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| 1 | Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China:a decision analysis and implications for practice显示文摘Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.Methods: A decision tree model with three scenarios(low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort(100,000 smokers aged45-80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality(primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables.Results: Among the 100,000 subjects, there were 448,541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively(17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, lowdose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths(relative numbers) with low-dose CT screening in the worst and optimal cases were16(5.4%) and 288(40.2%) over no screening, respectively.Conclusions: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China.However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed. | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2017 | Chinese Journal of Cancer2017，36，8： | 9 |
| 2 | Economic Value of Water Quality Improvement by One Grade Level in Erhai Lake: A Willingness-to-Pay Survey and a Benefit-Transfer Study显示文摘在中国的水质量严重在最近的年里败坏了。然而,很少的估价研究被进行了估计与水质量变化联系的钱的价值。作为结果,决定制造者几乎不能在水质量改进关于投资做合理选择。这份报纸论述在达利进行的估价研究,云南省,哪个到估计的目的由一等级水平改进厄海·莱克的水质量的全部的经济价值。偶然的估价方法和利益转移途径在这研究被采用。平均,偶然的估价评价策略揭示那位于达利的一个家庭愿意为水质量改进连续地每月付大约 27 元 5 年,等价于 1.7% 家庭月刊收入。关于收入的 willingness-to-pay 的弹性被估计是 0.28。建议污染控制工程的经济回来的内部率被估计是 13% 。利益转移锻练在心甘情愿上生产一个类似的评价到薪水(WTP ) 珍视,与与偶然的估价途径相比的不到 2% 的差别。结果显示在中国省为估价评价使用利益转移途径的潜在的可靠性。 | Hua Wang Yuyan Shi Yoonhee Kim Takuya Kamata | 2015 | Frontiers of Economics in China-Selected Publications from Chinese Universities2015，10，1： | 4 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | 中国城市人群低剂量计算机断层扫描筛查肺癌的死亡率结果:决策分析和实践意义显示文摘背景与目的不同低剂量计算机断层扫描(computed tomography,CT)筛查肺癌试验得出的死亡率结果不一致。本研究旨在评价中国城市CT筛查是否能够降低肺癌死亡率,并探讨影响筛查效果的因素。方法建立了3种场景(低剂量CT筛查、胸部X线筛查和无筛查)的决策树模型来比较模拟的中国城市人群(100,000例年龄45–80岁的吸烟者)的筛查结果。从国家登记和流行病学调查中获得了参与者特征数据并估算了肺癌患病比例。根据文献调研选择了低剂量CT和胸部X线筛查的灵敏度和特异度等其他树变量。计算了3种筛查方法间肺癌死亡率(主要结局)、误诊和误诊导致死亡的差异。通过敏感性分析找出了与筛查结果相关的因素,并确定了在变量可能范围内的最差和最优筛查效果。结果 100,000例研究对象中,低剂量CT、胸部X线和无筛查场景分别有448例、541例和591例肺癌死亡(低剂量CT筛查比胸部X线筛查死亡人数减少17.2%,比无筛查减少24.2%)。100,000例研究对象中,2种筛查场景的代价分别为9387例和2497例误诊及7例和2例误诊导致的死亡。低剂量CT筛查比无筛查的死亡数降低,影响最大的因素是筛查人群的肺癌患病比例、低剂量CT的灵敏度和低剂量CT检出肺癌中早期癌的比例。综合了所有可能性,低剂量CT筛查肺癌的死亡人数(相对数)在最坏和最好情况下分别比无筛查降低了16例(5.4%)和288例(40.2%)。结论就死亡率结局而言,我们的研究结果支持在中国城市人群中进行低剂量CT筛查。然而,急需策略来减少误诊和优化纳入标准等重要筛查条件。 | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2018 | 癌症2018，37，8： | 3 |
| 5 | Developing country experience with eco-industrial parks: a case study of the Tianjin economic- technological development area in China 显示文摘 | Shi Han Chertow M Song Yuyan | 2010 | Journal of Cleaner Production2010，18，3： | 1 |
| 6 | Developing country experience with eco-industrial parks:a case stud-y of the Tianjin Economic-Technological Development Area in China显示文摘 | SHI Han CHERTOW M SONG Yuyan | 2010 | Journal of Cleaner Production2010，18，3： | 1 |
| 7 | Developing country experience with eco-industrial parks: a case study of the Tianjin Economic-Technological Development Area in China显示文摘 | Han Shi Marian Chertow Yuyan Song | 2009 | Journal of Cleaner Production2009，，3： | 1 |
| 8 | Construction and Application of DNAzyme-based Nanodevices显示文摘The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing,drug delivery,and so on.DNAzymes are a class of DNA molecules with the specific catalytic activity.Owing to their unique catalytic activity and easy design and synthesis,the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years.In this review,the classification and properties of DNAzyme are first introduced.The construction of several common kinds of DNAzyme-based nanodevices,such as DNA motors,signal amplifiers,and logic gates,is then systematically summarized.We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields.In addition,current limitations and future directions are discussed. | WANG Bo WANG Menghui PENG Fangqi FU Xiaoyi WEN Mei SHI Yuyan CHEN Mei KE Guoliang ZHANG Xiao-Bing | 2023 | Chemical Research in Chinese Universities2023，39，1： | 1 |
| 9 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 10 | Electrochemical sensor for bisphenol A based on magnetic nanoparticles decorated reduced graphene oxide显示文摘 | Yixuan Zhang Yuxiao Cheng Yuyan Zhou Bingyu Li Wei Gu Xinhao Shi Yuezhong Xian | 2013 | Talanta2013，，： | 1 |
