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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Recent progress in engineering near-infrared persistent luminescence nanoprobes for time-resolved biosensing/bioimaging显示文摘Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing excitation.Due to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly improved.Since near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/bioimaging.In this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR PLNPs.Notably,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of PLNPs.Secondly,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence mechanism.It includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence centers.Given the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed. | Ling Liang Na Chen Yiyi Jia Qinqin Ma Jie Wang Quan Yuan Weihong Tan | 2019 | Nano Research2019，12，6： | 11 |
| 3 | Modeling of Filling and Solidification Process for TiAl Exhaust Valves During Suction Casting显示文摘Investment and suction casting (ISC) represents an economic and promising process route to fabricate automotive exhaust valves of γ-TiAl based alloys, but information available on the metal flow and the temperature changes during mould filling and solidification process for the ISC process is meager. A sequentially coupled mathematical flow-thermal model, based on the commercial finite-volume/finite-difference code FLOW-3D and the finite-element code PROCAST, has been developed to investigate the ISC process. In term of calculating the flow and temperature fields during the filling and solidification stages, potential defects including the gas bubbles and the surface air entrainment occurred in the mould filling process and the shrinkage porosities formed in the solidification process are predicted and the reasons for the formation of these defects are also analyzed. The effects of filling pressure difference control methods and moulds on gas bubble and surface air entrainment behavior are presented. It is found that by changing the filling pressure difference control methods from general suction casting to 'air leakage' suction casting and reducing air leakage flow rates, the gas bubbles are eliminated effectively, and the surface air entrainment attenuate dramatically. With resort to a mould with a tetragonal runner, the surface air entrainment decrease to the lowest level. Finally, the water analogue and suction casting experiments of exhaust valves are implemented for further validation of the simulation results. | Chao XIONG Yingche MA Bo CHEN Kui LIU Yiyi LI | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，1： | 7 |
| 4 | Vacancy formation enthalpies of high-entropy FeCoCrNi alloy via first-principles calculations and possible implications to its superior radiation tolerance显示文摘Because atoms in high-entropy alloys(HEAs) coordinate in very different and distorted local environments in the lattice sites, even for the same type of constituent, their point defects could highly vary.Therefore, theoretical determination of the thermodynamic quantities(i.e., defect formation enthalpies)of various point defects is rather challenging because each corresponding thermodynamic quantity of all involve constituents is not unique. The knowledge of these thermodynamic quantities is prerequisite for designing novel HEAs and understanding the mechanical and physical behaviors of HEAs. However,to date there has not been a good method to theoretically derive the defect formation enthalpies of HEAs. Here, using first-principles calculations within the density functional theory(DFT) in combination of special quasi-random structure models(SQSs), we have developed a general method to derive corresponding formation enthalpies of point defects in HEAs, using vacancy formation enthalpies of a four-component equiatomic fcc-type FeCoCrNi HEA as prototypical and benchmark examples. In difference from traditional ordered alloys, the vacancy formation enthalpies of FeCoCrNi HEA vary in a highly wide range from 0.72 to 2.89 eV for Fe, 0.88–2.90 eV for Co, 0.78–3.09 eV for Cr, and 0.91–2.95 eV for Ni due to high-level site-to-site lattice distortions and compositional