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| 1 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 2 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 3 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 4 | Nasopharyngeal carcinoma:Advances in genomics and molecular genetics显示文摘Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2]. | ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan | 2011 | Science China(Life Sciences)2011，54，10： | 13 |
| 5 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 6 | Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma显示文摘包含蛋白质 1 的 Oxidored-nitro 领域(NOR1 ) 基因是首先从鼻咽的癌(NPC ) 孤立的新奇 nitroreductase 基因。它为它的 nitrosation 功能在化学致癌物的形成和 NPC 的 carcinogenesis 起一个重要作用。在鼻咽的癌细胞的野类型的 NOR1 基因的 Overexpression 是有效的禁止细胞生长和增长。在这研究,第一次,我们产生了高度特定的 NOR1 抗体并且在人的纸巾和 NPC 活体检视分析了 NOR1 分发。结果证明那 NOR1 蛋白质主要在人的鼻咽和气管的纸巾被表示。人的心,肝,怒气,胃,冒号,肾,骨胳的肌肉,胸腺,和胰都 NOR1 蛋白质是缺乏的。更重要地,我们在 NPC 纸巾执行了 NOR1 蛋白质表示的 immunohistochemistry 试金,并且结果证明那 NOR1 蛋白质在 NPC 经常是下面表示的。这些数据使 NOR1 的潜在的生理的函数的选择清楚些并且提供不可缺少的引用给 NPC 的 carcinogenesis 进程并且到识别或验证织物特定的药目标。 | Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Ming Zhou Huaying Liu Minghua Wu Rong Wan Xiaoling Li Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 10 |
| 7 | Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas显示文摘Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been described.To determine how EBV miRNAs control the expression of host genes,and to understand their potential role in NPC tumorigenesis,we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues.We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC.Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC.A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated,suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis.An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis. | ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan | 2014 | Science China(Life Sciences)2014，57，3： | 10 |
| 8 | Effect of suppressing dust by multi-direction whirling air curtain on fully mechanized mining face显示文摘A combined method of numerical simulation and field testing was adopted in this study in the interest of solving the problem of hard to control high concentrate dusts on a fully mechanized mining face.In addition,the dust suppression effect of a multi-direction whirling air curtain was studied in this paper.Under the influence of the wall attachment effect,the compressed air which blows out from the two-phase or three-phase radial outlets on the generator of the air curtain can form a multi-direction whirling air curtain,which can cover the whole roadway section of a fully mechanized mining face.The traditional method of controlling dust is a forcing system with exhaust overlap which has the major disadvantage of lacking a jet effect and consequently results in poor dust control.It is difficult to form the air flow field within the range of L_p5Sr^(1/2).However,due to the effect of this novel system,the radial airflow can be turned into axial airflow allowing fresh air to flow through the length of the heading.The air flow field which is good at controlling dust diffusion can be formed 12.8 m from the heading face.Furthermore,the field measurement results show that before the application of a multi-direction whirling air curtain,the dust concentration is 348.6 mg/m^3 and 271.4 mg/m^3 respectively at the roadway cross-section measurement points which are 5 m and 10 m from the heading face.However,after the application of the multi-direction whirling air curtain,the dust concentration is only 61.2 mg/m^3 and 14.8 mg/m^3,respectively.Therefore,the dust control effect of a multi-direction whirling air curtain is obvious. | Nie Wen Liu Yanghao Wei Wenle Hu Xiangming Ma Xiao Peng Huitian | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
