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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 3 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 4 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 5 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 6 | Active corrosion protection of super-hydrophobic corrosion inhibitor intercalated Mg-Al layered double hydroxide coating on AZ31 magnesium alloy显示文摘Magnesium alloys,the advanced lightweight structural materials,have been successfully applied in the manufacturing field.Unfortunately,their poor corrosion resistance restrains the potential wide applications.In this work,anti-corrosion coatings were fabricated via the insitu growth of the corrosion inhibitors intercalated magnesium-aluminum layered double hydroxide(Mg-Al LDH)on AZ31 magnesium alloy and then post-sealing it by a super-hydrophobic coating.SEM,XRD,EDS,FTIR,XPS and contact angle test were conducted to analyze physical/chemical features of these coatings.Potentiodynamic polarization curves and electrochemical impedance spectroscopy were recorded to assess the anti-corrosion performance of prepared coatings.Surprisingly,Mg-Al LDH with molybdate intercalation and lauric acid modification achieves the excellent corrosion inhibition performance(99.99%)due to the multicomponent synergistic effect such as the physical protection of Mg-Al LDH,the corrosion inhibition of molybdate and super-hydrophobic properties of lauric acid.This work presents a scientific perspective and novel design philosophy to fabricate the efficient anti-corrosion coating to protect magnesium alloys and then expand their potential applications in other field. | Xin Wang Chuan Jing Yuxiang Chen Xiushuang Wang Gang Zhao Xing Zhang Liang Wu Xiaoying Liu Biqin Dong Yuxin Zhang | 2020 | Journal of Magnesium and Alloys2020，8，1： | 20 |
| 7 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 8 | Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice显示文摘METHODSCornealmicropocketswerecreatedinnudemice.Tumortissuesandlivertissueswereimplantedintothecornealmicropockets.Angiogenes... | SUN Hui Chuan, LI Xiao Ming, XUE Qiong, CHEN Jun, GAO Dong Mei and TANG Zhao You | 1999 | World Journal of Gastroenterology1999，5，2： | 17 |
| 9 | A dynamic N^6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors显示文摘 | Fei Yan Aref AI-Kali Zijie Zhang Jun Liu Jiuxia Pang Na Zhao Chuan He Mark R. Litzow Shujun Liu | 2018 | Cell Research2018，28，11： | 15 |
| 10 | Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes显示文摘背景长期的心失败( CHF )和糖尿病 mellitus 高预示因为互连的 pathophysiologic process.This ,大队学习试图分析流行的病态和死亡, clinicaI 特征和有 CHF 和有 NYHA functionaI 班的 1119 个病人的 diabetes.Methods A totaI 的病人的长期的结果-并且左室的喷射部分( LVEF )<45%在1995年1月和2009年5月之间是 recruited.Clinical 变量,生物化学并且 echocardiographic | SHI Chuan WANG Ling-jie HU Dan-feng LI Jin-ping ZHU Tian-qi SHAN Ying ZHAO Jian-rong ZHANG Feng-ru SHEN Wei-feng | 2010 | Chinese Medical Journal2010，，6： | 14 |
| 11 | Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy显示文摘Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury. | Liqing Yao Chuan He Ying Zhao Jirong Wang Mei Tang Jun Li Ying Wu Lijuan Ao Xiang Hu | 2013 | Neural Regeneration Research2013，8，5： | 14 |
| 12 | Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo显示文摘 | Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen | 2018 | Protein & Cell2018，9，10： | 11 |
| 13 | Isatin hybrids and their anti-tuberculosis activity显示文摘Tuberculosis(TB) is one of the most common and even fatal infectious diseases known to mankind.Millions of new cases are reported every year over the world,and one-third of the world's population is potentially infected with mycobacteria tuberculosis(MTB).Research to develop novel anti-TB drugs led to the identification of several isatin-based antimycobacterial agents,among which a number of potential candidates displayed excellent antimycobacterial activity and were found to be free of cytotoxicity.This review outlines the advances in the application of isatin hybrids as antimycobacterial agents and the critical aspects of design and structure-activity relationship of these derivatives. | Zhi Xu Shu Zhang Chuan Gao Jing Fan Feng Zhao Zao-Sheng Lv Lian-Shun Feng | 2017 | Chinese Chemical Letters2017，28，2： | 10 |