| 11 | Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway显示文摘Double cortin-like kinase 1(DCLK1)exhibits high expression levels across various cancers,notably in human colorectal cancer(CRC).Diacerein,a clinically approved interleukin(IL)-1βinhibitor for osteoarthritis treatment,was evaluated for its impact on CRC proliferation and migration,alongside its underlying mechanisms,through both in vitro and in vivo analyses.The study employed MTT assay,colony formation,wound healing,transwell assays,flow cytometry,and Hoechst 33342 staining to assess cell proliferation,migration,and apoptosis.Additionally,proteome microarray assay and western blotting analyses were conducted to elucidate diacerein’s specific mechanism of action.Our findings indicate that diacerein significantly inhibits DCLK1-dependent CRC growth in vitro and in vivo.Through high-throughput proteomics microarray and molecular docking studies,we identified that diacerein directly interacts with DCLK1.Mechanistically,the suppression of p-STAT3 expression following DCLK1 inhibition by diacerein or specific DCLK1 siRNA was observed.Furthermore,diacerein effectively disrupted the DCLK1/STAT3 signaling pathway and its downstream targets,including MCL-1,VEGF,and survivin,thereby inhibiting CRC progression in a mouse model,thereby inhibiting CRC progression in a mouse model. | YE Qiaobei ZHU Yu SHI Meng LV Linxi GONG Yuyan ZHANG Luyao YANG Lehe ZHAO Haiyang ZHAO Chengguang XU Huanhai | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
| 12 | Shear-wave Splitting in the Crust beneath Shandong and Its Adjacent Area显示文摘Based on the seismic data of near-field source from the Shandong Digital Seismic Network,this study obtained the shear-wave splitting parameters from multiple stations. The results show that dominant directions of polarizations of fast shear-waves reflect the spatial distribution characteristics of tectonic stress in this area,CHD and LIS stations show 2 dominant directions,and reveals that the crustal seismic anisotropy in the Shandong area is constrained by the regional stress background,local failure and structure. | Miao Qingjie Liu Xiqiang Shi Yuyan Qu Junhao Zheng Jianchang Tian Fengdong | 2016 | Earthquake Research in China2016，30，4： | 0 |
| 13 | Discussion on the Measurement Method for the Coda Wave Quality Factor显示文摘The Quality factor is the parameter that can be used to describe the energy attenuation on seismic wave. In theory, we can obtain the relationship between the change of the coda wave quality factor with time and the strong earthquake preparation process on the basis of the quality factor of a coda wave in a same ray path. However, in reality the coda wave quality factor measured by different seismic coda waves corresponds to different seismic wave ray paths. The change of the quality factor with time is related to non-elastic characteristics of the medium and the volume of scattering ellipsoid constrained by scattered wave phase fronts, besides the change of regional stress field. This paper discusses the relationship between quality factor, epicenter distance and different lapse time, and then discusses the relationship between quality factor and frequency. Furthermore the determination method of the coda wave quality factor is put forward. The improved determination method of the quality factor, which removes the influence of different earthquakes or propagation depth of scattered waves, may increase measurement precision, thus information pertaining to abnormal changes in quality factor and the relationship between the quality factor and earthquake preparation process can be acquired. | Liu Xiqiang Shi Yuyan Qu Junhao Li Hong Li Bo Zhang Kun | 2009 | Earthquake Research in China2009，23，4： | 0 |
| 14 | Bear bile powder alleviates Parkinson’s disease-like behavior in mice by inhibiting astrocyte-mediated neuroinflammation显示文摘Parkinson’s disease(PD)is a common neurodegenerative disease in middle-aged and elderly people.In particular,increasing evidence has showed that astrocyte-mediated neuroinflammation is involved in the pathogenesis of PD.As a precious traditional Chinese medicine,bear bile powder(BBP)has a long history of use in clinical practice.It has numerous activities,such as clearing heat,calming the liver wind and anti-inflammation,and also exhibits good therapeutic effect on convulsive epilepsy.However,whether BBP can prevent the development of PD has not been elucidated.Hence,this study