|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 3 | Targeting ERK,an Achilles' Heel of the MAPK pathway,in cancer therapy显示文摘The mitogen-activated protein kinases(MAPK) pathway, often known as the RAS-RAFMEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation, survival and death. As the most frequently mutated signaling pathway in human cancer, targeting the MAPK pathway has long been considered a promising strategy for cancer therapy. Substantial efforts in the past decades have led to the clinical success of BRAF and MEK inhibitors. However, the clinical benefits of these inhibitors are compromised by the frequently occurring acquired resistance due to cancer heterogeneity and genomic instability. This review briefly introduces the key protein kinases involved in this pathway as well as their activation mechanisms. We also generalize the correlations between mutations of MAPK members and human cancers, followed by a summarization of progress made on the development of small molecule MAPK kinases inhibitors. In particular, this review highlights the potential advantages of ERK inhibitors in overcoming resistance to upstream targets and proposes that targeting ERK kinase may hold a promising prospect for cancer therapy. | Feifei Liu Xiaotong Yang Meiyu Geng Min Huang | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 40 |
| 4 | ESCRT-I Component VPS23A Affects ABA Signaling by Recognizing ABA Receptors for Endosomal Degradation显示文摘受体在过去的十年在植物科学成为了很重要的进展之一的 PYR/PYL/RCAR-type abscisic 酸(骆驼毛的织物) 的最近的发现。在哺乳动物,排序的 endosomal 充当一条重要小径到 downregulate 受体的不同类型,而是它在植物荷尔蒙发信号的角色糟糕被理解。这里,我们报导那 ubiquitin 象 E2 一样蛋白质, VPS23A,是 ESCRT-I 的一个关键部件,否定地调整骆驼毛的织物发信号。VPS23A 与 PYR/PYL/RCAR-type 骆驼毛的织物受体和提高的 VPS23A 的混乱有 epistatic 关系在在骆驼毛的织物处理下面表明小径的 ABA 的关键 kinase OST1 的活动。而且, VPS23A 与 PYR1/PYLs 交往,连接 K63 的 diubiquitin,和 PYL4 在 vivo 拥有连接 K63 的 ubiquitinated 修正。进一步的分析表明 VPS23A 影响 PYR1 和 PYL4 的稳定性的 subcellular 本地化。一起拿,我们的结果建议 VPS23A 经由调停液泡的降级影响 PYR1/PYL4,提供两个的先进理解在植物荷尔蒙发信号的骆驼毛的织物受体和 ESCRT 的周转。 | Feifei Yu Lijuan Lou Miaomiao Tian Qingliang Li Yanglin Ding Xiaoqiang Cao Yaorong Wu Borja Belda-Palazon Pedro L. Rodriguez Shuhua Yang Qi Xie | 2016 | Molecular Plant2016，9，12： | 17 |
| 5 | Springback prediction of thick-walled high-strength titanium tube bending显示文摘Signifcant springback occurs after tube rotary-draw-bending(RDB),especially for a high-strength Ti–3Al–2.5V tube(HSTT) due to its high ratio of yield strength to Young's modulus.The combination scheme of explicit and implicit is preferred to predict the springback.This simulation strategy includes several numerical parameters,such as element type,number of elements through thickness(NEL),element size,etc.However,the influences of these parameters on springback prediction accuracy are not fully understood.Thus,taking the geometrical specifcation9.525 mm · 0.508 mm of a HSTT as the objective,the effects of numerical parameters on prediction accuracy and computation effciency of springback simulation of HSTT RDB are investigated.The simulated springback results are compared with experimental ones.The main results are:(1) solid and continuum-shell elements predict the experimental results well;(2) for C3D8R elements,NEL of at least 3 is required to obtain reliable results and a relative error of 29% can occur as NEL is varied in the range of 1–3;(3) specifying damping factor typically works well in Abaqus/Emplicit simulation of springback and the springback results are sensitive to the magnitude of damping factor.In addition,the explanations of the effect rules are given and a guideline is added. | Song Feifei Yang He Li Heng Zhan Mei Li Guangjun | 2013 | Chinese Journal of Aeronautics2013，26，5： | 15 |
| 6 | Bird watching in China reveals bird distribution changes显示文摘Using China Bird Report(2003-2007) as data source in combination with descriptions about bird habitats,we built up the China Bird Watching Database.We also developed spherical GIS software 'Global Analyst' to create the point-based database which contains accurate spatial-temporal information.The China Bird Watching Database can reflect the achievement of Chinese bird watchers and complement the basic knowledge of bird distribution.Now a total of 30936 records from 17 Orders,70 Families and 1078 Species of 5 years are included in the database,representing over 80% of all bird species in China.Till 2007,the geographic coverage has encompassed all provincial level administrative districts in