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| 1 | Further support for a Cretaceous age for the feathered-dinosaur beds of Liaoning,China:New ^(40)Ar/^(39)Ar dating of the Yixian and Tuchengzi Formations显示文摘We report new 40Ar/39Ar dating results ob-tained from total fusion and incremental-heating analyses of sanidine and biotite from three tuffs found interbedded within the fossil-bearing deposits of Liaoning, northeast China. The first is a new sample of the Bed 6 Sihetun tuff from the Yixian Formation, previously dated by our team as middle Early Cretaceous, and recently considered by Lo et al., partially reset due to metamorphism from a nearby ba-saltic sill. The second is the Yixian Bed 9 tuff from Heng-daozi considered by Lo et al. to be unaffected by metamor-phism and whose age, based on total fusion 40Ar/39Ar dating of biotite, argues for a Jurassic age for the Yixian Formation. The third tuff is a previously undated tuff from the upper part of the underlying Tuchengzi Formation. Single crystal total fusion 40Ar/39Ar analyses of the Sihetun sanidine showed homogeneous radiogenic Ar, Ca/K ratios, excellent reproducibility and gave a mean age of 125.0 ± 0.18 (1SD) ± 0.04 (SE) Ma. Single sanidine | C. C. Swisher III, WANG Xiaolin, ZHOU Zhonghe, WANG Yuanqing, JIN Fan, ZHANG Jiangyong , XU Xing, ZHANG Fucheng & WANG YuanDepartment of Geological Sciences, Wright Labs, Rutgers University, Piscataway, New Jersey 08854, USA (e-mail: cswish@rutgers. rci.e | 2002 | Chinese Science Bulletin2002，47，2： | 83 |
| 2 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 3 | Nitrogen Balance and Loss in a Greenhouse Vegetable System in Southeastern China显示文摘High rates of fertilizer nitrogen (N) are applied in greenhouse vegetable fields in southeastern China to maximize production;however,the N budgets of such intensive vegetable production remain to be explored.The goal of this study was to determine the annual N balance and loss in a greenhouse vegetable system of annual rotation of tomato,cucumber,and celery at five N (urea) application rates (0,348,522,696,and 870 kg N ha-1 year-1).Total N input to the 0-50 cm soil layer ranged from 531 to 1 053 kg ha-1,and N fertilizer was the main N source,accounting for 66%-83% of the total annual N input.In comparison,irrigation water,wet deposition,and seeds in total accounted for less than 1% of the total N input.The fertilizer N use efficiency was only 18% under the conventional application rate of 870 kg N ha-1 and decreased as the application rate increased from 522 to 870 kg N ha-1.Apparent N losses were 196-201 kg N ha-1,of which 71%-86% was lost by leaching at the application rates of 522-870 kg N ha-1.Thus,leaching was the primary N loss pathway at high N application rates and the amount of N leached was proportional to the N applied during the cucumber season.Moreover,dissolved organic N accounted for 10% of the leached N,whereas NH3 volatilization only contributed 0.1%-0.6% of the apparent N losses under the five N application rates in this greenhouse vegetable system. | MIN Ju ZHAO Xu SHI Wei-Ming XING Guang-Xi ZHU Zhao-Liang | 2011 | Pedosphere2011，21，4： | 91 |
| 4 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 5 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 6 | 5-methylcytosine promotes mRNA export--NSUN2 as the methyltransferase and ALYREF as an m5C reader显示文摘 | Yang, Xin Yang, Ying Sun, Bao-Fa Chen, Yu-Sheng Xu, Jia-Wei Lai, Wei-Yi Li, Ang Wang, Xing Bhattarai, Devi Prasad Xiao, Wen Sun, Hui-Ying Zhu, Qin Ma, Hai-Li Adhikari, Samir Sun, Min Hao, Ya-Juan Zhang, Bing Huang, Chun-Min Huang, Niu Jiang, Gui-Bin Zhao, Yong-Liang Wang, Hai-Lin Sun, Ying-Pu Yang, Yun-Gui | 2017 | Cell Research2017，27，5： | 62 |
