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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Carbonaceous and nitrogenous disinfection byproduct precursor variation during the reversed anaerobic–anoxic–oxic process of a sewage treatment plant显示文摘Disinfection byproduct(DBP)precursors in wastewater during the reversed anaerobic–anoxic–oxic(A^2/O)process,as well as their molecular weight(MW)and polarity-based fractions,were characterized with UV scanning,fluorescence excitation emission matrix,Fourier transform infrared and nuclear magnetic resonance spectroscopy.Their DBP formation potentials(DBPFPs)after chlorination were further tested.Results indicated that the reversed A^2/O process could not only effectively remove the dissolved organic carbon(DOC)and dissolved total nitrogen in the wastewater,but also affect the MW distribution and hydrophilic–hydrophobic properties of dissolved organic matter(DOM).The accumulation of low MW and hydrophobic(HPO)DOM was possibly due to the formation of soluble microbial product-like(SMP-like)matters in the reversed A^2/O treatment,especially in the anoxic and aerobic processes.Moreover,DOM in the wastewater displayed a high carbonaceous disinfection byproduct formation potential(C-DBPFP)in the fractions of MW>100 k Da and MW<5 k Da,and revealed an increasing tendency of nitrogenous disinfection byproduct formation potential(N-DBPFP)with decrease of MW.For polarity-based fractions,the HPO fraction of wastewater showed significantly higher C-DBPFP and N-DBPFP than hydrophilic and transphilic fractions.Therefore,although the reversed A^2/O process could remove most DBP precursors by DOC reduction,it led to the enhancement of DBPFP with the formation and accumulation of low MW and HPO DOM.In addition,strong correlations between C-DBPFPs and SUVA,and between N-DBPFPs and DON/DOC,were observed in the wastewater,which might be helpful for DBPFP prediction in wastewater and reclaimed water chlorination. | Huihui Han Hengfeng Miao Yajing Zhang Minfeng Lu Zhenxing Huang Wenquan Ruan | 2018 | Journal of Environmental Sciences2018，30，3： | 3 |
| 3 | A New Family of Ce6MoO15 as Fast Oxide Ion Conductor显示文摘A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs. | Feng Jing Bo Qibing Che Ping Wang Jingping Liu Jianfen Lu Minfeng Zhang Deping Fang Daqing Cao Xueqiang Meng Jian | 2004 | Journal of Rare Earths2004，22，z2： | 2 |
| 4 | The Research for Mo- bile Robot Obstacle Avoidance Algorithm 显示文摘 | ZHI Gongshan ZHANG Minfeng | 2010 | Science Times2010，7，： | 1 |
| 5 | The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway显示文摘Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently,there are no molecular targeted drugs approved for osteosarcoma treatment,particularly effective drugs for osteosarcoma with pulmonary metastases.It has been reported that fibroblast activation protein alpha(FAPa)is upregulated in osteosarcoma and critically associated with osteosarcoma progression and metastasis,demonstrating that FAPa-targeted agents might be a promising therapeutic strategy for osteosarcoma.In the present study,we reported that the FAPa-activated vinblastine prodrug Z-GP-DAVLBH exhibited potent antitumor activities against FAPa-positive osteosarcoma cells in vitro and in vivo.Z-GP-DAVLBH inhibited the growth and induced the apoptosis of osteosarcoma cells.Importantly,it also decreased the migration and invasion capacities and reversed epithelial-mesenchymal transition(EMT)of osteosarcoma cells in vitro and suppressed pulmonary metastasis of osteosarcoma xenografts in vivo.Mechanistically,Z-GP-DAVLBH suppressed the AXL/AKT/GSK-3β/β-catenin pathway,leading to inhibition of the growth and metastatic spread of osteosarcoma cells.These findings demonstrate that Z-GP-DAVLBH is a promising agent for the treatment of FAPa-positive osteosarcoma,particularly osteosarcoma with pulmonary metastases. | Geni Ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Wen Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin Wencai Ye Dongmei Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 6 | A real-time PCR method for quantifying mixed cashmere and wool based on hair mitochondrial DNA显示文摘 | Minfeng Tang Weiping Zhang Hui Zhou Jing Fei | 2013 | Textile Research Journal2013，，： | 1 |