China,with the exception of Hong Kong and Taiwan.The China Bird Watching Database also recorded a group of species which are additions at national and provincial levels,including 14 species which are additions to the national checklist and 109 species which appeared outside their original distributions.Comparing the new records with their original distributions,we found the trend that species move to higher latitude and higher elevation regions and some species of waterfowls in Xinjiang Uygur Autonomous Region,including a suite of rare seabirds in the China's Mainland.The majority of bird watchers come from the Eastern Region of China,but their covering range is spreading northwest.At the same time,we appeal to adopting a suite of new technologies for observation,and building up sharing platform of bird watching data to capture the distribution dynamics of birds in China and provide a direct foundation for bird conservation. | LI XueYan LIANG Lu GONG Peng LIU Yang LIANG FeiFei | 2013 | Chinese Science Bulletin2013，58，6： | 13 |
| 7 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 8 | A lentiviral vector-based therapeutic vaccine encoding Ag85B-Rv3425 potently increases resistance to acute tuberculosis infection in mice显示文摘为 multidrug 抵抗的肺结核(TB ) 和到为 TB 的新奇治疗学的途径的发展的广泛地药抵抗的 TB 电话注意的很少处理选择。因为他们能导致抗原特定的细胞的有免疫力的回答,治疗学的疫苗正在答应候选人,它在 Mycobacterium 肺结核(鱼雷快艇) 的消除起一个重要作用。在这研究,新奇 lentiviral 向量为交付鱼雷快艇特定的熔化蛋白质 Ag85B-Rv3425 的治疗学的疫苗被构造。结果证明这支 recombinant lentivirus 疫苗单个注射的能在老鼠触发抗原特定的 Th1 类型有免疫力的回答。更重要地,有急性感染的老鼠在肺和脾由显著地减少的鱼雷快艇负担从这支疫苗的一个单个剂量的政府有益于很多以及与未经治疗的老鼠相比在肺稀释了损害。这些结果为 TB 的免疫疗法显示了这支新奇疫苗的好前景。 | Enzhuo Yang Feifei Wang Ying Xu Honghai Wang Yong Hu Hongbo Shen Zheng W. Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 6 |
| 9 | Aerosol Data Assimilation Using Data from Fengyun-3A and MODIS:Application to a Dust Storm over East Asia in 2011显示文摘Aerosol optical depth(AOD) is the most basic parameter that describes the optical properties of atmospheric aerosols,and it can be used to indicate aerosol content. In this study, we assimilated AOD data from the Fengyun-3 A(FY-3 A) and MODIS meteorological satellite using the Gridpoint Statistical Interpolation three-dimensional variational data assimilation system. Experiments were conducted for a dust storm over East Asia in April 2011. Each 0600 UTC analysis initialized a24-h Weather Research and Forecasting with Chemistry model forecast. The results generally showed that the assimilation of satellite AOD observational data can significantly improve model aerosol mass prediction skills. The AOD distribution of the analysis field was closer to the observations of the satellite after assimilation of satellite AOD data. In addition, the analysis resulting from the experiment assimilating both FY-3 A/MERSI(Medium-resolution Spectral Imager) AOD data and MODIS AOD data had closer agreement with the ground-based values than the individual assimilation of the two datasets for the dust storm over East Asia. These results suggest that the Chinese FY-3 A satellite aerosol products can be effectively applied to numerical models and dust weather analysis. | Xiaoli XIA Jinzhong MIN Feifei SHEN Yuanbing WANG Chun YANG | 2019 | Advances in Atmospheric Sciences2019，36，1： | 6 |
| 10 | An Image Encryption Algorithm Based on BP Neural Network and Hyperchaotic System显示文摘To reduce the bandwidth and storage resources of image information in communication transmission, and improve the secure communication of information. In this paper, an image compression and encryption algorithm based on fractional-order memristive hyperchaotic system and BP neural network is proposed. In this algorithm, the image pixel values are compressed by BP neural network, the chaotic sequences of the fractional-order memristive hyperchaotic system are used to diffuse the pixel values. The experimental simulation results indicate that the proposed algorithm not only can effectively compress and encrypt image, but also have better security features. Therefore, this work provides theoretical guidance and experimental basis for the safe transmission and storage of image information in practical communication. | Feifei Yang Jun Mou Yinghong Cao Ran Chu | 2020 | China Communications2020，17，5： | 5 |