| 7 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 8 | PREVALENCE AND RISK FACTORS OF PERIPHERAL ARTERIAL DISEASE IN DIABETIC PATIENTS OVER 50 YEARS OLD IN CHINA显示文摘Objective To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. Methods In total 1 397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China. Results Mean patient age was 63.7±8.2 years and mean duration of diabetes mellitus was 9.39±7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI <0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin Alc, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI. Conclusions PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors. | Heng Guan Yong-jun Li Zhang-rong XU Guang-wei Li Xiao-hui Guo Zhi-min Liu Da-jin Zou Hui-li Xing Wei Liu Zheng-yan Sheng Hao-ming Tian Da-long Zhu De-min YU Wei-te Zhuang Lu-lu Chen Jian-ping Weng | 2007 | Chinese Medical Sciences Journal2007，22，2： | 41 |
| 9 | A nearly completely articulated rhamphorhynchoid pterosaur with exceptionally well-preserved wing membranes and 'hairs' from Inner Mongolia, northeast China显示文摘We report a new and nearly completely articu-lated rhamphorhynchoid pterosaur, Jeholopterus ningchen-gensis gen. et sp. nov., with excellently preserved fibres in the wing membrane and 'hairs' in the neck, body and tail re-gions. Many of its characteristics such as a short neck, short metacarpals and distinctively long fifth pedal digit are char-acteristic of rhamphorhynchoids. The new species can be further referred to the ’strange’ short-tailed rhamphorhyn-choid family Anurognathidae. It is much more complete than the other known members of the family, namely, Anurog-nathus from Solnhofen, Germany, Batrachognathus from Karatau, Kazakhstan, and Dendrorhynchoides from Beipiao, Liaoning Province, China. The new pterosaur also shows that the wing membrane is attached to the ankle of the hind limb. The pedal digits are webbed. Furthermore, the 'hair' of Jeholopterus bears some resemblance to the hair-like in-tegumental structures of the feathered dinosaur Sinosaurop-teryx although there is yet no direct | Xiaolin Wang Zhonghe Zhou Fucheng Zhang Xing Xu | 2002 | Chinese Science Bulletin2002，47，3： | 37 |
| 10 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 11 | Agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetlands: A case study in the Yellow River wetland in China显示文摘Riparian wetland is the major transition zone of matter, energy and information transfer between aquatic and terrestrial ecosystems and has important functions of water purification and non-point pollution control. Using the field experiment method and an isotope tracing technique, the agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetland was studied in the Kouma Section of the Yellow River. The results showed that the retention of agricultural non-point nitrogen pollution by riparian wetland soil occurs mainly in top 0-10 cm layer. The amount of nitrogen retained by surface soils associated with three types of vegetation are 0.045 mg/g for Phragmites communis Trin Linn, 0.036 mg/g for Scirpus triqueter Linn, and 0.032 mg/g for Typha angustifolia Linn, which account for 59.21%, 56.25%, and 56.14% of the total nitrogen interception, respectively. Exogenous nitrogen in 0-10 cm soil layer changes more quickly than in other layers. One month after adding K15NO3 to the tested vegetation, nitrogen content was 77.78% for P. communis Trin, 68.75% for T. angustifolia, and 8.33% for S. triqueter in the surface soil. After three months, nitrogen content was 93.33% for P. communis Trin, 72.22% for S. triqueter, and 37.50% for T. Angustifolia. There are large dierences among vegetation communities respecting to purification of agricultural non-point nitrogen pollution. The nitrogen uptake amount decreases in the sequence: new shoots of P. communis Trin (9.731 mg/g) > old P. communis Trin (4.939 mg/g) > S. triqueter (0.620 mg/g) > T. angustifolia (0.186 mg/g). Observations indicated that the presence of riparian wetlands as buers on and adjacent to stream banks could be recommended to control agricultural non-point pollution. | ZHAO Tongqian XU Huashan HE Yuxiao TAI Chao MENG Hongqi ZENG Fanfu XING Menglin | 2009 | Journal of Environmental Sciences2009，21，7： | 29 |
| 12 | H6 Non-isolated Full Bridge Grid-connected PV Inverters With Low Leakage Currents显示文摘为满足非隔离光伏并网发电系统对共模漏电流的限制,提出一种六开关逆变器拓朴(H6拓扑)。所提出的H6拓扑在功率传输模态时,进网电流半个工频周期流过3支开关管,而另半个工频周期流过2支开关管,故相对于H5拓扑,降低了通态损耗,有利于热应力均衡,且仍满足续流阶段光伏电池输出端与电网脱离的要求。详细分析拓扑的工作原理,并推论给出H6非隔离光伏并网逆变器的其它3种拓扑结构;比较分析了H5拓扑、Heric拓扑和H6拓扑的损耗和成本。通过1kW通用样机平台对比验证了上述3种拓扑的效率和共模特性。实验结果表明,H6拓扑的变换效率高于H5拓扑、但略低于Heric拓扑,共模特性优于Heric拓扑、但略劣于H5拓扑。 | ZHANG Li SUN Kai FENG Lanlan XING Yan XU Ming | 2012 | 中国电机工程学报2012，32，15： | 29 |
