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1A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 2020Military Medical Research2020,7,1:161
2Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission.Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li 2021China CDC weekly2021,3,27:51
3Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor显示文摘Liu HQ Zhang WY Luo XT Ye Y Zhu XZ 2006中国生物学文摘2006,20,10:34
4Association between serum homocysteine and arterial stiffness in elderly: a community-based study显示文摘BackgroundArterial 僵硬和 homocysteine 两个都是心血管的疾病的强大的预言者,特别在更旧的人口。以前的研究在人的题目与动脉的僵硬调查了 homocysteine 的协会,当时在 homocysteine 和动脉的僵硬在之间的关系老仍然是不定的。当前的学习在相关浆液在 780 个参加者 homocysteine 铺平到动脉的僵硬(颈动脉大腿骨的脉搏波浪速度( PWV )和颈动脉光线的 PWV )的二项措施的中国基于社区的老 persons.MethodsWe 与动脉的僵硬检验了 homocysteine 的协会(46.3%人,意味着年龄 71.9 年(变化 65-96 岁))从中国北京的二个社区。动脉的僵硬在二天 biomarker measurement.ResultsIn 多重调整模型,的时间以内被测量 homocysteine 层次强烈与颈动脉大腿骨的 PWV 被联系(标准化 β= 0.13, P <0.001 ) ,甚至在为心血管的疾病的古典风险因素的调整以后。当而有 homocysteine 的重要协会都没为颈动脉光线的 PWV.ConclusionsIn 中国老人,被观察,颈动脉大腿骨的 PWV 在正常上面被提高时,协会也更强壮浆液 homocysteine 层次与大动脉的僵硬的改变被联系。Song ZHANG Yong-Yi BAI Lei-Ming LUO Wen-Kai XIAO Hong-Mei WU Ping YE 2014Journal of Geriatric Cardiology2014,11,1:28
5The willow genome and divergent evolution from poplar after the common genome duplication显示文摘Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin 2014Cell Research2014,24,10:28
6Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio 2009Lancet Oncology2009,,1:23
7Energy-Theft Detection Issues for Advanced Metering Infrastructure in Smart Grid显示文摘With the proliferation of smart grid research,the Advanced Metering Infrastructure(AMI) has become the first ubiquitous and fixed computing platform. However,due to the unique characteristics of AMI,such as complex network structure,resource-constrained smart meter,and privacy-sensitive data,it is an especially challenging issue to make AMI secure. Energy theft is one of the most important concerns related to the smart grid implementation. It is estimated that utility companies lose more than $25 billion every year due to energy theft around the world. To address this challenge,in this paper,we discuss the background of AMI and identify major security requirements that AMI should meet. Specifically,an attack tree based threat model is first presented to illustrate the energy-theft behaviors in AMI. Then,we summarize the current AMI energy-theft detection schemes into three categories,i.e.,classification-based,state estimation-based,and game theory-based ones,and make extensive comparisons and discussions on them. In order to provide a deep understanding of security vulnerabilities and solutions in AMI and shed light on future research directions,we also explore some open challenges and potential solutions for energy-theft detection.Rong Jiang Rongxing Lu Ye Wang Jun Luo Changxiang Shen Xuemin(Sherman) Shen 2014Tsinghua Science and Technology2014,19,2:22
8CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan 2015Cell Research2015,25,3:23
9Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation显示文摘Bin LU Xu GONG Zong-qi WANG Ye DING Chen WANG Tian-fei LUO Mei-hua PIAO Fan-kai MENG Guang-fan CHI Yi-nan LUO Peng-fei GE 2017Acta Pharmacologica Sinica2017,38,11:22
10Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang 2015Cell Research2015,25,2:21
11Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China.Kaiwen Li Tianxin Lin Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang 2015Asian Journal of Urology2015,2,2:21
12Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored.Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo 2014World Journal of Gastroenterology2014,20,48:20
13Ecological response to the climate change on the northern slope of the Tianshan Mountains in Xinjiang显示文摘The Tianshan Mountains is a high and huge mountain body lying across the central part of Xinjiang, China, and is also the main area where the runoff forms in Xinjiang. In this paper, a set of RS-based study methods is put forward for deriving the information about the natural change of the ecology in arid areas, and the relationship between the climate change trend and the corresponding ecological response on the northern slope of the Tianshan Mountains since recent 40 years is analyzed from the scales of the land cover ecosystems and landscapes based on the observed data of climate, hydrology, modern glaciers and lakes on the northern slopes of the Tianshan Mountains since recent 40 years and the satellite RS data since recent 10 years by using the RS and GIS technologies. The results are as follows: (1) The overall trend of climate change on the northern slope of the Tianshan Mountains since recent 40 years is that both air temperature and precipitation are increased, especially the increase amplitudes of air tempera-ture, precipitation and annual runoff volume are high since the decade of the 1990s; (2) the in-tegrated indexes of the vegetation in all the geographical divisions on the northern slope of the Tianshan Mountains are obviously increased since recent 10 years, especially in the artificial oases and the foothill belts, such a change trend is advantageous for improving the vegetation ecology; and (3) the vegetation ecology in the arid areas is extremely sensitive to the climate change, the vegetation coverage and the biomass on the northern slope of the Tianshan Moun-tains are continuously increased because of the climate change since recent 10 years, their in-crease amplitudes in the plains and during the late stage are obviously higher than that in the mountainous regions and during the early stage.CHEN Xi1, LUO Geping1, XIA Jun2, ZHOU Kefa1, LOU Shaoping3 & YE Minquan4 1. Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China 2. Institute of Geographical and Resources Sciences, Chinese Academy of Sciences, Beijing 100101, China 3. Urumqi Meteorological-satellite Land Station, Urumqi 830011, China 4. Seismological Bureau of Xinjiang Uygur Autonomous Region, Urümqi 830011, China Correspondence should be addressed to Chen Xi 2005Science China Earth Sciences2005,48,6:19
14A Study of the Kunlun-Qilian-Qinling Suture System显示文摘The Late Neoproterozoic-Early Palaeozoic suture zones within theCentral Orogenic Belt of China can be considered a system-the Kunlun-Qilian-Qinling suture system (KQQ suture system). It is basically divided into the western, central and eastern sectors. The western sector consists of the Küda-Subashi suture zone, the Mazar Kangxiwar suture and the central West Kunlun microblock. The central sector covers the following five suture zones: the Altun, North Qilian, Qaidam northern marginal, Qimantag-Wutuo and East Kunlun southern marginal sutures, in