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| 1 | Optimization of clay material mixture ratio and filling process in gypsum mine goaf显示文摘Because there is neither waste rock nor mill tailings in the gypsum mine, and the buildings on the goaf of gypsum mine are needed to be protected, the research proposed the scheme of the clay filling technology. Gypsum, cement, lime and water glass were used as adhesive, and the strength of different material ratios were investigated in this study. The influence factors of clay strength were obtained in the order of cement, gypsum, water glass and lime. The results show that the cement content is the determinant influence factor, and gypsum has positive effects, while the water glass can enhance both clay strength and the fluidity of the filing slurry. Furthermore, combining chaotic optimization method with neural network, the optimal ratio of composite cementing agent was obtained. The results show that the optimal ratio of water glass, cement, lime and clay (in quality) is 1.17:6.74:4.17:87.92 in the process of bottom self-flow filling, while the optimal ratio is 1.78:9.58:4.71:83.93 for roof-contacted filling. A novel filling process to fill in gypsum mine goaf with clay is established. The engineering practice shows that the filling cost is low, thus, notable economic benefit is achieved. | Liu Zhixiang Dang Wengang Liu Qingling Chen Guanghui Peng Kang | 2013 | International Journal of Mining Science and Technology2013，23，3： | 11 |
| 2 | System integration of China's first PEMFC locomotive显示文摘In the face of growing environmental pollution,developing a fuel-cell-driven shunting locomotive is a great challenge in China for environmental protection and energy saving,which combines the environmental advantages of an electric locomotive with the lower infrastructure costs of a diesel-electric locomotive.In this paper,the investigation status and the development trend of the fuel-cell-driven shunting locomotive were introduced.Through innovation of the power system using fuel cells,an experiment prototype of a fuel-cell shunting locomotive was developed,which would reduce the effects on the environment of the existing locomotives.This was the first locomotive to use a proton exchange membrane fuel-cell(PEMFC) power plant in China.From October 2012,we started to test the fuel-cell power plant and further test runs on the test rail-line in Chengdu,Sichuan.The achieved encouraging results can provide fundamental data for the modification of the current individual fuel cell locomotives or further development of the fuel-cell hybrid ones in China. | WeiRong Chen Fei Peng Zhixiang Liu Qi Li Chaohua Dai | 2013 | Journal of Modern Transportation2013，21，3： | 7 |
| 3 | Trading platform for cooperation and sharing based on blockchain within multi-agent energy internet显示文摘With the release of the electricity sales side,large-scale small-capacity distributed power generation units are connected to the distribution side,forming multi-type market entities such as microgrids,integrated energy systems,and virtual power plants.With the large-scale integration of distributed energy,the energy market under the energy internet is different from a traditional transmission grid.It is currently developing in the direction of diversified entities and commodities,a flat structure,and a flexible and competitive multi-agent market mechanism.In this context,this study analyzes the value of combining blockchain and the electricity market presents the design of a blockchain trading framework for multi-agent cooperation and sharing of the energy internet.The nodes in market transactions are modeled through power system modeling in the physical layer and the transaction consensus strategy in the cyber layer;moreover,the nodes are verified in a modified IEEE 13 testing feeder of a distribution network.A transaction example is demonstrated using the multi-agent cooperation and sharing transaction platform based on the Ethereum private blockchain. | Xiaohui Wang Peng Liu Zhixiang Ji | 2021 | Global Energy Interconnection2021，4，4： | 6 |
