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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | The influence of tectonic evolution on the accumulation and enrichment of coalbed methane (CBM)显示文摘The current accumulation and enrichment of CBM reservoir is a result of the preservation and destruction of former CBM, after the superposing evolution of reversing-and-uplifting and the subsequent evolution within the coal-bearing basin. The critical moment of the CBM reservoir formation is the time when the burying depth of the overlying net thickness amounts to the least in geological history after the gas generation of coal beds. Except the coal-bearing basins of lower metamorphism, most basins suffered the evolution stage of reversion and uplift. The formation of the CBM reservoir is controlled by the beginning and lasting time, and the intensity of reversing and uplifting. The tectonic evolution after reversing and uplifting also affects the accumulation of CBM in coal-bearing basin. The CBM constantly dissipates in the area of chronically uplifting and de-nudating. The area developed overlying sedimentation is advantageous to the preservation of CBM, but also can lead to the reduction of CBM saturation. | SONG Yan ZHAO Mengjun LIU Shaobo WANG Hongyan CHEN Zhenhong | 2005 | Chinese Science Bulletin2005，50，S1： | 13 |
| 4 | Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy显示文摘Conventional PCR methods combined with linkage analysis based on short tandem repeats(STRs) or Karyomapping with single nucleotide polymorphism(SNP) arrays, have been applied to preimplantation genetic diagnosis(PGD) for spinal muscular atrophy(SMA), an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wildtype embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses(MARSALA) is a new method allowing embryo selection by a one-step next-generation sequencing(NGS) procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion(carriers) from the wild-type(normal) ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos(homozygous deletion), which can be regarded as probands for linkage analysis, in case that the affected family member is absent. In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation. | Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli Nie Yuan Wei Zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan | 2016 | Journal of Genetics and Genomics2016，43，9： | 9 |
| 5 | Hazard-evaluation-oriented Moving Horizon Parallel Steering Control for Driver-Automation Collaboration During Automated Driving显示文摘Prompted by emerging developments in connected and automated vehicles, parallel steering control, one aspect of parallel driving, has become highly important for intelligent vehicles for easing the burden and ensuring the safety of human drivers. This paper presents a parallel steering control framework for an intelligent vehicle using moving horizon optimization.The framework considers lateral stability, collision avoidance and actuator saturation and describes them as constraints, which can blend the operation of a human driver and a parallel steering controller effectively. Moreover, the road hazard and the steering operation error are employed to evaluate the operational hazardous of an intelligent vehicle. Under the hazard evaluation,the intelligent vehicle will be mainly operated by the human driver when the vehicle operates in a safe and stable manner.The automated steering driving objective will play an active role and regulate the steering operations of the intelligent vehicle based on the hazard evaluation. To verify the effectiveness of the proposed hazard-evaluation-oriented moving horizon parallel steering control approach, various validations are conducted, and the results are compared with a parallel steering scheme that does not consider automated driving situations. The results illustrate that the proposed parallel steering controller achieves acceptable performance under both conventional conditions and hazardous conditions. | Hongyan Guo Linhuan Song Jun Liu Fei-Yue Wang Dongpu Cao Hong Chen Chen Lv Partick Chi-Kwong Luk | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，6： | 8 |