| 9 | Secondary-Atom-Doping Enables Robust Fe-N-C Single-Atom Catalysts with Enhanced Oxygen Reduction Reaction显示文摘Single-atom catalysts(SACs) with nitrogen-coordinated nonprecious metal sites have exhibited inimitable advantages in electrocatalysis.However,a large room for improving their activity and durability remains.Herein,we construct atomically dispersed Fe sites in N-doped carbon supports by secondary-atom-doped strategy.Upon the secondary doping,the density and coordination environment of active sites can be efficiently tuned,enabling the simultaneous improvement in the number and reactivity of the active site.Besides,structure optimizations in terms of the enlarged surface area and improved hydrophilicity can be achieved simultaneously.Due to the beneficial microstructure and abundant highly active FeN_5 moieties resulting from the secondary doping,the resultant catalyst exhibits an admirable half-wave potential of 0.81 V versus 0.83 V for Pt/C and much better stability than Pt/C in acidic media.This work would offer a general strategy for the design and preparation of highly active SACs for electrochemical energy devices. | Xin Luo Xiaoqian Wei Hengjia Wang Wenling Gu Takuma Kaneko Yusuke Yoshida Xiao Zhao Chengzhou Zhu | 2020 | Nano-Micro Letters2020，12，11： | 5 |
| 10 | Clinicopathogenic studies of acute diarrhea in children显示文摘ClinicopathogenicstudiesofacutediarheainchildrenCAILiMin,ZHANGChang,CHENHe,JIANGWeiPingandMAOWenXiangDepartmentofInfectiou... | CAI Li Min, ZHANG Chang, CHEN He, JIANG Wei Ping and MAO Wen Xiang Department of Infectious Diseases, The First People′s Municipal Hospital of Wenling, Wenling City 317500, Zhejiang Province, China | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 11 | Changes of daily climate extremes in southwestern China during 1961–2008显示文摘 | Li Zongxing Yuanqing He Puyu Wang Wilfred H. Theakstone Wenling An Xufeng Wang Aigang Lu Wei Zhang Weihong Cao | 2011 | Global and Planetary Change2011，，： | 2 |
| 12 | Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function显示文摘Neuropeptide Y has been shown to inhibit the immunological activity of reactive microglia in the rat cerebral cortex, to reduce N-methyl-D-aspartate current(INMDA) in cortical neurons, and protect neurons. In this study, after primary cultured microglia from the cerebral cortex of rats were treated with lipopolysaccharide, interleukin-1β and tumor necrosis factor-α levels in the cell culture medium increased, and mRNA expression of these cytokines also increased. After primary cultured cortical neurons were incubated with the lipopolysaccharide-treated microglial conditioned medium, peak INMDA in neurons increased. These effects of lipopolysaccharide were suppressed by neuropeptide Y. After addition of the neuropeptide Y Y1 receptor antagonist BIBP3226, the effects of neuropeptide Y completely disappeared. These results suggest that neuropeptide Y prevents excessive production of interleukin-1β and tumor necrosis factor-α by inhibiting microglial reactivity. This reduces INMDA in rat cortical neurons, preventing excitotoxicity, thereby protecting neurons. | Qijun Li Changzheng Dong Wenling Li Wei Bu Jiang Wu Wenqing Zhao | 2014 | Neural Regeneration Research2014，9，9： | 1 |
| 13 | Atomically dispersed N-coordinated Fe-Fe dual-sites with enhanced enzyme-like activities显示文摘Replacement of enzymes with nanomaterials such as atomically dispersed metal catalysts is one of the most crucial steps in addressing the challenges in biocataiysis.Despite the breakthroughs of single-atom catalysts in enzyme-mimicking,a fundamental investigation on the development of an instructional strategy is still required for mimicking biatomic/multiatomic active sites in natural enzymes and constructing synergistically enhanced metal atom active sites.Herein,Fe_(2)NC catalysts with atomically dispersed Fe-Fe dual-sites supported by the metal-organic frameworks-derived nitrogen-doped carbon are employed as biomimetic catalysts to perform proof-of-concept investigation.The effect of Fe atom number toward typical oxidase(cytochrome C oxidase,NADH oxidase,and ascorbic acid oxidase)and peroxidase(NADH peroxidase and ascorbic acid