations,with and even | Hongming Weng Chen Fang Zhong Fang Xi Dai | 2017 | National Science Review2017，4，6： | 3 |
| 5 | Analysis of Gas-Solid Flow Characteristics in a Spouted Fluidized Bed Dryer by Means of Computational Particle Fluid Dynamics显示文摘In order to grasp the particle flow characteristics and energy consumption of industrial fluidized spouted beds,we conduct numerical simulations on the basis of a Computational Particle Fluid Dynamics(CPFD)approach.In particular,the traction model of Wen-Yu-Ergun is used and different inlet conditions are considered.Using a low-speed fluidizing gas,the flow state of the particles is better and the amount of particles accumulated at the bottom of the bed wall becomes smaller.For the same air intake,the energy loss of a circular nozzle is larger than that of a square nozzle. | Hongming Zhou Haozheng Gao Zheng Fang Jiangxin Yang Mingge Wu | 2020 | Fluid Dynamics & Materials Processing2020，16，4： | 3 |
| 6 | Topological nodal line semimetals predicted from first-principles calculations显示文摘拓扑的半金属是量物质的最新发现的状态,它从绝缘体扩大了拓扑的状态的概念到金属并且在最近的年里吸引了大研究兴趣。一般来说,有三种拓扑的半金属,也就是迪拉克半金属, Weyl 半金属,和节的线半金属。节的线半金属能为另外的拓扑的状态被看作先锋状态。例如,从如此的节的线开始说,节的线结构可能演变为 Weyl 点,把点变换成迪拉克,或由介绍联合的纺纱轨道(SOC ) 或集体术语成为拓扑的绝缘体。在这篇评论论文,我们介绍显示出节的线半金属状态的理论材料,包括所有碳 Mackay-Terrones 水晶( MTC ), anti-perovskite Cu 3 PdN ,压的黑磷,和材料的帽子3家庭,并且我们在场为获得物质的如此的新奇状态的设计原则。 | Rui Yu Zhong Fang Xi Dai Hongming Weng | 2017 | Frontiers of physics2017，12，3： | 3 |
| 7 | Topological electronic states in HfRuP family superconductors显示文摘Based on the first-principles calculations and experimental measurements,we report that the hexagonal phase of ternary transition metal pnictides TT’X(T=Zr,Hf;T’=Ru;X=P,As),which are well-known noncentrosymmetric superconductors with relatively high transition temperatures,host nontrivial bulk topology.Before the superconducting phase transition,we find that HfRuP belongs to a Weyl semimetal phase with 12 pairs of type-II Weyl points,while ZrRuAs,ZrRuP and HfRuAs belong to a topological crystalline insulating phase with trivial Fu-Kane Z_(2) indices but nontrivial mirror Chern numbers.High-quality single crystal samples of the noncentrosymmetric superconductors with these two different topological states have been obtained and the superconductivity is verified experimentally.The wide-range band structures of ZrRuAs have been identified by ARPES and reproduced by theoretical calculations.Combined with intrinsic superconductivity,the nontrivial topology of the normal state may generate unconventional superconductivity in both bulk and surfaces.Our findings could largely inspire the experimental searching for possible topological superconductivity in these compounds. | Yuting Qian Simin Nie Changjiang Yi Lingyuan Kong Chen Fang Tian Qian Hong Ding Youguo Shi Zhijun Wang Hongming Weng Zhong Fang | 2019 | npj Computational Materials2019，，1： | 1 |
| 8 | LiPF 6 and lithium difluoro(oxalato)borate/ethylene carbonate + dimethyl carbonate + ethyl(methyl)carbonate electrolyte for Li 4 Ti 5 O 12 anode显示文摘 | Hongming Zhou Zhenqi Fang Jian Li | 2012 | Journal of Power Sources2012，，： | 1 |
| 9 | The role of soot particles in the tribologieal behavior of engine lubricating oils 显示文摘 | Hu Enzhu Hu Xianguo Liu Tianxia Fang Ling Karl D D Xu Hongming | 2013 | Wear2013，304，： | 1 |
| 10 | Topological phases in pyrochlore thallium niobate Tl_(2)Nb_(2)O_(6+x)显示文摘The discovery of new topological electronic materials brings a chance to uncover new physics.Up to now,many materials have been theoretically proposed and experimentally proved to host different kinds of topological states.Unfortunately,there is little convincing experimental evidence for the existence of topological oxides.The reason is that oxidation of oxygen leads to ionic crystal in general and makes band inversion unlikely.In addition,the realization of different topological states in a single material is quite difficult,but strongly needed for exploring topological phase transitions. | Wei Zhang Kaifa Luo Zhendong Chen Ziming Zhu Rui Yu Chen Fang Hongming Weng | 2019 | npj Computational Materials2019，，1： | 0 |