| 6 | Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies显示文摘Dear Editor,Identifying pathogenic gene mutations and their combination is critical but challenging in dissecting the etiology of complex diseases when more than one gene is involved.1 The digenic/oligogenic/omnigenic models,holding that more than one gene could act synergistically,appeal to a wide range of genes responsible for complex phenotypes.1,2,3,4 These genetic models advanced our understanding of genetic factors underlying complex phenotypes,yet an accordingly rapid and efficient experimental assay for identifying pathogenic combinations of genetic variants at animal model level is lacking and urgently needed. | Lingbo Wang Ying Zhang Xiaoyi Fu Shuangshuang Dong Shuyan Tang Ning Zhang Chengcheng Song Nan Yang Lin Zhang Hongyan Wang Huijuan Shi Li Jin Feng Zhang Jinsong Li Keqin Hua | 2020 | Cell Research2020，30，1： | 8 |
| 7 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 8 | Driver-automation shared steering control for highly automated vehicles显示文摘A model predictive control(MPC)-based shared steering framework for intelligent vehicles is proposed in this paper.The road boundary and vehicle stability boundary are regarded as the safe envelope,and the tradeoff between the freedom of driver operation and safety assurance of intelligent vehicles is made within this safe envelope.Under this cooperative steering framework,the reliability of drivers is analyzed in dangerous situations and in the predictive time domain,and two improved schemes are proposed.Under the two improved schemes,the weight of the control objective can be adaptively changed according to the results of the threat assessment and predetermined strategy.At the same time,an evaluation index named control intervention rate and risk rate is proposed to evaluate the designed human-vehicle cooperation scheme.The simulation results show that the performance of the two improved schemes in ensuring the safety of intelligent vehicles has been improved. | Jun LIU Hongyan GUO Linhuan SONG Qikun DAI Hong CHEN | 2020 | Science China(Information Sciences)2020，63，9： | 6 |
| 9 | Benefit Evaluation of the Deep Peak-regulation Market in the Northeast China Grid显示文摘In the Northeast China Grid(NCG),the percentage of wind power has reached nearly 20%of the total installed generation capacity,which causes increasing demands for deep peak-regulation capacity(DPC)during the operation of power systems.The shortage of DPC has become a significant problem in the NCG which may lead to wind curtailments and affect the security of power systems as well as the heating needs for inhabitants.In order to cope with this DPC shortage issue,the deep peak-regulation market(DPM)was established and has been running steadily in the past few years in NCG.This paper elaborates on the roles of the market players and the operational processes of the DPM,of which the advancements in terms of management mechanism are summarized.Moreover,benefits of the DPM for social harmony,environmental protection and economic efficiency are analyzed,for which relevant evaluation indices are proposed.A five-unit simulation system is constructed to illustrate the operation and benefits of the DPM.And focusing on comparisons with the previous Two Rules,the case study of Liaoning Power Grid verifies further that the DPM is feasible and able to bring more benefits to grids. | Hongyan Ma Zheng Yan Mingjie Li Dong Han Xiao Han Yiqun Song Ping Wei Gang Li Yongjun Liu | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 6 |