peroxidase)activities is systematically evaluated by experimental and theoretical investigations.A peroxo-like O_(2) adsorption in Fe_(2)NC nanozymes could accelerate the O-O activation and thus achieve the enhanced enzyme-like activities.This work achieves the vivid simulation of the enzyme active sites and provides the theoretical basis for the design of high-performance nanozymes.As a concept application,a colorimetric biosensor for the detection of S^(2-) in tap water is established based on the inhibition of enzyme-like activity of Fe_(2)NC nanozymes. | Lei Jiao Wei Ye Yikun Kang Yu Zhang Weiqing Xu Yu Wu Wenling Gu Weiyu Song Yujie Xiong Chengzhou Zhu | 2022 | Nano Research2022，15，2： | 1 |
| 14 | Moisture Absorption and Mechanical Properties of Chemically Modified Linen/Polypropylene Composites显示文摘 | HU Qiuxue LI Li YAN Wenling ZHAO Qi ZHANG Niaona ZHANG Yumei DONG Jinbiao LIU Baijun HU Wei | 2017 | Chemical Research in Chinese Universities2017，33，6： | 1 |
| 15 | The first strain of monkeypox isolated in the Chinese Mainland and preserved at the National Pathogen Resource Center of China显示文摘On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future. | Qiang Wei Baoying Huang Wei Huang Jingdong Song Li Mei Li Zhao Jing Yin Juan Zhang Wenling Wang Fei Ye Caiyun Li Liling Bai Yanhai Wang Yao Deng Bo Liu Mengnan Jiang Guizhen Wu Jun Han Hua Zhao Hua Ling Wenjie Tan Jianjun Liu | 2022 | Infectious Medicine2022，1，4： | 1 |
| 16 | Research of cervical cytology screening in diagnosis of 370,000 cases with cervical lesion in Guangdong显示文摘由使用颈的基于液体的细胞学屏蔽的 3700 万个盒子的结果的客观分析,讨论在广东的颈的癌症和癌前期损害的状况省。从 2002 ~ 2006 的方法,在广东在 371,929 个女人以内屏蔽颈的损害的使用的基于液体的薄层的细胞学(TCT ) 方法。Cytological 诊断 adopt TBS (Bethesda 系统) 标准(TBS 改进了诊断标准的 2001 版本) ,到年龄和区域的统计的积极的率分别地。结果妇科学的 371,929 个盒子在广东的颈的样品, 331,251 个盒子是否定的,占了 91.23% ;细胞学积极盒子:32,548 个盒子是有鳞的 intraepithelial 损害(8.96%) , 486 个盒子是腺的上皮的损害(0.13%) ;根据年龄组织了:30 是 9.13% 到 50 岁的积极的率, 40 是 9.60% 到 50 岁的积极的率,后者有更高的细胞学积极的率;根据区域组织了:在 PRD 区域的全部的样品是 304.951 个盒子,占了81.99%,在哪个 24301 个盒子是积极的(8.14%)在 NON-PRD 区域的 66978 种情况(18.01%)中, 7645 个盒子是积极的(11.87%),有 1858 个盒子从 2004~2005 的有的活体检视/后续结果,并且率是2.88%。结论 cytological 颈的癌症和它的癌前期损害的积极的率在广东是9.09%(哪个 cytological 诊断的率作为癌前期损害是3.40%), 30~50 年龄组有颈的癌症和它的先锋损害的高发生,并且也,main 为颈的癌症预防上演。细胞学积极的率在经济发展不足非珍珠河三角洲区域是 11.87% ,比珍珠河三角洲区域高得多。 | Baowen Zheng Congde Chen Anxiang Wei Han Ran Dong Liu Wenling Yue Huirong Zhou Qingyi Zhu Juming Su | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 1 |
| 17 | Changes of daily climate extremes in southwestern China during 1961–2008显示文摘 | Li Zongxing Yuanqing He Puyu Wang Wilfred H. Theakstone Wenling An Xufeng Wang Aigang Lu Wei Zhang Weihong Cao | 2011 | Global and Planetary Change2011，，： | 1 |
| 18 | Carboxyl-functionalized Nanocellulose Reinforced Nanocomposite Proton Exchange Membrane显示文摘Nanocellulose(NCC) was prepared through the acid hydrolysis of microcellulose(MCC) and was reacted with maleic anliydride to obtain carboxyl-functionized nanocellulose(MA-NCCs). The presence of .OH and .SO3H on the surface of rod-like MA-NCC was confirmed by Fourier transfonn infrared spectrometry(FTIR). Sulfonated poly(aryl ether ether ketone ketone)(Ph-SPEEKK) was synthesized with bis(4-fluorophenyl-methanone) and 2-phenylhydroquinone as monomer. MA-NCC/Ph-SPEEKK nanocomposite membranes with different MA-NCCs content were prepared, and their properties were characterized. Compared with Ph-SPEEKK, MA-NCC/Ph-SPEEKK nanocomposite membrane showed better mechanical and thermal properties and higher proton conductivity. The proton conductivity of the composite membrane with 4%(mass fraction) MA-NCCs under 80℃ was 0.095 S/cm. And its tensile strength reached 30.3 MPa, which was 21.2% higher than that of Ph-SPEEKK pure polymer membrane. | YANG Xue WEI Yingcong CHU Xuefeng ZHAO Qi YAN Wenling DONG Chenjun LIU Baijun SUN Zhaoyan HU Wei ZHANG Niaona | 2019 | Chemical Research in Chinese Universities2019，35，4： | 0 |