| 13 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 14 | Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats显示文摘AIM: To observe the efficacy and mechanism of grainsized moxibustion at different acupoints in a rat model of ulcerative colitis(UC). METHODS: Sprague-Dawley rats were randomly divided into control, UC model, grain-sized moxibustion at a single acupoint(CV 12), grain-sized moxibustion at two acupoints(CV 12 and CV 4), grain-sized moxibustion at three acupoints(CV 12, CV 4, and ST 36), and medication groups(n = 8/group). The UC model was established by enema of trinitrobenzene sulfonic acid. Direct moxibustion was used once a day for 7 d. Disease activity index(DAI) was evaluated before and after the treatment. Morphologic changes of intestinal tissue were observed under an optical microscope. The expression of tumor necrosis factor(TNF)-α and p38 mitogen-activated protein kinase(p38MAPK) in colonic tissue was detected using Western blot, and the levels of occludin and zonula occludens-1(ZO-1) m RNAs were detected using reverse transcription PCR. RESULTS: Compared with the control group, the intestinal mucosae were incomplete in the model group, glandular structures were irregular, and submucosae were edematous, hyperemic, and infiltrated with inflammatory cells. The DAI scores and expression ofTNF-α and p38 MAPK were increased significantly in the model group compared to controls(P s < 0.01), while the m RNA levels of occludin and ZO-1 were reduced significantly(P s < 0.01). Compared with the model group, colonic mucosa and the arrangement of glands were complete and regular in the treatment groups. DAI scores and the expression of TNF-α and p38 MAPK were reduced significantly in moxibustion groups compared to controls(P s < 0.01), while the m RNA levels of occludin and ZO-1 were increased significantly(P s < 0.01). The improvements in the above indices in the three acupoints group and the medication group were superior to those in the single and two acupoints groups(all P < 0.05). CONCLUSION: Reduction of TNF-α and p38 MAPK and increased expression of occludin and ZO-1 in colonic tissue represent a potential mechanism for improved intestinal mucosal tissue repair with grain-sized moxibustion. | Tie-Ming Ma Na Xu Xian-De Ma Zeng-Hua Bai Xing Tao Hong-Chi Yan | 2016 | World Journal of Gastroenterology2016，22，8： | 30 |
| 15 | Biodegradation of Crude Oil in Contaminated Soils by Free and Immobilized Microorganisms显示文摘The effciencies of free and immobilized bacterial cultures of petroleum hydrocarbon degraders were evaluated and compared in this study. Hydrocarbon-degrading microbial communities with high tolerance to and high degrading ability of crude oil were obtained from the soil contaminated with crude oil in the Yellow River Delta. Then, the microbial cells were immobilized in sodium alginate (SA) beads and sodium alginate-diatomite (SAD) beads. The biodegradation of crude oil in soil by immobilized cells was compared with that by free cells at three inoculation concentrations, 1 × 104 colony forming units (cfu) kg-1 (low concentration, L), 5 × 104 cfu kg-1 (medium concentration, M), and 1 × 105 cfu kg-1 (high concentration, H). At 20 d after inoculation, the maximum degradation rate in the immobilized systems reached 29.8% (SAD-M), significantly higher (P < 0.05) than that of the free cells (21.1%), and the SAD beads showed greater degradation than the SA beads. Moreover, both microbial populations and total microbial activity reached significantly higher level (P < 0.05) in the immobilized systems than free cell systems at a same initial inoculation amount. The scanning electronic microscope (SEM) images also confirmed the advantages of the immobilized microstructure of SAD beads. The enhanced degradation and bacterial growth in the SAD beads indicated the high potential of SAD beads as an effective option for bioremediation of crude oil-contaminated soils in the Yellow River Delta. | WANG Zhen-Yu XU Ying WANG Hao-Yun ZHAO Jian GAO Dong-Mei LI Feng-Min B. XING | 2012 | Pedosphere2012，22，5： | 28 |
