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| 1 | The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome显示文摘MicroRNAs(miRNAs)are a novel class of small,non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases.Immune cells,especially T helper(Th)cells,are critical in the development of atherosclerosis and the onset of acute coronary syndrome(ACS).To assess whether inflammation-related miRNAs(such as miR-155,146a,21,125a-5p,125b,31)are involved in the imbalance of Th cell subsets in patients with ACS,we measured the expression of related miRNAs in patients with acute myocardial infarction(AMI),unstable angina(UA),stable angina(SA)and chest pain syndrome(CPS);analyzed the relationship between miRNA expression and the frequency of Th cell subsets;and observed the co-expression of miR-155 and IL-17A in peripheral blood mononuclear cells(PBMCs)of patients with ACS.The results showed that the expression of miR-155 in the PBMCs of patients with ACS was decreased by approximately 60%,while the expression of both miR-21 and miR-146a was increased by approximately twofold.The expression patterns of miRNAs in plasma correlated with those in PBMCs,except for miR-21,which was increased by approximately sixfold in the AMI group and showed no significant difference between the UA group and the CPS group.We also found that the expression of miR-155 inversely correlated with the frequency of Th17 cells(r520.896,P,0.01)and that miR-155 was co-expressed with IL-17A in patients with ACS.In conclusion,our study revealed the expression patterns of inflammation-related miRNAs in patients with ACS and found that miR-155 may be associated with Th17 cell differentiation. | Rui Yao Yulan Ma Youyou Du Mengyang Liao Huanhuan Li Wei Liang Jing Yuan Zhijun Ma Xian Yu Hong Xiao Yuhua Liao | 2011 | Cellular & Molecular Immunology2011，8，6： | 32 |
| 2 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 3 | Bone morphogenetic protein 2 promotes transforming growth factor β3-induced chondrogenesis of human osteoarthritic synovium-derived stem cells显示文摘有更高的 chondrogenic 潜力的背景导出 Synovium 的干细胞(SDSC ) 为软骨新生作为房间来源正在吸引可观的注意。我们调查了骨头的效果形态基因的蛋白质(BMP-2 ) 2 在转变生长因素 beta3 (TGF-3 ) 以后导致了在一个小团文化系统从人的 osteoarthritic synovium 孤立的 SDSC 的 chondrogenesis。clonogenicity,干细胞标记表示和孤立的 SDSC 的多区别潜力被殖民地形成统一试金,流动 cytometry 并且包括分别地染色的茜素红 S,油红 O 和 alcian 蓝色的特定的染色决定的方法。SDSC 小团在与或没有 TGF-3 或 / 并且 BMP-2 中等的 chondrogenic 是有教养的。在白天 21 点,直径和小团的重量被测量。SDSC 的 Chondrogenic 区别被藏红染料 O 染色,骨胶原类型染色的 immunohistochemical, sulfated glycosaminoglycan (sGAG ) 合成和骨胶原类型, aggrecan, SOX9,连接蛋白质,骨胶原类型 X 和 BMP 受体的 mRNA 表示评估。在优化 culturing 密度(104/60 cm2 ) 下面孤立的结果房间显示出 clonogenicity 和多区别潜力。这些房间是积极的(99 ) 为 CD44, CD90, CD105 并且否定(10 ) 为 CD34 和 CD71。在包含 TGF-3 与或没有 BMP-2 的 chondrogenic 媒介区分到 chondrocytic 显型的 SDSC。细胞外的矩阵染色的藏红染料 O 是积极的,骨胶原类型的表示被检测。房间小团独自与 TGF-3 对待, BMP-2 在直径和重量是更大的,生产了更多的 sGAGs,并且表示了骨胶原类型和另外的 chondrogenic 标记的高水平,比有 TGF-3 的媒介,除了 COL10A1。结论 SDSC 能从人的 osteoarthritic synovium 被孤立。有 BMP-2 的补充显著地支持了在里面 SDSC 的 vitro TGF-3-induced chondrogenic 区别。 | RUI Yun-feng DU Lin WANG You WANG Yang LUI Pauline po-yee TANG Ting-ting CHAN Kai-ming DAI Ke-rong | 2010 | Chinese Medical Journal2010，，21： | 19 |
| 4 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 5 | Early changes of procalcitonin predict bacteremia in patients with intensive care unit-acquired new fever显示文摘 | SHI Yan DU Bin XU Ying-chun RUI Xi DU Wei WANG Yao | 2013 | Chinese Medical Journal2013，，10： | 18 |
