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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Mesozoic and Cenozoic uplift and exhumation of the Bogda Mountain,NW China: Evidence from apatite fission track analysis显示文摘Apatite fission track(AFT)analysis on samples collected from a Paleozoic series is used to constrain the cooling history of the Bogda Mountain,northwest China.AFT ages range from 136.2 to 85.6 Ma and are younger than rock depositional ages and the mean confined track lengths(11.0e13.2 mm)mostly showing unimodal distribution are shorten,indicating significant track-annealing.Thermal histories modeling based on the distribution of fission-track lengths combined with the regional geological data show that two rapid cooling phases occurred in the latest Jurassiceearly Cretaceous and the OligoceneeMiocene.Those new data together with previous published data show that the AFT ages become younger from the southwest to northeast in the western Bogda Mountain and its adjacent areas.The fission-track ages of the southwest area are relatively older(>100 Ma),recording the earlier rapid uplift phase during the late JurassiceCretaceous,while the ages in the north piedmont of the Bogda Mountain(namely the northeast part)are younger(<60 Ma),mainly reflecting the later rapid uplift phase in the OligoceneeMiocene.The trend of younger AFT ages towards the northeast might be explained by post-Cretaceous large-scale crustal tilting towards the southwest.In the thrust fault-dominated northern limbs of the Bogda Mountain,AFT ages reveal a discontinuous pattern with age-jumps across the major fault zones,showing a possible strata tilting across each thrust faults due to the thrust ramps during the Cenozoic.The two rapid uplift stages might be related to the accretion and collision in the southern margin of the Asian continent during the late Jurassic and late Cenozoic,respectively. | Wenhao Tang Zhicheng Zhang Jianfeng Li Ke Li Zhiwen Luo Yan Chen | 2015 | Geoscience Frontiers2015，6，4： | 9 |
| 3 | Influence of rare earth Ce on hot deformation behavior of as-cast Mn18Cr18N high nitrogen austenitic stainless steel显示文摘The hot deformation behavior of Mn18Cr18N and Mn18Cr18N+Ce high nitrogen austenitic stainless steels at 1173-1473 K and 0.01-1 s^(-1) were investigated by thermal compression tests.The influence mechanism of Ce on the hot deformation behavior was analyzed by Ce-containing inclusions and segregation of Ce.The results show that after the addition of Ce,large,angular,hard,and brittle inclusions(TiN-Al_(2)O_(3),TiN,and Al_(2)O_(3)) can be modified to fine and dispersed Ce-containing inclusions(Ce-Al-O-S and TiN-Ce-Al-O-S).During the solidification,Ce-containing inclusions can be used as heterogeneous nucleation particles to refine as-cast grains.During the hot deformation,Ce-containing inclusions can pin dislocation movement and grain boundary migration,induce dynamic recrystallization(DRX)nucleation,and avoid the formation and propagation of micro cracks and gaps.In addition,during the solidification,Ce atoms enrich at the front of solid-li-quid interface,resulting in composition supercooling and refining the secondary dendrites.Similarly,during the hot deformation,Ce atoms tend to segregate at the boundaries of DRX grains,inhibiting the growth of grains.Under the synergistic effect of Ce-containing inclusions and Ce segregation,although the hot deformation resistance and hot deformation activation energy are improved,DRX is more likely to occur and the size of DRX grains is significantly refined,and the problem of hot deformation cracking can be alleviated.Finally,the microhardness of the samples was measured.The results show that compared with as-cast samples,the microhardness of hot-deformed samples increases signific-antly,and with the increase of DRX degree,the microhardness decreases continuously.In addition,Ce can affect the microhardness of Mn18Cr18N steel by affecting as-cast and hot deformation microstructures. | Yushuo Li Yanwu Dong Zhouhua Jiang Qingfei Tang Shuyang Du Zhiwen Hou | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，2： | 4 |
