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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Galloping Vibration Monitoring of Overhead Transmission Lines by Chirped FBG Array显示文摘A distributed online fiber sensing system based on the phase-sensitive optical time domain reflectometer(Φ-OTDR)enhanced by the drawing tower fiber Bragg grating(FBG)array is presented and investigated experimentally for monitoring the galloping of overhead transmission lines.The chirped FBG array enhanced Φ-OTDR sensing system can be used to measure the galloping behavior of the overhead transmission lines(optical phase conductor or optical power ground wire),which are helpful for monitoring the frequency response characteristics of the ice-induced galloping,evaluating the motion tendencies of these cables,and avoiding the risk of flashover during galloping.The feasibility of the proposed online monitoring system is demonstrated through a series of experiments at the Special Optical Fiber Cable Laboratory of State Grid Corporation of China(Beijing,China).Results show that the proposed system is effective and reliable for the monitoring of galloping shape and characteristic frequency,which can predict the trend of destructive vibration behavior and avoid the occurrence of cable breaking and tower toppling accidents,and these features are essential for the safety operation in smart grids. | Qizhong YAN Ciming ZHOU Xuebin FENG Chi DENG Wenyu HU Yimin XU | 2022 | Photonic Sensors2022，12，3： | 5 |
| 3 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 4 | A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs显示文摘The fertility of sows mainly depends on the embryo losses during gestation and the survival rate of the postfarrowing piglets.The selection of highly-prolific sows has been mainly focused on the selection of genotypes with high ovulatory quota.However,in the early-and post-implantation stages,the rate of embryo losses was increased with the increase of zygotes.Among the various factors,placental growth and development is the vital determinant for fetal survival,growth,and development.Despite the potential survival of fetuses with deficient placental development,their life-conditions and growth can be damaged by a process termed intrauterine growth retardation(IUGR).The newborn piglets affected by IUGR are prone to increased morbidity and mortality rates;meanwhile,the growth,health and welfare of the surviving piglets will remain hampered by these conditions,with a tendency to exacerbate with age.Functional amino acids such as glycine,proline,and arginine continue to increase with the development of placenta,which are not only essential to placental growth(including vascular growth)and development,but can also be used as substrates for the production of glutathione,polyamines and nitric oxide to benefit placental function in many ways.However,the exact regulation mechanism of these amino acids in placental function has not yet been clarified.In this review,we provide evidence from literature and our own work for the role and mechanism of dietary functional amino acids during pregnancy in regulating the placental functional response to fetal loss and birth weight of piglets.This review will provide novel insights into the response of nutritionally nonessential amino acids(glycine and proline)to placental development as well as feasible strategies to enhance the fertility of sows. | Chengquan Tan Zihao Huang Wenyu Xiong Hongxuan Ye Jinping Deng Yulong Yin | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 3 |
| 5 | New Diagnostic Systems on HL-2A Tokamak显示文摘 | DING Xuantong ZHOU Yan DENG Zhongchao XIAO Weiwen LIU Zetian SHI Zhongbing YAN Longwen HONG Wenyu YANG Qingwei | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
| 6 | Octacyclic and decacyclic ent‑abietane dimers with cytotoxic activity from Euphorbia fischeriana steud.显示文摘A novel Diels-Alder adduct possesses a 6/6/6/5/6/6/6/6 octacyclic skeleton featured with bicyclo[2.2.2]octane moiety,biseupyiheoid A(1),along with another decacyclic 6/6/6/3/5/6/5/6/6/6 fused diterpenoid dimer,bisfischoid C(2),were isolated from Euphorbia fischeriana.Their structures were determined by spectroscopic,X-ray crystallographic approaches,and quantum mechanical calculations.The structural features of 1 and 2 were hypothesized to involve intramolecular Diels-Alder reactions with different coupling patterns.Dimer 1 showed antiproliferative activity through apoptosis activation in LoVo cells. | Yulin Peng Yibo Chang Chengpeng Sun Weiyi Wang Chao Wang Yan Tian Baojing Zhang Sa Deng Wenyu Zhao Xiaochi Ma | 2022 | Chinese Chemical Letters2022，33，9： | 1 |