| 11 | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects显示文摘Cancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. It generates the tumor vasculature and it is highly implicated in the progression to metastasis. To maintain a suitable environment for tumor progression, there are special microenvironment in tumor cell, such as low pH, high level of glutathione(GSH) and reactive oxygen species(ROS), and more special enzymes, which is different to normal cell. Microenvironment-targeted therapy strategy could create new opportunities for therapeutic targeting. Compared to other targeting strategies, microenvironment-targeted therapy strategy will control the drug release into tumor cells more accurately. Redox responsive drug delivery systems(DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs. Under the synergistic reaction of two stimuli, redox dual-stimuli responsive DDSs will control the release of drugs more accurately and quickly and even increase the accumulation. This review summarizes strategies of redox dual-stimuli responsive DDSs such as pH, light, enzyme, ROS, and magnetic guide to delivery chemotherapeutic agents more accurately, aiming at providing new ideas for further promoting the drug release,enhancing tumor-targeting and improving anticancer effects. To better illustrate the redox dual-stimuli responsive DDS, preparations of carriers are also briefly described in the review. | Ruirui Li Feifei Peng Jia Cai Dandan Yang Peng Zhang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 5 |
| 12 | A new method for early detection of myocardial ischemia:cardiodynamicsgram(CDG)显示文摘Early detection of myocardial ischemia via electrocardiographic methods is important and challenging. In the study, based on the standard 12-lead electrocardiography(ECG), a new method called cardiodynamicsgram(CDG) is proposed for early detection of myocardial ischemia. Using a recently proposed deterministic learning algorithm, the cardiodynamics information is extracted from the ST-T segments of standard 12-lead ECG. The CDG is generated by plotting the three-dimensional cardiodynamics information. By analyzing CDG morphology, it is found that significant correlations exist between CDG and ischemia. By evaluating ischemia patients and healthy controls from the Physikalisch-Technische Bundesanstalt(PTB) database and the General Hospital of Guangzhou Military Command, the CDG method achieves a mean sensitivity of 90.3% and a mean specificity of 87.8%, which are higher than those of both the standard 12-lead ECG and the exercise ECG. As it is noninvasive, convenient, and inexpensive, it is hopeful that CDG may become a cost-effective screening method for early detection of ischemic heart diseases. | Cong WANG Xunde DONG Shanxing OU Wei WANG Junmin HU Feifei YANG | 2016 | Science China(Information Sciences)2016，59，1： | 5 |
| 13 | Cooperation of nitrogen-doping and catalysis to improve the Li-ion storage performance of lignin-based hard carbon显示文摘Hard carbon draws great interests as anode material in lithium ion batteries(LIBs)due to its high theoretical capacity,high rate capability and abundance of its precursors.Herein we firstly synthesize the lignin-melamine resins by grafting melamine onto lignin.Afterwards,nitrogen doped hard carbon is prepared by the pyrolysis of lignin-melamine resins with the aid of catalyst(Ni(NO_3)_2·6H_2O)at 1000°C.Compared with the samples without nitrogen-doping and catalysis,as-prepared nitrogen doped hard carbon exhibits higher reversible capacity(345 mAh g^(–1)at 0.1 A g^(-1)),higher rate capability(145 mAh g^(-1)at 5 A g^(–1))and excellent cycling stability.The superior electrochemical performance is ascribed to the synergistic effect of nitrogen doping,graphitic structure and amorphous structure.Among them,nitrogen doping could create the vacancies around the nitrogen sites,which enhance the reactivity and the electronic conductivity of materials.Additionally,graphitic structure also enhances the electronic conductivity of materials,thus improving the electrochemical performance of hard carbon.It is worthwhile that lignin,renewable and abundant biopolymer,is converted to hard carbon with good electrochemical performance,which realizes the high value utilization of lignin. | Zhewei Yang Huajun Guo Feifei Li Xinhai Li Zhixing Wang Lizhi Cui Jiexi Wang | 2018 | Journal of Energy Chemistry2018，27，5： | 5 |
