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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Enhanced Invasive and Metastatic Potential Induced by Transforming Growth Factor-β1 Might be Correlated with Glutathione-S-transferase-π, Cofilin and Heat Shock Protein 27 in SGC-7901 Gastric Cancer Cells显示文摘在我们的以前的学习,我们发现转变生长因素(TGF )-beta1 提高了胃的癌症房间的变形、侵略的潜力。Proteomics 在这研究被采用进一步说明内在的分子的机制。Aftertwo 维的电气泳动,图象分析,点鉴定,蛋白质鉴定和数据库分析,三蛋白质也就是, glutathione-S-transferase-pi (GST-pi ) , cofilin 和热震惊蛋白质 27 (HSP27 ) ,被发现在 TGF-beta1 起来调整对待的 SGC-7901 房间。Thefindings 被蛋白质印迹分析进一步证实。这些结果建议 GST-pi, cofilin 和 HSP27 可能参予 TGF-beta1 导致的提高的侵略潜力。 | Kuansong WANG Jinghe LI Changli ZHEN Jianhua ZHOU Desheng XIAO Jie LIU Ying LIU Haiying JIANG Chen CHEN Jifang WEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 11 |
| 3 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 4 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 5 | Comparative Study about Degradation of High-purity Magnesium Screw in Intact Femoral Intracondyle and in Fixation of Femoral Intracondylar Fracture显示文摘Bone screws encounter complex mechanical environment in fracture fixation of weight-bearing bone.In the present study, high-purity magnesium(HP Mg) screws were applied in fixation of rabbit femoral intracondylar fracture with 3 mm gap. In the control group, HP Mg screws of the same design were implanted at corresponding position of contralateral leg. At 4, 8 and 16 weeks after surgery, retrieved femurs went through micro-computed tomography(micro-CT) scanning and hard tissue processing. Under mechanical stress involved in fracture fixation, bending of screw bolt was observed at the portion exposed to facture gap at 4 weeks. Then local corrosion at the same portion was detected 16 weeks after surgery,which indicated the accumulation effect of mechanical stress on Mg corrosion. HP Mg screws in the fracture group had no significant difference with the control group in screw volume, surface area, surfaceto-volume ratio(S/V). And peri-implant bone volume/tissues volume(BV/TV) and bone volume density(BMD) in the fracture group was comparable to that in the control group. Furthermore, histological analysis showed new formed bone tissues in fracture gap and fracture healing 16 weeks after surgery. Under mechanical stress, HP Mg screw suffered bolt bending and local corrosion at the portion exposed to fracture gap. But it had no influence on the integral corrosion behaviors, osseointegration of HP Mg screw and the fracture healing. Therefore, HP Mg screws possessed good potential in fracture fixation of weightbearing bones. | Pei Han Pengfei Cheng Changli Zhao Shaoxiang Zhang Runhua Zhou Xiaonong Zhang Yimin Chai | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 6 | MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN显示文摘 | Boning Liu Xiang Wu Bin Liu Changli Wang Yunde Liu Qinghua Zhou Ke Xu | 2012 | BBA - Molecular Basis of Disease2012，，11： | 2 |
| 7 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 8 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 9 | Identification of drugs that interact with herbs in drug development显示文摘 | Shu-Feng Zhou Zhi-Wei Zhou Chun-Guang Li Xiao Chen Xiyong Yu Charlie Changli Xue Adrian Herington | 2007 | Drug Discovery Today2007，，15： | 1 |
| 10 | Chemical signals based on multi-channel wavelet denoising method 显示文摘 | ZHONG Hongbin ZHOU Changli LI Guanbin | 2006 | Computer and Applied Chemistry2006，23，10： | 1 |
| 11 | A Rotor Unbalance Response Based Approach to the Identification of the Closed-Loop Stiffness and Damping Coefficients of Active Magnetic Bearings显示文摘 | Zhou Jin Di Long Cheng Changli | 2016 | Mechanical Systems and Signal Processing2016，6667，： | 1 |
| 12 | A voronoi- based location privacy-preserving method for continuous query in LBS显示文摘 | Chunguang Ma Changli Zhou and Songtao Yang | 2015 | International Journal of Distributed Sensor Networks2015，2015，： | 1 |
| 13 | Electrochemical behavior of O-nitrophenol at hexagonal mesoporous silica modified carbon paste electrodes显示文摘 | ZHOU Changli LIU Zhen DONG Yanming | 2009 | Electroanalysis2009，21，7： | 1 |
| 14 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 15 | Assessment of Geological Security and Integrated Assessment Geo-environmental Suitability in Worst-hit Areas in Wenchuan Quake显示文摘在 2008 的 Wenchuan 地震和地震触发的 geo 危险为象建设,交通和电一样的基础结构引起了大损害和死亡以及破坏损坏。为与高大小地震在高多山的区域构造的镇区和城市选择相对安全的区域是迫切的。这篇论文与高大小地震在高山和沟壑为重建论述基本想法,评估索引和地质的安全评估,水和陆地资源安全示范和对 geo 环境的适用性的综合评价的评估方法,它在最糟点击的区域(12 个县) 被使用。综合评价显示出那:(1 ) 在 Longmenshan 差错地区定位了,评估区域具有差的地区性的外壳稳定性,在哪个不稳定并且第二个不稳定的区域说明 79% 总数;(2 )geo 危险危险性在评估区域高。地震触发的 geo 危险的点主要在中等、高的山区与更高的分发沿着活跃差错地区被散布,在哪个为 40.1% 总数的高、中等的危险性 zoning 报道的区域;(3 ) 地质的安全在评估区域是差的,在哪个区域不合适,建设分别地为 8.3% 评估区域, 9.3% 和 9.3% 在合适的构造区域,地质的安全的区域,第二安全和紧张 zoning 报道占据 73.1% ;(4 )geo 环境的适用性在评估区域,适用性的区域和基本适用性 zoning 在说明 3.5% 整个评估区域和 7.3% 是差的。 | LI Wenpeng WEN Dongguang ZHOU Aiguo SUN Xiaoming MENG Hui SHI Jusong CHEN Zongyu ZHANG Liqin FENG Xiaoming LIU Changli ZHOU Jianwei | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 1 |