addition to some microblocks such as the mid-south Qilian, Qaidam, Ayakkum and Maqen microblocks. The eastern sector is composed of the Shangdan suture zone, Mianlüe suture zone and central Qinling-Dabie microblock. The KQQ suture system experienced (1) extending-rifting of the Rodinia super-continent in the early-middle Sinian (~780-600 Ma); (2) the formation and evolution of the KQQ archipelagic ocean during the Late Sinian-Ordovician (~600-440 Ma), and (3) closing of the KQQ ocean and forming of the KQQ suture system during the Late Ordovician-early Silurian (~440-400 Ma). As a system comprising many suture zones and microblocks, the KQQ suture system consti tutes the foundation of the Central Orogenic Belt of China.CLC Number:P5 Document ID:Afoundation Item:This study was supported by the National Natural Science Foundation of China (grants 49872077 and 49572153), and the Lu Jiaxi Foundation of the Chinese Academy of Sciences.Author Resume:Bian Qiantao Born in 1945; graduated from the Department of Geology, South-Central University of Technology in 1970, and obtained his master's degree and doctor's degree at the Graduate School and the Institute of Geology, Chinese Academy of Sciences in 1981 and 1987, respectively. He is currently a professor of the Institute of Geology and Geophysics, Chinese Academy of Sciences, and has long been engaged in the research of tectonics, petrology, mineral deposits and geochemistry. Tel: (010) 62008058: E-mail:bianqt @igcas.igcas.ac.cn. 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15Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae显示文摘Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term survival.Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT.Results: With a median follow?up of 18 months(range, 3–39 months), patients' 1?year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P < 0.001) were sig= 0.003), increase i= 0.024), fistula closure(P = 0.011), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 11 patients(27.5%), and grade 3 cough was observed in 13 patients(32.5%); 2 patients(5.0%) died of massive bleeding during treatment.Conclusions: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be cured, especially those who experience complete response and have an increase in NRS score. Careful observation and nutrition support are required for patients with advanced T?category ESCC who undergo CCRT.Li Ma Guang-Yu Luo Yu-Feng Ren Bo Qiu Hong Yang Chun-Xia Xie Song-Ran Liu Shi-Liang Liu Zhao-Lin Chen Qun Li Jian-Hua Fu Meng-Zhong Liu Yong-Hong Hu Wen-Feng Ye Hui Liu 2017Chinese Journal of Cancer2017,36,1:19
16Effect of resection following downstaging of unresectable hepatocelluar carcinoma by transcatheter arterial chemoembolization显示文摘背景这回顾的研究被承担在这 52 个病人,之中与在2004年1月和2008年12月 .Methods 之间的 unresectable hepatocellular 癌( HCC )在 52 个病人分析肝的切除术的结果肿瘤的吝啬的直径是 7.9 厘米( 4.4-15.5 厘米,中部 8.5 厘米)在第一 transcatheter 以前动脉的 chemoembolization (不作声) .After 1-6 时间不作声(中部 2 ),中部的肿瘤直径在 resection.The 持续时间 betw 以前被归结为 4.2 厘米( 0-8.4 厘米)Shi Xian-jie Jin Xin Wang Mao-qiang Wei Li-xin Ye Hui-yi Liang Yu-rong Luo Ying Dong Jia-hong 2012Chinese Medical Journal2012,,2:19
