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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Convergence proof of the DSMC method and the Gas-Kinetic Unified Algorithm for the Boltzmann equation显示文摘This paper investigates the convergence proof of the Direct Simulation Monte Carlo(DSMC) method and the Gas-Kinetic Unified Algorithm in simulating the Boltzmann equation.It can be shown that the particle velocity distribution function obtained by the DSMC method converges to a modified form of the Boltzmann equation,which is the equation of the gas-kinetic unified algorithm to directly solve the molecular velocity distribution function.Their convergence is derived through mathematical treatment.The collision frequency is presented using various molecular models and the local equilibrium distribution function is obtained by Enskog expansion using the converged equation of the DSMC method.These two expressions agree with those used in the unified algorithm.Numerical validation of the converging consistency between these two approaches is illustrated by simulating the pressure driven Poiseuille flow in the slip transition flow regime and the two-dimensional and three-dimensional flows around a circular cylinder and spherical-cone reentry body covering the whole flow regimes from low speed micro-channel flow to high speed non-equilibrium aerothermodynamics. | LI Zhi Hui FANG Ming JIANG XinYu WU JunLin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 10 |
| 3 | In vitro and in silico analysis of dual-function peptides derived from casein hydrolysate显示文摘There is no study on food-derived peptide with both anticoagulant and angiotensin I-converting enzyme inhibitory (ACEI) activities yet. In this work, the anticoagulant and ACEI activities of the casein hydrolysates released by pepsin digestion were evaluated for the first time to the best of our knowledge. Results indicated that the casein hydrolysate exhibited potent anticoagulant activity by prolonging the thrombin time (TT) and the activated partial thromboplastin time (APTT). Compared with control samples, at 10 mg/mL, the TT and APTT of casein hydrolysate were 186.0 % ± 6.6 % and 163.5 % ± 7.4 %, respectively. The casein hydrolysate also showed a strong ACEI activity with an IC50 value of 1.775 mg/mL. The components of the bioactive casein hydrolysate were analyzed by nanoscale liquid chromatography quadrupole time-of-flight tandem mass spectrometry (NanoLC-Q-TOF-MS/MS). Total of 115 peptides were identified, among which 34, 9, 55 and 17 peptides were derived from α_(s1-), α_(s2-), β-, and κ-casein, respectively. The results of PeptideRanker and PepSite 2 analysis showed that 6 peptides (FRQFYQL, NENLLRF, NPWDQVKR, PVVVPPFLQ, PVRGPFPIIV, and ARHPHPHLSF) have both ACEI and anticoagulant activities by binding to the active sites of ACE and thrombin. This study indicated that casein is a potential functional food supplement that can be used for medical purposes. | Maolin Tu Xinyu Qiao Cong Wang Hanxiong Liu Shuzhen Cheng Zhe Xu Ming Du | 2021 | Food Science and Human Wellness2021，10，1： | 4 |
| 4 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 5 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 6 | Rabies virus co-localizes with early(Rab5) and late(Rab7) endosomal proteins in neuronal and SH-SY5Y cells显示文摘Rabies virus(RABV) is a highly neurotropic virus that follows clathrin-mediated endocytosis and p H-dependent pathway for trafficking and invasion into endothelial cells. Early(Rab5, EEA1) and late(Rab7, LAMP1) endosomal proteins play critical roles in endosomal sorting, maturity and targeting various molecular cargoes, but their precise functions in the early stage of RABV neuronal infection remain elusive. In this study, the relationship between enigmatic entry of RABV with these endosomal proteins into neuronal and SH-SY5 Y cells was investigated.Immunofluorescence, TCID_(50) titers, electron microscopy and western blotting were carried out to determine the molecular interaction of the nucleoprotein(N) of RABV with early or late endosomal proteins in these cell lines. The expression of N was also determined by down-regulating Rab5 and Rab7 in both cell lines through RNA interference. The results were indicative that N proficiently colocalized with Rab5/EEA1 and Rab7/LAMP1 in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of RABV. Down-regulation of Rab5 and Rab7 did not inhibit N expression, but it prevented productive infection via blocking the normal trafficking of RABV in a low pH environment. Ultrathin sections of cells studied by electron microscope also verified the close association of RABV with Rab5 and Rab7 in neurons. From the data it was concluded that primary entry of RABV strongly correlates with the kinetics of Rab-proteins present on early and late vesicles, which provides helpful clues to explain the early events of RABV in nerve cells. | Waqas Ahmad Yingying Li Yidi Guo Xinyu Wang Ming Duan Zhenhong Guan Zengshan Liu Maolin Zhang | 2017 | Virologica Sinica2017，32，3： | 3 |