| 14 | A new triterpenoid from Kadsura coccinea显示文摘A new triterpenoid,possessing a lanost-9(11)-3-one skeleton,was isolated from the roots of Kadsura coccinea,based on the spectral analysis,its structure was elucidated as 3-hydroxy-12-acetoxycoccinic acid. | Yan Song Qing Jie Zhao Yong Sheng Jin Chuan Wei Feng Hai Sheng Chen | 2010 | Chinese Chemical Letters2010，21，11： | 10 |
| 15 | LiFePO_4 doped with magnesium prepared by hydrothermal reaction in glucose solution显示文摘与镁做的锂铁磷酸盐(LiFePO4 ) 热水地在水溶液作为碳先锋与葡萄糖从商业 LiOH, FeSO4, H3PO4 和 MgSO4 被综合。样品被 X 光检查粉末衍射描绘,扫描电子显微检查法和骑车的经常的费用分泌物。结果证明综合粉末在与从葡萄糖的焦糖反应生产的碳先锋涂的 situ。在环境温度(28 ± 2 ° C ) ,准备的 LiFePO4 的电气化学的表演展出 135 mAh g 的高排出量 ? 1 在 5C 和超过 90 的 98% 的好能力保留骑车。优秀电气化学的表演应该与在碳和主要的 LiFePO4 之间的亲密接触被相关,源于,导致 LiFePO4 的电导率的增加并且二级粒子在里面 situ 积炭的形成先锋 / 碳。 | Xiu Qin Ou Guang Chuan Liang Jin Sheng Liang Sheng Zhao Xu Xia Zhao | 2008 | Chinese Chemical Letters2008，19，3： | 10 |
| 16 | Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnT^R141W transgenic mice显示文摘 | Hai-ping ZHAO Dan LV Wei ZHANG Li ZHANG Shu-mei WANG Chun-mei MA Chuan QIN Lian-feng ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，3： | 10 |
| 17 | Synthesis of new hyodeoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave显示文摘为在用微波的没有溶剂的条件下面的新 hyodeoxycholic 酸 thiosemicarbazone 衍生物的合成的一个有效、简单的方法被开发了。它的主要优点是短反应时间,好变换和这个过程的环境地友好的性质。初步的结果显示一些这些混合物对 E 拥有禁止的效果。coli。 | Zhi Chuan Shi Zhi Gang Zhao Xing Li Liu Yu Chen | 2011 | Chinese Chemical Letters2011，22，4： | 9 |
| 18 | The wheat MYB-related transcription factor TaMYB72 promotes flowering in rice显示文摘Through large-scale transformation analyses, Ta MYB72 was identified as a flowering time regulator in wheat. Ta MYB72 is a MYB family transcription factor localized to the nucleus. Three Ta MYB72 homologs,Ta MYB72-A, Ta MYB72-B and Ta MYB72-D, cloned from hexaploid wheat were mapped to the short arm of the group 6 chromosomes. Under the long-day conditions,over-expression of the Ta MYB72 in rice shortened the flowering time by approximately 12 d. Expression analyses suggest that Ta MYB72 may function through upregulation of florigen genes Hd3 a and RFT1. | Lichao Zhang Guoxiang Liu Jizeng Jia Guangyao Zhao Chuan Xia Lina Zhang Fu Li Qiang Zhang Chunhao Dong Shuangcheng Gao Longzhi Han Xiuping Guo Xin Zhang Jinxia Wu Xu Liu Xiuying Kong | 2016 | Journal of Integrative Plant Biology2016，58，8： | 8 |
| 19 | Early vitrectomy combined with pan retinal photocoagulation, anti-vascular endothelial growth factor, and gradual cyclophotocoagulation for treatment of neovascular glaucoma显示文摘To the editor: Neovascular glaucoma (NVG) is refractory glaucoma characterized by neovascularization of iris or anterior chamber angle, which often leads to dramatic elevation of intraocular pressure (IOP) and severe vision loss.[1] Series of studies have been reported regarding managing NVG with anti-vascular endothelial growth factor (VEGF) therapy or in combination with anti-glaucoma surgery.[2,3,4] However, the effect of anti-VEGF seems only temporary and it does not improve the prognosis in the long term.[5] Therefore, pan retinal photocoagulation (PRP) remains necessary for improving long term prognosis.[5] However, it is not easy to complete PRP early in NVG patients due to corneal edema, hyphema, or vitreous hemorrhage. We conducted this prospective interventional case series study to propose a protocol which could confine NVG in an early stage. The aims of our treatment modalities included that controlling IOP immediately, complete PRP as soon as possible, anti-VEGF as adjuvant and controlling residual glaucoma with gradual cyclophotocoagulation. | Chuan Sun Hong-Song Zhang Yu-Jie Yan Tong Zhao Ai-Hong Li Yan Tang Zhi-Jun Wang | 2019 | Chinese Medical Journal2019，，20： | 8 |
| 20 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
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