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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Induced earthquakes in the development of unconventional energy resources显示文摘It has long been known that human activities such as waste fluid disposal and reservoir impoundment may cause earthquakes. Recently, anthropogenic activities to tackle the increasing energy demand and to address climate change issues are also reported to induce earthquakes. These activities have a common attribute in that fluids are injected and extracted underground and induce spatiotemporal changes of pore pressure and stress, which may cause slip on faults. Induced earthquakes not only pose significant impacts on seismic hazard assessment and preparation, but also raise the question to the society as how to balance the economic needs of resources development and the public's concerns about potential environmental impacts. Here we review the observations of fluid-injection/extraction induced earthquakes, ground deformation associated with these activities, and their physical mechanisms. Furthermore, we discuss the influences of induced earthquakes on seismic hazard models, regulatory policies on these anthropogenic activities, and current development of academic, industrial and government initiatives and collaborations in order to understand this intriguing phenomenon and address associated challenges. | YANG HongFeng LIU YaJing WEI Meng ZHUANG JianCang ZHOU ShiYong | 2017 | Science China Earth Sciences2017，60，9： | 12 |
| 3 | A Domestication-Associated Gene GmPRR3b Regulates the Circadian Clock and Flowering Time in Soybean显示文摘Improved soybean cultivars have been adapted to grow at a wide range of latitudes,enabling expansion of cultivation worldwide.However,the genetic basis of this broad adaptation is still not clear.Here,we report the identification of GmPRR3b as a major flowering time regulatory gene that has been selected during domestication and genetic improvement for geographic expansion.Through a genome-wide association study of a diverse soybean landrace panel consisting of 279 accessions,we identified 16 candidate quantitative loci associated with flowering time and maturity time.The strongest signal resides in the known flowering gene E2,verifying the effectiveness of our approach.We detected strong signals associated with both flowering and maturity time in a genomic region containing GmPRR3b.Haplotype analysis revealed that GmPRR3bH6 is the major form of GmPRR3b that has been utilized during recent breeding of modern cultivars.mRNA profiling analysis showed that GmPRR3bH6 displays rhythmic and photoperiod-dependent expression and is preferentially induced under long-day conditions.Overexpression of GmPRR3bH6 increased main stem node number and yield,while knockout of GmPRR3bH6 using CRISPR/Cas9 technology delayed growth and the floral transition.GmPRR3bH6 appears to act as a transcriptional repressor of multiple predicted circadian clock genes,including GmCCAIa,which directly upregulates J/GmELF3a to modulate flowering time.The causal SNP(Chr12:5520945)likely endows GmPRR3bH6 a moderate but appropriate level of activity,leading to early flowering and vigorous growth traits preferentially selected during broad adaptation of landraces and improvement of cultivars. | Cong Li Ying-hui Li Yanfei Li Hongfeng Lu Huilong Hong Yu Tian Hongyu Li Tao Zhao Xiaowei Zhou Jun Liu Xinan Zhou Scott A.Jackson Bin Liu Li-juan Qiu | 2020 | Molecular Plant2020，13，5： | 11 |
| 4 | Less and shrunken pollen 1(LSP1) encodes a member of the ABC transporter family required for pollen wall development in rice(Oryza sativa L.)显示文摘Pollen fertility is an agronomic trait that strongly influences rice yield. Recent studies have revealed that the development of the pollen wall is required for pollen fertility and is regulated by several genes. However, the mechanisms underlying pollen and pollen wall development in rice remain largely unknown. In the present study, a point mutation in a gene on chromosome 1 was identified that resulted in the production of less and shrunken pollen(LSP) and led to defects in pollen wall formation. This gene was named LSP1 and was found to encode a member of the adenosine triphosphate-binding cassette(ABC)transporter G subfamily, OsABCG3. Two other loss-of-function mutants of LSP1/OsABCG3,generated using CRISPR/Cas9 technology, showed the same male sterile phenotype. The LSP1/OsABCG3 gene showed a spatio-temporal expression pattern in the developing anthers, and is an ortholog of the Arabidopsis genes At ABCG1 and At ABCG16, which play an important role in pollen wall development. Mutation of LSP1/OsABCG3 affected the expression of several genes involved in pollen and pollen wall formation. These results suggest that LSP1/OsABCG3 is critical for normal pollen fertility and shed light on the molecular mechanisms underlying rice pollen wall development. | Tao Luo Ting Zou Guoqiang Yuan Zhiyuan He Wenjie Li Yang Tao Miaomiao Liu Dan Zhou Hongfeng Zhao Jun Zhu Yueyang Liang Qiming Deng Shiquan Wang Aiping Zheng Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2020 | The Crop Journal2020，8，3： | 4 |