| 6 | Two surgical procedures for esophagogastric variceal bleeding in patients with portal hypertension显示文摘AIM:To determine the clinical value of a splenorenal shunt plus pericardial devascularization(PCVD)in portal hypertension(PHT)patients with variceal bleeding.METHODS:From January 2008 to November 2012,290 patients with cirrhotic portal hypertension were treated surgically in our department for the prevention of gastroesophageal variceal bleeding:207 patients received a routine PCVD procedure(PCVD group),and83 patients received a PCVD plus a splenorenal shunt procedure(combined group).Changes in hemodynamic parameters,rebleeding,encephalopathy,portal vein thrombosis,and mortality were analyzed.RESULTS:The free portal pressure decreased to 21.43±4.35 mmHg in the combined group compared with24.61±5.42 mmHg in the PCVD group(P<0.05).The changes in hemodynamic parameters were more significant in the combined group(P<0.05).The long-term rebleeding rate was 7.22%in the combined group,which was lower than that in the PCVD group(14.93%),(P<0.05).CONCLUSION:Devascularization plus splenorenal shunt is an effective and safe strategy to control esophagogastric variceal bleeding in PHT.It should be recommended as a first-line treatment for preventing bleeding in PHT patients when surgical interventions are considered. | Lin Yang Li-Juan Yuan Rui Dong Ji-Kai Yin Qing Wang Tao Li Jiang-Bin Li Xi-Lin Du Jian-Guo Lu | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 7 | Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats显示文摘AIM:To investigate whether electroacupuncture ST36 activates enteric glial cells,and alleviates gut inflammation and barrier dysfunction following hemorrhagic shock.METHODS:Sprague-Dawley rats were subjected to approximately 45% total blood loss and randomly divided into seven groups:(1) sham:cannulation,but no hemorrhage;(2) subjected to hemorrhagic shock(HS);(3) electroacupuncture(EA) ST36 after hemorrhage;(4) vagotomy(VGX)/EA:VGX before hemorrhage,then EA ST36;(5) VGX:VGX before hemorrhage;(6) a-bungarotoxin(BGT)/EA:intraperitoneal injection of a-BGT before hemorrhage,then EA ST36; and(7) a-BGT group:a-BGT injection before hemorrhage.Morphological changes in enteric glial cells(EGCs) were observed by immunofluorescence,and glial fibrillary acidic protein(GFAP; a protein marker of enteric glial activation) was evaluated using reverse transcriptase polymerase chain reaction and western blot analysis.Intestinal cytokine levels,gut permeability to 4-k Da fluorescein isothiocyanate(FITC)-dextran,and the expression and distribution of tight junction protein zona occludens(ZO)-1 were also determined.RESULTS:EGCs were distorted following hemorrhage and showed morphological abnormalities.EA ST36 attenuated the morphological changes in EGCs at 6 h,as compared with the VGX,a-BGT and HS groups.EA ST36 increased GFAP expression to a greater degree than in the other groups.EA ST36 decreased intestinal permeability to FITC-dextran(760.5 ± 96.43 ng/m L vs 2466.7 ± 131.60 ng/m L,P < 0.05) and preserved ZO-1 protein expression and localization at 6 h afterhemorrhage compared with the HS group.However,abdominal VGX and a-BGT treatment weakened or eliminated the effects of EA ST36.EA ST36 reduced tumor necrosis factor-a levels in intestinal homogenates after blood loss,while vagotomy or intraperitoneal injection of a-BGT before EA ST36 abolished its antiinflammatory effects.CONCLUSION:EA ST36 attenuates hemorrhageinduced intestinal inflammatory insult,and protects the intestinal barrier integrity,partly via activation of EGCs. | Sen Hu Zeng-Kai Zhao Rui Liu Hai-Bin Wang Chun-Yu Gu Hong-Min Luo Huan Wang Ming-Hua Du Yi Lv Xian Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 15 |