| 4 | Metallothionein expression induced by nickel accumulation in the midgut of Spodoptera litura Fabricius larvae exposed to nickel显示文摘Metallothionein expression induced by nickel accumulation in the midgut of Spodoptera litura Fabri- cius larvae was investigated by exposing S. litura larvae to the artificial diets amended with different doses of nickel for 3 generations. Nickel accumulations in the midgut of 6th instar larvae were detected by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), and the induced metal- lothionein expression in the midgut of 5th and 6th instar larvae in 120 h were quantified using cad- mium-hemoglobin total saturation methods. The accumulated nickel in the midgut of the 6th instar larvae within a generation increased with the increase of the nickel doses in the treated diets and showed significant dose-dependence with the nickel doses in diets. Metallothioneins induced by nickel accumulated in the larval midgut also increased with nickel doses in diets and with the increasing stressing time in a generation. Results also suggested that the metallothionein expression was differ- ent with the time of S. litura larvae stressed by nickel. | SUN HongXia ZHOU Qiang TANG WenCheng SHU YingHua ZOU ZhiWen ZHANG GuRent | 2007 | Chinese Science Bulletin2007，52，23： | 4 |
| 5 | Ribozyme probe based on molecular beacon for real time monitoring of enzymatic cleavage process显示文摘Ribozyme probe based on molecular beacon (MBR) for monitoring enzymatic cleavage process in real time is designed and studied. The approach relies on ri-bozyme substrates modified at the two arms, with a fluores-cent moiety attached to the end of one arm and a non-fluorescent quenching moiety attached to the end of the other arm. MBR is employed to directly convert the cleavage information into fluorescence signal in real time. Compared with traditional approach, this method provides a no-radiolabeling, sensitive and effective way to research on the ribozyme activity, enzymatic dynamic process and ri-bozyme function during gene therapy. The activity of the ribozyme against hepatitis C virus RNA (HCV-RNA) is stud-ied based on this assay. | MENG Xiangxian, WANG Kemin, TAN Weihong, LI Jun, TANG Zhiwen, GUO Qiuping, HUANG Shasheng & LI Du State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biological Technology, College of Chemistry and Chemical Engi-neering, Hunan University, Changsha 410082, China Correspondence should be addressed to Wang Kemin (e-mail: kmwang @hnu.net.cn) | 2003 | Chinese Science Bulletin2003，48，23： | 3 |
| 6 | Coaxial-printed small-diameter polyelectrolyte-based tubes with an electrostatic self-assembly of heparin and YIGSR peptide for antithrombogenicity and endothelialization显示文摘Low patency ratio of small-diameter vascular grafts remains a major challenge due to the occurrence of thrombosis formation and intimal hyperplasia after transplantation.Although developing the functional coating with release of bioactive molecules on the surface of small-diameter vascular grafts are reported as an effective strategy to improve their patency ratios,it is still difficult for current functional coatings cooperating with spatiotemporal control of bioactive molecules release to mimic the sequential requirements for antithrombogenicity and endothelialization.Herein,on basis of 3D-printed polyelectrolyte-based vascular grafts,a biologically inspired release system with sequential release in spatiotemporal coordination of dual molecules through an electrostatic self-assembly was first described.A series of tubes with tunable diameters were initially fabricated by a coaxial extrusion printing method with customized nozzles,in which a polyelectrolyte ink containing of ε-polylysine and sodium alginate was used.Further,dual bioactive molecules,heparin with negative charges and Tyr-Ile-Gly-Ser-Arg(YIGSR)peptide with positive charges were layer-by-layer assembled onto the surface of these 3D-printed tubes.Due to the electrostatic interaction,the sequential release of heparin and YIGSR was demonstrated and could construct a dynamic microenvironment that was thus conducive to the antithrombogenicity and endothelialization.This study opens a new avenue to fabricate a small-diameter vascular graft with a biologically inspired release system based on electrostatic interaction,revealing a huge potential for development of small-diameter artificial vascular grafts with good patency. | Zhiwen Zeng Chengshen Hu Qingfei Liang Lan Tang Delin Cheng Changshun Ruan | 2021 | Bioactive Materials2021，6，6： | 3 |
