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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Interfacial structure design of MXene-based nanomaterials for electrochemical energy storage and conversion显示文摘2D transition metal carbides,carbonitrides,and nitrides known as MXenes possess high electrical conductivity,large redox active surface area,rich surface chemistry,and tunable structures.Benefiting from these exceptional chemical and physical properties,the applications of MXenes for electrochemical energy storage and conversion have attracted increasing research interests around the world.Notably,the electrochemical performances of MXenes are directly dependent on their synthesis conditions,interfacial chemistries and structural configurations.In this review,we summarize the synthesis techniques of MXenes,as well as the recent advances in the interfacial structure design of MXene-based nanomaterials for electrochemical energy storage and conversion applications.Additionally,we provide an in-depth discussion on the relationship between interfacial structure and electrochemical performance from the perspectives of energy storage and electrocatalysis mechanisms.Finally,the challenges and insights for the future research of interfacial structure design of MXenes are outlined. | Jianmin Luo Edward Matios Huan Wang Xinyong Tao Weiyang Li | 2020 | InfoMat2020，2，6： | 10 |
| 3 | Brassinosteroids function in spikelet differentiation and degeneration in rice显示文摘Brassinosteroids(BRs) play crucial roles in many aspects of plant development. However, their function in spikelet differentiation and degeneration in rice(Oryza sativa L.) remains unclear. Here, we investigated the roles of these phytohormones in spikelet development in fieldgrown rice subjected to five different nitrogen(N)fertilization treatments during panicle differentiation. BR levels and expression of genes involved in BR biosynthesis and signal transduction were measured in spikelets. Pollen fertility and the number of differentiated spikelets were closely associated with 24-epicastasterone(24-epiCS) and 28-homobrassinolide(28-homoBL) levels in spikelets.Enhanced BR biosynthesis and signal transduction, in response to N treatment, enhanced spikelet differentiation, reduced spikelet degeneration, and increased grain yield. Increases in proton-pumping ATPase activity, ATPconcentration, energy charge, and antioxidant system(AOS) levels were consistent with 24-epiCS and28-homoBL concentrations. Exogenous application of 24-epiCS or 28-homoBL on young panicles induced a marked increase in endogenous 24-epiCS or 28-homoBL levels, energy charge, AOS levels, spikelet differentiation, and panicle weight. The opposite effects were observed following treatment with a BR biosynthesis inhibitor. Our findings indicate that, in rice, BRs mediate the effects of N fertilization on spikelet development and play a role in promoting spikelet development through increasing AOS levels and energy charge during panicle development. | Weiyang Zhang Kuanyu Zhu Zhiqin Wang Hao Zhang Junfei Gu Lijun Liu Jianchang Yang Jianhua Zhang | 2019 | Journal of Integrative Plant Biology2019，61，8： | 10 |
| 4 | Recent advances in carbon dioxide capture and utilization with amines and ionic liquids显示文摘Global warming and climate change due to anthropogenic carbon dioxide(CO_(2))have aroused significant concerns at the global scale due to rapid economic growth in industries and other fields.Therefore,CO_(2)capture,use,and storage have become particularly important.In this review,general background and methods for CO_(2)capture and separation,in particular,on ionic liquids(ILs)-based solvents and materials,are discussed.Comprehensive surveys of ILs for CO_(2)absorption are presented,which focused mainly on experimental researches,and then the concept is extended to functionalized absorbents and recent developments for CO_(2)capture.Major advantages and disadvantages of amines-based and ILs-based absorbents are discussed in this review.Solutions of traditional amines(MEA,MDEA,DEA,AMP,PZ,etc.)and ILs(conventional ILs,functionalized ILs,etc.)are summarized.Moreover,research progresses on CO_(2)separation are also introduced focusing mainly on amines and ILs-based membranes(e.g.supported amines membranes,SILMs).Futhermore,the fixation of CO_(2)into cyclic carbonates catalyzed by ILs(pure ILs,complex catalyst system with ILs,supported ILs,etc.)is summarized,clearly explaining the mechanism of CO_(2)fixation with ILs.Finally,exploration of some recent studies about CO_(2)capture and conversion by ILs and challenges for further progress are presented and related suggestions are put forward. | Yuxin Wu Jianhong Xu Kathryn Mumford Geoffrey W.Stevens Weiyang Fei Yundong Wang | 2020 | Green Chemical Engineering2020，1，1： | 9 |