complexities. On average, the vacancy formation enthalpies of 1.58 eV for Fe, 1.61 eV for Cr, 1.70 eV for Co and 1.89 eV for Ni are all larger than that(1.41 eV) of pure fcc nickel. This fact implies that the vacancies are much more difficult to be created than in nickel, indicating a reasonable agreement with the recent experimental observation that FeCoCrNi exhibits two orders of amplitudes enhancement of radiation tolerance with the suppression of void formation at elevated temperatures than in pure nickel. | Weiliang Chen Xueyong Ding Yuchao Feng Xiongjun Liu Kui Liu Z.P. Lu Dianzhong Li Yiyi Li C.T. Liu Xing-Qiu Chen | 2018 | Journal of Materials Science & Technology2018，34，2： | 6 |
| 5 | Factors Affecting Cr(Ⅲ) Oxidation by Manganese Oxides显示文摘The high oxidation ability of manganese oxides or soils was used to study effects of pH and coatingon Cr(Ⅲ) oxidation. The results indicated that Cr(Ⅲ) oxidation peaked in pH 4.0-6.5. The amount andrate of Cr(Ⅲ) being oxidized by uncoated δ-MnO2 were larger than those by Fe oxide- or CaCO3-coatedone. Inorganic Cr(Ⅲ) was more easi1y oxidized by MnO2 than organic complex Cr(Ⅲ) due to differentsurface affinities. Precipitated Cr(Ⅲ) and adsorbed Cr(Ⅲ) might be transferred onto MnO2 surface andthen oxidized to Cr(VI). | CHEN YINGXU CHEN YIYI LIN QI HU ZIQIANG HU HONG and WU JIANYANG(Dept. of Environ. Sci., Zhejiang Agricultural Univereity, Hangzhou, 310029 (China)) | 1997 | Pedosphere1997，7，2： | 5 |
| 6 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 7 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 8 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 9 | Vibration characteristics of floating slab track显示文摘 | Kuo Chenming Huang Chenghao Chen Yiyi | 2008 | Journal of Sound and Vibration2008，317，35： | 1 |
| 10 | Hysteretic behaviour of tubular joints under cyclic loading显示文摘 | Wang Wei Chen Yiyi | 2007 | Journal of Constructional Steel Research2007，63，10： | 1 |
| 11 | Hysteretic behaviour of tubular joints under cyclic loading显示文摘 | WANG Wei CHEN Yiyi | | 0，，10： | 1 |
| 12 | Hysteretic behaviour of tubular joints under cyclic loading 显示文摘 | Wang Wei Chen Yiyi | 2007 | Journal of Constructional Steel Research2007，63，： | 1 |
| 13 | Experimental investigation of beam-to-tubular column moment connections under column removal scenario 显示文摘 | LI Ling WANG Wei CHEN Yiyi | 2013 | Journal of Constructional Steel Research2013，88，： | 1 |
| 14 | Comparison between a cast steel joint and a welded circular hollow section joint显示文摘 | Tong Lewei Zheng Hongzhi Chen Yiyi | 2006 | Welding in the World2006，，： | 1 |
| 15 | SPECIAL ISSUE: RELIGION AND SOCIETY: CROSS-CULTURAL COMMUNICATION:Peking University's role in China's Anti-Christian Movement in 1922-1927显示文摘本文阐述了北京大学知识分子在中国20世纪初的非基督教运动中所起的作用,尤为重视北京大学学者中的“非主流”观点。虽然北京大学大部分知识分子的观点和反基督教的主流舆论相吻合,但是也有许多学者表现出了高度的理智和宽容,警醒“用宗教式的狂热来进行反宗教运动”属于过激行为。这种众口一声中的少数派声音的存在,反映了一个文化的成熟、城府和健康。在今天中华民族力图重振文化大国形象的努力中,仍然有借鉴意义。 | Chen Yiyi | 2010 | Social Sciences in China2010，31，1： | 1 |
| 16 | Hysteretic behaviour of tubular joints under cyclic loading显示文摘 | Wang Wei Chen Yiyi | 2007 | Journal of Constructional Steel Research2007，63，10： | 1 |
| 17 | Experimental study on H-shaped steel beam-columns with large width-thickness ratios under cyclic bending about weak-axis显示文摘 | Xin Cheng Yiyi Chen David A. Nethercot | 2013 | Engineering Structures2013，，： | 1 |
| 18 | The global registry of COVID-19 clinical trials: indicating the design of traditional Chinese medicine clinical trials显示文摘Objective:To analyze the registration information of Corona Virus Disease 2019(COVID-19)related clinical trials from all the clinical trial registry accepted by the International Committee of Medical Journal Editors(ICMJE).Methods:All the database of ICMJE-accepted clinical trial registry platform were searched for COVID-19 related clinical trials that registered from December 8,2019 to February 19,2020.Results:All the database totally contained data of 209 COVID-19 related clinical trials,including 66(31.6%)traditional Chinese medicine(TCM)related studies and 143(68.4%)non-TCM related studies.176(84.2%)clinical trials were registered in ChiCTR,as 33(15.8%)were registered in ClinicalTrials.gov.There