| 7 | Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer显示文摘 | Tingyan Liu Meixia Zhang Hongliang Zhang Chunyan Sun Xiaolin Yang Yihui Deng Wenyue Ji | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 8 | Marxism and the Future of Western Aesthetics——The Third Sino-British Bilateral Forum on Marxist Aesthetics显示文摘An event themed the Third Sino-British Bilateral Forum on Marxist Aesthetics,jointly organized by School of Humanities in Shanghai Jiao Tong University and the School of Arts,Language and Cultures,University of Manchester,was held at Shanghai Jiao Tong University from April 6th to 8th,2013.Attracting more than 17 foreign universities and about 80 scholars from over 50 domestic universities,research institutes and media attended the meeting. | Zhang Yunyan Deng Wenyu | 2013 | 外国文学研究2013，35，5： | 1 |
| 9 | Moving Multiple Curves/Surfaces Approximation of Mixed Point Clouds显示文摘We propose a local model called moving multiple curves/surfaces approximation to separate mixed scanning points received from a thin-wall object,where data from two sides of the object may be mixed due to measurement error.The cases of two curves(including plane curves and space curves)and two surfaces in one model are mainly elaborated,and a lot of examples are tested. | Wenyue Feng Zhouwang Yang Jiansong Deng | 2014 | Communications in Mathematics and Statistics2014，2，1： | 0 |
| 10 | A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field- effect transistors显示文摘5-hydroxymethylcytosine (5-hmC ) 是 cytosine 的重要 epigenetic 衍生物, 5-hmC 的量的察觉能为许多人的疾病被用作可靠 biomarker。在 5-hmC 察觉使用的当前的技术是复杂的并且时间 / 费用低效。在这个工作,我们从老鼠纸巾在 5-hmC 的量的察觉报导 antibody-functionalized 碳 nanotube 地效果晶体管(CNT 联邦货物税) 的第一应用。这个方法基于电的表演设备完成灵巧、极端敏感的 5-hmC 察觉并且避免为 DNA 样品的复杂处理。分别地,在 genomic DNA 介绍的正常老鼠大脑,小脑,怒气,肺,肝,和心样品的 5-hmC 内容百分比作为 0.653, 0.573, 0.002, 0.020, 0.076,和 0.009 被测量它与以前的报告一致。这种技术能被开发进监视设备的灵巧的平淡的 5-hmC 因为诊所人疾病诊断。 | Fang Yuan Yanyan Deng Wenyu Zhou Min Zhang Zigang Li | 2016 | Nano Research2016，9，6： | 0 |
| 11 | Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase显示文摘The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123(1),veramycin A(2),NFAT-133(3)and benwamycin I(4),which were discovered from Streptomyces species and demonstrated with antidiabetic and immunosuppressant activities.Though the biosynthetic pathway of 1-3 was reported as a type I polyketide synthase(PKS),the PKS assembly line was interpreted inconsistently,and it remains a mystery how the compound 3 was generated.Herein,the PKS assembly logic of 1-4 was revised by site-mutagenetic analysis of the PKS dehydratase domains.Based on gene deletion and complementation,the putative P450 monooxygenase nftE1 and metallo-beta-lactamase(MBL)fold hydrolase nftF1 were verified as essential genes for the biosynthesis of 1-4.The absence of nftE1 led to abolishment of 1-4 and accumulation of new products(5-8).Structural elucidation reveals 5-8 as the non-aromatic analogs of 1,suggesting the NftE1-catalyzed aromatic core formation.Deletion of nftF1 resulted in disappearance of 3 and 4 with the compounds 1 and 2 unaffected.As a rare MBL-fold hydrolase from type I PKSs,NftF1 potentially generates the compound 3 through two strategies:catalyze premature chain-offloading as a trans-acting thioesterase or hydrolyze the lactone-bond of compound 1 as an esterase. | Ming Yang Wanlu Li Lin Zhou Xiao Lin Wenyu Zhang Yaoyao Shen Hai Deng Hou-wen Lin Yongjun Zhou | 2023 | Synthetic and Systems Biotechnology2023，8，3： | 0 |
| 12 | Strategies for Video Producers to Tell Their Good Stories Under the 5W Model of Communication显示文摘In recent years,with the rise of video media such as YouTube and Tik Tok,the short video creation industry has emerged.How to spread China's excellent culture and how to“tell a good Chinese story”have become a hot concern.Using the 5W Model of Communication as a framework for analysis,this paper selects Chinese short videos with high popularity on YouTube as the object of the study.Studies found that the success of these videos was associated with five factors in the process of communication,which are communication main forces,communication content,communication channels,communication audience,and audience effects.Through theoretical and data analysis,the study concluded five strategies in video production to help promote Intercultural communication. | Wenqian Hong Yixuan Jiang Rui Wen Wenyu Chen Nan Lou Jinxuan Deng Jiayun Li Hanfei Li Dan Ye | 2024 | 教育技术与创新2024，6，1： | 0 |
