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| 1 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 2 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 3 | Effects of biological soil crusts on water infiltration and evaporation Yanchi Ningxia, Maowusu Desert, China显示文摘Biological soil crusts serve as a vanguard for improving the ecological environment in arid,semi-arid desertification areas.It is a good indicator of the level of improvement which the local ecological environment is undertaking.In desert areas,water condition is a key factor of improving the ecological environment.As a first layer protection,biological crusts play an important role in local vegetation succession due to their abilities to conserve and maintain moisture.Using Maowusu desert in Yanchi of Ningxia province as an example,after three years of research,this paper chooses three kinds of biological crusts including lichen,moss and cyanobacterial which are under the cover of Artemisia ordosica as research objects.The results of this study indicate that,the closer biological crusts are to Artemisia ordosica vegetation,the thicker they become.In the same position of Artemisia ordosica vegetation,the thickness of moss crusts is the highest,followed by lichen crusts,and the thickness of cyanobacterial crusts is the lowest.Biological soil crusts coverage protects the natural water content of soil layers from0 to 5 cm.Also,it effects falling water to infiltrate deeper,and cannot prevent the surface water content from evaporating effectively.The effect of biological crusts blocking water infiltration decreases with the increase of rainfall.At the same rainfall level,moss crusts provide the strongest water infiltration blockage,followed by lichen crusts and cyanobacterial crusts.With the increase of rainfall,the depth of water infiltration increases.At the same rainfall level,the relationship of water infiltration depth is as follows:cyanobacterial crusts > lichen crusts > moss crusts.With the increase of biological crusts thickness,they blocking water infiltration capacity is stronger,and the depth of water infiltration is smaller.Analysis on the characteristic of simulated rainfall process on biological crusts shows that sandy land can be fixed by applying appropriate artificial biological crusts to build a sustainable forest protection system and to create a stable ecosystem in desertification area. | Bai Li Jiarong Gao Xiuru Wang Lan Ma Qiang Cui Maik Vest | 2016 | International Journal of Sediment Research2016，31，4： | 10 |
| 4 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 5 | Preoperative albumin levels predict prolonged postoperative ileus in gastrointestinal surgery显示文摘BACKGROUND Prolonged postoperative ileus(PPOI) is a prolonged state of 'pathological'gastrointestinal(GI) tract dysmotility. There are relatively few studies examining the influence of preoperative nutritional status on the development of PPOI in patients who underwent GI surgery. The association between preoperative albumin and PPOI has not been fully studied. We hypothesized that preoperative albumin may be an independent indicator of PPOI.AIM To analyze the role of preoperative albumin in predicting PPOI and to establish a nomogram for clinical risk evaluation.METHODS Patients were drawn from a prospective hospital registry database of GI surgery.A total of 311 patients diagnosed with gastric or colorectal cancer between June 2016 and March 2017 were included. Potential predictors of PPOI were analyzed by univariate and multivariable logistic regression analyses, and a nomogram for quantifying the presence of PPOI was developed and internally validated.RESULTS The overall PPOI rate was 21.54%. Advanced tumor stage and postoperative opioid analgesic administration were associated with PPOI. Preoperative albumin was an independent predictor of PPOI, and an optimal cutoff value of 39.15 was statistically calculated. After adjusting multiple variables, per unit or per SD increase in albumin resulted in a significant decrease in the incidence of PPOI of 8%(OR = 0.92, 95%CI: 0.85-1.00, P = 0.046) or 27%(OR = 0.73, 95%CI:0.54-0.99, P = 0.046), respectively. Patients with a high level of preoperative albumin(≥ 39.15) tended to experience PPOI compared to those with low levels(< 39.15)(OR = 0.43, 95%CI: 0.24-0.78, P = 0.006). A nomogram for predicting PPOI was developed [area under the curve(AUC) = 0.741] and internally validated by bootstrap resampling(AUC = 0.725, 95%CI: 0.663-0.799).CONCLUSION Preoperative albumin is an independent predictive factor of PPOI in patients who underwent GI surgery. The nomogram provided a model to screen for early indications in the clinical setting. | Wen-Quan Liang Ke-Cheng Zhang Hua Li Jian-Xin Cui Hong-Qing Xi Ji-Yang Li Ai-Zhen Cai Yu-Hua Liu Wang Zhang Lan Zhang Bo Wei Lin Chen | 2020 | World Journal of Gastroenterology2020，26，11： | 10 |