| 4 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 5 | Study of probability integration method parameter inversion by the genetic algorithm显示文摘In order to obtain accurate probability integration method(PIM) parameters for surface movement of multi-panel mining, a genetic algorithm(GA) was used to optimize the parameters. As the measured surface movement is affected by more than one mining panel, traditional PIM parameter inversion model is difficult to ensure the reliability of the results due to the complexity of rock movement. With crossover,mutation and selection operators, GA can perform a global optimization search and has high computation efficiency. Compared with the pattern search algorithm, the fitness function can avoid falling into local minima traps. GA reduces the risk of local minima traps which improves the accuracy and reliability with the mutation mechanism. Application at Xuehu colliery shows that GA can be used to inverse the PIM parameters for multi-panel surface movement observation, and reliable results can be obtained. The research provides a new way for back-analysis of PIM parameters for mining subsidence under complex conditions. | Li Peixian Peng Di Tan Zhixiang Deng Kazhong | 2017 | International Journal of Mining Science and Technology2017，27，6： | 5 |
| 6 | Surface plasmon interference pattern on the surface of a silver-clad planar waveguide as a sub-micron lithography tool显示文摘A new sub-micron photolithography tool has been realized by utilizing the interference of surface plasmon waves(SPWs) on the near surface of a silver(Ag)-clad ultraviolet(UV) planar waveguide.A laser beam with a wavelength of 325 nm was incident into the waveguide core,and suffered a series of total internal reflections on the interfaces between the waveguide core and the cladding layers.The incident light and the reflected light induced two beams of SPWs traveling in contrary directions,which interfered with each other and formed a standing wave as a sub-micron photolithography tool.A near-field scanning optical microscope(NSOM) was employed to measure the intensity distribution of the stationary wave field of the near surface of the Ag layer of the waveguide,anastomosed with theoretical values acquired by use of finite difference time domain(FDTD) simulations.And with this sub-micron photolithography tool a SMG with a period of 79.3 nm,in good agreement with the theoretical value of 80.1 nm,was inscribed on the surface of a self-processing hybrid SiO2/ZrO2 solgel film for the first time. | ZHU QiuXiang HU CanDong WANG WenJie HE Miao ZHOU Jun ZHAO LingZhi PENG ZhiXiang LI ShuTi ZHU Ning ZHANG Yong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 3 |
| 7 | Smoothing effect in the broadband laser through a dispersive wedge显示文摘 | Peng Runwu Ye Yunxia Tang Zhixiang | 2006 | Opt Commun2006，265，1： | 1 |
| 8 | Transverse intensity distributions of a broadband laser modulated by a hard-edged aperture显示文摘 | Runwu Peng Yunxia Ye Zhixiang Tang | 2005 | Journal of Optical Society of America A2005，22，9： | 1 |
| 9 | Smoothing the side lobes of a focused pattern by spectral dispersion in the broadband laser显示文摘 | Runwu Peng Zhixiang Tang Yunxia Ye | 2007 | International Journal for Light and Electron Optics2007，118，12： | 1 |
| 10 | Smoothing effect in the broadband laser through a dispersive wedge显示文摘 | Runwu Peng Yunxia Ye Zhixiang Tang | 2006 | Optics Communications2006，265，1： | 1 |
| 11 | Smoothing effect in the broadband laser through a dispersive wedge显示文摘 | Runwu Peng Yunxia Ye Zhixiang Tang Chujun Zhao Shuangchun Wen Dianyuan Fan | 2006 | Optics Communications2006，，1： | 1 |
| 12 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 13 | Morphological, Mechanical and Thermal Properties of Poly(lactic acid)(PLA)/Cellulose Nanofibrils(CNF) Composites Nanofiber for Tissue Engineering显示文摘Composite nanofiber membranes based on biodegradable poly(lactic acid)(PLA) and cellulose nanofibrils(CNF) were produced via electrospinning. The influence of CNF content on the morphology, thermal properties, and mechanical properties of PLA/CNF composite nanofiber membranes were characterized by field scanning electron microscopy(FE-SEM), differential scanning calorimetry(DSC), thermogravimetric analysis(TGA), and dynamic mechanical analysis(DMA), respectively. The results show that the PLA/CNF