| 7 | Kernel position effects of grain morphological characteristics by X-ray micro-computed tomography (μCT)显示文摘Grain size and shape are important factors for yield and quality.The difference in grain phenotypic characteristics in the same maize hybrid is related to its position in the ear.This study aimed to clarify the distribution characteristics of grain morphological characteristics in the ear and to provide guidance for research of grain phenotype and kernel position effects.Three maize hybrids were used in the experiment,namely,Denghai 618(DH618),KX3564,and Xianyu 335(XY335),and the kernel number per row were 40,40,and 36,respectively.The X-rayμCT was applied to obtain five kernel morphological indicators,including grain length,width,thickness,volume,surface area.Grain sphericity,length-width ratio,specific surface area,and volume coefficient were further calculated.The results showed that there were three types of maize ear morphological indicators trends:grain length,width,volume,and surface area were parabolic;thickness and sphericity were inverted parabolic;length-to-width ratio and specific surface area were irregular.The volume coefficient of grain at different parts of the ear,namely the relation coefficient between grain volume and grain length,width,and thickness,was determined.The average value of the middle grains morphological indicators of the ear was taken to select kernels representing stable characteristics of the variety.Within the range of 5%deviation from the morphological mean value of the middle grains of the ear,the grains in the middle part accounted for 26.39%of the total ear,about 10 grains extending from the 14th grain at the base of the ear to the top.Within the range of 10%deviation,the middle accounted for 47.22%,about 18 grains extending from the 12th grain at the base of the ear to the top.This study found that grain morphological indicators were greatly different at different positions of the maize ear,and showed different change rules as extend from the base to the top of the ear.Therefore,there were different grain volume coefficients at different positions of maize ear.And the representative sampling range on maize ear was determined based on the comprehensive analysis of different morphological indexes variation of grain. | Xuebo Yin Junfeng Hou Bo Ming Ying Zhang Xinyu Guo Shang Gao Keru Wang Peng Hou Shaokun Li Ruizhi Xie | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 2 |
| 8 | Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Xinyu Zhou Jianjun Chen Qi Li Gaoping Ren Guoen Yao Ming Liu Qiang Dong Jìng Guo Leilei Li Jing Guo Peng Xie | 2012 | Stroke2012，，11： | 2 |
| 9 | Phenotypic changes in the metabolic profile and adiponectin activity during seasonal fattening and hibernation in female Daurian ground squirrels(Spermophilus dauricus)显示文摘Seasonal hibernation has provided an opportunity to study animals’phenotypic plasticity in adaptation to changing environment.In the present study focusing on the female Daurian ground squirrel(Spermophilus dauricus)-a well demonstrated seasonal hibernator-we examined their behavioral,morphological,and metabolic changes during fattening,hibernation,and emergence.Our data indicated high levels of food intake,fat deposition,and body mass increases during fattening compared to hibernation.The levels of serum glucose and triglycerides were also higher during fattening than during hibernation and emergence.Interestingly,although squirrels showed signs of obesity and elevated triglycerides in serum during fattening,triglyceride levels in the liver and skeletal muscles remained unchanged.Our data also indicated that adiponectin levels in serum and cerebrospinal fluid were different between fattening and hibernation.Levels of adiponectin receptor 1 in the skeletal muscle remained low during fattening but peaked in late hibernation.In contrast,adiponectin receptor 2 in the liver showed a steady increase during fattening,which was followed by a significant decrease at early hibernation.Our data indicate that adiponectin may play an important role in preventing heterotopic fat accumulation in a receptor-and organ-specific manner,as well as in facilitating the switch from glucose metabolism to lipid metabolism during fattening and hibernation in female Daurian ground squirrels. | Yue REN Shiyi SONG Xinyu LIU Ming YANG | 2022 | Integrative Zoology2022，17，2： | 2 |
| 10 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 11 | Parameter optimization of Nd:Yag laser scribing process on core loss of grain-oriented magnetic silicon steels显示文摘 | Yu Huang Wuyi Ming Mingzhen Li Yong Liu Jianwen Guo Jian Li Xinyu Shao Shuting Wang | 2014 | The International Journal of Advanced Manufacturing Technology (-)2014，，1： | 1 |