| 14 | Development of high-resolution multiple-SNP arrays for genetic analyses and molecular breeding through genotyping by target sequencing and liquid chip显示文摘Genotyping platforms,as critical supports for genomics,genetics,and molecular breeding,have been well implemented at national institutions/universities in developed countries and multinational seed companies that possess high-throughput,automatic,large-scale,and shared facilities.In this study,we integrated an improved genotyping by target sequencing(GBTS)system with capture-in-solution(liquid chip)technology to develop a multiple single-nucleotide polymorphism(mSNP)approach in which mSNPs can be captured from a single amplicon.From one 40K maize mSNP panel,we developed three types of markers(40K mSNPs,251K SNPs,and 690K haplotypes),and generated multiple panels with various marker densities(1K–40K mSNPs)by sequencing at different depths.Comparative genetic diversity analysis was performed with genic versus intergenic markers and di-allelic SNPs versus non-typical SNPs.Compared with the one-amplicon-one-SNP system,mSNPs and within-mSNP haplotypes are more powerful for genetic diversity detection,linkage disequilibrium decay analysis,and genome-wide association studies.The technologies,protocols,and application scenarios developed for maize in this study will serve as a model for the development of mSNP arrays and highly efficient GBTS systems in animals,plants,and microorganisms. | Zifeng Guo Quannv Yang Feifei Huang Hongjian Zheng Zhiqin Sang Yanfen Xu Cong Zhang Kunsheng Wu Jiajun Tao Boddupalli MPrasanna Michael SOlsen Yunbo Wang Jianan Zhang Yunbi Xu | 2021 | Plant Communications2021，2，6： | 5 |
| 15 | Transition prediction and sensitivity analysis for a natural laminar flow wing glove flight experiment显示文摘Natural laminar flow technology can significantly reduce aircraft aerodynamic drag and has excellent technical appeal for transport aircraft development with high aerodynamic efficiency.Accurately and efficiently predicting the laminar-to-turbulent transition and revealing the maintenance mechanism of laminar flow in a transport aircraft’s flight environment are significant for developing natural laminar flow wings.In this research,we carry out natural laminar flow flight experiments with different Reynolds numbers and angles of attack.The critical N-factor is calibrated as 9.0 using flight experimental data and linear stability theory from a statistical perspective,which makes sure that the relative error of transition location is within 5%.We then implement a simplified e^(N) transition prediction method with a similar accuracy compared with linear stability theory.We compute the sensitivity information for the simplified eN method with an adjointbased method,using the automatic differentiation technique(ADjoint).The impact of Reynolds numbers and pressure distributions on TS waves is analyzed using the sensitivity information.Through the sensitivity analysis,we find that:favorable pressure gradients not only suppress the development of TS waves but also decrease their sensitivity to Reynolds numbers;there exist three special regions which are very sensitive to the pressure distribution,and the sensitivity decreases as the local favorable pressure gradient increases.The proposed sensitivity analysis method enables robust natural laminar flow wings design. | Tihao YANG Hai ZHONG Yifu CHEN Yayun SHI Junqiang BAI Feifei QIN | 2021 | Chinese Journal of Aeronautics2021，34，8： | 5 |
| 16 | BpMADS12 gene role in lignin biosynthesis of Betula platyphylla Suk by transcriptome analysis显示文摘MADS-box transcription factors show highly diverse regulatory functions in a wide variety of organisms.In this study,we characterized a MADS-box gene(BpMADS12) from the white birch(Betula platyphylla Suk).This gene is a member of the suppressor of overexpression of CO 1/tomato MADS 3 class of MADS-box genes.We generated lines overexpressing BpMADS12 and found that these had higher levels of lignin compared to that observed in nontransgenic lines.Transcriptome analysis revealed numerous changes in gene expression patterns.In total,8794 differentially expressed genes were identified,including 5006 upregulated unigenes and 3788 downregulated unigenes in Bp MADS-overexpression lines.Differentially expressed genes involved in the pathways for lignin and brassinosteroid biosynthesis were significantly enriched and may have contributed to phenotypic changes.The results from a quantitative RT-PCR analysis were consistent those obtained with the transcriptome analysis.Our transcriptome analysis,in combination with measurement of lignin level,indicated that Bp MADS12 promotes lignin synthesis through regulation of key enzymes in response to brassinosteroid signaling.These results suggest that this MADS-box protein is crucial to all subsequent structural events and provide a good foundation for studies aiming to elucidate the developmental mechanisms underlying formation of wood. | Huiyu Li Yang Yang Zijia Wang Xiaohong Guo Feifei Liu Jing Jiang Guifeng Liu | 2016 | Journal of Forestry Research2016，27，5： | 4 |