| 7 | Aptamers evolved from live cells as effective molecular probes for cancer study显示文摘 | SHANGGUAN Dihua LI Ying TANG Zhiwen | 2006 | The National Academy of Sciences of the USA2006，103，11： | 1 |
| 8 | Gold nanoparti- cle-based colorimetric assay for the direct detection of cancerous cells 显示文摘 | Medley CD Smith JE Tang Zhiwen | 2008 | Anal Chem2008，80，4： | 1 |
| 9 | Analyzing three tier C/S application with the LPT algorithm显示文摘 | Chen Zhigang Zeng Zhiwen Tang Xiaolong | 2000 | IEEE Computer Society2000，1，5： | 1 |
| 10 | Tectonic Evolution and Key Geological Issues of the ProtoSouth China Sea显示文摘There are numerous controversies surrounding the tectonic properties and evolution of the Proto-South China Sea(PSCS).By combining data from previously published works with our geological and paleontological observations of the South China Sea(SCS),we propose that the PSCS should be analyzed within two separate contexts:its paleogeographic location and the history of its oceanic crust.With respect to its paleogeographic location,the tectonic properties of the PSCS vary widely from the Triassic to the mid-Late Cretaceous.In the Triassic,the Paleo-Tethys and the Paleo-Pacific Oceans were the major causes of tectonic changes in the SCS,while the PCSC may have been a remnant sea residing upon Tethys or Paleo-Pacific oceanic crust.In the Jurassic,the Meso-Tethys and the Paleo-Pacific oceans joined,creating a PSCS back-arc basin consisting of Meso-Tethys and/or Paleo-Pacific oceanic crust.From the Early Cretaceous to the midLate Cretaceous,the Paleo-Pacific Ocean was the main tectonic body affecting the SCS;the PSCS may have been a marginal sea or a back-arc basin with Paleo-Pacific oceanic crust.With respect to its oceanic crust,due to the subduction and retreat of the Paleo-Pacific plate in Southeast Asia at the end of the Late Cretaceous,the SCS probably produced new oceanic crust,which allowed the PSCS to formally emerge.At this time,the PSCS was most likely a combination of a new marginal sea and a remnant sea;its oceanic crust,which eventually subducted and became extinct,consisted of both new oceanic crust and remnant oceanic crust from the Paleo-Pacific Ocean.In the present day,the remnant PSCS oceanic crust is located in the southwestern Nansha Trough. | TIAN Zhiwen TANG Wu WANG Pujun ZHAO Zhigang SUN Xiaomeng TANG Huafeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 11 | Characteristics of the Density and Magnetic Susceptibility of Rocks in Northern Borneo and their Constraints on the Lithologic Identification of the Mesozoic Rocks in the Southern South China Sea显示文摘Based on the volume magnetic susceptibility and specific gravity measurements and mineral and lithologic identification results for 540 samples,the rock type,density,and magnetic susceptibility of rocks from northern Borneo were analyzed,and the applicability of gravity and magnetic data to the lithologic identification of the Mesozoic strata in the southern South China Sea was assessed accordingly.The results show that there are 3 types and 25 subtypes of rocks in northern Borneo,mainly intermediate-mafic igneous rocks and exogenous clastic sedimentary rocks,with small amounts of endogenous sedimentary rocks,felsic igneous rocks,and metamorphic rocks.The rocks that are very strongly-strongly magnetic and have high-medium densities are mostly igneous rocks,tuffaceous sandstones,and their metamorphic equivalents.The rocks that are weakly magnetic-non-magnetic and have medium-very low densities are mostly conglomerates,sandstones,siltstones,mudstones,and coal.The rocks that are weakly magnetic-diamagnetic and have highmedium densities are mostly limestones and siliceous rocks.The Cenozoic rocks are characterized by low densities and medium susceptibilities;the Mesozoic rocks are characterized by medium densities and medium-high susceptibilities;and the pre-Mesozoic rocks are characterized by high densities and low magnetism.Based on these results and the distribution characteristics of the various rock types,it was found that the pre-Mesozoic rocks produce weak regional gravity anomalies;the Mesozoic sedimentary rocks produce negative regional gravity anomalies;whereas the Mesozoic igneous rocks produce positive