| 12 | The cloning and preliminarily functional analysis of the human neurotrimin gene显示文摘Proteins of the immunoglobulin superfamily (IgSF) are involved in a variety of spe- cific cell-cell interactions in the developing nervous system. To identify and characterize new members of this protein family in human nervous system, we screen the human fetal brain cDNA library and isolate a full-length cDNA clone which contains a 1032 bp open reading frame en- coding a protein of 344 amino acids. Sequence analysis reveals that it is a glycoprotein com- prised of three C2-1ike immunoglobulin domains and is anchored to the plasma membrane via a post-translationally attached glycosyl-phosphatidylinositol (GPI) moiety. The protein shows high sequence similarity to the rat Ntm (97%), so we term it human neurotrimin (NTM). Northern blot analysis reveals that (HUMAN)NTM has three different transcripts with the length of 3.2 kb, 4.0 kb and 9.0 kb respectively. It has a wider expression pattern than that of (RAT) Ntm. Notably, the expression of NTM in fetal brain is higher than that in mature brain and is stronger in nervous tumors than that in normal brain tissues. We insert an HA epitope tag between the third Ig-like domain of NTM and the site of GPI attachment, then construct it into the eukaryotic expression vector pcDNA3.1+/Zeocin. The pcDNA3.1-HA-NTM is transfected into the Chinese Hamster Ovary (CHO) cells. The results demonstrate that HA-NTM is expressed on the surface of CHO cells and could strengthen the aggregation of CHO-NTM cells. | LIU Jin, LI Guangtao, PENG Xiaozhong, LIU Bingyan, YIN Bin, TAN Xinyu, FAN Ming, FAN Wenhong, QIANG Boqin & YUAN Jiangang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, National Human Genome North Center, Beijing 100005, China Department of Neuro- biology, Institute of Basic Medical Science, 27 Taiping Road, Beijing 100850, China | 2004 | Science China(Life Sciences)2004，47，2： | 1 |
| 13 | Green,Sustainable Architectural Bamboo with High Light Transmission and Excellent Electromagnetic Shielding as a Candidate for Energy-Saving Buildings显示文摘Currently,light-transmitting,energy-saving,and electromagnetic shielding materials are essential for reducing indoor energy consumption and improving the electromagnetic environment.Here,we developed a cellulose composite with excellent optical transmittance that retained the natural shape and fiber structure of bamboo.The modified whole bamboo possessed an impressive optical transmittance of approximately 60%at 6.23 mm,illuminance of 1000 luminance(lux),water absorption stability(mass change rate less than 4%),longitudinal tensile strength(46.40 MPa),and surface properties(80.2 HD).These were attributed to not only the retention of the natural circular hollow structure of the bamboo rod on the macro,but also the complete bamboo fiber skeleton template impregnated with UV resin on the micro.Moreover,a multilayered device consisting of translucent whole bamboo,transparent bamboo sheets,and electromagnetic shielding film exhibited remarkable heat insulation and heat preservation performance as well as an electromagnetic shielding performance of 46.3 dB.The impressive optical transmittance,mechanical properties,thermal performance,and electromagnetic shielding abilities combined with the renewable and sustainable nature,as well as the fast and efficient manufacturing process,make this bamboo composite material suitable for effective application in transparent,energy-saving,and electromagnetic shielding buildings. | Jing Wang Xinyu Wu Yajing Wang Weiying Zhao Yue Zhao Ming Zhou Yan Wu Guangbin Ji | 2023 | Nano-Micro Letters2023，15，1： | 1 |
| 14 | Extended asymmetric group key agreement for dynamic groups and its applications 显示文摘 | Wu Qianhong Zhang Xinyu Tang Ming | 2011 | China Communications2011，32，7： | 1 |
| 15 | A temporal programming model with atomic blocks based on projection temporal logic显示文摘 | Xiaoxiao YANG Yu ZHANG Ming FU Xinyu FENG | 2014 | Frontiers of Computer Science2014，8，6： | 1 |
| 16 | A multiplexed circulating tumor DNA detection platform engineered from 3D-coded interlocked DNA rings显示文摘Circulating tumor DNA(ctDNA)is a critical biomarker not only important for the early detection of tumors but also invaluable for personalized treatments.Currently ctDNA detection relies on sequencing.Here,a platform termed three-dimensional-coded interlocked DNA rings(3D-coded ID rings)was created for multiplexed ctDNA identification.The ID rings provide a ctDNA recognition ring that is physically interlocked with a reporter ring.The specific binding of ctDNA to the recognition ring initiates target-responsive cutting via a restriction endonuclease;the cutting then triggers rolling circle amplification on the reporter ring.The signals are further integrated with internal 3D codes for multiplexed readouts.ctDNAs from non-invasive clinical specimens including plasma,feces,and urine were detected and validated at a sensitivity much higher than those obtained through sequencing.This 3D-coded ID ring platform can detect any multiple DNA fragments simultaneously without sequencing.We envision that our platform will facilitate the implementation of future personalized/precision medicine. | Sha Yang Xinyu Zhan Xiaoqi Tang Shuang Zhao Lianyu Yu Mingxuan Gao Dan Luo Yunxia Wang Kai Chang Ming Chen | 2022 | Bioactive Materials2022，7，4： | 1 |