| 10 | TXNDC5 synergizes with HSC70 to exacerbate the inflammatory phenotype of synovial fibroblasts in rheumatoid arthritis through NF-κB signaling显示文摘The upregulated expression of thioredoxin domain-containing protein 5(TXNDC5)is associated with rheumatoid arthritis in patients and model mice.However,the underlying mechanism by which TXNDC5 influences the pathological activation of rheumatoid arthritis synovial fibroblasts(RASFs)remains unknown.In this study,we show that TXNDC5 expression in RASFs and their cytokine production are significantly upregulated in response to LPS,TNF-αand IL-6,but suppressed by transfection with TXNDC5-siRNA.TXNDC5 is further validated as the direct target of NF-κB signaling.Mechanistically,TXNDC5 directly interacts with heat shock cognate 70 protein(HSC70)to sequester it in the cytoplasm,and HSC70 silencing exerts the same effects as TXNDC5 on the biological activity of RASFs(for example,decreased cell viability,invasion and cytokine production).Furthermore,HSC70 activates NF-κB signaling by destabilizing IκBβprotein in the absence of LPS or facilitating its nuclear translocation in the presence of LPS.Importantly,TXNDC5 can also regulate the activity of NF-κB signaling in a HSC70-IκBβ-dependent manner.Taken together,by linking HSC70 and NF-κB signaling,TXNDC5 plays a pro-inflammatory role in RASFs,highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction. | Lin Wang Hongyan Dong Guanhua Song Rui Zhang Jihong Pan Jinxiang Han | 2018 | Cellular & Molecular Immunology2018，15，7： | 5 |
| 11 | Causes for different spatial distributions of minimum Arctic sea-ice extent in 2007 and 2012显示文摘Satellite records show the minimum Arctic sea ice extents(SIEs) were observed in the Septembers of 2007 and2012, but the spatial distributions of sea ice concentration reduction in these two years were quite different.Atmospheric circulation pattern and the upper-ocean state in summer were investigated to explain the difference.By employing the ice-temperature and ice-specific humidity(SH) positive feedbacks in the Arctic Ocean, this paper shows that in 2007 and 2012 the higher surface air temperature(SAT) and sea level pressure(SLP)accompanied by more surface SH and higher sea surface temperature(SST), as a consequence, the strengthened poleward wind was favorable for melting summer Arctic sea ice in different regions in these two years. SAT was the dominant factor influencing the distribution of Arctic sea ice melting. The correlation coefficient is –0.84 between SAT anomalies in summer and the Arctic SIE anomalies in autumn. The increase SAT in different regions in the summers of 2007 and 2012 corresponded to a quicker melting of sea ice in the Arctic. The SLP and related wind were promoting factors connected with SAT. Strengthening poleward winds brought warm moist air to the Arctic and accelerated the melting of sea ice in different regions in the summers of 2007 and 2012. Associated with the rising air temperature, the higher surface SH and SST also played a positive role in reducing summer Arctic sea ice in different regions in these two years, which form two positive feedbacks mechanism. | CUI Hongyan QIAO Fangli SHU Qi SONG Yajuan JIANG Chunfei | 2015 | Acta Oceanologica Sinica2015，34，9： | 5 |
| 12 | Small G Protein as a Novel Component of the Rice Bmssinosteroid Signal Transduction显示文摘Brassinosteroids (BR ) 是为植物生长和开发是必要的类固醇荷尔蒙的一个班。在 dicot 模型植物 Arabidopsis 的 BR 信号 transduction 小径很好被建立,但是连接在米饭表明步的 BR 的部件一直不是充分探索了。例如,特别在 BR 受体水平,发信号的 BR 怎么在米饭被调整,大部分是未知的。这里,我们显示出那 OsPRA2,米饭小 G 蛋白质,在发信号的 BR 起一个压抑的作用小径。薄板倾斜, coleoptile 延伸,和根抑制试金显示有 OsPRA2 的压制的表示的米饭植物比野类型的植物对外长地应用的 brassinolide 更敏感。相反地,米饭 overexpressing OsPRA2 对外长的 brassinolide 不太敏感。进一步的学习揭开了那 OsPRA2 禁止了 dephosphorylation,并且因此使抄写因素失去活性 BRASSINAZOLE 抵抗 1 (OsBZR1 ) 。更重要地, OsPRA2 被发现到共同本地化与并且直接绑在米饭 BR 受体 BRASSINOSTEROID 感觉迟钝 1 (OsBRI1 ) 在血浆膜。另外,在里面 vitro 试金证明 OsPRA2 禁止它的 autophosphorylation。这个 OsPRA2-OsBRI1 相互作用从它的合作受体 OsBAK1 导致了 OsBRI1 的分离,并且废除了 OsBAK1 的调停 OsBRI1 的 phosphorylation。一起,这些结果在 OsBRI1 和 OsBZR1 上作为一个新奇否定管理者揭示 OsPRA2 的可能的工作机制并且关于米饭 BR 发信号的规章的机制扩大知识。 | Ge Zhang Xiaoguang Song Hongyan Guo Yao Wu Xiaoying Chen Rongxiang Fang | 2016 | Molecular Plant2016，9，9： | 5 |
