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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | mm Wave communications for 5G: implementation challenges and advances显示文摘The requirement of the fifth generation(5 G) wireless communication for high throughput motivates the wireless industry to use the mm Wave(millimeter wave) communications for its wide bandwidth advantage. To compensate the heavy path loss and increase the communications capacity, phased array beamforming and massive multiple-input multiple-output(MIMO) techniques are employed at both the user equipment(UE) and base stations(BS). Considering the commercial requirements, 5 G mm Wave large array systems should be implemented in an energy-and cost-efficient way with a small form factor. To address above issues and realize a reliable communications link, taking into account the particular characteristics of5 G mm Wave systems, this paper firstly examines the design challenges and trade-offs in system implementations, then some of the design strategies are summarized. At last, recent advance in RF front-end circuits and receiver sub-systems is then highlighted. | Lianming LI Dongming WANG Xiaokang NIU Yuan CHAI Linhui CHEN Long HE Xu WU Fuchun ZHENG Tiejun CUI Xiaohu YOU | 2018 | Science China(Information Sciences)2018，61，2： | 19 |
| 3 | Effects of dietary protein restriction on muscle fiber characteristics and m TORC1 pathway in the skeletal muscle of growing-finishing pigs显示文摘Background: To investigate the effects of dietary crude protein(CP) restriction on muscle fiber characteristics and key regulators related to protein deposition in skeletal muscle, a total of 18 growing-finishing pigs(62.30 ± 0.88 kg)were allotted to 3 groups and fed with the recommended adequate protein(AP, 16 % CP) diet, moderately restricted protein(MP, 13 % CP) diet and low protein(LP, 10 % CP) diet, respectively. The skeletal muscle of different locations in pigs, including longissimus dorsi muscle(LDM), psoas major muscle(PMM) and biceps femoris muscle(BFM) were collected and analyzed.Results: Results showed that growing-finishing pigs fed the MP or AP diet improved(P < 0.01) the average daily gain and feed: gain ratio compared with those fed the LP diet, and the MP diet tended to increase(P = 0.09) the weight of LDM. Moreover, the ATP content and energy charge value were varied among muscle samples from different locations of pigs fed the reduced protein diets. We also observed that pigs fed the MP diet up-regulated(P < 0.05) muscular m RNA expression of all the selected key genes, except that myosin heavy chain(My HC) IIb,My HC IIx, while m RNA expression of ubiquitin ligases genes was not affected by dietary CP level. Additionally, the activation of mammalian target of rapamycin complex 1(m TORC1) pathway was stimulated(P < 0.05) in skeletal muscle of the pigs fed the MP or AP diet compared with those fed the LP diet.Conclusion: The results suggest that the pigs fed the MP diet could catch up to the growth performance and the LDM weight of the pigs fed the AP diet, and the underlying mechanism may be partly due to the alteration in energy status, modulation of muscle fiber characteristics and m TORC1 activation as well as its downstream effectors in skeletal muscle of different locations in growing-finishing pigs. | Yinghui Li Fengna Li Li Wu Hongkui Wei Yingying Liu Tiejun Li Bie Tan Xiangfeng Kong Kang Yao Shuai Chen Fei Wu Yehui Duan Yulong Yin | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 13 |
| 4 | Aflatoxin B1, zearalenone and deoxynivalenol in feed ingredients and complete feed from different Province in China显示文摘Background: The current study was carried out to provide a reference for monitory of aflatoxin B_1(AFB_1),zearalenone(ZEN) and deoxynivalenol(DON) contamination in feed ingredients and complete feeds were collected from different Province in China from 2013 to 2015.Methods: A total of 443 feed ingredients, including 220 corn, 24 wheat, 24 domestic distillers dried grains with soluble(DDGS), 55 bran, 20 wheat shorts and red dog, 37 imported DDGS, 34 corn germ meal and 29 soybean meal as well as 127 complete feeds including 25 pig complete feed(powder), 90 pig complete feed(pellet), six duck complete feed and six cattle complete feed were randomly collected from different Province in China,respectively, by high-performance chromatography in combined with UV or fluorescence analysis.Results: The incidence rates of AFB_1, ZEN and DON contamination of feed ingredients and complete feeds were80.8, 92.3 and 93.9 %, respectively. The percentage of positive samples for DON ranged from 66.7 to 100 %.Domestic DDGS and imported DDGS presented the most serious contamination AFB_1, ZEN and DON contamination levels