| 19 | Ionic liquids on uncharged and charged surfaces: In situ microstructures and nanofriction显示文摘In situ changes in the nanofriction and microstructures of ionic liquids(ILs)on uncharged and charged surfaces have been investigated using colloid probe atomic force microscopy(AFM)and molecular dynamic(MD)simulations.Two representative ILs,[BMIM][BF_(4)](BB)and[BMIM][PF_(6)](BP),containing a common cation,were selected for this study.The torsional resonance frequency was captured simultaneously when the nanoscale friction force was measured at a specified normal load;and it was regarded as a measure of the contact stiffness,reflecting in situ changes in the IL microstructures.A higher nanoscale friction force was observed on uncharged mica and highly oriented pyrolytic graphite(HOPG)surfaces when the normal load increased;additionally,a higher torsional resonance frequency was detected,revealing a higher contact stiffness and a more ordered IL layer.The nanofriction of ILs increased at charged HOPG surfaces as the bias voltage varied from 0 to 8 V or from 0 to−8 V.The simultaneously recorded torsional resonance frequency in the ILs increased with the positive or negative bias voltage,implying a stiffer IL layer and possibly more ordered ILs under these conditions.MD simulation reveals that the[BMIM]+imidazolium ring lies parallel to the uncharged surfaces preferentially,resulting in a compact and ordered IL layer.This parallel“sleeping”structure is more pronounced with the surface charging of either sign,indicating more ordered ILs,thereby substantiating the AFM-detected stiffer IL layering on the charged surfaces.Our in situ observations of the changes in nanofriction and microstructures near the uncharged and charged surfaces may facilitate the development of IL-based applications,such as lubrication and electrochemical energy storage devices,including supercapacitors and batteries. | Rong AN Yudi WEI Xiuhua QIU Zhongyang DAI Muqiu WU Enrico GNECCO Faiz Ullah SHAH Wenling ZHANG | 2022 | Friction2022，10，11： | 0 |
| 20 | Insight of unresolved complex mixtures of saturated hydrocarbons in heavy oil via GC×GC-TOFMS analysis显示文摘The saturated hydrocarbon fraction of a heavily biodegraded crude oil from Liaohe oilfield was analyzed by using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC-TOFMS). The 'humps', which was termed as unresolved complex mixtures (UCMs) in conventional gas chromatographic analysis, was separated for identification of the individual compound. Main compounds of UCMs were identified according to the combined information of characteristics of GC×GC chromatogram and time-of-flight mass spectra. It's found that UCMs are mainly composed of great number of ring compounds with extremely low concentration. The ring compounds are separated according to their boiling point diversity in the first dimension column, then to their polarity or ring number variety in the second dimension column. In the sample there are two groups of UCMs, i.e., the first group compounds with boiling point lower that of C24 and the second group compounds with boiling point higher than that of C24. The first group of UCMs mainly consists of monocyclic, bicyclic and tricyclic ring compounds. The first group of UCMs is mainly composed of saturated hydrocarbons, in which the percentage of ring compounds with signal-to-noise ratio above 100 is about 75% of the total quantity of saturated hydrocarbon, while its mass is over 80% of the total saturated hydrocarbon. The second group of UCMs is mainly composed of tetracyclic and pentacyclic ring compounds, in which the percentage of UCM compounds with signal-to-noise ratio over 100 is about 17% of the total quantity of saturated hydrocarbon, and its mass is about 0.5% of the total saturated hydrocarbon. The results of this study are helpful for heavy oil developing and genesis mechanism understanding. | WANG HuiTong ZHANG ShuiChang WENG Na WEI XiaoFang ZHU GuangYou YU Han BI LiNa MA WenLing | 2013 | Science China Chemistry2013，56，2： | 0 |
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