| 17 | Deciphering primate retinal aging at single-cell resolution显示文摘Dear Editor, The retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment in the elderly(Lin et al.,2016).In diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP)and diabetic retinopathy(DR),pathological process lacking effective treatments profoundly and negatively impact on the quality of life in the elderly(Lin et al.,2016;Chen et al.,2019).Thus,an in-depth molecular assessment of the mechanisms driv-ing retinal aging is of urgent scientific and medical importance. | Si Wang Yuxuan Zheng Qingqing Li Xiaojuan He Ruotong Ren Weiqi Zhang Moshi Song Huifang Hu Feifei Liu Guoqiang Sun Shuhui Sun Zunpeng Liu Yang Yu Piu Chan Guo-Guang Zhao Qi Zhou Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | Protein & Cell2021，12，11： | 4 |
| 18 | Backscatter t echnologies and the future of Internet of Things:Challenges and opportunities显示文摘Energy source and circuit cost are two critical challenges for the future development of the Internet of Things(IoT).Backscatter communications offer a potential solution to conveniently obtain power and reduce cost for sensors in IoT,and researchers are paying close attention to the technology.Backscatter technology originated from the Second World War and has been widely applied in the logistics domain.Recently,both the academic and industrial worlds are proposing a series of new types of backscatter technologies for communications and IoT.In this paper,we review the history of both IoT and backscatter,describe the new types of backscatter,demonstrate their applications,and discuss the open challenges. | Chaochao Yao Yang Liu Xusheng Wei Gongpu Wang Feifei Gao | 2020 | Intelligent and Converged Networks2020，1，2： | 4 |
| 19 | Three-dimensional nonlinear photonic crystal in naturally grown potassium–tantalate–niobate perovskite ferroelectrics显示文摘Since quasi-phase-matching of nonlinear optics was proposed in 1962,nonlinear photonic crystals were rapidly developed by ferroelectric domain inversion induced by electric or light poling.The three-dimensional(3D)periodical rotation of ferroelectric domains may add feasible modulation to the nonlinear coefficients and break the rigid requirements for the incident light and polarization direction in traditional quasi-phase-matching media.However,3D rotating ferroelectric domains are difficult to fabricate by the direct external poling technique.Here,we show a natural potassium-tantalate-niobate(KTN)perovskite nonlinear photonic crystal with spontaneous Rubik’s cube-like domain structures near the Curie temperature of 40℃.The KTN crystal contains 3D ferroelectric polarization distributions corresponding to the reconfigured second-order susceptibilities,which can provide rich reciprocal vectors to compensate for the phase mismatch along an arbitrary direction and polarization of incident light.Bragg diffraction and broadband second-harmonic generation are also presented.This natural nonlinear photonic crystal directly meets the 3D quasi-phase-matching condition without external poling and establishes a promising platform for all-optical nonlinear beam shaping and enables new optoelectronic applications for perovskite ferroelectrics. | Chang Li Xuping Wang Yang Wu Fei Liang Feifei Wang Xiangyong Zhao Haohai Yu Huaijin Zhang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 20 | A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres显示文摘The object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time(37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third,the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the most similar release profile with the real time release. Four different types of progesterone PLGA microspheres were used to verify the method, and all the deduced function correlated well with the real time releases, for R2 = 0.9912, 0.9781, 0.9918 and 0.9972, respectively. | Mingzhu Ye Hongliang Duan Lixia Yao Yicheng Fang Xiaoyu Zhang Ling Dong Feifei Yang Xinggang Yang Weisan Pan | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员