composite nanofibers with smooth, free-bead surface can be successfully fabricated with various CNF contents. The introduction of CNF is an effective approach to improve the crystalline ability, thermal stability and mechanical properties for PLA/CNF composite fibers. The Young's moduli and tensile strength of the PLA/CNF composite nanofiber reach 106.6 MPa and 2.7 MPa when the CNF content is 3%, respectively, which are one times higher and 1.5 times than those of pure PLA nanofiber. Additionally, the water contact angle of PLA/CNF composite nanofiber membranes decreases with the increase of the CNF loading, resulting in the enhancement of their hydrophilicity. | 杨章强 LI Xiaojie 司军辉 CUI Zhixiang PENG Kaiping | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 1 |
| 14 | A novel multi-fidelity coupled simulation method for flow systems显示文摘For the numerical simulation of flow systems with various complex components, the traditional one-dimensional (1D) network method has its comparative advantage in time consuming and the CFD method has its absolute advantage in the detailed flow capturing. The proper coupling of the advantages of different dimensional methods can strike balance well between time cost and accuracy and then significantly decrease the whole design cycle for the flow systems in modern machines. A novel multi-fidelity coupled simulation method with numerical zooming is developed for flow systems. This method focuses on the integration of one-, two-and three-dimensional codes for various components. Coupled iterative process for the different dimensional simulation cycles of sub-systems is performed until the concerned flow variables of the whole system achieve convergence. Numerical zooming is employed to update boundary data of components with different dimen-sionalities. Based on this method, a highly automatic, multi-discipline computing environment with integrated zooming is developed. The numerical results of Y-Junction and the air system of a jet engine are presented to verify the solution method. They indicate that this type of multi-fidelity simulationmethod can greatly improve the prediction capability for the flow systems. | Wang Peng Zheng Yun Zou Zhengping Qi Lei Zhou Zhixiang | 2013 | Chinese Journal of Aeronautics2013，26，4： | 1 |
| 15 | Expert consensus on organizing the multidisciplinary team(MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China显示文摘Multidisciplinary team(MDT) discussion has been well established in some European countries and widely carried out in various clinical professional fields(Festen et al.,2021;Fleissig et al.,2006).Many studies have reported the benefits of MDT,including improving survival and quality of cancer care(Munro et al.,2015;Nixon et al.,2021;Tsai et al.,2020). | Binhao Zhang Jian Zhou Weifen Xie Kaishan Tao Shichun Lu Xianglin Yuan Lianxin Liu Weilin Wang Yilei Mao Ping Bie Jingfeng Liu Xinyu Bi Zhiwei Zhang Changhong Liang Jianqiang Cai Zhixiang Jian Yi Lv Peng Zhu Wei Zhang Hongqiang Yang Weiping Zhou Bixiang Zhang Xiaoping Chen | 2022 | Science China(Life Sciences)2022，65，5： | 0 |
| 16 | XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer显示文摘Macrophages are among the most abundant immune cells in colorectal cancer (CRC). Re-educating tumor-associated macrophages (TAMs) to switch from protumoral to anti-tumoral activity is an attractive treatment strategy that warrants further investigation. However, little is known about the key pathway that is activated in TAMs. In this study, infitrating CD206^(+) TAMs in CRC were sorted and subjected to RNA-seq analysis. Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in TAMs. XBP1 activation in TAMs promoted the growth and metastasis of CRC. Ablation of XBP1 inhibited the expression of the pro-tumor cytokine signature of TAMs, including IL-6, VEGFA, and IL-4. Simultaneously, XBP1 depletion could directly inhibit the expression of SIRPα and THBS1, thereby blocking “don’t eat me” recognition signals and enhancing phagocytosis. Therapeutic XBP1 gene editing using AAV2-sgXBP1 enhanced the anti-tumor activity. Together, XBP1 activation in TAMs drives CRC progression by elevating pro-tumor cytokine expression and secretion, as well as inhibiting macrophage