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| 1 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 2 | A semi-physical sediment yield model for estimation of suspended sediment in loess region显示文摘Sediment yield is a complex function of many environmental factors including climate,hydrology,vegetation,basin topography,soil types,and land cover.We present a new semi-physical watershed sediment yield model for the estimation of suspended sediment in loess region.This model is composed by three modules in slope,gully,and stream phases.For slope sediment yield,a balance equation is established based on the concept of hydraulic erosion capacity and soil erosion resistance capacity.According to the statistical analysis of watershed characteristics,we use an exponential curve to approximately describe the spatial variability of watershed soil erosion resistance capacity.In gully phase,the relationship between gully sediment concentration and flow velocity is established based on the Bagnold' stream power function.In the stream phase,we assume a linear dependence of the sediment volume in the reach on the weighted sediment input and output.The proposed sediment yield model is operated in conjunction with a conceptual hydrologic model,and is tested over 16 regions including testing grounds,and small,medium and large watersheds in the loess plateau region in the mid-reach of Yellow River.Our results indicate that the model is reasonable in structure and is able to provide a good simulation of sediment generation and transportation processes at both flood event scale and inter-annual time scale.The proposed model is generally applicable to the watersheds with soil texture similar to that of the loess plateau region in the Yellow River basin in China. | Wei Si Weimin Bao Peng Jiang Liping Zhao Simin Qu | 2017 | International Journal of Sediment Research2017，32，1： | 7 |
| 3 | CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer显示文摘(CEACAM6 ) Carcinoembryonic 抗原相关的房间粘附分子 6 证明在许多 humancancers 的增加的表示,和它的在表示上与提高的移植被联系,侵略,并且在 vivo 转移。这里,我们报导 CEACAM6 在房间衬里的胃的癌症(GC ) 和肿瘤纸巾是起来调整的。在 MKN-45 和 SGC-7901 GC 房间的 Over-expressionof CEACAM6 在 athymic 老鼠在 vitro 和转移支持了移植和侵略,而 MKN-28 和 SNU-16 GC 房间的移植和侵略被 knockdownof CEACAM6 压制。当 CEACAM6 是 over-expressedin SGC-7901 房间时,我们也观察到类固醇受体激活剂(C-SRC ) phosphorylation 被增加。一起拿,这些结果建议 CEACAM6 在 GC 作为 oncoprotein 工作并且可以是 importantmetastatic biomarker 和治疗学的目标。 | Yunqiang Zhang Mingde Zang Jianfang Li Jun Ji Jianian Zhang Xiaolei Liu Ying Qu Liping Su Chen Li Yinyan Yu Zhenggang Zhu Bingya Liu Min yan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 5 |
| 4 | A Harmful-Intrusion Detection Method Based on Background Reconstruction and Two-Dimensional K-S Test in an Optical Fiber Pre-Warning System显示文摘为光纤维侵入警告前系统(OFIPS ) 的关键技术和主要困难是有害侵入的信号的抽取。在被阶段敏感的光时间域反射计处理以后(-OTDR), 颤动信号能 preliminarily 被提取。通常,这些包括噪音和侵入。这里,侵入能被划分成有害、无害的侵入。关于信号特征的仔细的学习,有害侵入的一个有效抽取方法在纸被建议。在背景重建的部分,第一,所有侵入信号被经常的虚惊率(CFAR ) 首先检测。我们然后重建由提取警报点,时间和振幅的由二部合成的信息的背景。这保证察觉背景由侵入信号组成。在二维的 Kolmogorov-Smirnov (K-S ) 测试的部分,第二提取了侵入以便从所有提取有害的,我们设计一个分离方法。它基于有害侵入的信号特征,它是更短的时间间隔和更高的振幅。在实际 OFIPS,察觉方法在一些典型场面被使用,它包括很多无害的侵入,例如构造地点和忙道路。结果证明我们能有效地提取有害侵入。 | Fukun BI Tong ZHENG Hongquan QU Liping PANG | 2016 | Photonic Sensors2016，6，2： | 5 |
| 5 | A New Detection Method Based on CFAR and DE for OFPS显示文摘光纤维警告前系统(OFPS ) 广泛地在管道运输域里被利用。OFPS 的侵入需要被定位。在这个系统,原来的信号由噪音,干扰,和侵入信号组成。这里,噪音是与高力量拥有的背景和无害的干扰,并且侵入信号是在这个系统的察觉的主要目标。因此,学习在提取上强调侵入从全部的发信号。建议方法能被划分成二部分,经常的虚惊率(CFAR ) 和膨胀和侵蚀(DE ) 。前者被使用消除噪音,并且后者是移开干扰。根据一些研究,噪音背景的特征与 CFAR 空间察觉一致。而且,在 CFAR 以后的察觉结果能表现为时空的一幅二进制图象。而且,干扰相对被断开。因而,他们能被从处理的图象被介绍的 DE 消除。总结,这个新奇方法基于能有效地消除噪音和干扰的 CFAR 和 DE。而且,它执行灿烂的察觉表演。一系列测试在中国北京,和可靠性的人 Tou Gou 被开发建议方法能被这些测试验证。 | Zezheng QIU Tong ZHENG Hongquan QU Liping PANG | 2016 | Photonic Sensors2016，6，3： | 5 |
| 6 | Study on the quantitative structureactivity relation-ship of C-10 substituted artemisinin(QHS)’s derivatives using rough set theory显示文摘The structure-activity relationship study of C-10 substituted artemisinin (QHS) derivatives that are used as antimalarial was performed with the RS (rough sets) method. An RS process is a concise nonlinear process, and it has broad application foreground in the data mining of nonlinear life courses. In this work, initially the parameters of C-10 substituted QHS’s derivatives were computed with the quantum chemistry method, and the information table was constructed from the parameters (condition attributes) and biological activity (decision attributes). Based on the analysis of rough set theory, the core and reduction of attributes sets were obtained. Then the decision rules were extracted and the struc-ture-activity relationship was analyzed. As a nonlinear system, RS theory can extract the special rela-tion in the database. It has the advantage of being nonlinear over multiple linear regression (MLR), principal component analysis (PCA), partial least square (PLS), etc., and the advantage of obtaining results with unambiguous physical meanings over artificial neuron networks (ANNs), etc. The result obtained in this study is instructive to the study of pharmacodynamics, resistance mechanism of QHS and development of QHS’s derivatives. | LIU Hao QU LingBo GAO HongBin WANG JinXiang HAN LiPing XIANG BingRen | 2008 | Science China Chemistry2008，51，10： | 5 |