| 8 | The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy显示文摘在母亲 / 胎儿的接口的 Th2 偏爱的规章的机制仍然保持不清楚。在这研究,我们在蜕膜的 stromal 描绘了 cytokine 生产房间(DSC ) ,蜕膜的有免疫力的房间(DIC ) 和导出胚胎的 trophoblast 房间,并且在早人的怀孕在母亲 / 胎儿的接口在 Th2 偏爱上调查了 CXCL12/CXCR4 相互作用的规定。我们由 trophoblasts, DSC 和 DIC 发现了 Th1 类型和 Th2 类型 cytokines 的微分生产。这些 cytokines 的分泌物在不同房间 cocultures 变化了,导致了到 Th2 偏爱。流动 cytometry 与 DSC 显示出 trophoblasts 的那 coculture, DIC 显著地在 DSC 在 trophoblasts,和 IL-10 生产增加了 IL-4 和 IL-10 生产。然而,有 DSC 和 DIC 的 trophoblasts 的 coculture 显著地增加了干扰素(IFN )-γ在 DSC,和肿瘤坏死因素(TNF )-α 的表示;在 DIC 的表示。没有变化在所有 cocultures 在 DIC 在 trophoblasts,并且在 Th2 类型 cytokine 生产在 Th1 类型 cytokine 生产被看见。而且,有抵销抗体 upregulated 的 anti-CXCR4 的预告的处理 Th1 类型 cytokines IFN-γ 的生产;并且 TNF-α,并且 downregulated Th2 类型 cytokines IL-4 和 IL-10 的生产在 trophoblasts, DSC, DIC 或他们的 cocultures。有趣地, rhCXCL12 禁止了 Th1 类型 cytokine TNF-α 的生产;并且在 DIC 提高了象 IL-4 和 IL-10 那样的 Th2 类型 cytokines 的表示;这效果被 anti-CXCR4 抗体废除。我们的现在的学习阐明了到塑造 Th2 的部件房间的单个贡献偏导,并且揭开经由在在早人的怀孕的母亲 / 胎儿的接口的 CXCL12/CXCR4 信号的复杂串音。 | Hai-Lan Piao Yu Tao Rui Zhu Song-Cun Wang Chuan-Ling Tang Qiang Fu Mei-Rong Du Da-Jin Li | 2012 | Cellular & Molecular Immunology2012，9，5： | 14 |
| 9 | Role of gut microbiota via the gut-liver-brain axis in digestive diseases显示文摘The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis. | Jian-Hong Ding Zhe Jin Xiao-Xu Yang Jun Lou Wei-Xi Shan Yan-Xia Hu Qian Du Qiu-Shi Liao Rui Xie Jing-Yu Xu | 2020 | World Journal of Gastroenterology2020，26，40： | 13 |
| 10 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 11 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 12 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 13 | Antiviral treatment of hepatitis B virus-transgenic mice by a marine organism, Styela plicata显示文摘瞄准:在肝炎 B 搬运人的一个鼠科的模型评估 Styela plicata 的有效成分的抗病毒的效果。方法:HBV 转基因的老鼠被划分成 3 个组(控制组, lamivudine 处理组和 Styela plicata 处理组的有效成分) 并且分配了收到正常饮食, lamivudine 或 Styela plicata 的有效成分连续星期。浆液肝炎 B 表面抗原被连接酶的免疫检测吸着剂试金(ELISA ) 方法。浆液 HBV DNA 被即时聚合酶链反应(RT-PCR ) 检测。浆液 T 助手(h) 1 cytokine interleukin (IL )-2 和 Th2 cytokine IL-6 被量的三明治酶免疫分析技术检测。另一组 HBV 转基因的老鼠被分配收到 Styela plicata 的有效成分连续星期。肝组织的组织学在治疗前后被评估。结果:12 个星期在开始治疗以后,浆液肝炎 B 表面抗原显著地在 Styela plicata 被降低与收到正常饮食的老鼠相比对待老鼠和对待 lamivudine 的老鼠(F (12wk )= 88.81, P (12wk )= 0.000 <0.01 ) 。浆液 HBV DNA 显著地在 Styela plicata 被降低与收到正常饮食的老鼠相比对待老鼠和对待 lamivudine 的老鼠(F (12wk )= 20.71, P (12wk )= 0.000 <0.01 ) 。然而, Styela plicata 的有效成分象 lamivudine 一样,不能完全禁止 HBV 的复制。在重量的单位的肝炎 B 表面抗原和 HBV DNA 的回缩现象一 could 在药的退却以后被发现 4 wk。八个星期在开始治疗以后,在 IL-2 的 Styela plicata 处理前后的浆液层次是 2.41 +/- 0.38 和 10.56 +/- 0.78 ng/L,分别地(t (8wk )=-16.51, P (8wk )= 0.000 <0.01 ) 。与在正常对待食谱的老鼠的 IL-2 的浆液层次相比(2.48+/-0.17 ng/L;t (8wk )= 13.23, P (8wk )= 0.000 <0.01 ) 。在 IL-6 的 Styela plicata 处理前后的浆液层次是 63.62 +/- 分别地, 6.22 ng/L 在正常对待食谱的老鼠 IL-6 与浆液相比铺平的 6.31 和 54.52 +/-(60.84 +/- 4.21 ng/L ) 。从 Styela 对待 plicata 的 HBV 转基因的老鼠的肝的组织学的分析也在发炎和肝炎 B 表面抗原显示出下降地位。结论:Styela plicata 可以是在对待长期的肝炎 B 的有效的抗病毒的药。 | Rui Wang Zhen-Lan Du Wen-Jun Duan Xin Zhang Fan-Lin Zeng Xin-Xiang Wan | 2006 | World Journal of Gastroenterology2006，12，25： | 12 |