| 13 | Synthesis and properties of p(NIPA-co-NVP)/clay hydrogels by radiation polymerization显示文摘In this study,hydrogels of P(NIPA-co-NVP)/clay were synthesized byγ-ray radiation.Different thermo-sensitive hydrogels were made under different experimental conditions such as dose,monomer ratio,and con- tent of clay.X-ray diffraction shows that the layer distance between Na-clays is changed from 1.6 to 2.7 nm because Na-clay pieces can be intercalated or exfoliated by HTMAB,and that between P(NIPA-co-NVP)/clay pieces is 3.4 nm. The swelling property tests show that the LCST of P(NIPA-co-NVP) is higher than PNIPA.With the increase of NVP content,LCST is higher.As the ratio of NIPA/NVP is 95/5,hydrogel shows the best swelling property and LCST is 37℃.LCST of P(NIPA-co-NVP)/clay hydrogel is not changed,but the strength and swelling properties are better. | SONG Hongyan YANG Mingcheng ZHU Chengshen HE Suqin GAO Ya | 2007 | Nuclear Science and Techniques2007，18，1： | 4 |
| 14 | SRWD1, a novel target gene of DELLA and WRKY proteins, participates in the development and immune response of rice (Oryza sativa L.)显示文摘SRWD1, a member of the WD40 protein subfamily, is induced by salt stress in rice and its homolog in barley can bind to GAMYB, implying that SRWD1 might be involved in plant defense against environmental stress and gibberellic acid(GA) signalings. In this study, we focused on the biological functions and regulation mechanisms of SRWD1 in rice. The results showed that SRWD1 expression was repressed by GA and induced by abscisic acid(ABA). Two WRKY-family transcription factors, Os WRKY45 and Os WRKY72, were found to regulate SRWD1 expression by directly binding to the W-box region in its promoter. Transient co-expression and yeast two-hybrid analyses showed that a DELLA protein strengthened the activation of Os WRKY45 and partly relieved the suppression of Os WRKY72 by binding to them.Interestingly, both SRWD1-overexpressing transgenic plants and SRWD1-knockout mutants showed dwarf phenotypes and resistance to Xanthomonas oryzae. | Chuanmiao Xie Ge Zhang Yuman Zhang Xiaoguang Song Hongyan Guo Xiaoying Chen Rongxiang Fang | 2017 | Science Bulletin2017，62，24： | 4 |
| 15 | Changes in extreme high-temperature tolerance and activities of antioxidant enzymes of sacred lotus seeds显示文摘Sacred lotus (Nelumbo nucifera Gaertn. ‘Tielian’) seed is long-lived and extremely tolerant of high temperature. Water content of lotus and maize seeds was 0.103 and 0.129 g H2O [g DW] ?1, respectively. Water content, germination percentage and fresh weight of seedlings produced by surviving seeds gradually decreased with increasing treatment time at 100℃. Germination percentage of maize (Zea mays L. ‘Huangbaogu’) seeds was zero after they were treated at 100℃ for 15 min and that of lotus seeds was 13.5% following the treatment at 100℃ for 24 h. The time in which 50% of lotus and maize seeds were killed by 100℃ was about 14.5 h and 6 min, respectively. With increasing treatment time at 100℃, relative electrolyte leakage of lotus axes increased significantly, and total chlorophyll content of lotus axes markedly decreased. When treatment time at 100℃ was less than 12 h, subcellular structure of lotus hypocotyls remained fully intact. When treatment time at 100℃ was more than 12 h, plasmoly-sis gradually occurred, endoplasmic reticulum became unclear, nuclei and nucleoli broke down, most of mitochondria swelled, lipid granules accumulated at the cell periphery, and organelles and plas-molemma collapsed. Malondialdehyde (MDA) content of lotus axes and cotyledons decreased during 0-12 h of the treatment at 100℃ and then increased. By contrast, the MDA content of maize embryos and endosperms increased during 5-10 min of the treatment at 100℃ and then decreased slightly. For lotus seeds: (1) activities of superoxide dismutase (SOD) and glutathione reductase (GR) of axes and cotyledons and of catalase (CAT) of axes increased during the early phase of treatment at 100℃ and then decreased; and (2) activities of ascorbate peroxidase (APX) and dehydroascorbate reductase (DHAR) of axes and cotyledons