| 7 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 8 | Vascular protection and regenerative effects of intranasal DL-3-N butylphthalide treatment after ischaemic stroke in mice显示文摘Objective To investigate the effects of DL-3-N butylphthalide(NBP)via intranasal delivery after ischaemic stroke in mice.Methods C57BL/6 mice were divided into three groups:sham,stroke with vehicle and stroke with NBP treatment.Ischaemic stroke was induced by permanent ligation of right middle cerebral artery with 7 min common carotid artery occlusion.NBP(100 mg/kg)or vehicle was intranasally administered at 1 hour after stroke and repeated once a day until sacrifice.Bromodeoxyuridine(BrdU)(50 mg/kg/day)was given from the third day until sacrifice.Sensorimotor function was tested during 1-21 days after stroke.Local cerebral blood flow in the ischaemic and peri-infarct regions was measured using laser Doppler flowmetry before,during and 3 days after ischaemia.Expressions of vascular endothelial growth factor(VEGF)and endothelial nitric oxide synthase as well as regenerative marker BrdU in the peri-infarct region were analysed by western blotting and immunohistochemical methods.Results Compared with the vehicle group,NBP treatment significantly increased the VEGF expression in the poststroke brain.Stroke mice that received NBP showed significantly less vascular damage after stroke and more new neurons and blood vessels in the peri-infarct region at 21 days after stroke.In the adhesive removal test,the sensorimotor function of stroke mice treated with NBP performed significantly better at 1,3 and 7 days after stroke compared with vehicle controls.Conclusion Daily intranasal NBP treatment provides protective and neurogenic/angiogenic effects in the poststroke brain,accompanied with functional improvements after a focal ischaemic stroke in mice. | Mengyao Qu Jingjie Zhao Yingying Zhao Jinmei Sun Liping Liu Ling Wei Yongbo Zhang | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 9 | Assessing the ecological vulnerability of protected areas by using Big Earth Data显示文摘The ecological vulnerability of global protected areas(PAs)is linked to the 2030 United Nations Sustainable Development Goals.We developed a novel degree of ecological vulnerability(DEV)index based on Big Earth Data to assess the ecological vulnerability of PAs.This is a transparent,repeatable,large-scale and rapid assessment method.We applied the method to case studies of International Union for Conservation of Nature(IUCN)PAs in the basins of the Aral Sea,the Caspian Sea,the Black Sea and the Lake Baikal.Between 2001 and 2015,the spatial pattern of ecological vulnerability in the study area was relatively stable.The Caspian Sea basin and protected landscape/seascape(category V)showed high ecological vulnerability,while the Black Sea basin and wilderness areas(category Ib)showed low ecological vulnerability.Big Earth Data shows great vitality in PAs ecological vulnerability assessment.Strengthening international cooperation is an important means to break the bottleneck of ecological environment and resource endowment in these important international basins. | Yaomin Zheng Shudong Wang Yue Cao Jinlian Shi Yi Qu Liping Li Tianjie Zhao Zhenguo Niu Rui Yang Peng Gong | 2021 | International Journal of Digital Earth2021，14，11： | 3 |
| 10 | Safety and efficacy of Compound Huangdai Tablets combined with all-trans retinoic acid for treatment of acute promyelocytic leukemia:Clinical evidence and potential mechanisms显示文摘Objective:To evaluate the safety and efficacy of Compound Huangdai Tablets(Realgar-Indigo Naturalis formula,RIF)combined with all-trans retinoic acid(ATRA)to treat acute promyelocytic leukemia(APL).Methods:This study was registered in PROSPERO(CRD42018108118).The relevant literatures on RIF treatment of APL were systematically searched in the following databases:China National Knowledge Infrastructure,Wanfang,VIP Medical Information System,Chinese Biomedical Database,EMBASE,Cochrane Library,and PubMed.The quality of the included studies was evaluated and Review Manager 5.3 software and Stata 13.0 software were used to perform the Meta-analysis.In addition,this study used the method of network pharmacology to conduct a