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| 1 | Effects of different resuscitation fluid on severe acute pancreatitis显示文摘AIM: To compare effects of different resuscitation fluid on microcirculation, inflammation, intestinal barrier and clinical results in severe acute pancreatitis (SAP). METHODS: One hundred and twenty patients with SAP were enrolled at the Pancreatic Disease Institute between January 2007 and March 2010. The patients were randomly treated with normal saline (NS group), combination of normal saline and hydroxyethyl starch (HES) (SH group), combination of normal saline, hydroxyethyl starch and glutamine (SHG group) in resuscitation. The ratio of normal saline to HES in the SH and SHG groups was 3:1. The glutamine (20% glutamine dipeptide, 100 mL/d) was supplemented into the resuscitation liquid in the SHG group. Complications and outcomes including respiratory and abdominal infection, sepsis, abdominal hemorrhage, intra-abdominal hypertension, abdominal compartment syndrome (ACS), renal failure, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), operation intervention, length of intensive care unit stay, length of hospital stay, and mortality at 60 d were compared. Moreover, blood oxygen saturation (SpO 2 ), gastric intramucosal pH value (pHi), intra-abdominal pressure (IAP), inflammation cytokines, urine lactulose/mannitol (L/M) ratio, and serum endotoxin were investigated to evaluate the inflammatory reaction and gut barrier. RESULTS: Compared to the NS group, patients in the SH and SHG groups accessed the endpoint more quickly (3.9 ± 0.23 d and 4.1 ± 0.21 d vs 5.8 ± 0.25 d, P < 0.05) with less fluid volume (67.26 ± 28.53 mL/kg/d, 61.79 ± 27.61 mL/kg per day vs 85.23 ± 21.27 mL/kg per day, P < 0.05). Compared to the NS group, incidence of renal dysfunction, ARDS, MODS and ACS in the SH and SHG groups was obviously lower. Furthermore, incidence of respiratory and abdominal infection was significantly decreased in the SH and SHG groups, while no significant difference in sepsis was seen. Moreover, less operation time was needed in the SH and SHG group than the NS group, but the difference was not significant. The mortality did not differ significantly among these groups. Blood SpO 2 and gastric mucosal pHi in the SH and SHG groups increased more quickly than in the NS group, while IAP was significantly decreased in the SH and SHG group. Moreover, the serum tumor necrosis factor-α, interleukin-8 and C-reactive protein levels in the SH and SHG groups were obviously lower than in the NS group at each time point. Furthermore, urine L/M ratio and serum endotoxin were significantly lower in the SH group and further decreased in the SHG group.CONCLUSION: Results indicated that combination of normal saline, HES and glutamine are more efficient in resuscitation of SAP by relieving inflammation and sustaining the intestinal barrier. | Gang Zhao Jun-Gang Zhang He-Shui Wu Jin Tao Qi Qin Shi-Chang Deng Yang Liu Lin Liu Bo Wang Kui Tian Xiang Li Shuai Zhu Chun-You Wang | 2013 | World Journal of Gastroenterology2013，19，13： | 56 |
| 2 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 3 | Expert consensus on the use of human serum albumin in critically ill patients显示文摘Introduction Human serum albumin(HSA)is a non-glycosylated,negatively charged,single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD.It is synthesized by the liver at a rate of approximately 200 mg·kg^(-1)·day^(-1),with a half-life of 21 days,and subjected to catabolism in the muscles,liver,and kidneys at a rate of 4%per day.[1]Albumin,accounting for 60%of the total plasma protein,has various physiological functions,[2]such as maintaining 70%to 80%of effective plasma colloid osmotic pressure,coordinating vascular endothelial integrity,anti-oxidant and anti-inflammatory activities,maintaining the acidbase balance,and participating in the transport,distribution,and metabolism of a variety of endogenous and exogenous substances. | Yue-Tian Yu Jiao Liu Bo Hu Rui-Lan Wang Xiang-Hong Yang Xiu-Ling Shang Gang Wang Chang-Song Wang Bai-Ling Li Ye Gong Sheng Zhang Xin Li Lu Wang Min Shao Mei Meng Feng Zhu You Shang Qiang-Hong Xu Zhi-Xiong Wu De-Chang Chen | 2021 | Chinese Medical Journal2021，，14： | 22 |