| 13 | How to Comprehensively Utilize the Discarded Fresh Tobacco Leaf ?显示文摘This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of biogas production facility in some villages of local tobacco area,this paper selects Longwan Village of Fengshiyan Town as the experimental site and explores the rational way of discarded fresh tobacco leaf biogas fermentation. Results show that cutting and fermentation of discarded fresh tobacco leaf before adding into biogas digester is conductive to improving p H in fermentation process,reducing crust amount,and effectively improving biogas production amount and rate. The study can provide reference for effective processing and rational utilization of discarded fresh tobacco leaf. | Xiqing LIU Weiping FENG Zhifu XU Dongyang HU Zairan DENG Wenyu LI | 2015 | Asian Agricultural Research2015，7，12： | 0 |
| 14 | Constrained geometry analysis to resolve 3-D deformations from three ground-based radars显示文摘When multiple ground-based radars(GB-rads)are utilized together to resolve three-dimensional(3-D)deformations,the resolving accuracy is related with the measurement geometry constructed by these radars.This paper focuses on constrained geometry analysis to resolve 3-D deformations from three GB-rads.The geometric dilution of precision(GDOP)is utilized to evaluate 3-D deformation accuracy of a single target,and its theoretical equation is derived by building a simplified 3-D coordinate system.Then for a 3-D scene,its optimal accuracy problem is converted into determining the minimum value of an objective function with a boundary constraint.The genetic algorithm is utilized to solve this constrained optimization problem.Numerical simulations are made to validate the correctness of the theoretical analysis results. | DENG Yunkai ZHU Jiaxin TIAN Weiming HU Cheng YANG Wenyu | 2021 | Journal of Systems Engineering and Electronics2021，32，6： | 0 |
| 15 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 16 | Attenuated plasmodium sporozoite expressing MAGE-A3 induces antigen-specific CD8+ T cell response against lung cancer in mice显示文摘Objective: Cancer vaccines that rely on tumor antigen-specific CD8^+ T cell responses, are promising anti-cancer adjuvant immunotherapies. This study investigated whether genetically attenuated Plasmodium sporozoite(GAS) could be used as a novel vector to induce antigen-specific CD8^+ T cell responses against lung cancer.Methods: We constructed GAS/MAGE-A3, a recombinant GAS engineered to express the lung cancer-specific antigen, melanomaassociated antigen 3(MAGE-A3), and assessed its therapeutic effects against lung cancer.Results: Robust parasite-specific CD8αlow CD11ahigh and CD49dhigh CD11ahigh CD4^+ T cell responses as well as a MAGE-A3-specific CD8^+ T cell response were induced in GAS/MAGE-A3-immunized mice. Adoptive transfer of GAS/MAGE-A3-induced CD8^+ T cells from HLA-A2 transgenic mice into lung cancer-bearing nude mice inhibited tumor growth and prolonged survival.Conclusions: These findings demonstrate that GAS/MAGE-A3 induces a strong MAGE-A3-specific CD8^+ T cell response against lung cancer in vivo, and indicate that GAS is a novel and efficacious antigen delivery vector for antitumor immunotherapy. | Dong Zhou Hong Zheng Quanxing Liu Xiao Lu Xufeng Deng Li Jiang Bing Hou Yong Fu Feng Zhu Yan Ding Wenyue Xu Jigang Dai | 2019 | Cancer Biology & Medicine2019，16，2： | 0 |
| 17 | Deep-ultraviolet photonics for the disinfection of SARS-CoV-2 and its variants(Delta and Omicron)in the cryogenic environment显示文摘Deep-ultraviolet(DUV)disinfection technology provides an expeditious and efficient way to suppress the transmission of coronavirus disease 2019(COVID-19).However,the influences of viral variants(Delta and Omicron)and low temperatures on the DUV virucidal efficacy are still unknown.Here,we developed a reliable and uniform planar light source comprised of 275-nm light-emitting diodes(LEDs)to investigate the effects of these two unknown factors and delineated the principle behind different disinfection performances.We found the lethal effect of DUV at the same radiation dose was reduced by the cryogenic environment,and a negative-U large-relaxation model was used to explain the difference in view of the photoelectronic nature.The chances were higher in the cryogenic environment for the capture of excited electrons within active genetic molecules back to the initial photo-ionised positions.Additionally,the variant of Omicron required a significantly higher DUV dose to achieve the same virucidal efficacy,and this was thanks to the genetic and proteinic characteristics of the Omicron.The findings in this study are important for human society using DUV disinfection in cold conditions(e.g.,the food cold chain logistics and the open air in winter),and the relevant DUV disinfection suggestion against COVID-19 is provided. | Wenyu Kang Jing Zheng Jiaxin Huang Lina Jiang Qingna Wang Zhinan Guo Jun Yin Xianming Deng Ye Wang Junyong Kang | 2023 | Opto-Electronic Advances2023，6，9： | 0 |