| 5 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 6 | The nodulation and nyctinastic leaf movement is orchestrated by clock gene LHY in Medicago truncatula显示文摘As sessile organisms,plants perceive,respond,and adapt to the environmental changes for optimal growth and survival.The plant growth and fitness are enhanced by circadian clocks through coordination of numerous biological events.In legume species,nitrogen-fixing root nodules were developed as the plant organs specialized for symbiotic transfer of ni-trogen between microsymbiont and host.Here,we report that the endogenous circadian rhythm in nodules is regulated by MtLHY in legume species Medicago truncatula.Loss of function of MtLHY leads to a reduction in the number of nodules formed,resulting in a diminished ability to assimilate nitrogen.The operation of the 24-h rhythm in shoot is further influenced by the availability of nitrogen produced by the nodules,leading to the irregulated nyctinastic leaf movement and reduced biomass in mtlhy mutants.These data shed new light on the roles of MtLHY in the orchestration of circadian oscillator in nodules and shoots,which provides a mechanistic link between nodulation,nitrogen assimilation,and clock function. | Yiming Kong Lu Han Xiu Liu Hongfeng Wang Lizhu Wen Xiaolin Yu Xiaodong Xu Fanjiang Kong Chunxiang Fu Kirankumar S.Mysore Jiangqi Wen Chuanen Zhou | 2020 | Journal of Integrative Plant Biology2020，62，12： | 4 |
| 7 | Selenium-functionalized metal-organic frameworks as enzyme mimics显示文摘 | Weiqiang Zhou Hongfeng Li Bin Xia Wenlan Ji Shaobo Ji Weina Zhang Wei Huang Fengwei Huo Huaping Xu | 2018 | Nano Research2018，11，10： | 3 |
| 8 | Study on the Ground Cover Plant in Tibetan Herb Garden显示文摘This paper conducts a comprehensive survey of the ground cover plant in Tibetan herb garden for the first time using ' five-point sampling method'. Survey results show that:(i) A total of 46 families,95 genera,119 species of ground cover plants in herb garden are applied in Tibet,and Asteraceae,Gramineae,Leguminosae,Labiatae,Iridaceae and Liliaceae are used most,with the species number of 22,15,8,7,6 and 5,respectively,accounting for 18. 49%,12. 61%,6. 72%,5. 88%,5. 04% and 4. 20% of the plants surveyed,respectively.(ii) In terms of importance value for the herbaceous layer,the top three plants are Poa pratensis L.,Festuca arundinace and Lolium multiflorum L.,with the importance value of 45. 950,34. 610 and 29. 880,respectively; in terms of importance value for the non-turf ground cover herb plants,the top three plants are Trifolium L.,Cosmos bipinnata Cav. and Althaea rosea(Linn.) Cavan.,with the importance value of4. 372,3. 437 and 2. 062,respectively.(iii) The overall level of greening is low and uneven in the region,with large regional differences. In terms of ground cover plant abundance,Nyingchi > Lhasa > Shannan > Changdu > Xigaze > Ali > Nagqu. | Zhineng LIU Hongfeng ZHANG Gang PAN Wei WANG Jin XU Peng ZHOU | 2016 | Asian Agricultural Research2016，8，11： | 2 |
| 9 | From genes to networks: The genetic control of leaf development显示文摘Substantial diversity exists for both the size andshape of the leaf,the main photosynthetic organofflowering plants.The two major forms of leaf aresimple leaves,in which the leaf blade is undivided,and compound leaves,which comprise severalleaflets.Leaves form at the shoot apical meristemfrom a group of undifferentiated cells,whichfirstestablish polarity,then grow and differentiate.Each of these processes is controlled by a com-bination of transcriptional regulators,microRNAsand phytohormones.The present review docu-ments recent advances in our understanding ofhow these various factors modulate the develop-ment of both simple leaves(focusing mainly on themodel plantArabidopsis thaliana)and compoundleaves(focusing mainly on the model legumespeciesMedicago truncatula). | Hongfeng Wang Fanjiang Kong Chuanen Zhou | 2021 | Journal of Integrative Plant Biology2021，63，7： | 2 |