| 4 | Laparoscopic resection of lower rectal cancer with telescopic anastomosis without abdominal incisions显示文摘AIM:To assess laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through transanal resection without abdominal incisions.METHODS:From March 2010 to June 2014, 30 patients(14 men and 16 women, aged 36-78 years, mean age 59.8 years) underwent laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through anus-preserving transanal resection.The tumors were 5-7 cm away from the anal margin in 24 cases, and 4 cm in six cases.In preoperative assessment, there were 21 cases of T1N0M0 and nine of T2N0M0.Through the middle approach, the sigmoid mesentery was freed at the root with an ultrasonic scalpel and the roots of the inferior mesenteric artery and vein were dissected, clamped and cut.Following the total mesorectal excision principle, the rectum was separated until the anorectal ring reached 3-5 cm from the distal end of the tumor.For perineal surgery, a ring incision was made 2 cm above the dentate line, and sharp dissection was performed submucosally towards the superior direction, until the plane of the levator ani muscle, to transect the rectum.The rectum and distal sigmoid colon were removed together from the anus, followed by a telescopic anastomosis between the full thickness of the proximal colon and the mucosa and submucosal tissue of the rectum.RESULTS:For the present cohort of 30 cases,the mean operative time was 178 min,with an average of 13 positive lymph nodes detected.One case of postoperative anastomotic leak was observed,requiring temporary colostomy,which was closed and recovered3 mo later.The postoperative pathology showed T1-T2N0M0 in 19 cases and T2N1M0 in 11 cases.Twelve months after surgery,94.4%patients achieved anal function Kirwan grade 1,indicating that their analfunction returned to normal.The patients were followed up for 1-36 mo,with an average of 23 mo.There was no local recurrence,and 17 patients survived for>3years(with a survival rate of 100%).CONCLUSION:Laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through transanal resection without abdominal incisions is safe and feasible. | Shi-Yong Li Gang Chen Jun-Feng Du Guang Chen Xiao-Jun Wei Wei Cui Fu-Yi Zuo Bo Yu Xing Dong Xi-Qing Ji Qiang Yuan | 2015 | World Journal of Gastroenterology2015，21，16： | 19 |
| 5 | Intravenous transplantation of mesenchymal stem cells attenuates oleic acid induced acute lung injury in rats显示文摘 | XU Yu-lin LIU Ying-long WANG Qiang LI Gang LU Xiao-dong KONG Bo | 2012 | Chinese Medical Journal2012，，11： | 13 |
| 6 | Gastrin,somatostatin,and experimental disturbance of the gastrointestinal tract in rats显示文摘INTRODUCTIONThe field of gastrointestinal hormones has expanded at a dizzying rate[1-4].Gastrointestinal hormones as regulatory peptides that appear to be major components of bodily integration and have important regulatory actions on physioligical function of the gastrointestinal tract .The successful isolation of some gastrointestinal hormones and the development of sensitive methods for their detection have led to the unexpected finding that they also exist in the brain . | Yong Li Yao~1 Bo Xu~2 Wan Dai Zhang~1 Yu Gang Song~1 ~1Institute of Gastrointestinal Diseases,Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2Department of Orthopedics Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaYong Li Yao graduated from First Military Mcdical University with a master degree in 1998.She now works in the Institute of Gastrointestinal Diseases,Nanfang Hospital as a doctoral candidate majoring gastrointestinal diseases and gastrointestinal hormones,she has published 8 papers. | 2001 | World Journal of Gastroenterology2001，7，3： | 12 |
| 7 | Age and Growth of Chub Mackerel (Scomber japonicus) in the East China and Yellow Seas Using Sectioned Otolith Samples显示文摘Although chub mackerel (Scomber japonicus) is a primary pelagic fish species,we have only limited knowledge on its key life history processes. The present work studied the age and growth of chub mackerel in the East China and Yellow Seas. Age was determined by interpreting and counting growth rings on the sagitta otoliths of 252 adult fish caught by the Chinese commercial purse seine fleet during the period from November 2006 to January 2007 and 150 juveniles from bottom trawl surveys on the spawn-ing ground in May 2006. The difference between the assumed birth date of 1st April and date of capture was used to adjust the age determined from counting the number of complete translucent rings. The parameters of three commonly used growth models,the von Bertalanffy,Logistic and Gompertz models,were estimated using the maximum likelihood method. Based on the Akaike Information Criterion (AIC),the von Bertalanffy growth model was found to be the most appropriate model. The size-at-age and size-at-maturity values were also found to decrease greatly compared with the results achieved in the 1950s,which was caused by heavy exploitation over the last few decades. | LI Gang CHEN Xinjun FENG Bo | 2008 | Journal of Ocean University of China2008，7，4： | 12 |
