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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 3 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 4 | Eclogite-melt/peridotite reaction: Experimental constrains on the destruction mechanism of the North China Craton显示文摘To study the mechanism of melt-peridotite reaction pertinent to the destruction of the North China Craton (NCC) lithosphere, a series of experiments were performed at a pressure of 2.0 GPa and temperatures from 1250 to 1400°C using Bixiling eclogite and Damaping peridotite as starting materials. The experimental results show that the reaction between eclogite melt and peridotite causes dissolution of olivine and orthopyroxene and precipitation of clinopyroxene in the melt. The experimental run products, characterized by a lherzolite/pyroxenite/garnet-pyroxenite sequence, are consistent with the mantle xenoliths in the Neogene Hannuoba basalt of the NCC found by Liu et al. (2005). It suggests that the mafic lower continental crust was probably recycled into the mantle during the Mesozoic Era. In the experiments conducted at 1300 and 1350°C, the resulting melts have a high Mg# andesite signature, indicating that the melt-peridotite reaction may have played a major role in the generation of high Mg# andesite. Our experimental results support the hypothesis that melts derived from foundered eclogite in the asthenosphere will consume the lithospheric peridotites. Therefore, melt-peridotite reaction is an important mechanism for the destruction/thinning of the lithosphere. | WANG Chao JIN ZhenMin GAO Shan ZHANG JunFeng ZHENG Shu | 2010 | Science China Earth Sciences2010，53，6： | 17 |
| 5 | Hypoxia induces PGC-la expression and mitochondrial biogenesis in the myocardium of TOF patients显示文摘 | Qiang Wang Lin Zhang Zhixiang Fang Fang Zhao Zhiyuan Lv Zuguang Gu Junfeng Zhang Jin Wang Ke Zen Yang Xiang Dongjin Wang Chen-Yu Zhang | 2010 | Cell Research2010，20，6： | 13 |
| 6 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 7 | NUMERICAL SIMULATION OF CHARGED GAS-LIQUID TWO PHASE JET FLOW IN ELECTROSTATIC SPRAYING显示文摘Multi-fluid k-e-kp, two phase turbulence model is used to simulate charged gas-liquid two phase coaxial jet, which is the transorting flow field in electrostatic spraying. Compared with the results of experiment, charged gas-liquid two-phase turbulence can be well predicted by this model. | Wang Ze,Jin Hanhui,Wang Junfeng,Luo Tiqian (School of Energy and Power,Jiangsu University of Science and Technology) | 2001 | Chinese Journal of Mechanical Engineering2001，14，3： | 5 |
| 8 | Depositional characteristics and petroleum geological significance of wetland显示文摘Wetland is a new type of sedimentary facies proposed for the first time in this paper.It is a type of sedimentary environment,transitional between land facies and water(sea or lake) facies.In this paper,wetland is redefined as 'a type of sedimentary environments whose ground surface is flat and wet throughout the year,which may be covered with very shallow water(less than 2 m deep),and is covered with lush plant growth'.Wetland is reclassified into two types,swamp wetland(swamp in brief) and wet plain wetland(wet plain in brief).Swamp deposits are coal,while wet plain deposits are dark colored mudstones or silty mudstones rich in plant fossils and carbon debris.The deposits of wet plain are different from those of lake and floodplain in the abundance of plant fossils,color,resistivity well logging curve,and other sedimentary characteristics.In boreholes,resistivity logging can be used to distinguish between wet plain mudstones and lake mudstones.Understanding the sedimentary characteristics of wet plain wetland can help to identify wet plain deposits which were formerly classified as floodplain or lake deposits.This will help to reconstruct the palaeogeography and to understand the history of basin and climate evolution accurately,and is especially important in evaluation of the hydrocarbon generating potential of a basin.With the Jurassic Sangonghe Formation of the Yanqi Basin as an example,the identification characteristics of wetland are described. | Jin Zhenkui Gu Junfeng Su Nina Wang Zhaofeng Huang Xiaoping | 2009 | Petroleum Science2009，6，4： | 5 |