were 152(72.7%)intervention trials,including 9(4.3%in total)preventive trials,136(65.1%in total)therapeutic trials and 7(3.3%in total)convalescent trials.Conclusion:At the present stage,clinical studies are still aiming at exploring the effective treatment of COVID-19,and the existing treatments need more high-quality clinical evidence supporting.Traditional Chinese medicine may have played an important role in all stages of the epidemic preventing and control,and the enthusiasm of carrying out scientific research has also been greatly improved.The relevant policies of clinical trial registration should be popularized among researchers,including traditional Chinese medicine researchers.And the methodological quality of clinical trials’design urges improving. | Xuxu Wei Mengzhu Zhao Chen Zhao Xiaoyu Zhang Ruijin Qiu Yiyi Lin Yang Sun Manke Guan Hongcai Shang | 2020 | TMR Modern Herbal Medicine2020，3，3： | 1 |
| 19 | Reasonable location of stopping line in close‑distance underlying coal seam and partition support of large cross‑section roadway显示文摘Close-distance coal seams are widely distributed over China,and the coal pillars left by the overlying coal seams afect the retracement channel of the underlying coal seam in the stopping stage.Based on the engineering background of close-distance seam mining in a coal mine,the reasonable position of the underlying coal seam's stopping line and the support method of the large section roadway during stopping are investigated using feld measurements,similar simulation experiments,and numerical simulations.There are three types of location relationships between the stopping line of the underlying coal seam and the stopping line of the overlying coal seam:'externally staggered with the upper stopping line'(ESUL,stops mining under the overlying goaf),'overlapped with upper stopping line'(OUL),and'internally staggered with the upper stopping line'(ISUL,ISUL-SD for shorter internal staggered distances,ISUL-LD for longer ones).There are diferent stress arch structures in the overlying strata of the above three positions,and the stress arch evolution process exists in the process of ESUL→OUL→ISUL-SD→ISUL-LD:a front and rear double stress arch structure→the front arch gradually decreases→the front arch dies out,and the double arch synthesizes the single arch→the single-arch range expands→the nested double arch.The relationship between the stress arch structure and the position of the stopping line is evaluated as follows:(1)ESUL:the stress concentration in the roof plate of the retracement channel of the underlying coal seam is the highest,because the overburden block of the extensive collapse zone acts directly on the roof plate of the retracement channel,resulting in relative difculties in roof support.(2)OUL:although the retracement channel roof pressure is minimal,the overlying rock structure has the potential for rotation or slippage instability.(3)ISUL-SD:the pressure on the roof of the retracement channel is small and the overburden structure is stable,which is conducive to the safe retraction of the support and not limited by the width of the end-mining coal pillar.(4)ISUL-LD:it is basically the same as the condition of stopping under the non-goaf;however,it has a limitation on the width of the end-mining coal pillar.The location of the stopping line is selected as ISUL-SD,and the retraction process of the self-excavating retraction channel was adopted.A partition asymmetric support scheme which is proven by feld practice is proposed,through a comprehensive analysis of the pre-stress feld simulation of the support scheme,based on the diferent control requirements of the roof above the support and the roof of the retracement channel in the stopping area.This method realizes safe and smooth withdrawal of the support. | Dongdong Chen Yiyi Wu Shengrong Xie Fangfang Guo Fulian He Ruipeng Liu | 2022 | International Journal of Coal Science & Technology2022，9，4： | 1 |
| 20 | An overview study on cross-section classification of steel H-sections显示文摘 | Yiyi Chen Xin Cheng David A. Nethercot | 2013 | Journal of Constructional Steel Research2013，，： | 1 |
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