| 5 | Numerical analysis of broadband noise reduction with wavy leading edge显示文摘Large Eddy Simulation(LES) is performed to investigate the airfoil broadband noise reduction with wavy leading edge under anisotropic incoming turbulence. The anisotropic incoming turbulence is generated by a rod with a diameter of 10 mm. The incoming flow velocity is 40 m/s and the corresponding Reynolds numbers based on airfoil chord and rod diameter are about 397000 and 26000, respectively. The far-field acoustic field is predicted using an acoustic analogy method which has been validated by the experiment. A straight leading edge airfoil and a wavy leading edge airfoil are simulated. The results show that wavy leading edge increases the airfoil lift and drag whereas the lift and drag fluctuations are substantially reduced. In addition, wavy leading edge can significantly change the flow pattern around the leading edge and a pair of counter-rotating streamwise vortices stemming from each wavy leading edge peak are observed.An averaged noise reduction of 9.5 dB is observed with the wavy leading edge at the azimuthal angle of 90°. Moreover, the wavy leading edge can mitigate noise radiation at all the azimuthal angles without significantly changing the noise directivity. The underlying noise reduction mechanisms are then analyzed in detail. | Fan TONG Weiyang QIAO Weijie CHEN Haoyi CHENG Renke WEI Xunnian WANG | 2018 | Chinese Journal of Aeronautics2018，31，7： | 8 |
| 6 | Initial carbon release characteristics, mechanisms and denitrification performance of a novel slow release carbon source显示文摘External carbon source addition is one of the effective methods for the treatment of wastewater with low carbon to nitrogen ratio(C/N). Compared with fast-release liquid carbon sources, slow-release solid carbon sources are more suitable for the denitrification process. A novel slow-release solid carbon source(corncob-polyvinyl alcohol sodium alginatepoly-caprolactone, i.e. CPSP) was prepared using corn cob(CC) and poly-caprolactone with polyvinyl alcohol sodium alginate as hybrid scaffold. The physical properties and carbon release characteristics of CPSP and three other carbon sources were compared. CPSP had stable framework and good carbon release performance, which followed the second order release equation. The formic acid, acetic acid, propionic acid and butyric acid released from CPSP accounted for 8.27% ± 1.66 %, 56.48% ± 3.71 %, 18.46% ± 2.69% and 16.79% ± 3.02% of the total released acids respectively. The start-up period of CPSP was shorter than that of the other carbon sources in denitrification experiment, and no COD pollution was observed in the start-up phase(25–72 h) and stable phase(73–240 hr). The composition and structure of the dissolved organic compounds released by CPSP and other carbon sources were analyzed by UV-Vis absorption spectroscopy and three-dimensional fluorescence spectroscopy,which indicated that CPSP was more suitable for denitrification than the other studied carbon sources. | Congyu Li Haiyan Wang Guokai Yan Weiyang Dong Zhaosheng Chu Huan Wang Yang Chang Yu Ling Yanjie Zhang | 2022 | Journal of Environmental Sciences2022，34，8： | 5 |
| 7 | The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series显示文摘Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)patients.Methods:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our center.PD-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were analyzed.Results:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic subtype.Both TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer progression.LADC could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic strategies.Conclusions:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC patients.These findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers. | Jianghua Wu Wei Sun Haiyue Wang Xiaozheng Huang Xinyu Wang Weiyang Jiang Ling Jia Ping Wang Qin Feng Dongmei Lin | 2019 | Cancer Biology & Medicine2019，16，4： | 5 |