of feeds ranged from 61.5 to 100 %, indicated that serious contamination over the studied 3-year period.Conclusion: The current data provide clear evidence that AFB_1, ZEN and DON contamination of feed ingredients and complete feeds in different Province in China is serious and differs over past 3-year. The use of corn, domestic DDGS, imported DDGS and corn germ meal, which may be contaminated with these three mycotoxins, as animal feed may triggered a health risk for animal. Feeds are most contaminated with DON followed by ZEN and AFB_1.Mycotoxins contamination in feed ingredients and complete feeds should be monitored routinely in China. | Li Wu Jianjun Li Yunhu Li Tiejun Li Qinghua He Yulong Tang Hongnan Liu Yongteng Su Yulong Yin Peng Liao | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 13 |
| 5 | Synthesis and Performance of Polyurethane Coated Urea as Slow/controlled Release Fertilizer显示文摘Polyurethane coated urea slow/controlled release fertilizer was prepared based on urea granules, isocyanate, polyols and paraffin. Isocyanate reacted with polyols to synthesize the polyurethane skin layer on urea granules surface. Paraffin serves as a lubricant during syntheses of polyurethane skin layers. The structure and nutrient release characteristics of the polyurethane skin layers were investigated by FTIR, SEM and TG. Urea nitrogen slow-release behavior of the polyurethane coated urea was tested. The experimental results indicated that compact and dense polyurethane skin layers with a thickness of 10-15 μm were formed on urea surface, the urea nitrogen slow-release time can reach 40-50 days. Paraffin proves to play a key role in inhibiting water to penetrate into urea, but excessive addition would decrease the polyurethane crosslinking density. | 李青山 WU Shu RU Tiejun 王利民 XING Guangzhong WANG Jinming | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 10 |
| 6 | Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars显示文摘Several potential oxidative agents have damaging effects on mammalian reproductive systems.This study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated boars.Glu and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone levels.Furthermore,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu.Glu and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and epididymis.These results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress. | Wenjie Tang Jian Wu Shunshun Jin Liuqin He Qinlu Lin Feijun Luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 7 | Effect of Exposure to Trace Elements in the Soil on the Prevalence of Neural Tube Defects in a High-Risk Area of China显示文摘Objective Our objective is to build a model that explains the association between the exposure to trace elements in the soil and the risk of neural tube defects. Methods We built a function with different parameters to describe the effects of trace elements on neural tube defects. The association between neural tube defects and trace element levels was transformed into an optimization problem using the maximum likelihood method. Results Tin, lead, nickel, iron, copper, and aluminum had typical layered effects (dosage effects) on the prevalence of neural tube defects. Arsenic, selenium, zinc, strontium, and vanadium had no effect, and molybdenum had one threshold value that affected the prevalence of birth defects. Conclusion As an exploratory research work, our model can be used to determine the direction of the effect of the trace element content of cultivated soil on the risk of neural tube defects, which shows the clues by the dosage effect of their toxicological characteristics. Based on our findings, future biogeochemical research should focus on the direct effects of trace elements on human health. | HUANG Jing WU JiLei LI TieJun SONG XinMing ZHANG BingZi ZHANG PingWen ZHENG XiaoYing | 2011 | Biomedical and Environmental Sciences2011，24，2： | 9 |
| 8 | Ethical Principles and Governance Technology Development of AI in China显示文摘Ethics and governance are vital to the healthy and sustainable development of artificial intelligence(AI).With the long-term goal of keeping AI beneficial to human society,governments,research organizations,and companies in China have published ethical guidelines and principles for AI,and have launched projects to develop AI governance technologies.This paper presents a survey of these efforts and highlights the preliminary outcomes in China.It also describes the major research challenges in AI governance research and discusses future research directions. | Wenjun Wu Tiejun Huang Ke Gong | 2020 | Engineering2020，6，3： | 8 |