| 14 | Prognostic value of plasma Epstein-Barr virus DNA level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy显示文摘Background: The value of Epstein-Barr virus(EBV) DNA assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma(NPC) presenting with different pretreatment plasma EBV DNA levels remains unclear. In the present study, we aimed to evaluate the prognostic value of plasma EBV DNA assay during posttreatment followup in the patients with NPC who have undergone intensity-modulated radiotherapy.Methods: The medical records of 385 NPC patients treated with intensity-modulated radiotherapy between November 2009 and February 2012 were reviewed. All patients underwent plasma EBV DNA assays before treatment, within3 months after treatment, and then every 3-12 months during posttreatment follow-up period. The recurrence rates for patients with different pretreatment and posttreatment follow-up plasma EBV DNA levels were analyzed.Results: Of the 385 patients, 267(69.4%) had detectable pretreatment plasma EBV DNA(> 0 copy/mL) and 93(24.2%) had detectable posttreatment EBV DNA during a median follow-up of 52.8 months(range 9.3-73.8 months).Detectable EBV DNA during posttreatment follow-up was found in 14.4%(17/118) and 28.5%(76/267) of patients with undetectable and detectable pretreatment EBV DNA, respectively, and was significantly associated with tumor recurrence in both patient groups. EBV DNA was detectable in 12.8%(40/313) of patients who remained disease-free,56.4%(22/39) of patients with locoregional recurrence alone, and 93.9%(31/33) of patients with distant metastasis as the first recurrence event(P < 0.001); 6.5%(19/292) of patients with undetectable EBV DNA and 57.0%(53/93) of patient with detectable EBV DNA during posttreatment follow-up experienced tumor recurrence. Compared with other cut-off values, the cut-off value of 0 copy/mL for EBV DNA during posttreatment follow-up had the highest area under the ROC curve(AUC) value(0.804,95% confidence interval 0.741-0.868) for predicting tumor recurrence(sensitivity, specificity, and accuracy: 73.6%, 87.2%, and 84.7%, respectively).Conclusion: Plasma EBV DNA level during posttreatment follow-up is a good marker for predicting distant metastasis but not locoregional recurrence in the patients with NPC irrespective of the pretreatment EBV DNA levels. | Wen-Fei Li Yuan Zhang Xiao-Bin Huang Xiao-Jing Du Ling-Long Tang Lei Chen Hao Peng Rui Guo Ying Sun Jun Ma | 2017 | Chinese Journal of Cancer2017，36，11： | 12 |
| 15 | Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats显示文摘人的良性的 prostatic 增生可能从雌激素 / 雄激素(E/T ) 产生,这被知道不平衡。我们学习了阉割的老鼠前列腺的反应到传播 E/T 的不同比率。阉割的男 Wistar 老鼠随机在不同比率与 E/T 被注射 4 个星期。染色的 prostatic 索引, hematoxylin 和曙红给不同 prostatic 增生回答看的 E/T (1:100 ) 组的前列腺,和光滑的肌肉肌动朊(SMA ) 的量的 immunohistochemical 分析。在这个组,为 Vimentin 积极的房间,非肌肉肌浆球蛋白重链(NMMHC ) 和原子抗原(PCNA ) 在基质和上皮增加了的增殖的房间。而且, mRNA 光滑的肌肉肌浆球蛋白铺平重链(SMMHC ) 和增加的 NMMHC。在 1:100 的比率的 E/T 能因此导致 stromal 在阉割的老鼠的前列腺的增生的反应。观察的主要变化是光滑的肌肉房间的增加,而一些上皮的变化也在老鼠前列腺被看见。 | Ying Zhou Xiang-Qian Xiao Lin-Feng Chen Rui Yang Jian-Dang Shi Xiao-Ling Du Helmut Klocker Irwin Park Chung Lee Ju Zhang | 2009 | Asian Journal of Andrology2009，11，4： | 10 |
| 16 | The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years显示文摘Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin(OCN) in predicting diabetes was reported, but with conflicting results. No study has explored the association between baseline bone resorption activity and incident diabetes or prediabetes during follow-up. Our objective was to examine the relationship between the baseline bone resorption marker crosslinked C-telopeptide of type I collagen(CTX) and glycemic dysregulation after 4 years. This longitudinal study was conducted in a university teaching hospital. A total of 195 