| 8 | Brassinosteroids mediate the effect of high temperature during anthesis on the pistil activity of photo-thermosensitive genetic male-sterile rice lines显示文摘Brassinosteroids(BRs)play critical roles in a wide range of plant developmental processes.However,it is unknown whether and how BRs mediate the effect of high temperature(HT)stress during anthesis on the pistil activity of photo-thermosensitive genetic male-sterile(PTSGMS)rice(Oryza sativa L.)lines.This study investigated the question.Three pot-grown PTSGMS rice lines were subjected to HT stress during anthesis.The contents of 24-epibrassinolide(24-EBL)and 28-homobrassinolide(28-HBL),the major forms of BR in rice plants,and levels of reactive oxygen species(ROS)or antioxidants(AOS),hydrogen peroxide(H2O2),1-aminocylopropane-1-carboxylic acid(ACC),ascorbic acid(AsA),and catalase activity in pistils,were determined.HT stress significantly reduced the contents of both 24-EBL and 28-EBL relative to those under normal temperatures,but the reduction varied by PTSGMS line.A line with higher BR contents under HT stress showed lower contents of ACC and H2O2,higher catalase activity and AsA content in pistils,and higher fertilization rate,seed-setting rate,and seed yield when the line was crossed with a restorer line,indicating that higher levels of BRs increase HT stress resistance.Applying 24-EBL,28-HBL or an inhibitor of BR biosynthesis confirmed the roles of BRs in response to HT stress.The results suggest that BRs mediate the effect of HT stress on pistil activity during anthesis and alleviate the harm of HT stress by increasing AOS and suppressing ROS generation. | Jing Chen Keqi Fei Weiyang Zhang Zhiqin Wang Jianhua Zhang | 2021 | The Crop Journal2021，9，1： | 4 |
| 9 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 10 | A 2.4 GHz low power CMOS transceiver for LR-WPAN applications显示文摘A 2.4 GHz low power transceiver for low-rate wireless personal area network(LR-WPAN)applications is presented.The optimized low-IF receiver consists of a novel current reuse RF front-end with an inductor-less-load balun LNA and quadrature mixer,and an adaptive analog baseband to reduce power and area.It achieves-94 dBm of sensitivity,-9 dBm of IIP3 and 28 dBc of image rejection.The phase-locked loop based direct phase modulated transmitter is proposed to reduce power and deliver a+3 dBm output power.The phase noise of the low power frequency synthesizer with current reuse stacked LC-VCO achieves-107.8 dBc/Hz at 1 MHz offset.An ultra-low power nonvolatile memory is used to store configuration data and save power.The chip is implemented in a 0.18μm CMOS process,and the area is less than 2.8 mm2.The transceiver consumes only 10.98 mW in the receiving mode and 13.32 mW in the transmitting mode. | LIU WeiYang CHEN JingJing LIU XiaoDong WANG HaiYong WU NanJian | 2014 | Science China(Information Sciences)2014，57，8： | 3 |
| 11 | A novel biodegradable Mg-1Zn-0.5Sn alloy:Mechanical properties,corrosion behavior,biocompatibility,and antibacterial activity显示文摘To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated antibacterial properties was constructed.A small amount of Sn added to Mg-1Zn alloy reduces the biocorrosion rate,which can be attributed to Sn participation in outer-layer film formation,significantly reducing the biocorrosion rate and hydrogen evolution rate after implantation in vivo.These Mg alloys,which are susceptible to degradation in the acidic bacterial microenvironment,degrade by releasing Mg,Zn and Sn,producing favorably alkaline and antibacterial conditions.Samples with the composition of Mg-1Zn-0.5Sn were found to be beneficial for promoting initial cell adhesion and proliferation,resulting in improved biocompatibility and biosafety.The biocompatibility of this alloy was confirmed by the healthy behavior of animals and the absence of acute or chronic toxicity in the liver,spleen,and kidneys.Our results demonstrate that Mg-1Zn-0.5Sn is safe for biological systems,enabling its efficacious use in biomedical applications. | Weikang Zhao Jingfeng Wang Jiang Weiyang Bo Qiao Yiyang Wang Yuling Li Dianming Jiang | 2020 | Journal of Magnesium and Alloys2020，8，2： | 3 |
| 12 | Sub-nm ruthenium cluster catalyst for decomposition as an efficient and robust and synthesis of ammonia: Break the "size shackles"显示文摘 | Jinpeng Li Weiyang wang Wenxing Chen Qinmei Gong Jun Luo Ruoqian Lin Huolin Xin Hui Zhang Dingsheng wang Qing Peng Wei Zhu Chen Chen Yadong Li | 2018 | Nano Research2018，11，9： | 3 |