| 16 | Rational design of Fe-N-C electrocatalysts for oxygen reduction reaction:From nanoparticles to single atoms显示文摘As an alternative energy,hydrogen can be converted into electrical energy via direct electrochemical conversion in fuel cells.One important drawback of full cells is the sluggish oxygen reduction reaction(ORR)promoted by the high-loading of platinum-group-metal(PGM)electrocatalysts.Fe-N-C family has been received extensive attention because of its low cost,long service life and high oxygen reduction reaction activity in recent years.In order to further enhance the ORR activity,the synthesis method,morphology regulation and catalytic mechanism of the active sites in Fe-N-C catalysts are investigated.This paper reviews the research progress of Fe-N-C from nanoparticles to single atoms.The structure-activity relationship and catalytic mechanism of the catalyst are studied and discussed,which provide a guidance for rational design of the catalyst,so as to promote the more reasonable design of Fe-N-C materials. | Mengru Sun Changli Chen Menghao Wu Danni Zhou Zhiyi Sun Jianling Fan Wenxing Chen Yujing Li | 2022 | Nano Research2022，15，3： | 0 |
| 17 | Study on Non-interlayer Liquid Phase Diffusion Bonding for SiCp/ZL101 Aluminum Matrix Composite显示文摘Through the vacuum diffusion bonding for SiCp/ZLl01 aluminum matrix composite, the influence of bonding parameters on the joint properties was reported, with the aim to obtain optimal bonding parameters. The microstructureof joints was analyzed by means of optical microscope and scanning electron microscope in order to study the relationship between the macro-properties of joints and the microstructures. It was found that diffusion bonding couldbe used for bonding aluminum matrix composites successfully. Meanwhile, the properties of the matrix and the jointwere all affected by some defects such as the reinforcement aggregation in aluminum matrix composites made bystirring casting. | Wei GUO Jitai NIU Jinfan ZHAI Changli WANG Jie YU Guangtao ZHOU | 2003 | Journal of Materials Science & Technology2003，19，z1： | 0 |
| 18 | An Improved Fine-Grained Encryption Method for Unstructured Big Data显示文摘In the big data protecting technologies, most of the existing data protections adopt entire encryption that leads to the researches of lightweight encryption algorithms, without considering from the protected data itself. In our previous paper (FGEM), it finds that not all the parts of a data need protections,the entire data protection can be supplanted as long as the critical parts of the structured data are protected. Reducing unnecessary encryption makes great sense for raising efficiency in big data processing. In this paper, the improvement of FGEM makes it suitable to protect semi-structured and unstructured data efficiently. By storing semi-structured and unstructured datum in an improved tree structure, the improved FGEM for the datum is achieved by getting congener nodes. The experiments show the improved FGEM has short operating time and low memory consumption. | Changli Zhou Chunguang Ma Songtao Yang | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 19 | Microcalorimetric Study on the Germination of Seeds显示文摘MicrocalorimetricStudyontheGerminationofSeeds￥ZhouPeijiang;Xiechangli;Songzhaohua;Wangcunxin;HuYunchu;Qusongsheng(Departmento... | Zhou Peijiang Xie changli Song zhaohua Wang cunxin Hu Yunchu Qu songsheng (Department of Chemistry, Wuhan University, Wuhan 430072,China)Zhu yingguo Zhou hantao (School of Life Science, Wuhan University, Wuhan 430072) | 1996 | Wuhan University Journal of Natural Sciences1996，1，1： | 0 |
| 20 | Triggered query with strong location privacy in mobile network显示文摘Location privacy is a hot-button topic that has to be taken into account if location-based services(LBS) are to succeed. Extensive researches focus on the nearest neighbor(NN) query or k-nearest neighbor(k NN) query about location privacy-preserving. However, no single technique can be applied to any situation and achieve high security and low cost. This manuscript focuses on the location privacy-preserving in the geo-fencing services, A secure two-party computation location privacy model and the corresponding solution was proposes based on triggered query. The author draw on the computational geometry and cryptography technologies, mainly to conquer such problems related to the users' location hidden, secret checking-in and secret authentication in the geo-fencing services. Performance assessment shows that the proposed solution can reduce the query-processing time and the size of query result set. | Yang Songtao Ma Chunguang Zhou Changli | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，2： | 0 |
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