| 16 | One-step strategy to graphene/Ni(OH)2 composite hy- drogels as advanced three-dimensional supercapacitor electrode materials显示文摘基于 Graphene 三维(3D ) 宏观的材料最近在电气化学的精力变换和存储由他们的令人激动的潜力的优点吸引了增加的兴趣。这里,我们报导灵巧的一步舞策略准备机械地强壮、电子上传导性的 graphene/Ni (哦) 有一个互连的多孔的网络的 2 合成 hydrogels。没有增加任何另外的文件夹或传导性的添加剂,合成 hydrogels 直接被用作 3D supercapacitor 电极材料。包含 82 wt.% Ni 的优化合成 hydrogel (哦) 2 与优秀骑车在 40 mV/s (63% 电容保留) 以 5 mV/s 和 785 F/g 的扫描率展出了 1,247 F/g 的一个特定的电容稳定性。3D hydrogels 的能力极大地超过 graphene 表和 Ni 的物理混合物的(哦) 2 nanoplates (在 40 mV/s 的 309 F/g ) 。一样的策略也被使用制作 graphene 碳 nanotube/Ni (哦) 有进一步改进的特定的电容(在 5 mV/s 的 1,352 F/g ) 和率能力(在 40 mV/s 的 66% 电容保留) 的 2 第三的合成 hydrogels。这里获得的两合成 hydrogels 能交付高精力密度(43 和 47 Wh/kg,分别地) 并且力量密度(8 和 9 kW/kg,分别地) ,为 supercapacitor 应用使他们成为吸引人的电极材料。这研究打开一条新小径到功能的 3D graphene 的设计和制造合成材料,和罐头显著地包括精力存储并且在以外影响宽广区域。 | Yuxi Xu Xiaoqing Huang Zhaoyang Lin Xing Zhong Yu Huang Xiangfeng Duan | 2013 | Nano Research2013，6，1： | 28 |
| 17 | 组合型复合地基的特性及其FEM模拟研究显示文摘以山西省某一工程为例,在以往诸多学者工作的基础上,对组合型复合地基进行了数值模拟研究,详细分析了其应力特性及变形特性,得出了一些有重要工程意义的结论(如在组合型复合地基中,柔性桩承担的荷载可传递至7倍桩径处,组合型复合地基呈现“整体效应”下的应力集中,地基内应力分布更加均匀,组合型复合地基表现为整体下沉等),与实测的结果达到了很好的吻合,表明该类复合地基具有良好的应用前景。 | 陈强 黄志义 左人宇 徐兴 Xu Xing | 2001 | 土木工程学报2001，34，1： | 27 |
| 18 | Self-tuning virtual synchronous generator control for improving frequency stability in autonomous photovoltaic-diesel microgrids显示文摘This paper investigates the use of a virtual synchronous generator(VSG) to improve frequency stability in an autonomous photovoltaic-diesel microgrid with energy storage. VSG control is designed to emulate inertial response and damping power via power injection from/to the energy storage system. The effect of a VSG with constant parameters(CP-VSG) on the system frequency is analyzed. Based on the case study, self-tuning algorithms are used to search for optimal parameters during the operation of the VSG in order to minimize the amplitude and rate of change of the frequency variations. The performances of the proposed self-tuning(ST)-VSG, the frequency droop method, and the CP-VSG are evaluated by comparing their effects on attenuating frequency variationsunder load variations. For both simulated and experimental cases, the ST-VSG was found to be more efficient than the other two methods in improving frequency stability. | Rongliang SHI Xing ZHANG Chao HU Haizhen XU Jun GU Wei CAO | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 27 |
| 19 | Immune checkpoint signaling and cancer immunotherapy显示文摘Immune checkpoint blockade therapy has become a major weapon in fighting cancer.Antibody drugs,such as anti-PD-1 and antiPD-L1,demonstrate obvious advantages such as broad applicability across cancer types and durable clinical response when treatment is effective.However,the overall response rates are still unsatisfying,especially for cancers with low mutational burden.Moreover,adverse effects,such as autoimmune symptoms and tumor hyperprogression,present a significant downside in some clinical applications.These challenges reflect the urgent need to fully understand the basic biology of immune checkpoints.In this review,we discuss regulation of immune checkpoint signaling at multiple levels to provide an overview of our current understanding of checkpoint biology.Topics include the regulation of surface expression levels for known immune checkpoint proteins via surface delivery,internalization,recycling,and degradation.Upon reaching the surface,checkpoints engage in both conventional trans and also cis interactions with ligands to induce signaling and regulate immune responses.Novel therapeutic strategies targeting these pathways in addition to classical checkpoint blockade have recently emerged and been tested in preclinical models,providing new avenues for developing next-generation immunotherapies. | Xing He Chenqi Xu | 2020 | Cell Research2020，30，8： | 24 |
| 20 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
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