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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Mechanical and dielectric properties of porous and wave-transparent Si3N4–Si3N4 composite ceramics fabricated by 3D printing combined with chemical vapor infiltration显示文摘Porous Si3N4–Si3N4 composite ceramics were fabricated by 3D printing combined with low-pressure chemical vapor infiltration(CVI).This technique could effectively improve the designability of porous Si3N4 ceramics and optimize the mechanical and dielectric properties.The effects of process parameters including the deposition time and heat treatment on the microstructure and properties of porous Si3N4–Si3N4 composite ceramics were studied.The study highlights following:When CVI processing time was increased from 0 to 12 h,the porosity decreased from68.65%to 26.07%and the density increased from 0.99 to 2.02 g/cm3.At the same time,the dielectric constant gradually increased from 1.72 to 3.60;however,the dielectric loss always remained less than0.01,indicating the excellent electromagnetic(EM)wave-transparent performance of porous Si3N4–Si3N4 composite ceramics.The maximum flexural strength of 47±2 MPa was achieved when the deposition time attained 6 h.After heat treatment,the porosity increased from 26.07%to 36.02%and the dielectric constant got a slight increase from 3.60 to 3.70 with the dielectric loss still maintaining lower than 0.01.It has been demonstrated that the porous Si3N4–Si3N4 composite ceramics are a promising structural and EM wave-transparent material suitable for high temperature service. | Zanlin CHENG Fang YE Yongsheng LIU Tianlu QIAO Jianping LI Hailong QIN Laifei CHENG Litong ZHANG | 2019 | Journal of Advanced Ceramics2019，8，3： | 10 |
| 3 | Controllable synthesis of mesoporous carbon hollow microsphere twined by CNT for enhanced microwave absorption performance显示文摘The low dielectric loss of mesoporous carbon hollow microsphere(PCHM)requires high filler loading(higher than 20 wt%)when it is used as microwave absorbers.In order to decrease the filler loading of PCHM,a new strategy for synergistic increase of polarization and conductive loss was developed by twining PCHM with carbon nanotube(CNT)according to theoretic calculation.By the optimization of CNT content,the minimum reflection coefficient was -34.6 dB with a filler loading of only 10 wt%,which was much lower than -2.1 dB of PCHM.In addition,the effective absorption bandwidth was 3.6 GHz at X band with a thickness of 2.8 mm.The enhanced microwave absorption performance can be ascribed to the unique combination of hollow PCHM and one-dimensional CNT with higher graphitization degree,leading to increase of conductivity and heterogeneous interfaces.As a result,the conductive loss increased from 0.12 to 2.27 and polarization loss increased from 0.15 to 0.67,achieving the balance between attenuation ability and impedance match. | Minghang Li Xiaomeng Fan Hailong Xu Fang Ye Jimei Xue Xiaoqiang Li Laifei Cheng | 2020 | Journal of Materials Science & Technology2020，59，24： | 4 |
| 4 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 5 | Oil Shale Resources and Its Distribution in China显示文摘油页岩是有高灰内容,油收益比 3.5% 高的一种稳固的易燃的器官的矿物质,热产量比 4187J/g 等于或高。它也在有机物的高内容展示,主要象 sapropel 腐殖一样 sapropel 和腐殖的物质创作了。页岩油能在低温度通过干燥蒸馏被获得。作为一种重要精力和非常规的油和煤气的资源,油页岩尽最大努力起一个重要作用燃料和热电。 | Liu Zhaojun Dong Qingshui Zhu Jianwei Guo Wei Ye Songqing Liu Rong Zhang Hailong | 2007 | China Oil & Gas2007，14，3： | 2 |
| 6 | Model of chloride penetration into cracked concrete subject to drying-wetting cycles 显示文摘 | YE Hailong JIN Nanguo JIN Xianyu | 2012 | Construction and Building Materials2012，36，： | 1 |
| 7 | Model of chloride penetration into cracked concrete subject to drying–wetting cycles显示文摘 | Hailong Ye Nanguo Jin Xianyu Jin Chuanqing Fu | 2012 | Construction and Building Materials2012，，： | 1 |