| 8 | Optimum design of hierarchical stiffened shells for low imperfection sensitivity显示文摘A concept of hierarchical stiffened shell is proposed in this study,aiming at reducing the imperfection sensitivity without adding additional weight.Hierarchical stiffened shell is composed of major stiffeners and minor stiffeners,and the minor stiffeners are generally distributed between adjacent major stiffeners.For various types of geometric imperfections,e.g.,eigenmode-shape imperfections,hierarchical stiffened shell shows significantly low imperfection sensitivity compared to traditional stiffened shell.Furthermore,a surrogate-based optimization framework is proposed to search for the hierarchical optimum design.Then,two optimum designs based on two different optimization objectives(including the critical buckling load and the weighted sum of collapse loads of geometrically imperfect shells with small-and large-amplitude imperfections)are compared and discussed in detail.The illustrative example demonstrates the inherent superiority of hierarchical stiffened shells in resisting imperfections and the effectiveness of the proposed framework.Moreover,the decrease of imperfection sensitivity can finally be converted into a decrease of structural weight,which is particularly important in the development of large-diameter launch vehicles. | Bo Wang Peng Hao Gang Li Jia-Xin Zhang Kai-Fan Du Kuo Tian Xiao-Jun Wang Xiao-Han Tang | 2014 | Acta Mechanica Sinica2014，30，3： | 12 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 11 | Ice radar investigation at Dome A, East Antarctica:Ice thickness and subglacial topography显示文摘Dome A, located in the central East Antarctic ice sheet (EAIS), is the highest summit of the Antarctic ice sheet. From ice-sheet evolution modeling results, Dome A is likely to preserve over one million years of the Earth's paleo-climatic and -environmental records, and considered an ideal deep ice core drilling site. Ice thickness and subglacial topography are critical factors for ice-sheet models to determine the timescale and location of a deep ice core. During the 21st and 24th Chinese National Antarctic Research Expedition (CHINARE 21, 2004/05; CHINARE 24, 2007/08), ground-based ice radar systems were used to a three-dimensional investigation in the central 30 km×30 km region at Dome A. The successfully obtained high resolution and accuracy data of ice thickness and subglacial topography were then interpolated into the ice thickness distribution and subglacial topography digital elevation model (DEM) with a regular grid resolution of 140.5 m×140.5 m. The results of the ice radar investigation indicate that the average ice thickness in the Dome A central 30 km×30 km region is 2233 m, with a minimal ice thickness of 1618 m and a maximal ice thickness of 3139 m at Kunlun Station. The subglacial topography is relatively sharp, with an elevation range of 949-2445 m. The typical, clear mountain glaciation morphology is likely to reflect the early evolution of the Antarctic ice sheet. Based on the ice thickness distribution and subglacial topography characteristics, the location of Kunlun Station was suggested to carry out the first high-resolution, long time-scale deep ice core drilling. However, the internal structure and basal environments at Kunlun Station still need further research to determine. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，4： | 11 |
| 12 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 13 | Damage characteristics and constitutive modeling of the 2D C/Si C composite: Part I – Experiment and analysis显示文摘This paper reports an experimental investigation on the macroscopic mechanical behaviors and damage mechanisms of the plain-woven(2D) C/Si C composite under in-plane on- and offaxis loading conditions. Specimens with 15, 30, and 45 off-axis angles were prepared and tested under monotonic and incremental cyclic tension and compression loads. The obtained results were compared with those of uniaxial tension, compression, and shear specimens. The relationships between the damage modes and the stress state were analyzed based on scanning electronic microscopy(SEM) observations and acoustic emission(AE) data. The test results reveal the remarkable axial anisotropy and unilateral behavior of the material. The off-axis tension test results show that the material is fiber-dominant and the evolution rate of damage and inelastic strain is accelerated under the corresponding combined biaxial tension and shear loads. Due to the damage impediment effect of compression stress, compression specimens show higher mechanical properties and lower damage evolution rates than tension specimens with the same off-axis angle. Under cyclic tension–compression loadings, both on-axis and off-axis specimens exhibit progressive damage deactivation behaviors in the compression range, but with different deactivation rates. | Li Jun Jiao Guiqiong Wang Bo Yang Chengpeng Wang Gang | 2014 | Chinese Journal of Aeronautics2014，27，6： | 10 |