phagocytosis. Targeting XBP1 signaling in TAMs may be a potential strategy for CRC therapy. | Yahui Zhao Weina Zhang Miaomiao Huo Peng Wang Xianghe Liu Yu Wang Yinuo Li Zhixiang Zhou Ningzhi Xu Hongxia Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 17 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 18 | Investigation of charge transfer between donor and acceptor for small-molecule organic solar cells by scanning tunneling microscopy and ultrafast transient absorption spectroscopy显示文摘Small-molecule organic solar cell is a category of clean energy potential device since charge transfers between donor and acceptor.The morphologies,co-assembly behavior,interaction sites,and charge transfer of BTID-nF(n=1,2)/PC71BM donor-acceptor system in the active layer of organic solar cell have been studied employing scanning tunneling microscopy(STM),scanning tunneling spectroscopy(STS),density functional theory(DFT)calculations,and transient absorption(TA)spectroscopy.The results show that BTID-1F and BTID-2F form bright strip structures,whereas BTID-nF(n=1,2)/PC71BM form ridge-like structures with each complex composed of one BTID-nF(n=1,2)molecule and four PC71BM molecules which adsorbed around the BTID-nF(n=1,2)molecule by S···πinteraction.With the assistance of S···πinteraction between BTID-nF(n=1,2)and PC71BM,BTID-nF(n=1,2)/PC71BM co-assembled ridge-like structures are more stable than the BTID-nF(n=1,2)ridge structures.To investigate the charge transfer of BTID-nF(n=1,2)/PC71BM system,STS measurements,DFT calculation,and TA spectroscopy are further performed.The results show that charge transfer occurs in BTID-nF(n=1,2)/PC71BM system with the electron transferring from BTID-nF(n=1,2)molecules to PC71BM. | Yuchuan Xiao Linxiu Cheng Xinyu Sui Qi Wang Jie Chen Dan Deng Jianqi Zhang Xuan Peng Xiaokang Li Xunwen Xiao Ke Deng Xinfeng Liu Zhixiang Wei Qingdao Zeng | 2022 | Nano Research2022，15，9： | 0 |
| 19 | Prevalence and Clinical Implication of t(11;14)in Light-Chain Amyloidosis with or without Coexistent Multiple Myeloma in the Era of Proteasome Inhibitors显示文摘Background Light-chain amyloidosis(AL)and multiple myeloma(MM)may coexist in some patients and,although they share some cytogenetic abnormalities,they usually present with different clinical phenotypes.Translocation(11;14)is the most common cytogenetic abnormality in AL,but the prevalence and clinical implication of t(11;14)in patients with AL,with or without coexistent MM,remains unclear.Methods A total of 119 consecutive newly diagnosed AL patients with available fluorescence in situ hybridization(FISH)data were retrospectively included and classified as primary AL alone(pAL-alone)or AL with coexistent MM(AL-MM).Clinical characteristics,FISH profiles,and hematologic and survival outcomes were analyzed.Results There were 53 patients in the pAL-alone group and 66 in the AL-MM group.The prevalence of t(11;14)was significantly higher in the pAL-alone group than the AL-MM group(49.1%vs.26.2%,P=0.012).A significantly higher proportion of the pAL-alone group achieved hematologic response compared with the AL-MM group(60.4%vs.39.4%,P=0.023).Patients with AL-MM experienced significantly shorter hematologic event-free survival(hemEFS)than those with pAL-alone(median,4.8 months vs.44.3 months,P<0.001),as well as significantly shorter overall survival(OS;median,15.2 months vs.not reached,P<0.001).When stratified by the presence or absence of coexistent MM and t(11;14),AL-MM patients with t(11;14)had the worst hemEFS(median,3.8 months,P<0.001)and OS(median,5.4 months,P=0.001).Conclusions Patients with pAL-alone had a higher prevalence of t(11;14)than those with AL-MM.The AL-MM group had poorer outcomes,despite the availability of proteasome inhibitor treatment,with AL-MM patients with t(11;14)showing the worst outcomes.Better diagnostic and treatment approaches are warranted for this population. | Tianhong XU Zheng WEI Jing LI Jiadai XU Yang YANG Wenjing WANG Jingli ZHUANG Zhimei WANG Lili JI Luya CHENG Weiguang WANG Zhixiang CHENG Yang KE Ling YUAN Peng LIU | 2022 | Clinical Cancer Bulletin2022，1，1： | 0 |
| 20 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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