| 6 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 7 | Effects of PM2.5 Exposure in Different Air Quality Grades on Daily Outpatient Visits for Childhood Asthma in Shijiazhuang, China显示文摘Asthma is a common chronic inflammatory disorder that is more prevalent in children than in adults. China has seen an increasing prevalence of childhood asthma in recent decades[1]. Earlier studies have shown that air particulate matter (PM), particularly fine particulate matter (PM2.5)[2], is an important factor triggering childhood asthma. Since national PM2.5 data were not available until 2013, the effects of PM2.5 on childhood asthma are less known, and most of the related research has been conducted primarily in some metropolises in China. Moreover, the majority of these studies focus on the impact of a unit increase (1 or 10 μg/m3) or an interquartile range increase in PM2.5 on childhood asthma based on the same pollutant background concentrations. Assessment of the impact of air quality grades (AQGs) based on PM2.5 concentration related to health effects is rarely considered[3]. Thus, the purpose of this study is to confirm the effects of PM2.5 on daily outpatient visits for childhood asthma in Shijiazhuang, a heavily polluted city with a high prevalence of childhood asthma in China, for the period 2013-2015, and to evaluate the association between PM2.5 exposure in different national AQGs and outpatient visits for childhood asthma in this city. | FU Gui Qin JIANG Yan Feng LIU Lan Ping LIU Hua Yue ZHOU Ji CUI Xiao Wei WANG Shi Gong | 2018 | Biomedical and Environmental Sciences2018，31，12： | 7 |
| 8 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 9 | HIV and syphilis infections among street-based female sex workers in China, 2010-2012显示文摘 | Li Dongmin Wang Lu Lin Wen Li Peilong Wang Lan Guo Wei Ge Lin Ding Zhengwei Cui Yan Wang Ning | 2014 | Chinese Medical Journal2014，，4： | 7 |
| 10 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044scbuqw6xbb00q69c9.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 11 | Scalp-cluster acupuncture with electrical stimulation can improve motor and living ability in convalescent patients with post-stroke hemiplegia显示文摘OBJECTIVE: To determine whether patients with post-stroke hemiplegia could benefit from long-term treatment with scalp cluster(SC) acupuncture combined with electrical stimulation(ES)and to evaluate the feasibility of this treatment to improve motor and living abilities.METHODS: Twenty patients were enrolled and divided into two groups: SC acupuncture and SC acupuncture with ES(SC and SC + ES, respectively). All participants also received rehabilitation training.All participants were blindly evaluated using the Fugl-Meyer assessment scale for motor ability, the modified Barthel Index for living ability, and a scale for the degree of neurological deficits. Outcome was assessed at three points before randomized grouping, at the beginning or treatment, and after4 weeks of treatment.RESULTS: Following 4 weeks treatment, all the patients exhibited significant improvements in aspects of motor ability, living ability, and the severity of neurological deficits. The experimental group(SC + ES) scored higher on the Fugl-Meyer assessment scale(68 ± 12) and the modified Barthel Index(49 ± 9) than the control(SC) group(50 ± 13,36 ± 13, respectively).CONCLUSION: When patients with post-stroke hemiplegia are treated using SC acupuncture with ES, motor and living ability can improve more than if they were treated with SC acupuncture alone. | Wang Xiaohong Zhang Qi Cui Baojuan Sun Junhua Ye Lan Huang Laigang Wang Daoqing | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 7 |
| 12 | The Unfolding of Equivariant Bifurcation Problems with Two Types of State Variables in the Presence of Parameter Symmetry显示文摘与二展开 equivariant 分叉问题在组的行动下面州的变量打字(螕,螖) 被使用 DA 鈥揳l gebraic 工具讨论。主要结果之一是展开定理的 equivariant versal。关键词 equivariant 分叉问题 - 展开的 versal -( 螕,螖)鈥揺q uivalence 先生(2000 ) 题目分类 58C27 由 P. R 的国家自然科学基础支持了。中国(号码 10271023 ) 和湖南省(号码 04JJ3072 ) | Deng Lan CUI Yang Cheng LI | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 6 |
| 13 | Intraoperative microvascular Doppler monitoring in intracranial aneurysm surgery显示文摘 | HUI Pin-jing YAN Yan-hong ZHANG Shi-ming WANG Zhong YU Zheng-quan ZHOU You-xin LI Xiang-dong CUI Gang ZHOU Dai HUI Guo-zhen LAN Qing | 2013 | Chinese Medical Journal2013，，13： | 6 |