| 7 | Liquid-phase sintering enabling mixed ionic-electronic interphases and free-standing composite cathode architecture toward high energy solid-state battery显示文摘Solid-state batteries(SSBs)will potentially offer increased energy density and,more importantly,improved safety for next generation lithium-ion(Li-ion)batteries.One enabling technology is solid-state composite cathodes with high operating voltage and area capacity.Current composite cathode manufacturing technologies,however,suffer from large interfacial resistance and low active mass loading that with excessive amounts of polymer electrolytes and conductive additives.Here,we report a liquidphase sintering technology that offers mixed ionic-electronic interphases and free-standing electrode architecture design,which eventually contribute to high area capacity.A small amount(~4 wt.%)of lithium hydroxide(LiOH)and boric acid(H_(3)BO_(3))with low melting point are utilized as sintering additives that infiltrate into single-crystal Ni-rich LiNi_(0.8)Mn_(0.1)Co_(0.1)(NMC811)particles at a moderately elevated temperature(~350℃)in a liquid state,which not only enable intimate physical contact but also promote the densification process.In addition,the liquid-phase additives react and transform to ionic-conductive lithium boron oxide,together with the indium tin oxide(ITO)nanoparticle coating,mixed ionic-electronic interphases of composite cathode are successfully fabricated.Furthermore,the liquid-phase sintering performed at high-temperature(~800℃)also enables the fabrication of highly dense and thick composite cathodes with a novel free-standing architecture.The promising performance characteristics of such composite cathodes,for example,delivering an area capacity above 8 mAh·cm^(−2) within a wide voltage window up to 4.4 V,open new opportunities for SSBs with a high energy density of 500 Wh·kg^(−1) for safer portable electronic and electrical transport. | Xiang Han Weijun Zhou Minfeng Chen Linshan Luo Lanhui Gu Qiaobao Zhang Jizhang Chen Bo Liu Songyan Chen Wenqing Zhang | 2022 | Nano Research2022，15，7： | 0 |
| 8 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 9 | Risk factors for post-hepatectomy liver dysfunction in primary liver cancer patients with concurrent hepatic schistosomiasis and chronic hepatitis显示文摘Objective:The purpose of this study was to analyze risk factors for development of post-hepatectomy liver dysfunction in primary liver cancer(PLC)patients with concurrent hepatic schistosomiasis and chronic hepatitis.Methods:A retrospective analysis of 73 PLC patients with concurrent hepatic schistosomiasis and chronic hepatitis,of which 16 patients developed liver dysfunction(persistent ascites or pleural effusion or occurrence of liver-related potentially fatal complications)following hepatectomy,was performed.After clinical characteristics were recorded,preoperative liver function parameters and surgery-related parameters in these patients were assessed.Seventeen potential risk factors for post-hepatectomy liver dysfunction were identified.The association between these potential risk factors and post-hepatectomy liver dysfunction then was analyzed.Results:Univariate analysis showed that liver cirrhosis,intraoperative blood loss,and preoperative total bilirubin were associated with the development of post-hepatectomy liver dysfunction.Multivariate logistic regression analysis of these three factors revealed that intraoperative blood loss≥600 mL and cirrhosis were two independent risk factors for post-hepatectomy liver dysfunction in PLC patients with concurrent hepatic schistosomiasis and chronic hepatitis.Conclusion:Keeping intraoperative blood loss below 600 mL can help avoid the development of post-hepatectomy liver dysfunction in liver cancer patients with concurrent hepatic schistosomiasis and chronic hepatitis.For patients with concomitant liver cirrhosis,every effort should be made to minimize potential liver function impairment induced by other adverse factors. | ZHANG Minfeng SHEN Weifeng ZHONG Wei LIU Qu SHEN Rongxi YANG Jiamei | 2013 | Journal of Medical Colleges of PLA(China)2013，28，4： | 0 |
| 10 | Vertical,capacitive microelectromechanical switches produced via direct writing of copper wires显示文摘Three-dimensional(3D)direct writing based on the meniscus-confined electrodeposition of copper metal wires was used in this study to develop vertical capacitive microelectromechanical switches.Vertical microelectromechanical switches reduce the form factor and increase the area density of such devices in integrated circuits.We studied the electromechanical characteristics of such vertical switches by exploring the dependence of switching voltage on various device structures,particularly with regard to the length,wire diameter,and the distance between the two wires.A simple model was found to match the experimental measurements made in this study.We found that the electrodeposited copper microwires exhibit a good elastic modulus close to that of bulk copper.By optimizing the 3D structure of the electrodes,a volatile electromechanical switch with a sub-5 V switching voltage was demonstrated in a vertical microscale switch with a gap distance as small as 100 nm created with a pair of copper wires with diameters of~1μm and heights of 25μm.This study establishes an innovative approach to construct microelectromechanical systems with arbitrary 3D microwire structures for various applications,including the demonstrated volatile and nonvolatile microswitches. | Zhiran Yi Jianjun Guo Yining Chen Haiqing Zhang Shuai Zhang Gaojie Xu Minfeng Yu Ping Cui | 2016 | Microsystems & Nanoengineering2016，2，1： | 0 |