| 8 | Tensile fracture behavior and strength distribution of SiC f /SiC composites with different SiBN interface thicknesses显示文摘 | Yongsheng Liu Nan Chai Hailong Qin Zan Li Fang Ye Laifei Cheng | 2014 | Ceramics International2014，，： | 1 |
| 9 | Model of Chloride Penetration into Cracked Concrete Subject to Drying-Wetting Cycles显示文摘 | Ye Hailong Nanguo Jin Xianyu Jin | 2012 | Construction and Building Materials2012，36，： | 1 |
| 10 | Model of chloride pen- etration into cracked concrete subject to drying wetting cyeles 显示文摘 | Ye Hailong Jin Nanguo Jin Xianyu | 2012 | Construction and Building Material: Construction and Building Ma terials2012，，36： | 1 |
| 11 | Influence of cracking on chloride diffusivity and moisture influential depth in concrete sub- jected to simulated environmental conditions 显示文摘 | Ye Hailong Ye Tian Jin Nanguo et aI | 2013 | Construction and Building Materials2013，，47： | 1 |
| 12 | Theoretical and experimental investigation of loading effects on chloride diffusion insaturated concrete显示文摘 | FU Chuanqing JIN Xianyu YE Hailong | 2015 | J Adv Concr Technol2015，13，： | 1 |
| 13 | Influence of cracking on chloride diffusivity and moisture influential depth in concrete subjected to simulated environmental conditions显示文摘 | Hailong Ye Ye Tian Nanguo Jin Xianyu Jin Chuanqing Fu | 2013 | Construction and Building Materials2013，，： | 1 |
| 14 | Model of chloride penetration into cracked concrete subject to drying–wetting cycles显示文摘 | Hailong Ye Nanguo Jin Xianyu Jin Chuanqing Fu | 2012 | Construction and Building Materials2012，，： | 1 |
| 15 | A mesoporous silica nanoparticulate/ β -TCP/BG composite drug delivery system for osteoarticular tuberculosis therapy显示文摘 | Min Zhu Huixue Wang Jiyong Liu Hailong He Xuguo Hua Qianjun He Lingxia Zhang Xiaojian Ye Jianlin Shi | 2010 | Biomaterials2010，，7： | 1 |
| 16 | Pterostilbene antagonizes homocysteine-induced oxidative stress,apoptosis and lipid deposition in vascular endothelial cells显示文摘Hyperhomocysteinemia(HHcy)causes oxidative stress, induces apoptosis, and leads to damage to the vascular endothelium is the starting point of atherosclerosis. Pterostilbene(Pte)has been reported to have antioxidant and anti-apoptotic effects under various pathological conditions. The purpose of this study was to explore whether Pte can inhibit the oxidative stress and apoptosis of vascular endothelium induced by homocysteine(Hcy)and to explain the possible mechanism by which it occurs. The results showed that 20 μmol/L Pte significantly reduced the accumulation of reactive oxygen species, malondialdehyde, and lipids in cells induced by Hcy and promoted the activities of superoxide dismutase and catalase. The Hoechst 33342/PI staining assay showed that Pte antagonized Hcy-induced apoptosis. Pte inhibited Hcy-induced Akt dephosphorylation, increased p53, and decreased the Bcl-2/Bax ratio and caspase-9/caspase-3 activation in a dose-dependent manner. LY294002 pretreatment partially reversed the protective effect of Pte by blocking the PI3K/Akt pathway. Moreover, Pte reduced lipid deposition in human umbilical vein endothelial cells(HUVECs). This study proposes that Pte can inhibit Hcy-induced oxidative stress and apoptosis of HUVECs, and the PI3K/Akt/p53 signaling pathway of apoptosis was revealed. These results suggest that Pte exhibits significant potential for dealing with HHcy-induced vascular endothelial injury, such as atherosclerosis. | Qiao Jiang Li Wang Xu Si Yuanyuan Bian Weijia Zhang Huijun Cui Hailong Gui Ye Zhang Bin Li Dehong Tan | 2023 | Food Science and Human Wellness2023，12，5： | 1 |