| 14 | Selection of Heat Treatment Process and Wear Mechanism of High Wear Resistant Cast Hot-Forging Die Steel显示文摘Dry sliding wear tests of a Cr-Mo-V cast hot-forging die steel was carried out within a load range of 50-300 N at 400 ℃ by a pin-on-disc high-temperature wear machine. The effect of heat treatment process on wear resistance was systematically studied in order to select heat treatment processes of the steel with high wear resistance. The morphology, structure and composition were analyzed using scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS); wear mechanism was also discussed. Tribo-oxide layer was found to form on worn surfaces to reduce wear under low loads, but appear inside the matrix to increase wear under high loads. The tribo-oxides were mainly consisted of Fe3O4 and Fe2O3, FeO only appeared under a high load. Oxidative mild wear, transition of mild-severe wear in oxidative wear and extrusive wear took turns to operate with increasing the load. The wear resistance strongly depended on the selection of heat treatment processes or microstructures. It was found that bainite presented a better wear resistance than martensite plus bainite duplex structure, martensite structure was of the poorest wear resistance. The wear resistance increased with increasing austenizing temperature in the range of 920 to 1 120 ℃, then decreased at up to 1 220 ℃. As for tempering temperature and microstructure, the wear resistance increased in following order: 700 ℃ (tempered sorbite), 200 ℃ (tempered martensite), 440 to 650 ℃ (tempered troostite). An appropriate combination of hardness, toughness, microstructural thermal stability was required for a good wear resistance in high-temperature wear. The optimized heat treatment process was suggested for the cast hot-forging steel to be austenized at 1 020 to 1 120 ℃, quenched in oil, then tempered at 440 to 650 ℃ for 2 h. | WEI Min-xian WANG Shu-qi WANG Lan CUI Xiang-hong CHEN Kang-min | 2012 | Journal of Iron and Steel Research(International)2012，19，5： | 6 |
| 15 | Extensive full-thickness eyelid reconstruction with rotation flaps through 'subcutaneous tunnel' and palatal mucosal grafts显示文摘· AIM: To reconstruct the extensive full-thickness defects of eyelids is a challenge for the plastic surgeon because of their complex anatomy and special functions.This article presents and discusses an improved surgical technique in which the orbicularis oculi myocutaneous flap is rotated through a 'subcutaneous tunnel' in conjunction with a palatal mucosal graft employed for lining.·METHODS: Data from 22 eyes with extensive full-thickness eyelid defects from various causes between2009 and 2013 were analyzed in this study. After the different layers of eyelid were separated completely, a temporally based orbicularis oculi myocutaneous flap was designed following fishtail lines and was mobilized,leaving the base of the pedicle intact with a submuscular tissue attachment. The flap was then rotated through a 'subcutaneous tunnel' to the defect, and the donor site was closed primarily. Posterior lamellar reconstruction was performed with a mucosal graft harvested from the hard palate.·RESULTS: All the flaps were survived without any healing problems. There was no corneal irritation, flap contraction, or significant donor-site morbidity in the follow-up period. The incision scars were almost invisible.The defects were repaired completely, and the evaluations showed satisfactory function and appearance.·CONCLUSION: This technique is an improved singlestage operation and can be applied to repair large, full-thickness eyelid defects from various causes. With our method, the functional and aesthetic results can be obtained in either the upper or lower eyelids. | Jian-Xia Cheng Lan Zuo Xin-Yu Huang Ji-Zhe Cui Shuai Wu Yuan-Yuan Du | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 6 |
| 16 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 17 | Relationship between excessive erythrocytosis and acute mountain sickness: A field study显示文摘Background: Alterations in hematology, especially erythroid changes, may be involved in acute mountain sickness(AMS) at high altitude. This study aimed to identify the relationship between excessive erythrocytosis and AMS following different durations of high-altitude exposure.Methods: A total of 692 healthy young Chinese men were recruited for the study in June and July of 2012 and were divided into the following five groups: I) the 24-h group(24 hours after arrival at Lhasa, 3,700 m, n=261); II) the 7-d group(exposed at Lhasa, 3,700 m for seven days, n=99); III) the re-exposure group(re-exposed at Yang Bajing, 4,400 m for seven days after >1 year of acclimation at 3,700 m, n=94); IV) the acclimated group(>1 year of acclimation at 3,700 m, Lhasa, n=42); and V) the sea-level control(control group, Chengdu, n=196). Case report forms were used to record the subjects' demographic information and AMS-related symptoms. All of the subjects underwent routine blood tests.Results: The red blood cell(RBC) count fell slightly but was not significant upon acute exposure to high altitude, whereas the hemoglobin concentration([Hb]) increased significantly. After high-altitude re-exposure, both of the [Hb] and RBC count showed significant increases. The incidence of AMS was 65.1%, 26.3% and 51.1%, respectively in the 24-h, 7-d and re-exposure groups. The [Hb](P=0.024) and hematocrit(P=0.017) were greater in the AMS+ individuals than in the AMS– individuals in 7-d group. A correlation analysis revealed that the [Hb] and hematocrit were closely related with AMS score in 7-d and re-exposure groups, while the RBC showed a correlation with AMS score only in the re-exposure group. The AMS incidence was lowest when the [Hb] was between 140 and 160 g/L in the 24-h and 7-d groups.Conclusions: AMS is associated with both [Hb] and excessive erythrocytosis. Additionally, our findings indicate the existence of an optimal [Hb] for preventing AMS. | Xiao-Han Ding Ji-Hang Zhang Bin Cui Lan Huang | 2014 | Journal of Medical Colleges of PLA(China)2014，29，2： | 4 |