| 11 | Influence of Hydrodynamic Pore Pressure Damage on the Performance of Hot-Mixed Renewable Asphalt Mixture显示文摘For evaluating the water stability of hot-mixed renewable asphalt mixture(HRM),the traditional methods are all tested under still water conditions.Except for damage in still water conditions,the hydrodynamic pore pressure generated by the tire driving on the surface water has a great impact.Thus,the RAP contents of the HRMs were designed at 0%,30%,45%and 60%with AC-25 gradation.Then,the self-designed evaluation methods of water stability and dynamic modulus were studied.Finally,the mechanism of the influence of hydrodynamic pore pressure damage on HRMs was studied.The results show that the water stability of HRM containing 30%RAP is equivalent to that of 45%RAP,and the water stability of HRM containing 60%RAP decreases significantly.The Contabro test after MIST treatment can be used as an evaluation method for hydrodynamic pore pressure damage on HRM.Low-speed,heavy-load traffic and larger RAP content have greater damage to the mixture after hydrodynamic pore pressure damage.The performance differences between the aged bitumen and pure bitumen,as well as the aged minerals and new minerals,are continuing to be enlarged in hydrodynamic pore pressure conditions,finally affecting the water stability and dynamic modulus of the HRMs. | Guodong Zeng Chao Li Yang Fang Hongming Huang Hao Li Yishen Xu | 2023 | Journal of Renewable Materials2023，11，5： | 0 |
| 12 | Evolution of Weyl nodes in Ni-doped thallium niobate pyrochlore Tl_(2-x)Ni_(x)Nb_(2)O_(7)显示文摘The magnetic Weyl semimetal(WSM)is important for fundamental physics and potential applications due to its spontaneous magnetism,robust band topology,and enhanced Berry curvature.It possesses many unique quantum effects,including a large intrinsic anomalous Hall effect,Fermi arcs,and chiral anomaly.In this work,using ab initio calculations,we propose that Nidoped pyrochlore Tl2Nb2O7is a magnetic WSM caused by the exchange field splitting on bands around its quadratic band crossing point.The exchange field tuned by Ni 3d on-site Coulomb interaction parameter U drives the evolution of Weyl nodes and the resulting topological phase transition.As Weyl nodes can exist at generic points in the Brillouin zone and are hard to identify exactly,their creation and annihilation,i.e.,the change in their number,chirality,and distribution,have been consistently confirmed with a combined theoretical approach,which employs parity criterion,symmetry indicator analysis,and the Wilson loop of the Wannier center.We find that Weyl nodes remain in a large range of U and are close to the Fermi level,which makes the experimental observation very possible.We think that this method and our proposal of magnetic WSM will be useful in finding more WSMs and add to the understanding of the topological phase transition. | Yuefang Hu Changming Yue Danwen Yuan Jiacheng Gao Zhigao Huang Zhong Fang Chen Fang Hongming Weng Wei Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，9： | 0 |
| 13 | Layer construction of topological crystalline insulator LaSbTe显示文摘Topological crystalline insulator(TCI)is one of the symmetry-protected topological states.Any TCI can be deformed into a simple product state of several decoupled two-dimensional(2 D)topologically nontrivial layers in its lattice respecting its crystalline symmetries called the layer construction(LC)limit.In this work,based on first-principles calculations we have revealed that both tetragonal LaSbTe(t-LaSbTe)and orthorhombic LaSbTe(o-LaSbTe)can be interpreted as stacking of 2 D topological insulators in each lattice space.The structural phase transition from t-LaSbTe to o-LaSbTe due to soft phonon modes demonstrates how the real space change can lead to the modification of topological states.Their symmetry-based indicators and topological invariants have been analyzed based on LC.We propose that LaSbTe is an ideal example demonstrating the LC paradigm,which bridges the crystal structures in real space to the band topology in momentum space. | YuTing Qian ZhiYun Tan Tan Zhang JiaCheng Gao ZhiJun Wang Zhong Fang Chen Fang HongMing Weng | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 0 |