was designed to explore the effect and mechanism of BBP on suppressing astrocyte-mediated neuroinflammation in a mouse model of PD.PD-like behavior was induced in the mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)(30 mg·kg−1)for five days,followed by BBP(50,100,and 200 mg·kg−1)treatment daily for ten days.LPS stimulated rat C6 astrocytic cells were used as a cell model of neuroinflammation.THe results indicated that BBP treatment significantly ameliorated dyskinesia,increased the levels of tyrosine hydroxylase(TH)and inhibited astrocyte hyperactivation in the substantia nigra(SN)of PD mice.Furthermore,BBP decreased the protein levels of glial fibrillary acidic protein(GFAP),cyclooxygenase 2(COX2)and inducible nitric oxide synthase(iNOS),and up-regulated the protein levels of takeda G protein-coupled receptor 5(TGR5)in the SN.Moreover,BBP significantly activated TGR5 in a dose-dependent manner,and decreased the protein levels of GFAP,iNOS and COX2,as well as the mRNA levels of GFAP,iNOS,COX2,interleukin(IL)-1β,IL-6 and tumor necrosis factor-α(TNF-α)in LPS-stimulated C6 cells.Notably,BBP suppressed the phosphorylation of protein kinase B(AKT),inhibitor of NF-κB(IκBα)and nuclear factor-κB(NF-κB)proteins in vivo and in vitro.We also observed that TGR5 inhibitor triamterene attenuated the anti-neuroinflammatory effect of BBP on LPS-stimulated C6 cells.Taken together,BBP alleviates the progression of PD mice by suppressing astrocyte-mediated inflammation via TGR5. | WANG Lupeng BAI Yuyan TAO Yanlin SHEN Wei ZHOU Houyuan HE Yixin WU Hui HUANG Fei SHI Hailian WU Xiaojun | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 0 |
| 15 | DeepPurpose-based drug discovery in chondrosarcoma显示文摘Background:Chondrosarcoma(CS)is the second most common primary bone tumor,accounting for approximately30%of all malignant bone tumors.Unfortunately,the efficacy of currently available drug therapies is limited.Therefore,this study aimed to explore drug therapies for CS using novel computational methods.Methods:In this study,text mining,Gene Codis STRING,and Cytoscape were used to identify genes closely related to CS,and the Drug Gene Interaction Database(DGIdb)was used to select drugs targeting the genes.Drug-target interaction prediction was performed using Deep Purpose,to finally obtain candidate drugs with the highest predicted binding affinities.Results:Text-mining searches identified 168 genes related to CS.Gene enrichment and protein-protein interaction analysis generated 14 genes representing 10 pathways using Gene Codis,STRING,and Cytoscape.Seventy drugs targeting genes closely related to CS were analyzed using DGIdb.Deep Purpose recommended 25 drugs,including integrin beta 3 inhibitors,hypoxia-inducible factor 1 alpha inhibitors,E1A binding protein P300 inhibitors,vascular endothelial growth factor A inhibitors,AKT1 inhibitors,tumor necrosis factor inhibitors,transforming growth factor beta 1 inhibitors,interleukin 6 inhibitors,mitogen-activated protein kinase 1 inhibitors,and protein tyrosine kinase inhibitors.Conclusion:Drug discovery using in silico text mining and Deep Purpose may be an effective method to explore drugs targeting genes related to CS. | Jianrui Li Mingyue Shi Zhiwei Chen Yuyan Pan | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，4： | 0 |
| 16 | Simultaneous Determination of Gallic Acid and Cinnamic Acid Content in Rhubarb by HPLC显示文摘[Objective]The paper was to determine the contents of gallic acid and cinnamic acid in Chinese herb rhubarb by HPLC.[Method]High performance liquid chromatography(HPLC)was established with the following conditions:Thermo SCIENTIFIC Hypersil GOLD Dim column(4.6 mm×250 mm,5μm),mobile phase methanol-0.1%phosphoric acid solution,gradient elution,detection wavelength 278 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10 pL.[Result]The content of gallic acid and cinnamic acid in rhubarb was determined by HPLC,and they showed good linear relationship in the linear ranges of 0.125-1.250 pg(E2=0.9998)and 0.0382-0.3820μg(E2=0.9994),respectively.[Conclusion]A HPLC method is established to determine gallic acid and cinnamic acid content in rhubarb.The method will provide a scientific basis for quality control of rhubarb and its traditional Chinese medicine. | Han Qian Wei Jiangcun Chen Yong Shi Xianyi Wu Yuyan Fu Zhenying Huang Zhouyan Liu Wenjun | 2020 | Plant Diseases and Pests2020，11，3： | 0 |
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