| 17 | A novel and simple nitrogen-doped carbon/polyaniline electrode material for supercapacitors显示文摘We demonstrated a simple and environment-friendly method in thepreparation of N-doped carbon/PANI(NCP)composite without binder.The structureand the property of NCP have been characterized by XPS,IR,XRD,SEM,CV,GCD and EIS.The results reveal that NCP has high capacitance performance of up to 615 F·g^(-1)at 0.6A·g^(-1).Additionally,the asymmetric NCP_(300)/lcarbon supercapacitor delivers a highcapacitance(111 F·g^(-1)at 1A·g^(-1))and a capacity retention rate of 82%after 1200 cyclesat 2A·g^(-1).The ASC cell could deliver a high energy density of 39.1 W·h·kg^(-1)at a powerdensity of 792.6 W·kg^(-1). | Liangshuo LI Lin QIN Xin FAN Xinyu LI Ming DENG | 2021 | Frontiers of Materials Science2021，15，1： | 1 |
| 18 | Study of the machining process of nano-electrical discharge machining based on combined atomistic-continuum modeling method显示文摘 | Guojun Zhang Jianwen Guo Wuyi Ming Yu Huang Xinyu Shao Zhen Zhang | 2014 | Applied Surface Science2014，，： | 1 |
| 19 | Self-sustainable and recyclable ternary Au@Cu2O–Ag nanocomposites:application in ultrasensitive SERS detection and highly efficient photocatalysis of organic dyes under visible light显示文摘Ternary noble metal–semiconductor nanocomposites(NCs)with core–shell–satellite nanostructures have received widespread attention due to their outstanding performance in detecting pollutants through surface-enhanced Raman scattering(SERS)and photodegradation of organic pollutants.In this work,ternary Au@Cu2O–Ag NCs were designed and prepared by a galvanic replacement method.The effect of different amounts of Ag nanocrystals adsorbed on the surfaces of Au@Cu2O on the SERS activity was investigated based on the SERS detection of 4-mercaptobenzoic acid(4-MBA)reporter molecules.Based on electromagnetic field simulations and photoluminescence(PL)results,a possible SERS enhancement mechanism was proposed and discussed.Moreover,Au@Cu2O–Ag NCs served as SERS substrates,and highly sensitive SERS detection of malachite green(MG)with a detection limit as low as 10−9 M was achieved.In addition,Au@Cu2O–Ag NCs were recycled due to their superior self-cleaning ability and could catalyze the degradation of MG driven by visible light.This work demonstrates a wide range of possibilities for the integration of recyclable SERS detection and photodegradation of organic dyes and promotes the development of green testing techniques. | Tong Wu Hui Zheng Yichuan Kou Xinyue Su Naveen Reddy Kadasala Ming Gao Lei Chen Donglai Han Yang Liu Jinghai Yang | 2021 | Microsystems & Nanoengineering2021，7，2： | 1 |
| 20 | Alpha-tubulin deacetylase as a potential and novel target for the prevention of Parkinson's disease progression显示文摘Parkinson's disease(PD)is the second most common neurodegenerative disorder and is characterized by its progressive course.The current therapies are aimed at alleviating symptoms by rescuing the unbalanced physiological dopamine metabolism and recovery of damaged neuronal circuits.However,these strategies result in insufficient clinical benefits for many patients and fail to halt disease progression.Therefore,new therapeutic targets could serve as the gateway against PD degeneration.One pathological hallmark of PD is the formation of intracytoplasmic protein inclusions or Lewy bodies,in neurons.Recent studies have suggested that Lewy bodies are formed similarly to aggresomes,and results have supported the concept that the novel cellular organelle,the aggresome,is a cytoprotective response that sequesters and facilitates clearance of potentially toxic protein aggregates.In addition,α-tubulin deacetylase has been shown to regulate aggresome formation and rescue neural cell viability in response to misfolded protein.Therefore,the regulation of aggresome formation to trigger cellular self-protection system could arrest PD progression.The present study discusses research progress related to Lewy bodies,aggresomes,and histone deacetylases,with an emphasis on histone deacetylase 6 and sirtuin type 2. | Guoyi Li Ming Chang Huiyi Jiang Hongrong Xie Xinyu Hu Linsen Hu | 2011 | Neural Regeneration Research2011，6，2： | 0 |
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