and of CAT of cotyledons gradually decreased with increasing treat-ment time at 100℃. For maize seeds: (1) activities of SOD and DHAR of embryos and endosperms and of GR of embryos increased during the early phase of the treatment at 100℃ and then decreased; and (2) activities of APX and CAT of embryos and endosperms and of GR of endosperms rapidly decreased with increasing treatment time at 100℃. With decrease in seed germination, activities of SOD, APX, CAT, GR and DHAR of axes and cotyledons of lotus seeds decreased slowly, and those of embryos and endosperms of maize seeds decreased rapidly. | DING YanFen CHENG HongYan SONG SongQuan | 2008 | Science China(Life Sciences)2008，51，9： | 4 |
| 16 | Weaving 3D highly conductive hierarchically interconnected nanoporous web by threading MOF crystals onto multi walled carbon nanotubes for high performance Li-Se battery显示文摘Lithium-selenium(Li-Se)battery has attracted growing attention.Nevertheless,its practical application is still impeded by the shuttle effect of the formed polyselenides.Herein,we report in-situ hydrothermal weaving the three-dimensional(3 D)highly conductive hierarchically interconnected nanoporous web by threading microporous metal organic framework MIL-68(Al)crystals onto multi-walled carbon nanotubes(MWCNTs).Such 3 D hierarchically nanoporous web(3 D MIL-68(Al)@MWCNTs web)with a very high surface area,a large amount of micropores,electrical conductivity and elasticity strongly traps the soluble polyselenides during the electrochemical reaction and significantly facilitates lithium ion diffusion and electron transportation.Molecular dynamic calculation confirmed the strong affinity of MIL-68(Al)for the adsorption of polyselenides,quite suitable for Li-Se battery.Their hexahedral channels(1.56 nm)are more efficient for the confinement of polyselenides and for the diffusion of electrolytes compared to their smaller triangular channels(0.63 nm).All these excellent characteristics of 3 D MIL-68(Al)@MWCNTs web with suitable confinement of a large amount of selenium and the conductive linkage between MIL-68(Al)host by MWCNTs result in a high capacity of 453 m Ah/g at 0.2 C with 99.5%coulombic efficiency after 200 cycles with significantly improved cycle stability and rate performance.The 3 D MIL-68(Al)@MWCNTs web presents a good performance in Li-Se battery in term of the specific capacity and cycling stability and also in terms of rate performance compared with all the metal-organic framework(MOF)based or MOF derived porous carbons used in Li-Se battery. | Chao Li Yingying Wang Hongyan Li Jing Liu Jianping Song Luca Fusaro Zhi-Yi Hu Yanxin Chen Yu Li Bao-Lian Su | 2021 | Journal of Energy Chemistry2021，30，8： | 4 |
| 17 | Pool-Forming Stages and Enrichment Models of Medium- to High-Rank Coalbed Methane显示文摘coalbed 甲烷的形成水池的机制有它的自己的特征。在这份报纸,基于在中国的典型的忍受煤的盆上的研究,这被指出媒介的水库形成 -- 到高等级的 coalbed,甲烷经历了三个批评阶段:coalbed 甲烷产生和吸附阶段和保藏舞台。地区性的构造进化,水动力学条件和封上的条件在 coalbed 甲烷解吸附作用散开和保藏的阶段起重要作用。中等 -- 到高等级的 coalbed,甲烷有丰富模型的三种类型,也就是说最有利,相对有利,并且相反的丰富模型。 | SONG Yan ZHAO Mengjun HONG Feng LIU Shaobo QIN Shengfei WANG Hongyan | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 4 |
| 18 | miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis显示文摘风湿性关节炎(RA ) 是反常发炎, angiogenesis,和软骨破坏描绘的长期的自体免疫的疾病。我们的以前的学习在 RA 的 synovial 纸巾表明了包含 5 的 thioredoxin 领域(TXNDC5 ) 的增加的表情,并且它的 overexpression 在 RA 病理被含有。尽管 TXNDC5 变化被连接到基因危险性到 RA,它的反常表示的规定一直不是明确的。这里,我们证明 TXNDC5 被 microRNA (米尔) 直接指向接着, -573, 和 TXNDC5 调停 RA (RASF ) 的 synovial 成纤维细胞的侵略上的 miR-573 的镇压效果。miR-573 overexpression 压制了 interleukin 的表示 6 (IL-6 ) 并且 cyclooxygenase 2 在由响应 lipopolysaccharide (LPS ) 的激活的 THP-1 房间的肿瘤坏死 factor-alpha 和 interleukin-1 贝它的 RASF,以及生产刺激。而且,有有 miR-573 的 RASF transfected 的调节媒介的处理模仿禁止了人的脐的静脉 endothelial 房间(HUVEC ) 的 angiogenic 能力。笔记,表皮的生长因素受体和像使用费的受体, 2 作为 miR-573 的新直接目标被验证,并且调停象 HUVEC 的 angiogenesis 一样的 IL-6 生产上的 miR-573 的规定。另外,外长的 miR-573 表示压制了激活 mitogen 的蛋白质的激活 kinase (MAPK ) ,信号变换器和抄写 3 的使活跃之物,和在响应 LPS 的 RASF 的 phosphatidylinositol-3 kinase/activate 蛋白质 kinase B。