| 14 | The electrochemical advanced oxidation processes coupling of oxidants for organic pollutants degradation: A mini-review显示文摘The electrochemical advanced oxidation processes(EAOPs) have been extensively applied in the treatment of organic pollutants degradation.Herein,the mini review provides the coupling systems about EAOPs and different oxidants(e.g.,persulfate(PS),peroxymonosulfate(PMS),and ozone(O3)),including EAOPs-PS systems,EAOPs-PMS systems,EAOPs-peroxone systems,and photoelectro-oxidants systems,for the organic compounds degradation.The coupling system of EAOPs with oxidants is an effective way to improve the generated free radicals(e.g.,HO^·and SO4^·-) concentration and to accelerate pollutant degradation.In this review,we make a summary of the homogeneous and heterogeneous EAOPs-oxidant processes.The reaction mechanisms of EAOPs combined with different oxidants are elucidated in detail,as well as the synergistic effect for improving the degradation and mineralization efficiency. | Jun Li Yangju Li Zhaokun Xiong Gang Yao Bo Lai | 2019 | Chinese Chemical Letters2019，30，12： | 10 |
| 15 | Relationship between serum sex hormones levels and degree of benign prostate hyperplasia in Chinese aging men显示文摘良性的 prostatic 增生(BPH ) 是最普通的医药条件在之一中年并且老人。这研究在中国的变老的男人口调查了在性别荷尔蒙的浆液层次和 BPH 的措施之间的关系。前列腺症状作为为人 ≥ 屏蔽节目的免费健康的部分被估计; 40 岁。考试包括了数字直肠的检查,前列腺特定的抗原铺平的浆液的决心,国际前列腺症状分数(IPSS ) 和 transrectal ultrasonography。全部的睾丸激素(TT ) 的浆液层次,性别荷尔蒙绑定血球素(SHBG ) ,免费睾丸激素(英尺) , luteinizing 荷尔蒙(LH ) ,刺激滤泡的荷尔蒙(FSH ) ,催乳激素(PRL ) 和 estradiol (E 2) 被评估。这些人也完成了一张健康和人口分布问询表并且收到了详细物理考试。最后的学习人口与 58.9 年的吝啬的年龄由 949 个人组成了。皮尔森关联分析显示除了 TT,在所有性别荷尔蒙的年龄和层次之间,并且在年龄和前列腺体积之间有重要关联(PV;r=0.243;P< 0.01 ) 或 IPSS (r=0.263;P< 0.01 ) 。另外的重要关联在 IPSS 和 LH 的浆液层次之间被发现(r=0.112;P< 0.01 ) 并且 FSH (r=0.074;P< 0.05 ) ,但是在性别荷尔蒙层次和 PV 之间没有重要关联。Multivariate 线性回归分析与 PV 显示出在年龄和身体团索引(BMI ) 之间的重要关联(P< 0.0001 ) 。另外,与 IPSS 在年龄和 PV 之间有重要关联(P< 0.0001 ) 。浆液性别荷尔蒙层次没与 PV 或 IPSS 相关。在使人变老的 BPH 的措施上的内分泌的变化的效果要求进一步的调查在纵并且与 BPH 的所有严厉包括病人的 multicenter 研究。 | Qin-Song Zeng Chuan-Liang Xu Zhi-Yong Liu Hui-Qing Wang Bo Yang Wei-Dong Xu Tai-Le Jin Cheng-Yao Wu Gang Huang Zheng Li Bo Wang Ying-Hao Sun | 2012 | Asian Journal of Andrology2012，14，5： | 9 |
| 16 | Study on biomass catalytic pyrolysis for production of bio-gasoline by on-line FTIR显示文摘The pyrolysis of biomass is a promising way for production of bio-gasoline if the stability and quality problems of the bio-crude-oil can be solved by catalytic cracking and reforming.In this paper,an on-line infrared spectrum was used to study thecharacteristics of catalytic pyrolysis with the following preliminary results.The removal of C O of organic acid is more difficultthan that of aldehydes and ketones.HUSY/γ-Al_2O_3 and REY/γ-Al_2O_3 catalysts exhibited better deoxygenating activities whileHZSM-5/γ-Al_2O_3 catalyst exhibited preferred selectivities for production of iso-alkanes and aromatics.Finally,possiblemechanisms of biomass catalytic pyrolysis are discussed as well. | Chang Bo Lu Jian Zhong Yao Wei Gang Lin Wen Li Song | 2007 | Chinese Chemical Letters2007，18，4： | 9 |
| 17 | Preliminary results of ice radar investigation along the traverse between Zhongshan and Dome A in East Antarctic ice sheet:Ice thickness and subglacial topography显示文摘During the 24th Chinese National Antarctic Research Expedition(CHINARE 24,2007/08),a ground-based ice radar was used to survey ice thickness and subglacial topography along the 1170 km traverse between Zhongshan and Dome A in East Antarctic ice sheet(EAIS).Ice-bedrock interface was detected along 82%of the traverse and data was collected at a horizontal resolution of <5.6 m.The data was processed to produce curves of ice thickness distribution and subglacial topography along the traverse.The results indicate that,along the traverse,the average ice thickness is 2037 m,smaller than the average ice thickness in EAIS;the thickest ice is at 730 km,and the thinnest ice(891 m)is at the edge of the ice sheet,but the slightly larger ice thickness(1078 m) in inland appears at 1020 km;the average subglacial topography elevation is 728 m,greatly larger than the average value in EAIS, and the largest elevation reaches up to 2650 m at 1034 km.The lowest terrain is located at 765 km.In further inland of 900?1170 km,the subglacial topography is relatively high due to the existence of the Gamburtsev Subglacial Mountains in the region.Generally,the influence of subglacial topography on ice surface is not significant,except at 900 km where great rise of subglacial topography causes evident uplift of ice surface.Where ice-bedrock interface was detected,the frequent and strong change of ice thickness and subglacial topography in small-scale means large bedrock roughness along the traverse,and is considered as the result of the integrated influence of ice flow,basal environments and geology.The segment where bedrock was not detected has very large ice thickness.The strong ice flow there also makes internal structure more complicated and induces serious attenuation of radar signals. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，24： | 8 |
| 18 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 19 | Impacts of algal blooms removal by chitosan-modified soils on zooplankton community in Taihu Lake,China显示文摘It is important to assess the eflect on zooplankton when perform the environmental protection or restoration technology,especially removing algal blooms,because algae were the major primary producer in algal lakes.The influence on zooplankton community after half a year of algal blooms removed by chitosan-modified soils in Taihu Lake was assessed and the rationality of carrying out the process semiannually was evaluated in the present study.Morphological composition and genetic diversity of zooplankton community were investigated by microscope checkup and polymerase chain reaction-denatured gradient gel electrophoresis(PCR-DGGE) .A total of 44 zooplankton taxa(23 protozoa,17 rotifers,3 copepoda and 1 cladocera) were detected by microscope checkup,and a total of 91 bands(28 bands amplified by primers F1427-GC and R1616,63 bands amplified by primers Fung-GC and NS1) were detected by PCR-DGGE.The results of cluster analysis or detrended correspondence analysis indicated that there was no considerable diflerence in morphological composition of zooplankton and DGGE profiles between experimental and control sites,and DGGE profiles could represent the biologic diversity.The study showed that zooplankton community could recover original condition after half year of algal blooms removed by chitosan-modified soils and it was acceptable to apply this process semiannually.In addition,the results revealed that PCR-DGGE could be applied to investigate the impacts of the environmental protection or restoration engineering on zooplankton community diversity. | Jiajia Ni Yuhe Yu Weisong Feng Qingyun Yan Gang Pan Bo Yang Xiang Zhang Xuemei Li | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 20 | Developmental changes in intercellular junctions and Kv channels in the intestine of piglets during the suckling and post-weaning periods显示文摘Background: The intestinal epithelium is an important barrier that depends on a complex mixture of proteins and these proteins comprise different intercellular junctions. The purpose of this study was to investigate the postnatal and developmental changes in morphology, intercellular junctions and voltage-gated potassium(Kv) channels in the intestine of piglets during the suckling and post-weaning periods.Results: Samples of the small intestine were obtained from 1-, 7-, 14-, and 21-d-old suckling piglets and piglets on d 1, 3, 5, and 7 after weaning at 14 d of age. The results showed that the percentage of proliferating cell nuclear antigen(PCNA)-positive cells and alkaline phosphatase(AKP) activity, as well as the abundances of E-cadherin,occludin, and Kv1.5 m RNA and claudin-1, claudin-3, and occludin protein in the jejunum were increased from d 1to d 21 during the suckling period(P < 0.05). Weaning induced decreases in the percentage of PCNA-positive cells,AKP activity and the abundances of E-cadherin, occludin and zonula occludens(ZO)-1 m RNA or protein in the jejunum on d 1, 3 and 5 post-weaning(P < 0.05). There were lower abundances of E-cadherin, occludin and ZO-1m RNA as well as claudin-1, claudin-3 and ZO-1 protein in the jejunum of weanling piglets than in 21-d-old suckling piglets(P < 0.05). The abundances of E-cadherin, occludin, ZO-1 and integrin m RNA were positively related to the percentage of PCNA-positive cells.Conclusion: Weaning at 14 d of age induced damage to the intestinal morphology and barrier. While there was an adaptive restoration on d 7 post-weaning, the measured values did not return to the pre-weaning levels, which reflected the impairment of intercellular junctions and Kv channels. | Jing Wang Liming Zeng Bie Tan Guangran Li Bo Huang Xia Xiong Fengna Li Xiangfeng Kong Gang Liu Yulong Yin | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 8 |
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