preliminary exploration of the mechanism of RIF on APL.Results:The study included 12 studies involving 775 APL patients.The Meta-analysis showed that there was no significant difference(P>0.05)between the RIF group and the arsenic trioxide(ATO)group for primary outcomes,secondary outcomes apart from liver dysfunction.The incidence of liver dysfunction(P=0.006)in the RIF group were significantly lower than those in the ATO group.In addition,the cost of maintenance therapy in the RIF group was significantly lower(P<0.05)than the ATO group.Besides,the active ingredients in RIF mainly act on targets proteins such as ACHE,NCOA2,RXRA,and then play a role in the treatment of APL through regulating multiple molecular mechanisms,such as TP53 regulates transcription of cell cycle genes,nuclear receptor transcription pathway.Conclusion:There was no significant difference in efficacy of oral RIF combined with ATRA compared with intravenous ATO combined with ATRA for the treatment of APL.The oral RIF exposed patients to less risk,offered more convenience and had lower prices.RIF can treat APL by multi-target and multipathway interventions that inducing apoptosis of APL cells and inhibiting the proliferation of APL cells,and so on.Therefore,oral RIF in the treatment of APL is worthy of further research and development. | Qianqian Huang Tao Wang Yan Xiong Liping Qu Qiaozhi Yin Wenjun Zou | 2022 | Chinese Herbal Medicines2022，14，1： | 3 |
| 11 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 12 | Impact of gravitation on gaseous pollutant source identification显示文摘It is necessary to identify a gaseous pollutant source rapidly so that prompt actions can be taken, but this is one of the difficulties in the inverse problem areas. In this paper, an approach to identifying a sudden continuous emission pollutant source based on single sensor information is developed to locate a source in an enclosed space with a steady velocity field. Because the gravity has a very important influence on the gaseous pollutant transport and the source identification, its influence is analyzed theoretically and a conclusion is drawn that the velocity of fluid is a key factor to effectively help weaken the gravitational influence. Further studies for a given 2-D case by using the computational fluid dynamics (CFD) method show that when the velocity of inlet is less than one certain value, the influence of gravity on the pollutant transport is very significant, which will change the velocity field obviously. In order to quantitatively judge the practical applicability of identification approach, a synergy degree of the velocity fields before and after a source appearing is proposed as a condition for considering the influence of gravity. An experimental device simulating pollutant transmission was set up and some experiments were conducted to verify the practical application of the above studies in the actual gravitational environment. The results show that the proposed approach can successfully locate the sudden constant source when the experimental situations meet the identified conditions. | Pang Liping Zhang Yu Qu Hongquan Hu Tao Zhao Jingquan | 2013 | Chinese Journal of Aeronautics2013，26，2： | 2 |
| 13 | Adsorptive removal of phosphate by a nanostructured Fe–Al–Mn trimetal oxide adsorbent显示文摘 | Jianbo Lǚ Huijuan Liu Ruiping Liu Xu Zhao Liping Sun Jiuhui Qu | 2013 | Powder Technology2013，，： | 2 |
| 14 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 15 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 16 | Application of prepara-tive high-speed counter-current chromatography for isolation and sepa-ration of sehizandrin and gomisin A from Schisandra chinensis显示文摘 | PENG Jinyong FAN Guorong QU Liping | 2005 | Jour-nal of Chromatography A2005，1082，2： | 1 |
| 17 | Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer显示文摘 | Xiongyan Wu Xuehua Chen Quan Zhou Pu Li Beiqin Yu Jianfang Li Ying Qu Jun Yan Yingyan Yu Min Yan Zhenggang Zhu Bingya Liu Liping Su | 2013 | Cancer Letters2013，，1： | 1 |
| 18 | Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms显示文摘 | Yuhan Tang Jian Xu Wei Qu Xiaolin Peng Peng Xin Xuefeng Yang Chenjiang Ying Xiufa Sun Liping Hao | 2012 | The Journal of Nutritional Biochemistry2012，，11： | 1 |
| 19 | Kinetics of the action of three selenides on Staphylococcus aureus growth as studied by microcalorimetry显示文摘 | Huigang Liang Jun Wu Yi Liu Liping Yang Liming Hu Songsheng Qu | 2003 | Biological Trace Element Research2003，，2： | 1 |
| 20 | Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population显示文摘 | Fujiao Duan Wei Xie Lihong Cui Peng Wang Chunhua Song Honghong Qu Kaijuan Wang Jianying Zhang Liping Dai | 2013 | Cancer Epidemiology2013，，： | 1 |
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