| 9 | Braided river and distribution patterns of sand bodies of Jurassic Badaowan formation in Block T13 of Junggar basin显示文摘In order to determine the planar and volume distribution of sand bodies of the Jurassic Badaowan formation in Block T13 of Junggar basin,we used analysis of field outcrop and 3D seismic data,which play an essential role in areas of sparse well coverage.We describe sedimentary facies characteristics,sand body planforms,width and connectivity patterns of sand bodies,and vertical associations and successions by acoustic impedance inversion technology and sedimentological theory.Results of our study show braided fluvial strata deposits in the Jurassic Badaowan formation.Each sand body is approximately lenticular in shape.The width of each sand body falls in the range 100~800 m,with most between 200 and 400 m.The sand bodies vary in thickness from 4 to 13 m,with most below 9 m.The width/thickness ratios lie in the range 20~55.The connectivity of braided fluvial channel sand bodies is controlled by changes of accommodation space.One fining-upward sedimentary cycle of base-level rise is recognized in Badaowan formation,representing an upward rise of base level.The connectivity of sand bodies was found to be greatest in the early stage of base-level rise,becoming progressively worse with increasing base-level rise. | SUN Xiaofang JIN Zhenkui WANG Zhaofeng HUANG Xiaoping GU Junfeng | 2010 | Mining Science and Technology2010，20，3： | 4 |
| 10 | Ammonium Salt Deposition Characteristics in an Air Cooler System Based on the Coupling of Fluid Flow and Heat Transfer Simulation显示文摘The ammonium salt corrosion is a typical failure mode for the hydrogenation reaction effluent air cooler(REAC) system. In order to investigate the corrosion characteristics in the REAC system, numerical simulations were performed by using the mixture model, the heating transfer model, and the particles tracking model. The results show that the differences between the temperature and the velocity at each cross section of the first-row and second-row tubes are small. The inertia of the particles plays an important role in the particle’s deposition, and the smaller particles distribute more uniformly in the air cooler. However, for larger particles, they prefer falling from the inner side of the vertical elbow, and preferentially depositing at the inlet header and pipes before saturation. In the heat exchanger tubes, the particle deposition number is larger in the second-row tubes than that in the first-row tubes, and the high-risk tubes mainly concentrate on the middle and right side of the air cooler. The kinetic parameters of the particles are in accordance with the blocking-prone position in many real operating conditions. | Jin Haozhe Zhou Junfeng Liu Wenwen Liu Xiaofei Ou Guofu | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 4 |
| 11 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 12 | Late Cretaceous-Cenozoic Multi-Stage Denudation at the Western Ordos Block: Constraints by the Apatite Fission Track Dating on the Langshan显示文摘The apatite fission track dating of samples from the Dabashan(i.e., the Langshan in the northeastern Alxa Block) by the laser ablation method and their thermal history modeling of AFT ages are conducted in this study. The obtained results and lines of geological evidence in the study region indicate that the Langshan has experienced complicated tectonic-thermal events during the the Late Cretaceous-Cenozoic. Firstly, it experienced a tectonic-thermal event in the Late Cretaceous(~90–70 Ma). The event had little relation with the oblique subduction of the Izanagi Plate along the eastern Eurasian Plate, but was related to the Neo-Tethys subduction and compression between the Lhasa Block and Qiangtang Block. Secondly, it underwent the dextral slip faulting in the Eocene(~50–45 Ma). The strike slip fault may develop in the same tectonic setting as sinistral slip faults in southern Mongolia and thrusts in West Qinling to the southwest Ordos Block in the same period, which is the remote far-field response to the India-Eurasia collision. Thirdly, the tectonic thermal event existed in the late Cenozoic(since ~10 Ma), thermal modeling shows that several samples began their denudation from upper region of partial annealing zone(PAZ), and the denudation may have a great relationship with the growth of Qinghai-Tibetan Plateau to the northeast. In addition, the AFT ages of Langshan indicate that the main body of the Langshan may be an upper part of fossil PAZ of the Late Cretaceous(~70 Ma). The fossil PAZ were destroyed and deformed by tectonic events repeatedly in the Cenozoic along with the denudation. | CUI Xianyue ZHAO Qihua ZHANG Jin WANG Yannan ZHANG Beihang NIE Fengjun QU Junfeng ZHAO Heng | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 13 | Deformation at the Easternmost Altyn Tagh Fault: Constraints on the Growth of the Northern Qinghai–Tibetan Plateau显示文摘How the Altyn Tagh fault(ATF) extends eastwards is one of the key questions in the study of the growth of the Qinghai–Tibetan Plateau. Detailed fieldwork at the easternmost part of the ATF shows that the ATF extends eastward and bypasses the Kuantan Mountain;it does not stop at the Kuantan Mountain, but connects with the northern Heishan fault in the east. The ATF does not enter the Alxa Block but extends eastward along the southern Alxa Block to the Jintanan Mountain. The Heishan fault is not a thrust fault but a