| 17 | Advances in emission control of diesel vehicles in China显示文摘Diesel vehicles have caused serious environmental problems in China.Hence,the Chinese government has launched serious actions against air pollution and imposed more stringent regulations on diesel vehicle emissions in the latest China VI standard.To fulfill this stringent legislation,two major technical routes,including the exhaust gas recirculation(EGR)and high-efficiency selective catalytic reduction(SCR)routes,have been developed for diesel engines.Moreover,complicated aftertreatment technologies have also been developed,including use of a diesel oxidation catalyst(DOC)for controlling carbon monoxide(CO)and hydrocarbon(HC)emissions,diesel particulate filter(DPF)for particle mass(PM)emission control,SCR for the control of NOx emission,and an ammonia slip catalyst(ASC)for the control of unreacted NH3.Due to the stringent requirements of the China VI standard,the aftertreatment system needs to be more deeply integrated with the engine system.In the future,aftertreatment technologies will need further upgrades to fulfill the requirements of the near-zero emission target for diesel vehicles. | Guangyan Xu Wenpo Shan Yunbo Yu Yulong Shan Xiaodong Wu Ye Wu Shaojun Zhang Liqiang He Shijin Shuai Hailong Pang Xuefeng Jiang Heng Zhang Lei Guo Shufen Wang Feng-Shou Xiao Xiangju Meng Feng Wu Dongwei Yao Yan Ding Hang Yin Hong He | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 18 | Model of chloride penetration into cracked concrete subject to drying-wetting cycles显示文摘 | Hailong Ye Nanguo Jin Xianyu Jin | 2012 | Construction and Building Material Construction and Building Materials2012，，： | 1 |
| 19 | Economic Critical Resources for the Industrial Exploitation of Natural Gas Hydrate显示文摘Since the implementation of several pilot production tests were in natural gas hydrate(NGH) reservoirs in terrestrial and marine settings, the study of NGH has entered a new stage of technological development for industrial exploitation. Prior to the industrial exploitation of any given NGH reservoir, the economic feasibility should be examined. The first step of economic evaluation of a NGH reservoir is to know whether its resource amount meets the requirement for industrial exploitation. Unfortunately, few relevant studies have been conducted in this regard. In this study, the net present value(NPV) method is employed to estimate the economic critical resources required for the industrial exploitation of NGHs under different production scenarios. Sensitivity analysis is also performed in order to specify the effects of key factors, such as the number of production wells, gas price, technological improvement and tax incentive, on the economic critical resources. The results indicate that China requires the lowest economic critical resource for a NGH reservoir to be industrially exploited, ranging from 3.62 to 24.02 billion m3 methane. Changes in gas price and tax incentives also play significant roles in affecting the threshold and timeline for the industrial exploitation of NGH. | CHEN Xuejun LU Hailong ZHANG Jiecheng YE Jianliang XIE Wenwei | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 1 |
| 20 | Hydrodearomatization Kinetics of Diesel Fraction and Catalyst Stacking Simulation显示文摘The kinetics of hydrodearomatization (HDA) is studied in an isothermal high-throughput reactor over three catalysts (CoMo, NiMo, and NiMoW) to produce clean diesel fuel according to China’s latest emission standards. The influences of reaction temperature, pressure, the ratio of H2 to oil, and space time were systematically investigated. By analyzing the reaction mechanism, a four-lump kinetic model considering the influence of competitive adsorption was proposed for the hydrodearomatization reaction, and the model parameters were optimized with good fitting. It was found that nitrogen compounds inhibited the hydrodearomatization reaction. The simulation of various catalyst stacking schemes based on the HDA kinetic model is close to the experimental data, proving the reliability of the model. The concentration of aromatic compounds of different loading sequences was predicted with the catalyst gradation model. | Wei Ye Sun Xinge LüHailong Jiang Hongbo Chen Wenbin Qin Kang Li Mingfeng Nie Hong | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，3： | 0 |
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