normal glucose tolerant(NGT) women at baseline were invited for follow-up. The incidence of diabetes and prediabetes(collectively defined as dysglycemia) was recorded. A total of 128 individuals completed the 4-year study. The overall conversion rate from NGT to dysglycemia was 31.3%. The incidence of dysglycemia was lowest in the middle tertile [16.3%(95% confidence interval(CI), 6.8%–30.7%)] compared with the lower [31.0%(95%CI, 17.2%–46.1%)] and upper [46.5%(95% CI, 31.2%–62.6%)] tertiles of CTX, with a significant difference seen between the middle and upper tertiles(P = 0.002 5). After adjusting for multiple confounding variables, the upper tertile of baseline CTX was associated with an increased risk of incident dysglycemia, with an odds ratio of 7.09(95% CI, 1.73–28.99) when the middle tertile was the reference. Osteoclasts actively regulate glucose homeostasis in a biphasic model that moderately enhanced bone resorption marker CTX at baseline provides protective effects against the deterioration of glucose metabolism, whereas an overactive osteoclastic function contributes to an increased risk of subsequent dysglycemia. | Ting-ting Liu Dong-mei Liu Yan Xuan Lin Zhao Li-hao Sun Dian-dian Zhao Xiao-feng Wang Yang He Xing-Zhi Guo Rui Du Ji-qiu Wang Jian-min Liu Hong-yan Zhao Bei Tao | 2017 | Bone Research2017，5，3： | 10 |
| 17 | Association of miRNA-122-binding site polymorphism at the interleukin-1 a gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk显示文摘 | Yan Du Xue Han Rui Pu Jiaxin Xie Yuwei Zhang Guangwen Cao | 2014 | Frontiers of Medicine2014，8，2： | 9 |
| 18 | Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine显示文摘Dear Editor,COVID-19 vaccination campaigns are being conducted in countries worldwide,and 47.4% of the world population has received at least one dose of a COVID-19 vaccine.1 Although vaccination has shaped COVID-19 epidemic curves,waning antibody levels and relatively short-duration protection provided by current COVID-19 vaccines have been observed,especially against SARS-CoV-2 variants of concern(VOCs)and among older individuals. | Yunlong Cao Xiaohua Hao Xi Wang Qianhui Wu Rui Song Dong Zhao Weiliang Song Yao Wang Ayijiang Yisimayi Wei Wang Juan Du Hongjie Yu Xiaoliang Sunney Xie Ronghua Jin | 2022 | Cell Research2022，32，1： | 8 |
| 19 | Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity显示文摘Antimicrobial peptides(AMPs)are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics [1].Importantly,AMPs kill pathogens via a different mechanism compared to antibiotics [2].Therefore, | GAO Yu ZHAO Hong Lei FENG Xin ZHAI Rui Dong ZHU Seng DU Chong Tao SUN Chang Jiang LEI Lian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，4： | 7 |
| 20 | Global Analysis of Gene Expression Profiles in Brassica napus Developing Seeds Reveals a Conserved Lipid Metabolism Regulation with Arabidopsis thaliana显示文摘以便学习 Brassica 马来麝丰满的酸(FA ) 新陈代谢和相关规章的网络,丰满的酸(FA ) 的系统的鉴定生合成相关的基因被进行。后面的基因鉴定,基因表示侧面在 B 期间。马来麝种子开发和 FA 新陈代谢被 cDNA 薄片杂交执行(> 从种子的 8000 EST 克隆) 。结果显示出那 FA 生合成和规定,和碳流动,在 B 之间被保存。马来麝和 Arabidopsis。然而,淀粉新陈代谢的一个更关键的角色为 B 被检测。马来麝种子 FA 新陈代谢和存储部件累积什么时候与 Arabidopsis 相比。另外,为 seed-to-sink 织物的转变的一个关键阶段是 1721 ? 在 flowering (DAF ) 以后的 d,而 FA 生合成相关的基因高度首先在 21 点被表示 ? DAF。发信号的荷尔蒙(植物生长素和 jasmonate ) 被发现为 FA 新陈代谢重要。这研究帮助在开发 B 揭示 FA 新陈代谢的全球规章的网络。马来麝种子。 | Ya Niu Guo-Zhang Wu Rui Ye Wen-Hui Lin Qiu-Ming Shi Liang-Jiao Xue Xiao-Dong Xu Yao Li Yu-Guang Du Hong-Wei Xue | 2009 | Molecular Plant2009，2，5： | 7 |
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