regional gravity anomalies;and the Cenozoic igneous rocks produce positive regional gravity anomalies.The regional high magnetic anomalies in the southern part of the South China Sea originate from the Mesozoic mafic igneous rocks and their metamorphic equivalents;and the regional medium magnetic anomalies may be produced by the felsic igneous rocks and their metamorphic equivalents.Accordingly,the identification of the Mesozoic lithology in the southern South China Sea shows that the Mesozoic sedimentary rocks are distributed over a large area of the southern South China Sea.Thus,it is concluded that the Mesozoic strata in this area have the potential for oil and gas exploration. | TANG Huafeng ZHAO Zhigang TIAN Zhiwen LU Baoliang TANG Wu HE Kailun ZHU Chenxi WANG Pujun | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 12 | Underlying mechanism of hemodynamics and intracranial aneurysm显示文摘In modern society,subarachnoid hemorrhage,mostly caused by intracranial aneurysm rupture,is accompanied by high disability and mortality rate,which has become a major threat to human health.Till now,the etiology of intracranial aneurysm has not been entirely clarified.In recent years,more and more studies focus on the relationship between hemodynamics and intracranial aneurysm.Under the physiological condition,the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood vessels.When the blood vessels are stimulated by the continuous abnormal blood flow,the functional structure of the blood vessels changes,which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial aneurysm.This review will focus on the relationship between hemodynamics and intracranial aneurysms,will discuss the mechanism of occurrence and development of intracranial aneurysms,and will provide a new perspective for the research and treatment of intracranial aneurysms. | Haishuang Tang Qingsong Wang Fengfeng Xu Xiaoxi Zhang Zhangwei Zeng Yazhou Yan Zhiwen Lu Gaici Xue Qiao Zuo Yin Luo Jianmin Liu Qinghai Huang | 2022 | Chinese Neurosurgical Journal2022，8，2： | 1 |
| 13 | Real time monitoring of nucleic acids ligation based on molecular beacon显示文摘A novel method has been developed to monitor the nucleic acids ligation process. Molecular beacon was employed here to convert the ligation information into fluo-rescence signal quickly and quantitatively. This method pro-vides effective and original approach to researching the dy-namic ligation process and the interactions between nucleic acids and ligase. An analytical method for T4 DNA ligase based on this way has been built up with a linear detection range from 2.3×10-4 U/mL to 0.23 U/mL. It is rapid and sensitive to detect 2.8×10-5 U T4 DNA ligase in 10 min. | Zhiwen Tang Kemin Wang Weihong Tan Jun Li Lingfeng Liu Qiuping Guo Xiangxian Meng Shasheng Huang Du Li Weifang Luo | 2003 | Chinese Science Bulletin2003，48，12： | 1 |
| 14 | Aptamer switch probe based on intramolecular dis- placement显示文摘 | Tang Zhiwen Mallikaratchy P Yang Ronghua | 2008 | J Am Chem Soc2008，130，11： | 1 |
| 15 | Ultrasensitive monitoring of ribozyme cleavage product using molecular-beacon-ligation system显示文摘This paper reports a new approach to detect ribozyme cleavage product based on the molecular-beacon-ligation system. The molecular beacon, designed in such a way that one-half of its loop is complementary to ribozyme cleavage product, is used to monitor ligation process of RNA/DNA com-plex in a homogeneous solution and to convert directly cleavage product information into fluorescence signal. The method need not label ribozyme and ribozyme substrate, which is fast, simple and ultra-sensitive for detection of cleavage product. Detection limit of the assay is 0.05 nmol/L. The cleavage product of hammerhead ribozyme against hepatitis C virus RNA (HCV-RNA) was detected perfectly based on this assay. Owing to its ultrasensitivity, excellent specificity, convenience and fidelity, this method might hold out great promise in ribozyme reaction and ribozyme gene therapy. | MENG XiangXian TANG ZhiWen WANG KeMin TAN WeiHong YANG XiaoHai LI Jun GUO QiuPing | 2007 | Chinese Science Bulletin2007，52，5： | 1 |