| 9 | Advances in direct production of value-added chemicals via syngas conversion显示文摘Syngas conversion to fuels and chemicals is one of the most challenging subjects in the field of C1 chemistry. It is considered as an attractive alternative non-petroleum-based production route. The direct synthesis of olefins and alcohols as high value-added chemicals from syngas has drawn particular attention due to its process simplicity, low energy consumption and clean utilization of carbon resource, which conforms to the principles of green carbon science. This review describes the recent advances for the direct production of lower olefins and higher alcohols via syngas conversion. Recent progress in the development of new catalyst systems for enhanced catalytic performance is highlighted. We also give recommendations regarding major challenges for further research in syngas conversion to various chemicals. | Yunlei An Tiejun Lin Fei Yu Yanzhang Yang Liangshu Zhong Minghong Wu Yuhan Sun | 2017 | Science China Chemistry2017，60，7： | 8 |
| 10 | Enhanced thermoelectric performance of n-type bismuth-telluridebased alloys via In alloying and hot deformation for mid-temperature power generation显示文摘Bismuth telluride-based alloys are the most widely used commercial thermoelectric(TE)material for room temperature refrigeration.Here,we successfully shift up the optimum figure of merit of n-type bismuth-telluride-based TE materials for mid-temperature power generation.SbI_(3)doping is used to regulate the carrier concentration and Indium alloying to increase the bandgap,suppressing the detrimental bipolar conduction in the mid-temperature range.The lattice thermal conductivity is significantly reduced due to the multiscale microstructures induced via hot deformation.As a result,a peak zT of~1.1 was attained at 625 K for Bi_(1.85)In_(0.15)Te_(2)Se+0.25 wt%SbI_(3)alloy after hot deformation,showing a great application prospect of this alloy in mid-temperature TE power generation. | Feng Li Renshuang Zhai Yehao Wu Zhaojun Xu Xinbing Zhao Tiejun Zhu | 2018 | Journal of Materiomics2018，4，3： | 5 |
| 11 | Broadband transmission-type 1-bit coding metasurface for electromagnetic beam forming and scanning显示文摘Coding metasurfaces make it possible to manipulate electromagnetic(EM)waves digitally by means of several discrete particles.Hence,there have been rapid advances in this field recently.Here we propose a novel design of a broadband transmission-type coding metasurface,which is valid to both x-and y-polarized EM incidences from 8.1-12.5 GHz while satisfies the requirements of 1-bit coding without changing the polarization.Two types of multi-layer coding particles with different geometrical parameters are adopted to represent the digital states'0'and'1',which are easily promoted to terahertz and optics through modifying the size scale.To verify the ability to manipulate the EM waves,we first adopt the coding metasurface to achieve broadband beam forming by converting spherical waves to plane waves and realize high-directivity pencil beam in far field with low side lobes.We further arrange the particles according to the coding sequence 010101…to steer two symmetrical beams in different directions controlled by frequencies with the maximum range of the scanning angle of 30°-50.5°.The good agreements between the simulated and measured results validate the proposed broadband coding metasurface,indicating its huge potential in communication and radar imaging systems. | RuiYuan Wu Lei Bao LiangWei Wu TieJun Cui | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，8： | 5 |
| 12 | Sensor fault diagnosis of nonlinear processes based on structured kernel principal component analysis显示文摘A new sensor fault diagnosis method based on structured kernel principal component analysis (KPCA) is proposed for nonlinear processes. By performing KPCA on subsets of variables, a set of structured residuals, i.e., scaled powers of KPCA, can be obtained in the same way as partial PCA. The structured residuals are utilized in composing an isolation scheme for sensor fault diagnosis, according to a properly designed incidence matrix. Sensor fault sensitivity and critical sensitivity are defined, based on which an incidence matrix optimization algorithm is proposed to improve the performance of the structured KPCA. The effectiveness of the proposed method is demonstrated on the simulated continuous stirred tank reactor (CSTR) process. | Kechang FU Liankui DAI Tiejun WU Ming ZHU | 2009 | 控制理论与应用(英文版)2009，7，3： | 5 |