17Isolation and Identification of a Di-(2-Ethylhexyl)Phthalate-Degrading Bacterium and Its Role in the Bioremediation of a Contaminated Soil显示文摘Di-(2-ethylhexyl) phthalate(DEHP) is a high-molecular-weight phthalate ester(PAE) that has been widely used in the manufacture of polyvinylchloride and contributes to environmental pollution.The objectives of the present study were to isolate a DEHP degrader that can utilize DEHP as a carbon source and to investigate its capacity to biodegrade DEHP in both liquid culture and soil.A bacterial strain WJ4 was isolated from an intensively managed vegetable soil,which was contaminated with PAEs.The strain WJ4 was affiliated to the genus Rhodococcus and was able to remove DEHP from soil effectively.A period of only 7 d was required to degrade about 96.4%of DEHP(200 mg L^(-1)) in the liquid culture,and more than 55%of DEHP(1.0 g kg^(-1)) in the artificially contaminated soil was removed within 21 d.Furthermore,Rhodococcus sp.strain WJ4 had a strong ability to degrade DEHP without additional nutrients in liquid minimal medium culture and DEHP-contaminated soil and to degrade the homologue of DEHP in both liquid culture and soil.Strain WJ4 represents a novel tool for removing PAEs from contaminated soils and it may have great potential for application in the remediation of environmental pollution by PAEs.WANG Jun ZHANG Man-Yun CHEN Ting ZHU Ye TENG Ying LUO Yong-Ming Peter CHRISTIE 2015Pedosphere2015,25,2:18
18Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer.xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue 2017Journal of Integrative Medicine2017,15,6:18
19在初治和经治丙型肝炎病毒基因1b型慢性感染的非肝硬化亚洲成年患者中评价奥比帕利联合达塞布韦治疗的有效性和安全性:随机、双盲、安慰剂对照研究显示文摘目的 评估奥比帕利(奥比他韦/帕立瑞韦/利托那韦,OBV/PTV/r)25/150/100mg,1次/d,联合达塞布韦250mg,2次/d,在丙型肝炎病毒基因1b型感染的初治和经治非肝硬化中国成年患者中的有效性和安全性.方法 采用随机、双盲、安慰剂对照、多中心Ⅲ期临床试验,在中国大陆、韩国、中国台湾地区进行.纳入基因1b型初治和普通干扰素/聚乙二醇干扰素α联合利巴韦林经治非肝硬化患者,随机分为2组,分别接受OBV/PTV/r联合达塞布韦方案立即治疗12周(A组),或接受安慰剂治疗12周后再继续接受OBV/PTV/r联合达塞布韦方案治疗12周(B组).评估患者停药12周获得的持续病毒学应答(SVR12)及停药24周获得的持续病毒学应答(SVR24)率,及双盲阶段和开放标签阶段治疗后的不良事件和实验室异常发生率. 结果 共纳入410例中国大陆患者资料,按1∶1比例随机分至A组和B组(每组205例).A组(205例)中初治患者的SVR12及SVR24率均为99% (95%CI:94.8% ~ 99.8%),经治患者的SVR12及SVR24率均为100% (95% CI:96.3%~ 100%),不同基线特征对SVR12及SVR24率没有影响.发生的大多数不良事件为轻度,治疗期间≥3级实验室异常少见,主要包括丙氨酸氨基转移酶升高(双盲阶段A组2例)、天冬氨酸氨基转移酶升高(双盲阶段A组3例)和总胆红素升高(开放标签阶段B组1例),通常无症状,用药中断或停药后可恢复.仅有1例因不良事件停药(B组,开放标签阶段). 结论 疗程为12周的OBV/PTV/r联合达塞布韦方案治疗中国基因1b型初治和经治非肝硬化慢性丙型肝炎患者可获得99%~ 100%的SVR12及SVR24率,且耐受性和安全性良好.魏来 成军 Luo Yan 李军 段钟平 侯金林 贾继东 张明香 黄燕 谢青 王贵强 杨东亮 赵伟 赵彩彦 唐红 蔺淑梅 龚国忠 牛俊奇 高志良 Sarah Kopecky-Bromberg Linch Fredrick Niloufar Mobashery Wang Ye 王介非 2018中华肝脏病杂志2018,26,5:18
20在初治和经治丙型肝炎病毒基因1b型慢性感染的代偿期肝硬化亚洲成年患者中评价奥比帕利和达塞布韦联合利巴韦林治疗的有效性和安全性显示文摘目的 评估奥比帕利(奥比他韦/帕立瑞韦/利托那韦)25/150/100mg,1次/d和达塞布韦(DSV) 250 mg,2次/d联合利巴韦林在丙型肝炎病毒基因1b型感染的代偿期肝硬化中国大陆成年患者中的有效性和安全性. 方法 采用开放标签、多中心Ⅲ期临床试验,在中国大陆、中国台湾地区和韩国开展,纳入初治和经治基因1b型丙型肝炎病毒感染的代偿期肝硬化(Metavir 评分纤维化分期=F4)成年患者,接受奥比他韦/帕立瑞韦/利托那韦和达塞布韦联合利巴韦林治疗12周.评估患者停药12周获得的持续病毒学应答(SVR)及24周获得的SVR率,并在接受至少1次研究药物的患者中评估有效性和安全性. 结果 共纳入63例中国大陆患者,其中62例(98.4%)患者基线Child-Pugh评分为5分.患者总体SVR12率及SVR24率为100% (95% CI:94.3% ~ 100.0%).发生的大多数不良事件为轻度.常见(发生率≥10%)所有级别不良事件和实验室异常包括总胆红素升高(36.5%)、乏力(19.0%)、非结合胆红素升高(19.0%)、结合胆红素升高(17.5%)和贫血(14.3%).3例(4.8%)患者发生≥3级不良事件,均被研究者判定为与研究药物无关.无患者出现导致提前停药的不良事件. 结论 丙型肝炎病毒基因1b型感染的代偿期肝硬化中国大陆患者接受奥比他韦/帕立瑞韦/利托那韦和达塞布韦联合利巴韦林治疗12周,停药12周和24周的SVR均为100%.耐受性及安全性良好,大多数不良事件为轻度.魏来 王贵强 Sarah Kopecky-Bromberg 成军 诩青 汪茂荣 许敏 段钟平 侯金林 张明香 张跃新 唐红 赵伟 蔺淑梅 贾战生 牛俊奇 高志良 袁宏 林明华 周新民 Luo Yan Linda Fredrick Niloufar Mobashery Wang Ye 贾继东 2018中华肝脏病杂志2018,26,5:17
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