| 18 | On the accurate characterization of quantum-dot light-emitting diodes for display applications显示文摘Quantum dot light-emitting diodes(QLEDs)are a class of high-performance solution-processed electroluminescent(EL)devices highly attractive for next-generation display applications.Despite the encouraging advances in the mechanism investigation,material chemistry,and device engineering of QLEDs,the lack of standard protocols for the characterization of QLEDs may cause inaccurate measurements of device parameters and invalid comparison of different devices.Here,we report a comprehensive study on the characterizations of QLEDs using various methods.We show that the emission non-uniformity across the active area,nonLambertian angular distributions of EL intensity,and discrepancies in the adopted spectral luminous efficiency functions could introduce significant errors in the device efficiency.Larger errors in the operational-lifetime measurements may arise from the inaccurate determination of the initial luminance and inconsistent methods for analyzing the luminance-decay curves.Finally,we suggest a set of recommended practices and a checklist for device characterizations,aiming to help the researchers in the QLED field to achieve accurate and reliable measurements. | Wangxiao Jin Yunzhou Deng Bingbing Guo Yaxiao Lian Baodan Zhao Dawei Di Xiaowei Sun Kai Wang Shuming Chen Yixing Yang Weiran Cao Song Chen Wenyu Ji Xuyong Yang Yuan Gao Shuangpeng Wang Huaibin Shen Jialong Zhao Lei Qian Fushan Li Yizheng Jin | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 19 | Fair hierarchical clustering of substations based on Gini coefficient显示文摘For the load modeling of a large power grid,the large number of substations covered by it must be segregated into several categories and,thereafter,a load model built for each type.To address the problem of skewed clustering tree in the classical hierarchical clustering method used for categorizing substations,a fair hierarchical clustering method is proposed in this paper.First,the fairness index is defined based on the Gini coefficient.Thereafter,a hierarchical clustering method is proposed based on the fairness index.Finally,the clustering results are evaluated using the contour coefficient and the t-SNE two-dimensional plane map.The substations clustering example of a real large power grid considered in this paper illustrates that the proposed fair hierarchical clustering method can effectively address the problem of the skewed clustering tree with high accuracy. | Dajun Si Wenyue Hu Zilin Deng Yanhui Xu | 2021 | Global Energy Interconnection2021，4，6： | 0 |
| 20 | [^(18)F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models显示文摘Monoacylglycerol lipase(MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol(2-AG) into the proinflammatory eicosanoid precursor arachidonic acid(AA). MAGL and other endogenous cannabinoid(EC) degrading enzymes are involved in the fibrogenic signaling pathways that induce hepatic stellate cell(HSC) activation and ECM accumulation during chronic liver disease. Our group recently developed an;F-labeled MAGL inhibitor([18F]MAGL-4-11)for PET imaging and demonstrated highly specific binding in vitro and in vivo. In this study, we determined [18F]MAGL-4-11 PET enabled imaging MAGL levels in the bile duct ligation(BDL) and carbon tetrachloride(CCl_(4)) models of liver cirrhosis;we also assessed the hepatic gene expression of the enzymes involved with EC system including MAGL, NAPE-PLD, FAAH and DAGL that as a function of disease severity in these models;[18F]MAGL-4-11 autoradiography was performed to assess tracer binding in frozen liver sections both in animal and human. [18F]MAGL-4-11 demonstrated reduced PET signals in early stages of fibrosis and further significantly decreased with disease progression compared with control mice. We confirmed MAGL and FAAH expression decreases with fibrosisseverity, while its levels in normal liver tissue are high;in contrast, the EC synthetic enzymes NAPE-PLD and DAGL are enhanced in these different fibrosis models. In vitro autoradiography further supported that[18F]MAGL-4-11 bound specifically to MAGL in both animal and human fibrotic liver tissues. Our PET ligand [18F]MAGL-4-11 shows excellent sensitivity and specificity for MAGL visualization in vivo and accurately reflects the histological stages of liver fibrosis in preclinical models and human liver tissues. | Tuo Shao Zhen Chen Jian Rong Vasily Belov Jiahui Chen Andre Jeyarajan Xiaoyun Deng Hualong Fu Qingzhen Yu Steve H.Rwema Wenyu Lin Mikhail Papisov Lee Josephson Raymond T.Chung Steven H.Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 0 |
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