| 16 | Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs显示文摘A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria.Compound 33a(IMBZ18G)is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant(MDR)Gram-negative strains,with a highly druglike nature.The checkerboard assay reveals its significant synergistic effect withβ-lactamase inhibitor avibactam,and the MIC values against MDR enterobacteria were reduced up to 4—512folds.X-ray co-crystal and chemoproteomic assays indicate that the anti-MDR bacteria effect of 33a results from the dual inhibition of the common PBP3 and some class A and Cβ-lactamases.Accordingly,preclinical studies of 33a alone and 33a-avibactam combination as potential innovative candidates are actively going on,in the treatment ofβ-lactamase-producing MDR Gram-negative bacterial infections. | Zhiwen Li Zhihao Guo Xi Lu Xican Ma Xiukun Wang Rui Zhang Xinxin Hu Yanxiang Wang Jing Pang Tianyun Fan Yonghua Liu Sheng Tang Haigen Fu Jingpu Zhang Yinghong Li Xuefu You Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 17 | U-Pb zircon ages and petrogeochemistry and tectonic implications of gabbro and granite in southwest Lahad Datu area of Sabah, Malaysia显示文摘The southwest Lahad Datu felsic rocks were previously thought to have formed in the late Triassic as part of the microcontinental crystalline basement.Based on U-Pb ages,geochemistry,and the Hfisotopes of zircon from the southeastern Sabah gabbro and granite,in this study,the tectonic properties of the Sabah area during the Triassic were investigated.The weighted average U-Pb zircon ages of the gabbro and granite samples were determined to be(230.9±2.5)Ma and(207.1±3.3)Ma,respectively.The granite had SiO_(2) contents of 66.54%-79.47%,low TiO_(2) contents of 0.08%-0.3%,Al_(2)O_(3) contents of 10.97%-16.22%,Na_(2)O contents of 5.91 %-6.39%,and low K_(2)O contents of 0.15%-0.65%.The chondrite-normalized rare earth element(REE) patterns exhibit light REE enrichment,with right-sloping curves.The primitive mantle-normalized trace element spider diagrams exhibit Th,U,La,Sr,and Zr enrichment and Nb,Ta,P and Ti depletions,i.e.,the geochemical characteristics of typical island arc igneous rocks.The tectonic discriminant diagram indicates that the granite is a volcanic arc granite.The Hf isotopic an alysis of gabbro zircon revealed that the zircons have ε_(Hf)(t)values of 12.08-16.24(mean of 14.32) and two-stage model ages(t_(DM2)) of 223-491 Ma(mean of 347 Ma).This indicates that the diagenetic magma of the gabbro was mainly derived from melting of newly formed crustal materials.The ophiolite in southeast Sabah has existed since the early Late Triassic.The crystalline basement granite in southeastern S abah was emplaced lasted from late Triassic to early Cretaceous.Based on previous studies and global plate reconstruction models,it is speculated that the southeastern Sabah granite may have been formed in an island arc setting,i.e.,where the oceanic crust of the Paleo-Tethys Ocean collided with the oceanic crust of the Panthalassa Ocean. | Zhigang Zhao Wu Tang Shixiang Liu Huafeng Tang Pujun Wang Zhiwen Tian | 2024 | Acta Oceanologica Sinica2024，43，2： | 0 |
| 18 | Structures of magnetic null points in reconnection diffusion region:Cluster observations显示文摘Magnetic reconnection is a very important and fundamental plasma process in transferring energy from magnetic field into plasma. Previous theory, numerical simulations and observations mostly concen-trate on 2-dimensional (2D) model; however, magnetic reconnection is a 3-dimensional (3D) nonlinear process in nature. The properties of reconnection in 3D and its associated singular structure have not been resolved completely. Here we investigate the structures and characteristics of null points inside the reconnection diffusion region by introducing the discretized Poincaré index through Gauss integral and using magnetic field data with high resolution from the four satellites of Cluster mission. We esti-mate the velocity and trajectory of null points by calculating its position in different times, and compare and discuss the observations with different reconnection models with null points based on character-istics of electric current around null points. | HU YunHui DENG XiaoHua ZHOU Meng TANG RongXin ZHAO Hui FU Song SU ZhiWen WANG JingFang YUAN ZhiGang R. NAKAMURA W. BAUMJOHANN H. REME C. M. CARR | 2008 | Chinese Science Bulletin2008，53，12： | 0 |
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