| 13 | Study on traveling magnetic field casting of sheet components显示文摘The distribution of a magnetic field over an inductor used for sheet castings has been investigated experimentally.With an increase in height from the surface, the magnetic field density decreases according to the exponential law.In the transverse direction, the magnetic field density is approximately uniform except near the edges.The magnetic field density is direct proportional to the number of turns multiplied by the current in amperes.Ferro-magnetic material in the upper mould can enhance the magnetic field density.Under the electromagnetic force, the mould-filling process of sheet casings has been studied by physical simulation method.The difference in filling capability between gravity casting and travelling magnetic field casting has been studied.The electromagnetic force can enhance the filling process, but it also brings a problem.With an increase in the magnetic field density, the surface quality of the aluminum alloy sheet castings becomes poor.The reason is discussed. | Su Yanqing Xu Yanjin Zhao Lei Zhang Tiejun Wu Shiping Guo Jingjie | 2010 | China Foundry2010，7，3： | 3 |
| 14 | Decentralized adaptive iterative learning control for interconnected systems with uncertainties显示文摘In many applications,the system dynamics allows the decomposition into lower dimensional subsystems with interconnections among them.This decomposition is motivated by the ease and flexibility of the controller design for each subsystem.In this paper,a decentralized model reference adaptive iterative learning control scheme is developed for interconnected systems with model uncertainties.The interconnections in the dynamic equations of each subsystem are considered with unknown boundaries.The proposed controller of each subsystem depends only on local state variables without any information exchange with other subsystems.The adaptive parameters are updated along iteration axis to compensate the interconnections among subsystems.It is shown that by using the proposed decentralized controller,the states of the subsystems can track the desired reference model states iteratively.Simulation results demonstrate that,utilizing the proposed adaptive controller,the tracking error for each subsystem converges along the iteration axis. | Lili SUN Tiejun WU | 2012 | 控制理论与应用(英文版)2012，10，4： | 2 |
| 15 | Permanence and almost periodic solution of a predator-prey discrete system with Holling IV functional response显示文摘 | Tiejun Zhou Xiaolan Zhang Meihong Xiang Zhaohua Wu | 2016 | International Journal of Biomathematics2016，9，3： | 2 |
| 16 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 17 | Reduced dietary nitrogen with a high Lys:CP ratio restricted dietary N excretion without negatively affecting weaned piglets显示文摘We hypothesized that balancing the content of exogenous amino acids, especially lysine, to reduce protein content in swine diets could reduce nitrogen(N) pollution associated with animal husbandry. Two experiments(45 d each experiment) were performed on weaned piglets(Duroc x Landrace x Yorkshire,28 d of age) to test this and to determine the optimal lysine to crude protein(Lys:CP) ratio in diet. In Exp. 1,12 piglets(6 replicates [n = 6]) were fed diets containing different levels of CP(17% and 20%) but the same level of Lys, Increased CP content resulted in significant increases(P < 0.05) of average daily gain(ADG), average daily feed intake(ADFI), and body weight(BW);but did not affect the feed to gain ratio. In Exp. 2,24 piglets(8 replicates [n = 8]) were fed 1 of 3 diets as follows: 1) 20% CP with a regular Lys:CP ratio(6.23%, control);2) 17% CP with a reduced Lys:CP ratio(6.14%, LL);or 3) 17% CP with a standard Lys:CP ratio(7.32%, SL). The ADG, final BW, serum concentrations of growth hormone and insulin-like growth factor-1, villus height in the jejunum, and villus height to crypt depth ratio were the lowest in piglets fed LL diet, whereas blood urea N concentration was the lowest and the value of lipase activity was the highest in the piglets fed SL diet. The SL diet did not affect growth performance,intestinal morphology, or serum hormone concentrations, indicating that reduced dietary N with a high Lys:CP ratio can efficiently reduce dietary N excretion without negatively affecting weaned piglets. | Hongnan Liu Li Wu Hui Han Yuying Li Lijian Wang Jie Yin Wenjun Fan Miaomiao Bai Jiming Yao Xingguo Huang Tiejun Li | 2019 | Animal Nutrition2019，，2： | 2 |
| 18 | A fusion–fission hybrid reactor with water-cooled pressure tube blanket for energy production显示文摘 | Hongchun Wu Tiejun Zu Suizheng Qiu Xinli Gao Youqi Zheng Liangzhi Cao Wenxi Tian | 2012 | Progress in Nuclear Energy2012，，： | 1 |
| 19 | Local heat transfer measurements of steam/air mixtures in horizontal condenser tubes显示文摘 | Tiejun Wu Karen Vierow | | 0，，49： | 1 |
| 20 | Local heat transfer measurements of steam/air mixtures in horizontal condenser tubes 显示文摘 | Wu Tiejun Vierow Karen | 2009 | InternationalJournal of Heat and Mass Transfer2009，49，： | 1 |
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