| 13 | Efficient fixation of CO_(2) into propylene carbonate with [BMIM]Br in a continuous-flow microreaction system显示文摘Utilization of carbon dioxide(CO_(2)) is of great significance in the development of CO_(2) absorption and the solution of greenhouse gas effect.Highly efficient conversion of CO_(2) into cyclic carbonate with green catalysts is essential for the more sustainable expansion of CO_(2) fixation.Traditional batch reactor is limited by low efficiency, high cost and low security. Meanwhile, continuous flow system showcased a myriad of virtues, including shortening the residence time from hours to seconds, and decreasing reaction temperature, and possessing the nature of easy industrial scale-up. In this paper, a continuous-flow microreaction system was developed to synthesis propylene carbonate(PC) from propylene oxide(PO) and CO_(2) using 1-butyl-3-methylimidazolium bromide([BMIM]Br) as catalyst. By observing the flow patterns inside microreaction system, the effects of reaction temperature, molar fraction of catalyst, operating pressure, residence time, molar ratio of CO_(2)/PO as well as recycling performance of catalyst on the overall performances were comprehensively evaluated into details. Under different reaction conditions,the flow patterns were set to vary between slug flow and annular flow. The results showed that the yield of propylene carbonate(PC) can reach99.7% at 140℃ and 3.0 MPa with the residence time of 166 s, while the recycling performance of the designed system greatly conforms the future trend of green chemistry. | Yuxin Wu Yuncheng Ding Jianhong Xu Yundong Wang Kathryn Mumford Geoffrey WStevens Weiyang Fei | 2021 | Green Energy & Environment2021，6，2： | 3 |
| 14 | Study on Thermal Insulation Performance of Cross-Laminated Bamboo Wall显示文摘In recent years,bamboo,as a green building material,has attracted more and more attention worldwide.Inspired by the investigation of cross-laminated timber in structural systems,a new engineered cross-laminated bamboo(CLB)consisting of the cross lamination of bamboo scrimber plates is proposed in this paper.To evaluate its potential in structural applications,the thermal insulation performances of the CLB walls and CLB walls with the EPS foam plate were studied and evaluated by the temperature-controlled box-heat flow meter method.Test results indicated that the thermal insulation performance improved with the increase of thickness,but different wall configurations had little effect on the thermal insulation performance under the same thickness of the CLB wall.The thermal insulation performance of EPS-CLB composite wall was much better than that of CLB wall.In addition,a relatively acceptable accuracy of the theoretical calculations was proved.Finally,the influence of different locations of the EPS foam plate on heat transfer coefficient can be neglected as it was studied based on the validated numerical models. | Qingfang Lv Weiyang Wang Ye Liu | 2019 | Journal of Renewable Materials2019，7，11： | 3 |
| 15 | Hypoxia response element-directed expression of bFGF in dental pulp stem cells improve the hypoxic environment by targeting pericytes in SCI rats显示文摘Cell-based transplantation strategies possess great potential for spinal cord injury(SCI)repair.Basic fibroblast growth factor(bFGF)has been reported to have multiple neuro-promoting effects on developing and adult nervous system of mammals and considered a promising therapy for nerve injury following SCI.Human dental pulp stem cells(DPSCs)are abundant stem cells with low immune rejection,which can be considered for cell replacement therapy.The purpose of this study was to investigate the roles of DPSCs which express bFGF under the regulation of five hypoxia-responsive elements(5HRE)using an adeno-associated virus(AAV-5HRE-bFGF-DPSCs)in SCI repairing model.In this study,DPSCs were revealed to differentiate into CD13^(+)pericytes and up-regulate N-cadherin expression to promote the re-attachment of CD13^(+)pericytes to vascular endothelial cells.The re-attachment of CD13^(+)pericytes to vascular endothelial cells subsequently increased the flow rate of blood in microvessels via the contraction of protuberance.As a result,increased numbers of red blood cells carried more oxygen to the damaged area and the local hypoxia microenvironment in SCI was improved.Thus,this study represents a step forward towards the potential use of AAV-5HRE-bFGF-DPSCs in SCI treatment in clinic. | Sipin Zhu Yibo Ying Yan He Xingxing Zhong Jiahui Ye Zhiyang Huang Min Chen Qiuji Wu Yifan Zhang Ziyue Xiang Yurong Tu Weiyang Ying Jian Xiao Xiaokun Li Qingsong Ye Zhouguang Wang | 2021 | Bioactive Materials2021，6，8： | 2 |