| 14 | Predicting Dirac semimetals based on sodium ternary compounds显示文摘Predicting new Dirac semimetals,as well as other topological materials,is challenging since the relationship between crystal structure,atoms and band topology is complex and elusive.Here,we demonstrate an approach to design Dirac semimetals via exploring chemical degree of freedom.Based on understanding of the well-known Dirac semimetal,Na3Bi,three compounds in one family,namely Na_(2)MgSn,Na_(2)MgPb,and Na2CdSn,are located.Furthermore,hybrid-functional calculations with improved accuracy for estimation of band inversion show that Na_(2)MgPb and Na_(2)CdSn have the band topology of Dirac semimetals.The nontrivial surface states with Fermi arcs on the(100)and(010)surfaces are shown to connect the projection of bulk Dirac nodes.Most importantly,the candidate compounds are dynamically stable and have been experimentally synthesized.The ideas in this work could stimulate further predictions of topological materials based on understanding of existing ones. | Bo Peng Changming Yue Hao Zhang Zhong Fang Hongming Weng | 2018 | npj Computational Materials2018，，1： | 0 |
| 15 | Modulation bandwidth enhancement in monolithic integrated two-section DFB lasers based on the detuned loading effect显示文摘Modulation bandwidth enhancement in a directly modulated two-section distributed feedback(TS-DFB)laser based on a detuned loading effect is investigated and experimentally demonstrated.The results show that the 3-dB bandwidth of the TS-DFB laser is increased to 17.6 GHz and that chirp parameter can be reduced to 2.24.Compared to the absence of a detuned loading effect,there is a 4.6 GHz increase and a 2.45 reduction,respectively.After transmitting a 10 Gb/s non-return-to-zero(NRZ)signal through a 5-km fiber,the modulation eye diagram still achieves a large opening.Eight-channel laser arrays with precise wavelength spacing are fabricated.Each TS-DFB laser in the array has side mode suppression ratios(SMSR)>49.093 dB and the maximum wavelength residual<0.316 nm. | Yunshan Zhang Yifan Xu Shijian Guan Jilin Zheng Hongming Gu Lianyan Li Rulei Xiao Tao Fang Hui Zou Xiangfei Chen | 2023 | Journal of Semiconductors2023，44，11： | 0 |
| 16 | Exploration and Practice of the Reform of Postgraduate Award System-Taking Wuhan University of Science and Technology as an Example显示文摘China began to implement the charging policy for postgraduate students in 2014.Various universities at all levels have formulated a scholarship and stipend system for postgraduate students,which is in line with the needs of schools in talent training along with the spirit of relevant documents of the Ministry of Education and the actual situation of the schools.This study investigates and analyzes the advantages and disadvantages of the postgraduate funding by Wuhan University of Science and Technology.This article then provides advice for the reform of the scholarship and stipend system from improving the precision funding system,to increasing funding,to expanding the scope of postgraduate funding,and standardizing the treatment of deferred postgraduate students in hope that it would provide a basis for the funding system and provide guarantee for postgraduate students to complete their studies successfully. | Hongming Fang Shaowei Lu Shuang Yan Shijie Wang Lei Zhao Xiaohua Zuo Hui Jin | 2021 | Journal of Contemporary Educational Research2021，5，10： | 0 |
| 17 | Highly in-plane anisotropic optical properties of fullerene monolayers显示文摘Both the intrinsic anisotropic optical materials and fullerene-assembled 2D materials have attracted much interest in fundamental science and potential applications.The synthesis of a monolayer(ML)fullerene makes the combination of these two features plausible.In this work,using first-principles calculations,we systematically study the electronic structure and optical properties of quasi-hexagonal phase(qHP)ML and quasi-tetragonal phase(qTP)ML fullerenes.The calculations of q HP ML show that it is a semiconductor with small anisotropic optical absorption,which agrees with the recent experimental measurements.However,the results for qTP ML reveal that it is a semimetal with highly in-plane anisotropic absorption.The dichroic ratio,namely the absorption ratio of x-and y-polarized lightα_(xx)/α_(yy),is around 12 at photon energy of 0.29 eV.This anisotropy is much more pronounced when the photon energy is between 0.7 and 1.4 eV,whereα_(xx)becomes nearly zero whileα_(yy)is more than two orders of magnitude larger.This indicates qTP ML as a candidate for long-pursuit lossless metal and a potential material for atomically thin polarizer.We hope this will stimulate further experimental eforts in the study of qTP ML and other fullerene-assembled 2D materials. | Danwen Yuan Hanqi Pi Yi Jiang Yuefang Hu Liqin Zhou Yujin Jia Gang Su Zhong Fang Hongming Weng Xinguo Ren Wei Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，4： | 0 |