sinistral strike-slip fault with a component of thrusting and is a part of the ATF. Further to the east, the Heishan fault may connect with the Jintananshan fault. A typical strike-slip duplex develops in the easternmost part of the ATF. The cut and deformed Quaternary sediments and displaced present gullies along the easternmost ATF indicate that it is an active fault. The local highest Mountain(i.e., the Kuantan Mountain) in the region forms in a restraining bend of the ATF due to the thrusting and uplifting. The northward growth of the Qinghai–Tibetan Plateau and the active deformation in South Mongolia are realized by sinistral strike-slipping on a series of NE–SW-trending faults and thrusting in restraining bends along the strike-slip faults with the northeastward motion of blocks between these faults. | ZHANG Jin YUN Long ZHANG Beihang QU Junfeng ZHAO Heng HUI Jie WANG Yannan ZHANG Yiping | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 3 |
| 14 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 15 | Carbon-based optical limiting materials显示文摘In this mini-review, special attention has been paid to carbon-based optical limiting materials. After a brief introduction to optical limiting mechanisms of carbon-based optical materials and their characterization technique, this mini-review presents the recent progress of carbon-based optical limiting materials including carbon black suspensions(CBS), carbon nanotubes(CNTs), fullerenes, graphene and detonation nanodiamond. Finally, perspectives on carbon-based optical limiting are given. | Yan Wang Mingzhe Lv Jin Guo Tingfeng Wang Junfeng Shao Dong Wang Ying-Wei Yang | 2015 | Science China(Information Sciences)2015，58，12： | 1 |
| 16 | Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration显示文摘The restoration of bone defects caused by osteoporosis remains a challenge for surgeons.Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model.The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility.Moreover,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in vitro.The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation.Furthermore,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting osteogenesis.This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis. | Qianju Wu Longwei Hu Ran Yan Junfeng Shi Hao Gu Yuwei Deng Ruixue Jiang Jin Wen Xinquan Jiang | 2022 | Bone Research2022，10，4： | 1 |
| 17 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 18 | Opportunities for graphene,single-walled and multi-walled carbon nanotube applications in agriculture:A review显示文摘Nanotechnology is an important driver leading to the revolution in the fields of agriculture.Here,we presented insights into the application of carbon nanomaterials(single-and multi-walled carbon nanotubes and graphene)in biomolecule delivery for crop breeding.We also reviewed the application of graphene to biosensors and the utilization efficiency of water,fertilizers and insecticides in agriculture to better manage environmental stresses.Finally,potential molecular interaction mechanisms between graphene and plant roots were discussed.It can be expected that carbon nanomaterials will hold strong promise in developing a more efficient agricultural production system. | Zhiwen Chen Jianguo Zhao Junfeng Cao Yongyan Zhao Jinquan Huang Zishou Zheng Weijia Li Shang Jiang Jun Qiao Baoyan Xing Jin Zhang | 2022 | Crop Design2022，1，1： | 1 |
| 19 | High expression of STIM1 in the early stages of diffuse axonal injury显示文摘 | Yu Li Jinning Song Xiaobin Liu Ming Zhang Jiyang An Peng Sun Dandong Li Tao Jin Junfeng Wang | 2012 | Brain Research2012，，： | 1 |
| 20 | Ultra-thin metal-organic framework nanoribbons显示文摘Structure engineering of metal-organic frameworks(MOFs)at the nanometer scale is attracting increasing interest due to their unique properties and new functions that normally cannot be achieved in bulk MOF crystals.Here,we report the preparation of ultra-thin MOF nanoribbons(NRBs)by using metal-hydroxide nanostructures as the precursors.Importantly,this general method can be used to synthesize various kinds of ultra-thin MOF NRBs,such as MBDC(M=Co,Ni;BDC=1,4-benzenedicarboxylate),NiCoBDC,CoTCPP(TCPP=tetrakis(4-carboxyphenyl)porphyrin)and MIL-53(Al)NRBs.As a proof-of-concept application,the as-prepared ultra-thin Co BDC NRBs have been successfully used as a fluorescent sensing platform for DNA detection,which exhibited excellent sensitivity and selectivity.The present strategy might open an avenue to prepare MOF nanomaterials with new structures and unique properties for various promising applications. | Bingqing Wang Meiting Zhao Liuxiao Li Ying Huang Xiao Zhang Chong Guo Zhicheng Zhang Hongfei Cheng Wenxian Liu Jing Shang Jing Jin Xiaoming Sun Junfeng Liu Hua Zhang | 2020 | National Science Review2020，7，1： | 1 |
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