确实, MAPK 发信号是必要的保证 miR-573 的功能。一起拿,我们的学习在 RA 的病理学的过程向 miR-573 的保护的角色指并且在 RA 的处理建议一个潜在的目标。 | Lin Wang Guanhua Song Yabing Zheng Dan Wang Hongyan Dong Jihong Pan Xiaotian Chang | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 19 | Ecosystem service delivery in Karst landscapes: anthropogenic perturbation and recovery显示文摘Covering extensive parts of China, Karst landscapes are exceptional because rapid and intensive land use change has caused severe ecosystem degradation within only the last 50 years. The twentieth century intensification in food production through agriculture has led to a rapid deterioration of soil quality, evidenced in reduced crop production and rapid loss of soil. In many areas, a tipping point appears to have been passed as basement rock is exposed and 'rocky desertification' dominates. Through the establishment of the 'Soil processes and ecological services in the karst critical zone of SW China'(SPECTRA)Critical Zone Observatory(CZO) we will endevaour to understand the fundmental processes involved in soil production and erosion, and investigate the integrated geophysical-geochemical-ecological responses of the CZ to perturbations. The CZ spans a gradient from undisturbed natural vegetation through human perturbed landscapes.We seek to understand the importance of heterogeneity insurface and below-ground morphology and flow pathways in determining the spatial distribution of key stocks(soil,C, vegetation, etc.) and their control on ecosystem service delivery. We will assess the extent to which the highly heterogeneous critical zone resources can be restored to enable sustainable delivery of ecosystem services. This paper presents the CZO design and initial assessment of soil and soil organic carbon stocks and evidence for their stability based on caesium-137(^(137) Cs) data. | Timothy Quine Dali Guo Sophie M.Green Chenglong Tu Iain Hartley Xinyu Zhang Jennifer Dungait Xuefa Wen Zhaoliang Song Hongyan Liu Heather Buss Timothy Barrows Richard Evershed Penny Johnes Jeroen Meersmans | 2017 | Acta Geochimica2017，36，3： | 3 |
| 20 | Active loading liposomal irinotecan hydrochloride:Preparation,in vitro and in vivo evaluation显示文摘The aim of the present study was to investigate the effect of various transmembrane ammonium salt gradients and different lipid composition on the loading efficiency of liposomal formulations of irinotecan hydrochloride(CPT-11),their behavior in vivo and cytotoxicity.Among ammonium salts studied,ammonium sulfate was successfully used to load CPT-11 into liposomes with the highest encapsulation efficiency.Subsequently,liposomal CPT-11 with different lipid composition was prepared by ammonium sulfate gradient method.CPT-11 can be loaded to a level over 90%into liposomes composed of soybean phospholipids/cholesterol(SPC-L)or hydrogenated natural soybean phospholipids/cholesterol(HSPC-L).In vitro release profiles were also investigated,indicating that HSPC-L had a lower release than that in SPC-L.In vivo,encapsulation of CPT-11 in both liposomal formulations showed higher area under the curve(AUC),a lower rate of clearance(CL)and smaller volume of distribution for CPT-11 than those of irinotecan hydrochloride solution(CPT-11-S).However,CL and AUC of 7-ethyl-10-hydroxycamptothecin(SN-38)were moderately improved in HSPC-L group.Based on the results of comparative pharmacokinetics of liposomal CPT-11 with different lipid composition,the in vitro cytotoxicity of HSPC-L was evaluated with human tumor cell.The result indicated that liposomal CPT-11 showed a great enhancement in vitro cytotoxicity.The results suggested that entrapment of CPT-11 in liposomes especially in those with high phase-transition temperature lipid by ammonium sulfate gradient would be a promising formulation with a better in vivo behavior. | Hongyan Wei Juan Song Hao Li Yang Li Shanshan Zhu Xiaodan Zhou Xiwen Zhang Li Yang | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 3 |
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