| 18 | Awareness Status of Chronic Disabling Neurological Diseases among Elderly Veterans显示文摘 | Ji-Ping Tan Lin-Qi Zhu Jun Zhang Shi-Min Zhang Xiao-Yang Lan Bo Cui Yu-Cheng Deng Ying-Hao Li Guang-Hua Ye Lu-Ning Wang | 2015 | Chinese Medical Journal2015，，10： | 4 |
| 19 | Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation显示文摘Numerous valuable studies on electron dynamics have focussed on the extraordinary properties of molybdenum disulfide(MoS_(2));however,most of them were confined to the level below the damage threshold.Here the electron dynamics of MoS_(2) under intense ultrafast laser irradiation was investigated by experiments and simulations.Two kinds of ablation mechanisms were revealed,which led to two distinct types of electron dynamics and final ablation morphology.At a higher fluence,the emergence of superheated liquid induced a dramatic change in the transient reflectivity and micro-honeycomb structures.At a lower fluence,the material was just removed by sublimation,and the ablation structure was relatively flat.X-ray photoelectron spectroscopic(XPS)measurements demonstrated that thermal decomposition only occurred at the higher fluence.Furthermore,a theoretical model was developed to deeply reveal the ultrafast dynamics of MoS_(2) ablation.The simulation results were in good agreement with the temporal and spatial reflectivity distribution obtained from the experiment.The electron and lattice temperature evolution was also obtained to prove the ablation mechanism.Our results revealed ultrafast dynamics of MoS_(2) above the damage threshold and are helpful for understanding the interaction mechanism between MoS_(2) and intense ultrafast lasers,as well as for MoS_(2) processing applications. | Changji Pan Lan Jiang Jingya Sun Qingsong Wang Feifei Wang Kai Wang Yongfeng Lu Yeliang Wang Liangti Qu Tianhong Cui | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 20 | Efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in treatment of advanced gastric cancer or gastroesophageal junction cancer: A meta-analysis显示文摘BACKGROUND Faced with limited and inadequate treatment options for patients with advanced gastric cancer or gastroesophageal junction cancer(GC/GEJC), researchers have turned toward, with the support of promising clinical trials, anti-PD-1/anti-PD-L1 antibody therapy. But there are also different clinical trial results. To better assess its efficacy and safety, we integrated data from 13 eligible studies for a systematic review and meta-analysis.AIM To comprehensively evaluate the efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in the treatment of advanced GC/GEJC patients.METHODS PubMed, Web of Science, Cochrane Library,and EMBASE databases were searched to identify eligible articles with outcomes including objective response rate(ORR), disease control rate(DCR), overall survival(OS), progression-free survival(PFS), and adverse events(AEs) of anti-PD-1/anti-PD-L1 antibody therapy.RESULTS Our study encompassed a total of 13 trials totaling 1618 patients. The outcomes showed a pooled ORR and DCR of 15%(95% confidence interval [CI]: 14%-18%) and 40%(95%CI: 33%-46%), respectively. The pooled 6-mo OS and PFS were 54%(95%CI: 45%-64%) and 26%(95%CI: 20%-32%), respectively, and the 12-mo OS and PFS were 42%(95%CI: 21%-62%) and 11%(95%CI: 8%-13%), respectively. In addition, the incidence of any-grade AEs and grade ≥ 3 AEs was 64%(95%CI: 54%-73%) and 18%(95%CI: 16%-20%), respectively. Most importantly, PD-L1 positive patients exhibited a higher ORR rate than PD-L1 negative patients(odds ratio = 2.54, 95%CI: 1.56-4.15).CONCLUSION Anti-PD-1/anti-PD-L1 antibody therapy has shown promising anti-tumor efficacy with manageable AEs in advanced GC/GEJC patients, with PD-L1 overexpressing patients exhibiting a higher ORR. What is more, the clinical efficacy of anti-PD-1/PD-L1 combined with traditional chemotherapy drugs is even better, although the occurrence of AEs still causes considerate concerns. | Li Yang Xian-Zhe Dong Xiao-Xuan Xing Xiao-Hui Cui Lin Li Lan Zhang | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 4 |
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