| 16 | A shear-thinning,ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis显示文摘Spinal cord injury(SCI)is a serious clinical disease.Due to the deformability and fragility of the spinal cord,overly rigid hydrogels cannot be used to treat SCI.Hence,we used TPA and Laponite to develop a hydrogel with shear-thinning ability.This hydrogel exhibits good deformation,allowing it to match the physical properties of the spinal cord;additionally,this hydrogel scavenges ROS well,allowing it to inhibit the lipid peroxidation caused by ferroptosis.According to the in vivo studies,the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism.In addition,dental pulp stem cells(DPSCs)were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses.It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI. | Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang | 2023 | Bioactive Materials2023，，4： | 2 |
| 17 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 18 | Enabling stable sodium metal cycling by sodiophilic interphase in a polymer electrolyte system显示文摘Enabling highly reversible sodium(Na) metal anodes in a polymer electrolyte(PE) system is critical for realizing next-generation batteries with lower cost,higher energy,and improved safety.However,the uneven Na deposition and high Na/PE interphase resistance lead to poor reversibility and short cycle life of Na metal anodes.To tackle these problems,here a variety of metal nanoparticles(M-np,M=Al,Sn,In or Au) are deposited onto copper(Cu) foils to synthesize binder-free M-np@Cu substrates for Na plating/stripping.Notably,the Au-np@Cu substrate provides abundant preferential nucleation/growth sites,decreasing Na nucleation barrier and thus promoting uniform Na deposition.Accordingly,stable Na metal anodes are achieved with high reversible capacities,long cycle life,and high usage of Na.With the Au-np@Cu/Na anode and PE,the full cell using a commercial bulk sulfur cathode exhibits a reversible capacity of>400 mAh g^(-1) with near-100% Coulombic efficiency over 200 cycles. | Xiaofei Hu Edward Matios Yiwen Zhang Chuanlong Wang Jianmin Luo Weiyang Li | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
| 19 | Analysis and optimum design of rider-bicycle mechanisms:Design of bicycle parameters for a specified rider显示文摘Optimum design of rider-bicycle mechanisms is very important for customizing bicycles and plays a crucial role in the improvement of athletes' performances and in protection of the riders.Since the birth of the first bicycle,people have been keeping optimizing bicycles with respect to physical conditions of human.In modern design,the basic structure of a bicycle has been formulized,while many geographic parameters remain uncertain.In this paper,the bicycle and the human body are considered as a kinematic mechanism,called rider-bicycle mechanism.The optimum design is implemented from the perspective of mechanism.Effort-saving and comfortableness are considered at the same time.The corresponding performance charts are drawn and the relationship between the performances and parameters of seat height,crank length and body parameters are discussed.By using these charts,the optimal design method of bicycle's parameters for a specified person is then founded.Optimum solutions to get suitable seat height and crank length for a person are obtained accordingly.The research is of significance for customizing bicycles and design of bicycle robot. | LIU XinJun WANG Jing YU WeiYang WU JinHua | 2011 | Science China(Technological Sciences)2011，54，11： | 2 |
| 20 | Structural optimization of a settler via CFD simulation in a mixer-settler显示文摘This work is aimed at optimizing a settler structure in a mixer-settler.Two different aspects have been considered.Firstly,the flowcharacteristics of a settler have been examined by computational fluid dynamics(CFD)simulation with various agitation speeds of the mixer,as well as organic phase volume fractions ranging from 0.075 to 0.6.The aqueous and organic phase turbulent flow fields were measured by particle image velocimetry(PIV)technique to verify the CFD simulation.Two organic phases with different physical properties were assessed in the CFD simulation to simulate the liquid-liquid systems related to rare earth element extraction,i.e.,0.072 mol·L^-1 P507/kerosene and 1.8 mol·L^-1 P507/kerosene.Secondly,the CFD simulation was carried out in a settler equipped with baffles.The effects of number and location of the baffle in the settler on flow features and entrainments of the aqueous and organic outlet were analyzed.Meanwhile,different settler/mixer volume ratios were also examined.By analyses and comparisons,an optimal design for settler was proposed.CFD can provide a significant guidance to better mixer-settler design. | Sishi Ye Qiao Tang Yundong Wang Weiyang Fei | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 1 |
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