| 11 | The Northern End of the Xiannvshan Fault at the Three Gorges Area显示文摘The Xiannvshan fault zone, lying along the western margin of the Huangling anticline, is one of the most important fault zones in the Three Gorges reservoir area. The fault experienced strong activity during the Cenozoic Era. The question of whether the fault zone goes through the Yangtze River has been one of the key problems faced in previous studies as it has a significant influence upon the assessment of geological hazards and earthquake stability in the reservoir area. Based on tectonic and geomorphic observations along the fault zone between the Baixianchi village in Changyang county and Huangkou village in Zigui town, together with the comparisons between the geology in Guizhou and Quyuan town in the north bank of the Yangtze River and the Xiannvshan fault zone, it is suggested that the north end of this fault zone is located around Huangkou village and does not go through the Yangtze rivers northward. The evidence is as follows: ① On the basis of field data collection, it is found that the Xiannvshan Fault zone, which stretches 80km, underwent thrust movement in the Cenozoic period, resulting in ravines and fault scarps, topographically. Whereas, on the northern bank of the Yangtze River, faults are rarely found, and most of the faults are developed in the Jurassic strata,without topographical effects. Therefore, the Xiannvshan Fault zone has not stretched to the north bank of the Yangtze River. ② The fault gouge and tectonite zone were found developed on the Xiannvshan Fault zone at Baixianchi village, but only a tectonite zone was found at Zhouping village. There are also some branch faults close to the northern end of the fault zone. So, the activity of the fault zone weakened from south to north in Cenozoic. The fault zone extends northward and dies out at Huangkou. It doesn't stretch forward any longer as indicated by continuous strata, sparse joints, and small folds, etc. | Bi Minfeng Chu Quanzhi Deng Zhihui Pan Bo Zhang Changhou Zhou Qing | 2012 | Earthquake Research in China2012，26，4： | 0 |
| 12 | Interfacial nitrogen engineering of robust silicon/MXene anode toward high energy solid-state lithium-ion batteries显示文摘Replacing the conventional carbonate electrolyte by solid-state electrolyte (SSE) will offer improved safety for lithium-ion batteries.To further improve the energy density,Silicon (Si) is attractive for next generation solid-state battery (SSB) because of its high specific capacity and low cost.High energy density and safe Si-based SSB,however,is plagued by large volume change that leads to poor mechanical stability and slow lithium ions transportation at the multiple interfaces between Si and SSE.Herein,we designed a self-integrated and monolithic Si/two dimensional layered T_(3)C_(2)T_(x)(MXene,T_(x) stands for terminal functional groups) electrode architecture with interfacial nitrogen engineering.During a heat treatment process,the polyacrylonitrile not only converts into amorphous carbon (a-C) that shells Si but also forms robust interfacial nitrogen chemical bonds that anchors Si and MXene.During repeated lithiation and delithiation processes,the robust interfacial engineered Si/MXene configuration enhances the mechanical adhesion between Si and MXene that improves the structure stability but also contributes to form stable solid-electrolyte interphase (SEI).In addition,the N-MXene provides fast lithium ions transportation pathways.Consequently,the Si/MXene with interfacial nitrogen engineering (denoted as Si-N-MXene) deliveres high-rate performance with a specific capacity of 1498 m Ah g^(-1) at a high current of 6.4 A g^(-1).A Si-N-MXene/NMC full cell exhibited a capacity retention of 80.5%after 200 cycles.The Si-N-MXene electrode is also applied to SSB and shows a relative stable cycling over 100 cycles,demonstrating the versatility of this concept. | Xiang Han Weijun Zhou Minfeng Chen Jizhang Chen Guanwen Wang Bo Liu Linshan Luo Songyan Chen Qiaobao Zhang Siqi Shi Ching-Ping Wong | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 13 | Author correction to“The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway”[Acta Pharm Sin B 12(2022)1288–1304]显示文摘We deeply regret that the representative image of invaded 143B cells treated with Z-GP-DAVLBH + AXL-KD in the lower panel of Fig. 6C was incorrect due to inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Illustrator software. The image has now been corrected, and the quantification of cell invasion in Fig. 6C remains correct. The corrected version of Fig. 6C has been provided below, and the change did not affect the results and conclusions of this study. We have provided the original data of this figure to Editorial Office, and the Editorial Office or the corresponding authors can be contacted for original data access. | Geni Ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Weng Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin Wencai Ye Dongmei Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
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