| 10 | Construction of recombinant adenovirus vector with connexin 43 gene显示文摘 | Jin Wu Wentao Liu Yongqing Li Brett Schroeder Hongfeng Zhou Dan Liu Xiaolong Yue Guangyue Shi Xiwen Sun Yanbin Zhao Yali Wang Xin Qiu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 1 |
| 11 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 12 | The 9L^(LUC)/Wistar rat glioma model is not suitable for immunotherapy显示文摘The availability of a well-characterized animal brain tumor model will play an important role in identifying treatments for human brain tumors. Wistar rats bearing 9L glioma cells can develop solid, well-circumcised tumors, and may be a useful animal model for the evaluation of various therapeutic approaches for gliosarcomas. In this study, the 9L/Wistar rat glioma model was produced by intracerebral implantation of 9LLUC glioma cells syngenic to Fischer 344 (F344) rats. Bioluminescence imaging showed that tumors progressively grew from day 7 to day 21 in 9LLUC/F344 rats, and tumor regression was found in some 9LLUC/Wistar rats. Hematoxylin-eosin staining verified that intracranial tumors were gliomas. Immunohistochemistry results demonstrated that no CD4- and CD8-positive cells were found in the syngeneic 9LLUC/F344 model. However, many infiltrating CD4- and CD8-positive cells were observed within the tumors of the 9LLUC/Wistar model. Our data suggests that compared with 9L/F344 rats, 9L glioma Wistar rats may not be suitable for evaluating brain glioma immunotherapies, even though the model induced an immune response and exhibited tumor regression. | Liping Yang Jingxiang Zhao Guihong Zhou Yunfang Wang Lusi Li Hongfeng Yuan Xue Nan Lidong Guan Xuetao Pei | 2012 | Neural Regeneration Research2012，7，18： | 1 |
| 13 | Comparable charge transport property based on S…S interactions with that of π-π stacking in a bis-fused tetrathiafulvalene compound显示文摘Compact molecular packing with short π-π stacking and large π-overlap in organic semiconductors is desirable for efficient charge transport and high carrier mobility.Thus charge transport anisotropy along different directions is commonly observed in organic semiconductors.Interestingly,in this article,we found that comparable charge transport property were achieved based on the single crystals of a bis-fused tetrathiafulvalene derivative(EM-TTP) compound along two interaction directions,that is,the multiple strong S…S intermolecular interactions and the π-π stacking direction,with the measured electrical conductivity and hole mobility of 0.4 S cm^(-1),0.94 cm^2 V^(-1) s^(-1) and 0.2 S cm^(-1),0.65 cm2 V^(-1) s^(-1),respectively.This finding provides us a new molecular design concept for developing novel organic semiconductors with isotropic charge transport property through the synergistic effect of multiple intermolecular interactions(such as S…S interactions) and π-π stacking. | Ke Zhou Hongfeng Chen Huanli Dong Qi Fang Wenping Hu | 2017 | Science China Chemistry2017，60，4： | 1 |
| 14 | Investigation of Garden Nurseries in Linzhi City of Tibet显示文摘Garden nurseries in Linzhi City, Tibet were comprehensively investigated, 132 garden plant species were covered. The investigation showed that garden nurseries in the local area remained in the initial development stage, and the scale of most nurseries was small, and there was blank in many aspects of the landscape architecture industry. Most seedlings were introduced from the interior regions of China, self-bred seedlings in local nurseries accounted for only 32.68%. On the basis of the investigation results, garden nurseries in Linzhi City were analyzed specifi cally to fi gure out advantages and defi ciencies of local garden nurseries. | LIU Zhineng PAN Gang ZHANG Hongfeng FANG Jiangping ZHOU Peng XU Jin | 2016 | Journal of Landscape Research2016，8，3： | 1 |
| 15 | Local delivery of superagonist gene based on polymer nanoparticles for cancer immunotherapy显示文摘Cancer is the leading cause that threatens human life expectancy due to the lack of effective therapies.Cancer immunotherapy has been explored to improve the body's immune system against cancer and accompanied by promising results in recent years.Interleukin 15(IL-15),a pleiotropic immunomodulator,is critical for immune cells development and displays great anti-tumor potential in both preclinical and clinical trials.In this study,superagonist IL-15 plasmid(psIL-15)consisting of IL-15Rα-sushi-linker-IL-15 was constructed in order to secret superagonist IL-15(sIL-15)in tumor site.A gene delivery system through self-assembly by methylated