| 18 | Unprotected quadratic band crossing points and quantum anomalous Hall effect in FeB_(2) monolayer显示文摘Quadratic band crossing points(QBCPs)and quantum anomalous Hall effect(QAHE)have attracted the attention of both theoretical and experimental researchers in recent years.Based on first-principle calculations,we find that the FeB_(2) monolayer is a nonmagnetic semimetal with QBCPs at K.Through symmetry analysis and k·p invariant theory,we find that the QBCP is not protected by rotation symmetry and consists of two Dirac points with the same chirality(Berry phase of 2π).Once introducing Coulomb interactions,we find that there is a spontaneous-time-reversal-breaking instability of the spinful QBCPs,which gives rise to a C=2 QAH insulator with orbital moment ordering. | DongYu Wu YunPeng Huang Song Sun JiaCheng Gao ZhaoPeng Guo HongMing Weng Zhong Fang Kun Jiang ZhiJun Wang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，5： | 0 |
| 19 | Large Spin Hall Conductivity and Excellent Hydrogen Evolution Reaction Activity in Unconventional PtTe1.75 Monolayer显示文摘Two-dimensional(2D)materials have gained lots of attention due to the potential applications.In this work,we propose that based on first-principles calculations,the(2×2)patterned PtTe_(2)monolayer with kagome lattice formed by the well-ordered Te vacancy(PtTe_(1.75))hosts large and tunable spin Hall conductivity(SHC)and excellent hydrogen evolution reaction(HER)activity.The unconventional nature relies on the A1@1b band representation of the highest valence band without spin–orbit coupling(SOC).The large SHC comes from the Rashba SOC in the noncentrosymmetric structure induced by the Te vacancy.Even though it has a metallic SOC band structure,theℤ_(2)invariant is well defined because of the existence of the direct bandgap and is computed to be nontrivial.The calculated SHC is as large as 1.25×10^(3)h/e(Ωcm)^(−1)at the Fermi level(EF).By tuning the chemical potential from EF−0.3 to EF+0.3 eV,it varies rapidly and monotonically from−1.2×10^(3)to 3.1×10^(3)h/e(Ωcm)^(−1)In addition,we also find that the Te vacancy in the patterned monolayer can induce excellent HER activity.Our results not only offer a new idea to search 2D materials with large SHC,i.e.,by introducing inversion–symmetry breaking vacancies in large SOC systems,but also provide a feasible system with tunable SHC(by applying gate voltage)and excellent HER activity. | Dexi Shao Junze Deng Haohao Sheng Ruihan Zhang Hongming Weng Zhong Fang Xing-Qiu Chen Yan Sun Zhijun Wang | 2023 | Research2023，，3： | 0 |
| 20 | Internet of light: Technologies and applications显示文摘Intelligent lighting has attracted lots of research interests to investigate all the possible schemes to support this need as human has spent more and more time indoor.Semiconductor-based illumination network is an ideal bearer to carry on this mission.In this paper,we propose the concept of Internet of Light(IoL)and define its key functionalities by introducing the information and communication technologies to the illumination networks.Our latest research progress on high-speed transmission,resource optimization,and light stroboscopic irradiation experiment based on IoL platform show that IoL can not only provide value-added services such as positioning and information transmission but also act like a sensor network as part of Internet of Things infrastructure.It confirms that with sensors for different purposes integrated into the lamp,IoL helps people be aware of the environmental changes and make the adjustment accordingly,can provide cost-effective information service for Internet of Things applications,and supports the non-intrusive optical therapy in the future. | Jian Song Jintao Wang Fang Yang Hongming Zhang Chao Zhang Hui Yang Changyong Pan Xiaofei Wang Yongqiang Lyu Luoxi Hao | 2022 | Intelligent and Converged Networks2022，3，3： | 0 |
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