polyethylene glycol-b-polylactic acid-b-methylated polyethylene glycol(m PEG-PLA-m PEG)and 1,2-dioleoyl-3-trimethylammonium-propane(DOTAP),named DMAM,was designed to deliver psIL-15.Further study showed that DMAM/psIL-15 could successfully deliver psIL-15 to tumor cells and the supernatants of the tumor cells could further stimulate lymphocytes proliferation as well as activation in vitro.Local delivery of DMAM/psIL-15 in animal models demonstrated significant tumor inhibition through enhancing immune cells responses,reducing angiogenesis,promoting tumor cell apoptosis and inhibiting proliferation,with no evidence of system toxicities.These results indicate that DMAM/psIL-15 may be a promising strategy for cancer immunotherapy. | Zehua Hong Xin Zan Ting Yu Yuzhu Hu Hongfeng Gou Songping Zheng Xiang Gao Peizhi Zhou | 2023 | Chinese Chemical Letters2023，34，3： | 1 |
| 16 | An analysis of the relationship of the expression of Cx32 and Cx43 with the invasion and metastasis of Gastric Carcinoma显示文摘 | Jin Wu Jincai Wang Hongfeng Zhou | 2010 | The International Journal of Integrative Ontology2010，4，1： | 1 |
| 17 | Constant Color-leaved Species in Tibet and Their Application in Landscaping显示文摘To analyze the basic conditions of constant colored-leaved tree species in Tibet, this study applied the 'biological five-point method' to investigate the plant communities layer by layer, investigated landscape plant species and their landscaping application in Tibet. The results showed that(a) there are 40 constant color-leaved species(including varieties) in Tibet, belonging to 35 genera, 22 families, including 26 tree species and 16 shrub species. In terms of color, 22 species are yellow, 9 purple, 7 red and 2 others, occupying 55.00%, 22.50%, 17.50% and 5.00% of the total constant color-leaved species, respectively.(b) In the tree layer, the species ranking the top 2 of the importance value list are Prunus cerasifera Ehrhar f. atropurpurea Rehd. and Photiniax serrulata ‘Rubens' with an importance value of 26.063 and 9.035; in the shrub layer, the species ranking the top 3 of the importance value list are Ligustrum × vicaryi Hort, Berberis thunbergi var. atropurpurea Chenault, Platycladus orientalis cv. Aurea Nana with an importance value of 22.577, 18.987 and 10.529.(c) The most-applied species belong to the Rosaceae(9), Leguminosae(5), and Oleaceae(3), accounting for 22.50%, 12.50% and 7.50% of the total investigated constant color-leaved species, respectively.(d) Most of the investigated species grow well, but some of them including Berberis thunbergii var. atropurpurea Chenault grow moderately, Loropetalum chinense var. rubrum, Aucuba chinensis var. iegata grow poorly, and the causes of poor growth should be explored further or application of these species should be controlled. In addition, pertinent suggestions were put forward in view of major problems in the application of constant color-leaved species in Tibet. | LIU Zhineng ZHANG Hongfeng PAN Gang XU Jin HAO Wenyuan WANG Wei ZHOU Peng | 2017 | Journal of Landscape Research2017，9，3： | 1 |
| 18 | Lower bounds for the Randic index R of trees显示文摘 | Lu Hongfeng Zhou Bo | 2005 | Match Commun Math Comput Chem2005，54，： | 1 |
| 19 | In situ phase separation of NiAu alloy nanoparticles for preparing highly active Au/NiO CO oxidation catalysts显示文摘 | Zhou Shenghu Yin Hongfeng | 2008 | Chem Phys Chem2008，9，17： | 1 |
| 20 | Research and practice on system engineering management of a mobile payment project显示文摘The popularization of the mobile internet has given rise to demand for flexible and convenient payment methods. For China, it is necessary to keep pace with or even lead the trend of innovation and development in the age of mobile payment. From the perspective of systems engineering, this paper introduces research and implementation of China Union Pay's mobile payment project. The general requirements and core engineering problems of the mobile payment project are summarized based on analyses of the characteristics and engineering difficulties of this project. Integration of innovative technologies is introduced to resolve the contradiction between ease-of-use and security. A rapid iterative development process is adopted to improve the product release efficiency as well as the users' experience. The launch of the mobile payment project also opens the window to coordinating and upgrading the whole payment industry chains. | Yongkai ZHOU Hongfeng CHAI | 2017 | Frontiers of Engineering Management2017，4，2： | 1 |
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